{"id":"https://openalex.org/W2086442829","doi":"https://doi.org/10.1016/j.biopha.2013.02.003","title":"Transport of biguanides by human organic cation transporter OCT2","display_name":"Transport of biguanides by human organic cation transporter OCT2","publication_year":2013,"publication_date":"2013-02-27","ids":{"openalex":"https://openalex.org/W2086442829","doi":"https://doi.org/10.1016/j.biopha.2013.02.003","mag":"2086442829","pmid":"https://pubmed.ncbi.nlm.nih.gov/23582785"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2013.02.003","doi":"https://doi.org/10.1016/j.biopha.2013.02.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopha.2013.02.003","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078390167","display_name":"Yoshihisa Sogame","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I31591830","display_name":"Sumitomo Dainippon Pharma (Japan)","ror":"https://ror.org/04sapgw72","country_code":"JP","type":"company","lineage":["https://openalex.org/I31591830"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshihisa Sogame","raw_affiliation_strings":["Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. sogamey@sc.sumitomo-chem.co.jp","Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan","Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 1-98 Kasugade-naka 3-chome, Konohana-ku, Osaka, 554-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. sogamey@sc.sumitomo-chem.co.jp","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 1-98 Kasugade-naka 3-chome, Konohana-ku, Osaka, 554-0022, Japan","institution_ids":["https://openalex.org/I31591830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047891831","display_name":"Atsushi Kitamura","orcid":"https://orcid.org/0000-0003-0303-1198","observed_orcids":["https://orcid.org/0000-0003-0303-1198"]},"institutions":[{"id":"https://openalex.org/I31591830","display_name":"Sumitomo Dainippon Pharma (Japan)","ror":"https://ror.org/04sapgw72","country_code":"JP","type":"company","lineage":["https://openalex.org/I31591830"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Kitamura","raw_affiliation_strings":["Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 1-98 Kasugade-naka 3-chome, Konohana-ku, Osaka, 554-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 1-98 Kasugade-naka 3-chome, Konohana-ku, Osaka, 554-0022, Japan","institution_ids":["https://openalex.org/I31591830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049724669","display_name":"Masashi Yabuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31591830","display_name":"Sumitomo Dainippon Pharma (Japan)","ror":"https://ror.org/04sapgw72","country_code":"JP","type":"company","lineage":["https://openalex.org/I31591830"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Yabuki","raw_affiliation_strings":["Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 1-98 Kasugade-naka 3-chome, Konohana-ku, Osaka, 554-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 1-98 Kasugade-naka 3-chome, Konohana-ku, Osaka, 554-0022, Japan","institution_ids":["https://openalex.org/I31591830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036087532","display_name":"Setsuko Komuro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31591830","display_name":"Sumitomo Dainippon Pharma (Japan)","ror":"https://ror.org/04sapgw72","country_code":"JP","type":"company","lineage":["https://openalex.org/I31591830"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Setsuko Komuro","raw_affiliation_strings":["Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 1-98 Kasugade-naka 3-chome, Konohana-ku, Osaka, 554-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co. Ltd., 1-98 Kasugade-naka 3-chome, Konohana-ku, Osaka, 554-0022, Japan","institution_ids":["https://openalex.org/I31591830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046770993","display_name":"Mikihisa Takano","orcid":"https://orcid.org/0000-0003-2865-3129","observed_orcids":["https://orcid.org/0000-0003-2865-3129"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mikihisa Takano","raw_affiliation_strings":["Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078390167"],"corresponding_institution_ids":["https://openalex.org/I113306721","https://openalex.org/I31591830"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":1.4886,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.81881964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"67","issue":"5","first_page":"425","last_page":"430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biguanides","display_name":"biguanides","score":0.9610000252723694},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/phenformin","display_name":"phenformin","score":1.0},{"id":"https://openalex.org/keywords/organic-cation-transporter-2","display_name":"organic cation transporter 2","score":0.925000011920929},{"id":"https://openalex.org/keywords/oct2","display_name":"OCT2","score":0.7599999904632568},{"id":"https://openalex.org/keywords/renal-drug-transport","display_name":"renal drug transport","score":0.8289999961853027},{"id":"https://openalex.org/keywords/lactic-acidosis","display_name":"lactic acidosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-induced-lactic-acidosis","display_name":"drug-induced lactic acidosis","score":0.5870000123977661},{"id":"https://openalex.org/keywords/oocyte-expression","display_name":"oocyte expression","score":0.5220000147819519},{"id":"https://openalex.org/keywords/substrate-affinity","display_name":"substrate affinity","score":0.6100000143051147},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.5360000133514404},{"id":"https://openalex.org/keywords/blood-lactate","display_name":"blood lactate","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C189613389","wikidata":"https://www.wikidata.org/wiki/Q70479817","display_name":"Organic cation transport proteins","level":4,"score":0.7652416229248047},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5595951080322266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49829959869384766},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42197442054748535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27427467703819275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1782897412776947},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04836711287498474}],"mesh":[{"descriptor_ui":"D000075102","descriptor_name":"Organic Cation Transporter 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010629","descriptor_name":"Phenformin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D027701","descriptor_name":"Organic Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2013.02.003","doi":"https://doi.org/10.1016/j.biopha.2013.02.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopha.2013.02.003","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:23582785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23582785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5722872032","display_name":"Analysis of low temperature tolerance of membrane transporters and development of pan-transporter inhibitors","funder_award_id":"23659081","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1967943195","https://openalex.org/W1973776136","https://openalex.org/W1974497290","https://openalex.org/W1984877756","https://openalex.org/W1994789088","https://openalex.org/W1997003352","https://openalex.org/W1997038641","https://openalex.org/W2013793754","https://openalex.org/W2016744967","https://openalex.org/W2023434765","https://openalex.org/W2030371995","https://openalex.org/W2035556663","https://openalex.org/W2046029184","https://openalex.org/W2046503553","https://openalex.org/W2047944613","https://openalex.org/W2048256564","https://openalex.org/W2058802517","https://openalex.org/W2059781478","https://openalex.org/W2063765944","https://openalex.org/W2071283070","https://openalex.org/W2075803060","https://openalex.org/W2080271817","https://openalex.org/W2086288829","https://openalex.org/W2086818413","https://openalex.org/W2087748318","https://openalex.org/W2088411588","https://openalex.org/W2091831319","https://openalex.org/W2107572009","https://openalex.org/W2125732432","https://openalex.org/W2126914591","https://openalex.org/W2129889918","https://openalex.org/W2134594247","https://openalex.org/W2138226825","https://openalex.org/W2141065273","https://openalex.org/W2151903621","https://openalex.org/W2153795107","https://openalex.org/W2172232346","https://openalex.org/W2315982688","https://openalex.org/W2419030438"],"related_works":["https://openalex.org/W2088411588","https://openalex.org/W2013793754","https://openalex.org/W2474456876","https://openalex.org/W2734514900","https://openalex.org/W2053422488","https://openalex.org/W2003534761","https://openalex.org/W2151903621","https://openalex.org/W2064485343","https://openalex.org/W2293535897","https://openalex.org/W2144280397"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
