{"id":"https://openalex.org/W2086472923","doi":"https://doi.org/10.2174/1874440001105010105","title":"Loss of Coherence of Low Frequency Fluctuations of BOLD FMRI in Visual Cortex of Healthy Aged Subjects","display_name":"Loss of Coherence of Low Frequency Fluctuations of BOLD FMRI in Visual Cortex of Healthy Aged Subjects","publication_year":2011,"publication_date":"2011-11-04","ids":{"openalex":"https://openalex.org/W2086472923","doi":"https://doi.org/10.2174/1874440001105010105","mag":"2086472923","pmid":"https://pubmed.ncbi.nlm.nih.gov/22216081","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245404"},"language":"en","primary_location":{"id":"doi:10.2174/1874440001105010105","doi":"https://doi.org/10.2174/1874440001105010105","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874440001105010105","pdf_url":"https://openneuroimagingjournal.com/VOLUME/5/PAGE/105/PDF/","source":{"id":"https://openalex.org/S155686663","display_name":"The Open Neuroimaging Journal","issn_l":"1874-4400","issn":["1874-4400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Neuroimaging Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://openneuroimagingjournal.com/VOLUME/5/PAGE/105/PDF/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101881933","display_name":"Lirong Yan","orcid":"https://orcid.org/0000-0002-5173-7059","observed_orcids":["https://orcid.org/0000-0002-5173-7059"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lirong Yan","raw_affiliation_strings":["Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105350252","display_name":"Yan Zhuo","orcid":"https://orcid.org/0000-0002-7806-9898","observed_orcids":["https://orcid.org/0000-0002-7806-9898"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhuo","raw_affiliation_strings":["Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408060","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0002-1310-869X","observed_orcids":["https://orcid.org/0000-0002-1310-869X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Wang","raw_affiliation_strings":["Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China;","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066687350","display_name":"Danny J.J. Wang","orcid":"https://orcid.org/0000-0002-0840-7062","observed_orcids":["https://orcid.org/0000-0002-0840-7062"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Danny J.J Wang","raw_affiliation_strings":["Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066687350"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":1.6823,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.82216479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"05","issue":"1","first_page":"105","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.7919999957084656},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"visual cortex","score":0.7110000252723694},{"id":"https://openalex.org/keywords/low-frequency-fluctuations","display_name":"low-frequency fluctuations","score":0.8759999871253967},{"id":"https://openalex.org/keywords/amplitude-of-low-frequency-fluctuation","display_name":"amplitude of low-frequency fluctuation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/regional-homogeneity","display_name":"regional homogeneity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8500000238418579},{"id":"https://openalex.org/keywords/intra-individual-variability","display_name":"within-person variability","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.7521071434020996},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.7020106315612793},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.604266881942749},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.5783986449241638},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.5505632162094116},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.5439037084579468},{"id":"https://openalex.org/C2780238834","wikidata":"https://www.wikidata.org/wiki/Q796855","display_name":"Blood-oxygen-level dependent","level":3,"score":0.5320701599121094},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48680374026298523},{"id":"https://openalex.org/C2781181686","wikidata":"https://www.wikidata.org/wiki/Q4226068","display_name":"Coherence (philosophical gambling strategy)","level":2,"score":0.44089236855506897},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.43975698947906494},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.4353397488594055},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.4216090440750122},{"id":"https://openalex.org/C26170363","wikidata":"https://www.wikidata.org/wiki/Q1981408","display_name":"Haemodynamic response","level":4,"score":0.41244742274284363},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.3243114650249481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21538183093070984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14090901613235474},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.139472097158432},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.07195672392845154},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2174/1874440001105010105","doi":"https://doi.org/10.2174/1874440001105010105","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874440001105010105","pdf_url":"https://openneuroimagingjournal.com/VOLUME/5/PAGE/105/PDF/","source":{"id":"https://openalex.org/S155686663","display_name":"The