{"id":"https://openalex.org/W2086495248","doi":"https://doi.org/10.1089/ten.tea.2008.0628","title":"Expansion and Redifferentiation of Chondrocytes from Osteoarthritic Cartilage: Cells for Human Cartilage Tissue Engineering","display_name":"Expansion and Redifferentiation of Chondrocytes from Osteoarthritic Cartilage: Cells for Human Cartilage Tissue Engineering","publication_year":2009,"publication_date":"2009-05-20","ids":{"openalex":"https://openalex.org/W2086495248","doi":"https://doi.org/10.1089/ten.tea.2008.0628","mag":"2086495248","pmid":"https://pubmed.ncbi.nlm.nih.gov/19456239","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792054"},"language":"en","primary_location":{"id":"doi:10.1089/ten.tea.2008.0628","doi":"https://doi.org/10.1089/ten.tea.2008.0628","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2008.0628","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085252027","display_name":"Nancy D. Hsieh-Bonassera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy D. Hsieh-Bonassera","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, University of California\u2013San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of California\u2013San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Iwen Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iwen Wu","raw_affiliation_strings":["Department of Bioengineering, University of California\u2013San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California\u2013San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001004872","display_name":"Jonathan K. Lin","orcid":"https://orcid.org/0000-0001-6295-2304","observed_orcids":["https://orcid.org/0000-0001-6295-2304"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan K. Lin","raw_affiliation_strings":["Department of Bioengineering, University of California\u2013San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California\u2013San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111791589","display_name":"Barbara L. Schumacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara L. Schumacher","raw_affiliation_strings":["Department of Bioengineering, University of California\u2013San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California\u2013San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101924251","display_name":"Albert C. Chen","orcid":"https://orcid.org/0000-0002-0953-3992","observed_orcids":["https://orcid.org/0000-0002-0953-3992"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert C. Chen","raw_affiliation_strings":["Department of Bioengineering, University of California\u2013San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California\u2013San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000662848","display_name":"Koichi Masuda","orcid":"https://orcid.org/0000-0002-5361-4415","observed_orcids":["https://orcid.org/0000-0002-5361-4415"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koichi Masuda","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California\u2013San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California\u2013San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026308037","display_name":"William D. Bugbee","orcid":"https://orcid.org/0000-0002-4250-6849","observed_orcids":["https://orcid.org/0000-0002-4250-6849"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D. Bugbee","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California\u2013San Diego, La Jolla, California","Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California\u2013San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026261610","display_name":"Robert L. Sah","orcid":"https://orcid.org/0000-0002-5493-9502","observed_orcids":["https://orcid.org/0000-0002-5493-9502"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert L. Sah","raw_affiliation_strings":["Department of Bioengineering, University of California\u2013San Diego, La Jolla, California","Institute of Engineering in Medicine, University of California\u2013San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California\u2013San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institute of Engineering in Medicine, University of California\u2013San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026261610"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":3.8189,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.93013632,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"11","first_page":"3513","last_page":"3523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9390000104904175},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cartilage-tissue-engineering","display_name":"cartilage tissue engineering","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chondrocyte-expansion","display_name":"chondrocyte expansion","score":0.9039999842643738},{"id":"https://openalex.org/keywords/chondrocyte-redifferentiation","display_name":"chondrocyte redifferentiation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/alginate-bead-culture","display_name":"alginate bead culture","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.890999972820282},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.9670000076293945},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9729999899864197},{"id":"https://openalex.org/keywords/growth-factor-supplementation","display_name":"growth factor supplementation","score":0.5609999895095825},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.6430000066757202},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cartilage-defects","display_name":"cartilage