{"id":"https://openalex.org/W2086451674","doi":"https://doi.org/10.1016/j.yexmp.2014.05.003","title":"Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells","display_name":"Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells","publication_year":2014,"publication_date":"2014-05-14","ids":{"openalex":"https://openalex.org/W2086451674","doi":"https://doi.org/10.1016/j.yexmp.2014.05.003","mag":"2086451674","pmid":"https://pubmed.ncbi.nlm.nih.gov/24836676"},"language":"en","primary_location":{"id":"doi:10.1016/j.yexmp.2014.05.003","doi":"https://doi.org/10.1016/j.yexmp.2014.05.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yexmp.2014.05.003","pdf_url":null,"source":{"id":"https://openalex.org/S111757857","display_name":"Experimental and Molecular Pathology","issn_l":"0014-4800","issn":["0014-4800","1096-0945"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Molecular Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034965627","display_name":"Taryn L. Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taryn L. Green","raw_affiliation_strings":["Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079735526","display_name":"Mark F. Santos","orcid":"https://orcid.org/0000-0002-6347-8576","observed_orcids":["https://orcid.org/0000-0002-6347-8576"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark F. Santos","raw_affiliation_strings":["Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077329648","display_name":"Ahmed A. Ejaeidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed A. Ejaeidi","raw_affiliation_strings":["Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108575044","display_name":"Barbara S. Craft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara S. Craft","raw_affiliation_strings":["Division of Oncology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072416990","display_name":"Robert E. Lewis","orcid":"https://orcid.org/0000-0002-3616-2971","observed_orcids":["https://orcid.org/0000-0002-3616-2971","https://orcid.org/0009-0005-0177-220X"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Lewis","raw_affiliation_strings":["Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108591334","display_name":"Julius M. Cruse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julius M. Cruse","raw_affiliation_strings":["Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I29606459"],"apc_list":{"value":2640,"currency":"USD","value_usd":2640},"apc_paid":null,"fwci":1.674,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.8344282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"97","issue":"1","first_page":"44","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.18029999732971191,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cytotoxic-cd8-t-cells","display_name":"CD8+ cytotoxic T lymphocytes","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.968999981880188},{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.972000002861023},{"id":"https://openalex.org/keywords/tlr8","display_name":"TLR8","score":1.0},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cd11c","display_name":"CD11c","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6477949619293213},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.6380185484886169},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6033148169517517},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5822305679321289},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5442789196968079},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48017826676368713},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4658986032009125},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4514618217945099},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4447932243347168},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4364761412143707},{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.43149319291114807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4232482612133026},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.422113299369812},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4164890646934509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4014222025871277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16444867849349976},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051200","descriptor_name":"Toll-Like Receptor 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.yexmp.2014.05.003","doi":"https://doi.org/10.1016/j.yexmp.2014.05.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yexmp.2014.05.003","pdf_url":null,"source":{"id":"https://openalex.org/S111757857","display_name":"Experimental and Molecular Pathology","issn_l":"0014-4800","issn":["0014-4800","1096-0945"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Molecular Pathology","raw_type":"journal-article"},{"id":"pmid:24836676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24836676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and molecular pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1520365933","https://openalex.org/W1537143297","https://openalex.org/W1794516118","https://openalex.org/W1970916626","https://openalex.org/W1976478640","https://openalex.org/W1981293666","https://openalex.org/W1983419107","https://openalex.org/W1986178107","https://openalex.org/W1989748451","https://openalex.org/W1991732600","https://openalex.org/W1993065073","https://openalex.org/W1996302215","https://openalex.org/W1996736315","https://openalex.org/W2001740313","https://openalex.org/W2002227642","https://openalex.org/W2003982318","https://openalex.org/W2011567073","https://openalex.org/W2017469353","https://openalex.org/W2025969318","https://openalex.org/W2041836607","https://openalex.org/W2046056065","https://openalex.org/W2046527429","https://openalex.org/W2047573521","https://openalex.org/W2049449911","https://openalex.org/W2052523188","https://openalex.org/W2057419005","https://openalex.org/W2058315838","https://openalex.org/W2061217549","https://openalex.org/W2068025977","https://openalex.org/W2071261883","https://openalex.org/W2074075011","https://openalex.org/W2075940962","https://openalex.org/W2076361525","https://openalex.org/W2083261882","https://openalex.org/W2088851260","https://openalex.org/W2090640877","https://openalex.org/W2093424661","https://openalex.org/W2101430062","https://openalex.org/W2102333202","https://openalex.org/W2104910525","https://openalex.org/W2106181914","https://openalex.org/W2106271594","https://openalex.org/W2109491705","https://openalex.org/W2111976640","https://openalex.org/W2117206813","https://openalex.org/W2117522253","https://openalex.org/W2123105952","https://openalex.org/W2129319296","https://openalex.org/W2129530019","https://openalex.org/W2138402519","https://openalex.org/W2138950473","https://openalex.org/W2140445812","https://openalex.org/W2161091841","https://openalex.org/W2166311080","https://openalex.org/W2171316676","https://openalex.org/W2177619023","https://openalex.org/W6663687618"],"related_works":["https://openalex.org/W2023359997","https://openalex.org/W4213109765","https://openalex.org/W7097303872","https://openalex.org/W2386267599","https://openalex.org/W3163674905","https://openalex.org/W2094704890","https://openalex.org/W3169312985","https://openalex.org/W7096299997","https://openalex.org/W2980477847","https://openalex.org/W6946741704"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}