Open Neuroimaging Journal","issn_l":"1874-4400","issn":["1874-4400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Neuroimaging Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2258630","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3245404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245404","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Neuroimag J","raw_type":"Text"},{"id":"pmid:22216081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22216081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The open neuroimaging journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.2458","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.2458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ab/8f/Open_Neuroimag_J_2011_Nov_4_5_105-111.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2174/1874440001105010105","doi":"https://doi.org/10.2174/1874440001105010105","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874440001105010105","pdf_url":"https://openneuroimagingjournal.com/VOLUME/5/PAGE/105/PDF/","source":{"id":"https://openalex.org/S155686663","display_name":"The Open Neuroimaging Journal","issn_l":"1874-4400","issn":["1874-4400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Neuroimaging Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7975999712944031,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3830746813","display_name":"UCLA Alzheimer's Disease Research Center","funder_award_id":"P50AG016570","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4491538668","display_name":null,"funder_award_id":"30621004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5108628062","display_name":"\u6ce8\u610f\u7684\u8ba4\u77e5\u673a\u5236\u548c\u795e\u7ecf\u8868\u8fbe\uff0d\u521b\u7acb\u548c\u53d1\u5c55\"\u5927\u8303\u56f4\u9996\u5148\"\u7684\u57fa\u4e8e\u7269\u4f53\u7684\u6ce8\u610f\u7406\u8bba","funder_award_id":"90820307","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2086472923.pdf","grobid_xml":"https://content.openalex.org/works/W2086472923.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1583973342","https://openalex.org/W1688033190","https://openalex.org/W1970695058","https://openalex.org/W1994726732","https://openalex.org/W1998444969","https://openalex.org/W1998475172","https://openalex.org/W2001555513","https://openalex.org/W2003067498","https://openalex.org/W2007213925","https://openalex.org/W2022504317","https://openalex.org/W2036622325","https://openalex.org/W2037417910","https://openalex.org/W2038618926","https://openalex.org/W2049161753","https://openalex.org/W2085954597","https://openalex.org/W2094243598","https://openalex.org/W2095642798","https://openalex.org/W2105220251","https://openalex.org/W2110169236","https://openalex.org/W2113255962","https://openalex.org/W2131867635","https://openalex.org/W2132776439","https://openalex.org/W2134550866","https://openalex.org/W2137026143","https://openalex.org/W2138092999","https://openalex.org/W2144563820","https://openalex.org/W2148842755","https://openalex.org/W2164246240","https://openalex.org/W2413279628"],"related_works":["https://openalex.org/W7098323319","https://openalex.org/W2132776439","https://openalex.org/W2009621566","https://openalex.org/W2354103659","https://openalex.org/W4414237794","https://openalex.org/W4401084259","https://openalex.org/W2607316180","https://openalex.org/W2904577524","https://openalex.org/W2057280125","https://openalex.org/W2154152782"],"abstract_inverted_index":{"Aging":[0],"effects":[1],"on":[2],"blood-oxygen-level-dependent":[3],"(BOLD)":[4],"functional":[5,55,88],"MRI":[6],"(fMRI)":[7],"have":[8],"been":[9],"studied":[10],"using":[11,32],"task":[12,66,173],"induced":[13,67,174],"hemodynamic":[14],"responses":[15],"with":[16,65,153],"controversial":[17],"findings.":[18],"The":[19],"present":[20],"study":[21],"systematically":[22],"investigated":[23],"the":[24,29,71,109,116,130,167],"normal":[25,148],"aging":[26,149],"effect":[27],"in":[28,70,100,138,141,166],"visual":[30,72,168],"cortex":[31,73],"3":[33,59],"indices":[34],"of":[35,39,46,74,77,93,97,112,119,123,155,157,161],"low":[36,47,94,120,158],"frequency":[37,48,95,121,159],"fluctuations":[38,49,96,122,160],"resting":[40,60,162],"state":[41,61,163],"BOLD":[42,68,98,113,124,164,175],"fMRI,":[43],"i.e.,":[44],"amplitude":[45,118],"(ALFF),":[50],"regional":[51,91],"homogeneity":[52,92],"(ReHo)":[53],"and":[54,80,90,115,170,180],"connectivity":[56,89],"(FC).":[57],"These":[58,144],"measurements":[62],"were":[63,136],"compared":[64,104],"activation":[69,114],"2":[75,131],"groups":[76],"10":[78,81],"young":[79,106],"elderly":[82],"subjects.":[83,107,143],"Our":[84],"results":[85],"showed":[86],"reduced":[87],"fMRI":[99,125,165],"aged":[101,142],"subjects":[102],"as":[103],"to":[105],"While":[108],"mean":[110,117],"magnitude":[111],"did":[126],"not":[127],"vary":[128],"between":[129],"age":[132],"groups,":[133],"larger":[134],"variances":[135],"observed":[137],"both":[139],"measures":[140],"data":[145],"suggest":[146],"that":[147],"may":[150,171],"be":[151],"associated":[152],"\"loss":[154],"coherence\"":[156],"cortex,":[169],"affect":[172],"response":[176],"through":[177],"increased":[178],"inter-":[179],"intra-subject":[181],"variability.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}