{"id":"https://openalex.org/W2086483797","doi":"https://doi.org/10.1247/csf.28.495","title":"Searching for Genes Involved in Arteriosclerosis: Proteomic Analysis of Cultured Human Umbilical Vein Endothelial Cells Undergoing Replicative Senescence","display_name":"Searching for Genes Involved in Arteriosclerosis: Proteomic Analysis of Cultured Human Umbilical Vein Endothelial Cells Undergoing Replicative Senescence","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2086483797","doi":"https://doi.org/10.1247/csf.28.495","mag":"2086483797","pmid":"https://pubmed.ncbi.nlm.nih.gov/15004419"},"language":"en","primary_location":{"id":"doi:10.1247/csf.28.495","doi":"https://doi.org/10.1247/csf.28.495","is_oa":true,"landing_page_url":"https://doi.org/10.1247/csf.28.495","pdf_url":"https://www.jstage.jst.go.jp/article/csf/28/6/28_6_495/_pdf","source":{"id":"https://openalex.org/S89337528","display_name":"Cell Structure and Function","issn_l":"0386-7196","issn":["0386-7196","1347-3700"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313151","host_organization_name":"Japan Society of Cell Biology","host_organization_lineage":["https://openalex.org/P4310313151"],"host_organization_lineage_names":["Japan Society of Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Structure and Function","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/csf/28/6/28_6_495/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086960288","display_name":"Hiroki Kamino","orcid":"https://orcid.org/0000-0002-2489-0453","observed_orcids":["https://orcid.org/0000-0002-2489-0453"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Kamino","raw_affiliation_strings":["Department of Molecular and Cell Genetics, Graduate School of Medical Science, Tottori University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Genetics, Graduate School of Medical Science, Tottori University","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108563415","display_name":"Masaharu Hiratsuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaharu Hiratsuka","raw_affiliation_strings":["Department of Human Genome Science (Kirin Brewery), Graduate School of Medical Science, Tottori University","Department of Molecular and Cell Genetics, Graduate School of Medical Science, Tottori University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genome Science (Kirin Brewery), Graduate School of Medical Science, Tottori University","institution_ids":["https://openalex.org/I4588055"]},{"raw_affiliation_string":"Department of Molecular and Cell Genetics, Graduate School of Medical Science, Tottori University","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113999756","display_name":"Tosifusa Toda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tosifusa Toda","raw_affiliation_strings":["Proteomics Collaboration Research Group, Tokyo Metropolitan Institute of Gerontology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Collaboration Research Group, Tokyo Metropolitan Institute of Gerontology","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027235482","display_name":"Ryuichi Nishigaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuichi Nishigaki","raw_affiliation_strings":["Department of Human Genome Science (Kirin Brewery), Graduate School of Medical Science, Tottori University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genome Science (Kirin Brewery), Graduate School of Medical Science, Tottori University","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033310099","display_name":"Mitsuhiko Osaki","orcid":"https://orcid.org/0009-0002-5202-1543","observed_orcids":["https://orcid.org/0009-0002-5202-1543"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiko Osaki","raw_affiliation_strings":["Department of Biomedical Science, Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University","Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University","institution_ids":["https://openalex.org/I4588055"]},{"raw_affiliation_string":"Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103275712","display_name":"Hisao Ito","orcid":"https://orcid.org/0009-0003-0326-903X","observed_orcids":["https://orcid.org/0009-0003-0326-903X"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisao Ito","raw_affiliation_strings":["Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110087573","display_name":"Toshiaki Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Inoue","raw_affiliation_strings":["Department of Human Genome Science (Kirin Brewery), Graduate School of Medical Science, Tottori University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genome Science (Kirin Brewery), Graduate School of Medical Science, Tottori University","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108409966","display_name":"Mitsuo Oshimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuo Oshimura","raw_affiliation_strings":["Department of Biomedical Science, Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University","institution_ids":["https://openalex.org/I4588055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":100000,"currency":"JPY","value_usd":753},"apc_paid":null,"fwci":0.7552,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.63859776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"6","first_page":"495","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arteriosclerosis","display_name":"arteriosclerosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.968999981880188},{"id":"https://openalex.org/keywords/endothelial-senescence","display_name":"endothelial cell senescence","score":0.847000002861023},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.8650000095367432},{"id":"https://openalex.org/keywords/senescence-associated-proteins","display_name":"senescence-associated proteins","score":0.6809999942779541},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cytoskeletal-proteins","display_name":"cytoskeletal proteins","score":0.9229999780654907},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.597000002861023},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7870230674743652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6825113296508789},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.6644769906997681},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6254302859306335},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5576305389404297},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33690309524536133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32534468173980713},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18339058756828308},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16702115535736084}],"mesh":[{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056649","descriptor_name":"Cathepsin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1247/csf.28.495","doi":"https://doi.org/10.1247/csf.28.495","is_oa":true,"landing_page_url":"https://doi.org/10.1247/csf.28.495","pdf_url":"https://www.jstage.jst.go.jp/article/csf/28/6/28_6_495/_pdf","source":{"id":"https://openalex.org/S89337528","display_name":"Cell