{"id":"https://openalex.org/W2086453249","doi":"https://doi.org/10.1016/s0006-3495(03)70067-8","title":"Effects of Elevated Extracellular Potassium on the Stimulation Mechanism of Diastolic Cardiac Tissue","display_name":"Effects of Elevated Extracellular Potassium on the Stimulation Mechanism of Diastolic Cardiac Tissue","publication_year":2003,"publication_date":"2003-05-01","ids":{"openalex":"https://openalex.org/W2086453249","doi":"https://doi.org/10.1016/s0006-3495(03)70067-8","mag":"2086453249","pmid":"https://pubmed.ncbi.nlm.nih.gov/12719272","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1302903"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-3495(03)70067-8","doi":"https://doi.org/10.1016/s0006-3495(03)70067-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(03)70067-8","pdf_url":"http://www.cell.com/article/S0006349503700678/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349503700678/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003506688","display_name":"Veniamin Y. Sidorov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veniamin Y. Sidorov","raw_affiliation_strings":["Department of Physics and Astronomy, Vanderbilt Institute for Integrative Biosystems, Research and Education, Nashville, TN 37235-1807, USA","Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee","Vanderbilt Institute for Integrative Biosystems, Research and Education, Vanderbilt University, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, Vanderbilt Institute for Integrative Biosystems, Research and Education, Nashville, TN 37235-1807, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Institute for Integrative Biosystems, Research and Education, Vanderbilt University, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111670357","display_name":"Marcella C. Woods","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcella C. Woods","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027130614","display_name":"John P. Wikswo","orcid":"https://orcid.org/0000-0003-2790-1530","observed_orcids":["https://orcid.org/0000-0003-2790-1530"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John P. Wikswo","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee","Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee","Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee","Vanderbilt Institute for Integrative Biosystems, Research and Education, Vanderbilt University, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Institute for Integrative Biosystems, Research and Education, Vanderbilt University, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027130614"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.0995,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.81842168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"84","issue":"5","first_page":"3470","last_page":"3479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-potassium","display_name":"extracellular potassium","score":0.824999988079071},{"id":"https://openalex.org/keywords/hyperkalemia","display_name":"hyperkalemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/virtual-cathode","display_name":"virtual cathode","score":0.7620000243186951},{"id":"https://openalex.org/keywords/virtual-anode","display_name":"virtual anode","score":0.8930000066757202},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.8085707426071167},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7849135398864746},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.662720799446106},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.6415677666664124},{"id":"https://openalex.org/C2780243291","wikidata":"https://www.wikidata.org/wiki/Q605259","display_name":"Hyperkalemia","level":2,"score":0.6031821966171265},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4994504451751709},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48730170726776123},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.47975027561187744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47180238366127014},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.4287331700325012},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3330113887786865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3304484486579895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18648377060890198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15270644426345825},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002304","descriptor_name":"Cardiac Pacing, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0006-3495(03)70067-8","doi":"https://doi.org/10.1016/s0006-3495(03)70067-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(03)70067-8","pdf_url":"http://www.cell.com/article/S0006349503700678/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1302903","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1302903","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"},{"id":"pmid:12719272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12719272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0006-3495(03)70067-8","doi":"https://doi.org/10.1016/s0006-3495(03)70067-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(03)70067-8","pdf_url":"http://www.cell.com/article/S0006349503700678/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G444256263","display_name":null,"funder_award_id":"R01 HL 58241-05","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4947044436","display_name":"Training in Cardiovascular Research","funder_award_id":"T32HL007411","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G737899393","display_name":"Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism","funder_award_id":"R01HL058241","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2086453249.pdf"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W20548118","https://openalex.org/W574413806","https://openalex.org/W643665271","https://openalex.org/W958783644","https://openalex.org/W1518428823","https://openalex.org/W1597203058","https://openalex.org/W1608100607","https://openalex.org/W1963876002","https://openalex.org/W1970015267","https://openalex.org/W1972673540","https://openalex.org/W1978536974","https://openalex.org/W1981404395","https://openalex.org/W1984336411","https://openalex.org/W1989686259","https://openalex.org/W1996401324","https://openalex.org/W2013302830","https://openalex.org/W2016302489","https://openalex.org/W2020961679","https://openalex.org/W2022751629","https://openalex.org/W2034550379","https://openalex.org/W2052287378","https://openalex.org/W2061285290","https://openalex.org/W2063614586","https://openalex.org/W2080685147","https://openalex.org/W2083432549","https://openalex.org/W2083456832","https://openalex.org/W2089097301","https://openalex.org/W2093217795","https://openalex.org/W2094542138","https://openalex.org/W2097718589","https://openalex.org/W2101283789","https://openalex.org/W2110428402","https://openalex.org/W2114194829","https://openalex.org/W2115783791","https://openalex.org/W2116895717","https://openalex.org/W2142202377","https://openalex.org/W2147203062","https://openalex.org/W2148406640","https://openalex.org/W2153797429","https://openalex.org/W2260369761","https://openalex.org/W2414685349","https://openalex.org/W2428140734","https://openalex.org/W2513891021"],"related_works":["https://openalex.org/W2101964180","https://openalex.org/W2146714262","https://openalex.org/W1972021115","https://openalex.org/W2597817978","https://openalex.org/W2301215191","https://openalex.org/W2144090106","https://openalex.org/W1600265243","https://openalex.org/W2047393098","https://openalex.org/W2212036742","https://openalex.org/W7110505101"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}