defects","score":0.7160000205039978},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7717040777206421},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.593376636505127},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5814388394355774},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5595904588699341},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.5275779962539673},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5067487359046936},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.4858081340789795},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46243560314178467},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.44659489393234253},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.43618714809417725},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.4109903573989868},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.22508841753005981},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20505687594413757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1942504644393921},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.18610849976539612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1773538887500763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12378710508346558},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.09851804375648499},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/ten.tea.2008.0628","doi":"https://doi.org/10.1089/ten.tea.2008.0628","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tea.2008.0628","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2023434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792054","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2792054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792054","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part A","raw_type":"Text"},{"id":"pmid:19456239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19456239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part A","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2023434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792054","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1039064104","display_name":"Studies of Joint Aging and Osteoarthritis","funder_award_id":"P01AG007996","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6848186632","display_name":"Cartilage Integration: in Vitro to In Vivo Translation","funder_award_id":"R21EB004905","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8787437337","display_name":"Bioengineering the Maturation, Size and Shape of Articular Cartilage Grafts","funder_award_id":"R01AR044058","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W130920127","https://openalex.org/W1482679004","https://openalex.org/W1551310212","https://openalex.org/W1561858686","https://openalex.org/W1569612555","https://openalex.org/W1954624720","https://openalex.org/W1967269017","https://openalex.org/W1967723211","https://openalex.org/W1974694084","https://openalex.org/W1981437490","https://openalex.org/W1981935743","https://openalex.org/W1985606434","https://openalex.org/W1988592246","https://openalex.org/W1992750250","https://openalex.org/W1994578076","https://openalex.org/W1996584907","https://openalex.org/W2002963723","https://openalex.org/W2009824273","https://openalex.org/W2011693143","https://openalex.org/W2015906081","https://openalex.org/W2020280102","https://openalex.org/W2029499881","https://openalex.org/W2036545517","https://openalex.org/W2037178326","https://openalex.org/W2038243239","https://openalex.org/W2039488563","https://openalex.org/W2039655817","https://openalex.org/W2042511089","https://openalex.org/W2049049871","https://openalex.org/W2051970854","https://openalex.org/W2059551184","https://openalex.org/W2065516502","https://openalex.org/W2065824624","https://openalex.org/W2070655637","https://openalex.org/W2088824573","https://openalex.org/W2094955354","https://openalex.org/W2097399478","https://openalex.org/W2098982723","https://openalex.org/W2104043422","https://openalex.org/W2105367621","https://openalex.org/W2107400599","https://openalex.org/W2108790008","https://openalex.org/W2121155300","https://openalex.org/W2122883560","https://openalex.org/W2125361012","https://openalex.org/W2129083253","https://openalex.org/W2147512399","https://openalex.org/W2154822388","https://openalex.org/W2162515752","https://openalex.org/W2168221175","https://openalex.org/W2236789517","https://openalex.org/W2334047224"],"related_works":["https://openalex.org/W2996353495","https://openalex.org/W7171427203","https://openalex.org/W2997867771","https://openalex.org/W1561858686","https://openalex.org/W2566081975","https://openalex.org/W1968298531","https://openalex.org/W4207040237","https://openalex.org/W2161887455","https://openalex.org/W2090918566","https://openalex.org/W2066221839"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2,44],"if":[3],"selected":[4],"culture":[5,146],"conditions":[6,131],"enhance":[7],"the":[8,45],"expansion":[9,52,202],"and":[10,55,73,84,89,93,113,134,155,166,178,203],"redifferentiation":[11,58,160],"of":[12,24,28,47,75,129,172,184],"chondrocytes":[13],"isolated":[14,37],"from":[15,38,69,82,193],"human":[16,148,173],"osteoarthritic":[17,39,194],"cartilage":[18,30,40,195,218],"with":[19,147,163,187],"yields":[20],"appropriate":[21],"for":[22,26,216],"creation":[23],"constructs":[25],"treatment":[27],"joint-scale":[29,217],"defects,":[31],"damage,":[32],"or":[33,99,150,180],"osteoarthritis.":[34],"METHODS:":[35],"Chondrocytes":[36,192],"were":[41,175],"analyzed":[42],"to":[43,126,199],"effects":[46],"medium":[48],"supplement":[49],"on":[50],"cell":[51,57,66,119,135,214],"in":[53,59,122],"monolayer":[54,123],"then":[56,204],"alginate":[60,144],"beads.":[61],"Expansion":[62],"was":[63,79,124,161],"assessed":[64],"as":[65,212],"number":[67,136],"estimated":[68],"DNA,":[70],"growth":[71,101,106,110,115,120,152],"rate,":[72],"day":[74],"maximal":[76],"growth.":[77],"Redifferentiation":[78],"evaluated":[80],"quantitatively":[81],"proteoglycan":[83,165],"collagen":[85,167],"type":[86,117,168],"II":[87,169],"content,":[88],"qualitatively":[90],"by":[91],"histology":[92],"immunohistochemistry.":[94],"RESULTS:":[95],"Using":[96],"either":[97],"serum":[98,149,158,174],"a":[100,213],"factor":[102,107,111,116,153],"cocktail":[103],"(TFP:":[104],"transforming":[105,151],"beta1,":[108],"fibroblast":[109],"2,":[112],"platelet-derived":[114],"bb),":[118],"rate":[121],"increased":[125,137,164],"5.5x":[127],"that":[128,207],"corresponding":[130],"without":[132],"TFP,":[133],"100-fold":[138,201],"within":[139],"17":[140],"days.":[141],"In":[142],"subsequent":[143],"bead":[145],"beta1":[154],"insulin-transferrin-selenium-linoleic":[156],"acid-bovine":[157],"albumin,":[159],"enhanced":[162],"production.":[170],"Effects":[171],"dose":[176],"dependent,":[177],"5%":[179],"higher":[181],"induced":[182],"formation":[183],"chondron-like":[185],"structures":[186],"abundant":[188],"proteoglycan-rich":[189],"matrix.":[190],"CONCLUSION:":[191],"can":[196],"be":[197,210],"stimulated":[198],"undergo":[200],"redifferentiation,":[205],"suggesting":[206],"they":[208],"may":[209],"useful":[211],"source":[215],"tissue":[219],"engineering.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