Structure and Function","issn_l":"0386-7196","issn":["0386-7196","1347-3700"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313151","host_organization_name":"Japan Society of Cell Biology","host_organization_lineage":["https://openalex.org/P4310313151"],"host_organization_lineage_names":["Japan Society of Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Structure and Function","raw_type":"journal-article"},{"id":"pmid:15004419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15004419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell structure and function","raw_type":"Journal Article"},{"id":"pmh:oai:repository.lib.tottori-u.ac.jp:4175","doi":null,"is_oa":false,"landing_page_url":"http://repository.lib.tottori-u.ac.jp/4175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400575","display_name":"Tottori University research result repository (Tottori University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4588055","host_organization_name":"Tottori University","host_organization_lineage":["https://openalex.org/I4588055"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1247/csf.28.495","doi":"https://doi.org/10.1247/csf.28.495","is_oa":true,"landing_page_url":"https://doi.org/10.1247/csf.28.495","pdf_url":"https://www.jstage.jst.go.jp/article/csf/28/6/28_6_495/_pdf","source":{"id":"https://openalex.org/S89337528","display_name":"Cell Structure and Function","issn_l":"0386-7196","issn":["0386-7196","1347-3700"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313151","host_organization_name":"Japan Society of Cell Biology","host_organization_lineage":["https://openalex.org/P4310313151"],"host_organization_lineage_names":["Japan Society of Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Structure and Function","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2086483797.pdf","grobid_xml":"https://content.openalex.org/works/W2086483797.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W94842645","https://openalex.org/W1233997596","https://openalex.org/W1479809193","https://openalex.org/W1492654684","https://openalex.org/W1493971026","https://openalex.org/W1967536667","https://openalex.org/W1970926420","https://openalex.org/W1977600524","https://openalex.org/W1982950140","https://openalex.org/W1988665275","https://openalex.org/W1988757615","https://openalex.org/W2011482325","https://openalex.org/W2014807848","https://openalex.org/W2019188838","https://openalex.org/W2024142657","https://openalex.org/W2038689649","https://openalex.org/W2039278502","https://openalex.org/W2040516403","https://openalex.org/W2041855656","https://openalex.org/W2047817578","https://openalex.org/W2056254778","https://openalex.org/W2060231586","https://openalex.org/W2072837560","https://openalex.org/W2075801984","https://openalex.org/W2076382090","https://openalex.org/W2104908670","https://openalex.org/W2108106334","https://openalex.org/W2116941878","https://openalex.org/W2133544300","https://openalex.org/W2162280157","https://openalex.org/W2172157091"],"related_works":["https://openalex.org/W2269312368","https://openalex.org/W1994918016","https://openalex.org/W2004205775","https://openalex.org/W370485077","https://openalex.org/W6996266111","https://openalex.org/W1602150050","https://openalex.org/W2061775959","https://openalex.org/W2092194549","https://openalex.org/W2936555292","https://openalex.org/W2099424788"],"abstract_inverted_index":{"It":[0],"is":[1,163],"known":[2,164],"that":[3],"replicative":[4,59,96,219],"senescence":[5,97,133,220],"of":[6,98,116,129,134,187,192],"endothelium":[7,199],"in":[8,25,45,82,106,125,143,157,168,174,184,198,218,223,226],"vivo":[9],"contributes":[10],"at":[11],"least":[12],"partially":[13],"to":[14,29,40,87,153,165],"age-related":[15],"vascular":[16,227],"disorders":[17],"such":[18],"as":[19,54,85,236],"arteriosclerosis.":[20],"However,":[21],"the":[22,126,185],"genes":[23,43,131],"involved":[24,183,215],"this":[26,33],"process":[27],"remain":[28],"be":[30,154,166,214],"identified.":[31],"In":[32],"study,":[34],"we":[35,73],"employed":[36],"a":[37,140,207],"proteomics-based":[38,208],"approach":[39,209],"identify":[41],"candidate":[42],"using":[44,70,110,210],"vitro":[46],"cultured":[47,211],"human":[48,100],"umbilical":[49],"vein":[50],"endothelial":[51,228],"cells":[52,229],"(HUVECs)":[53],"an":[55],"experimental":[56],"model":[57],"for":[58,239],"senescence.":[60],"By":[61],"comparing":[62],"protein":[63],"spots":[64],"from":[65],"young":[66,88],"and":[67,78,147,160,181,190,233],"senescent":[68,83,158],"HUVECs":[69,84,159,212],"two-dimensional":[71],"electrophoresis,":[72],"identified":[74,205],"three":[75],"up-regulated":[76,156,167],"proteins":[77,81,180,182,204],"five":[79],"down-regulated":[80],"compared":[86],"HUVECs,":[89],"whose":[90,161,196],"alteration":[91],"was":[92,151,200],"not":[93,216],"observed":[94,152],"during":[95,132],"primary":[99],"fibroblasts.":[101],"Consistent":[102],"results":[103],"were":[104,121,194],"obtained":[105],"Western":[107],"blotting":[108],"analysis":[109],"specific":[111],"antibodies":[112],"raised":[113],"against":[114],"some":[115],"these":[117,130,240],"proteins,":[118,177],"whereas":[119],"there":[120],"no":[122],"significant":[123],"changes":[124],"mRNA":[127],"levels":[128],"HUVECs.":[135],"Among":[136],"them,":[137],"cathepsin":[138],"B,":[139],"protease":[141],"participating":[142],"both":[144],"intracellular":[145],"proteolysis":[146],"extracellular":[148],"matrix":[149],"remodeling":[150],"dramatically":[155],"activity":[162],"atherosclerotic":[169],"lesions":[170],"with":[171,230],"senescence-associated":[172,231],"phenotypes":[173,232],"vivo.":[175],"Additional":[176],"including":[178],"cytoskeletal":[179],"processes":[186],"synthesis,":[188],"turnover":[189],"modification":[191],"protein,":[193],"identified,":[195],"function":[197],"previously":[201],"unsuspected.":[202],"These":[203],"by":[206],"may":[213,234],"only":[217],"but":[221],"also":[222],"functional":[224],"alterations":[225],"serve":[235],"molecular":[237],"markers":[238],"processes.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
