{"id":"https://openalex.org/W2086433172","doi":"https://doi.org/10.1111/j.1365-2125.1976.tb04872.x","title":"EFFECT OF DIAZEPAM AND FOSAZEPAM (A SOLUBLE DERIVATIVE OF DIAZEPAM) ON SLEEP IN MAN","display_name":"EFFECT OF DIAZEPAM AND FOSAZEPAM (A SOLUBLE DERIVATIVE OF DIAZEPAM) ON SLEEP IN MAN","publication_year":1976,"publication_date":"1976-08-01","ids":{"openalex":"https://openalex.org/W2086433172","doi":"https://doi.org/10.1111/j.1365-2125.1976.tb04872.x","mag":"2086433172","pmid":"https://pubmed.ncbi.nlm.nih.gov/22216491","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1428904"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.1976.tb04872.x","doi":"https://doi.org/10.1111/j.1365-2125.1976.tb04872.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1976.tb04872.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1976.tb04872.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1976.tb04872.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113780692","display_name":"A. N. Nicholson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.N. NICHOLSON","raw_affiliation_strings":["Royal Air Force Institute of Aviation Medicine, Farnborough, Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Air Force Institute of Aviation Medicine, Farnborough, Hampshire","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056536534","display_name":"Barbara M. Stone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BARBARA M. STONE","raw_affiliation_strings":["Royal Air Force Institute of Aviation Medicine, Farnborough, Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Air Force Institute of Aviation Medicine, Farnborough, Hampshire","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052008616","display_name":"Coral H Clarke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CORAL H. CLARKE","raw_affiliation_strings":["Royal Air Force Institute of Aviation Medicine, Farnborough, Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Air Force Institute of Aviation Medicine, Farnborough, Hampshire","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":11.1736,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.98347107,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"3","issue":"4","first_page":"533","last_page":"541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":1.0},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.746999979019165},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sleep-stages","display_name":"sleep stages","score":0.5019999742507935},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.7820000052452087},{"id":"https://openalex.org/keywords/awakening","display_name":"awakening","score":0.6309999823570251},{"id":"https://openalex.org/keywords/carryover-effects","display_name":"residual effects","score":0.8100000023841858},{"id":"https://openalex.org/keywords/subjective-sleep-quality","display_name":"subjective sleep quality","score":0.6549999713897705},{"id":"https://openalex.org/keywords/well-being","display_name":"well-being","score":0.824999988079071},{"id":"https://openalex.org/keywords/stage-1-sleep","display_name":"stage 1 sleep","score":0.656000018119812},{"id":"https://openalex.org/keywords/stage-2-sleep","display_name":"stage 2 sleep","score":0.8519999980926514},{"id":"https://openalex.org/keywords/stage-3-sleep","display_name":"stage 3 sleep","score":0.875}],"concepts":[{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.8709062337875366},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.843734860420227},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.6845921277999878},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5445459485054016},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5397826433181763},{"id":"https://openalex.org/C2781053850","wikidata":"https://www.wikidata.org/wiki/Q7539763","display_name":"Sleep onset latency","level":4,"score":0.4825715124607086},{"id":"https://openalex.org/C2910364982","wikidata":"https://www.wikidata.org/wiki/Q35831","display_name":"Sleep Stages","level":4,"score":0.4658570885658264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36313992738723755},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.3531111776828766},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3272581398487091},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.19793862104415894},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19539517164230347},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.1584259569644928},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2125.1976.tb04872.x","doi":"https://doi.org/10.1111/j.1365-2125.1976.tb04872.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1976.tb04872.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1976.tb04872.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:22216491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22216491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:1428904","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1428904/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2125.1976.tb04872.x","doi":"https://doi.org/10.1111/j.1365-2125.1976.tb04872.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1976.tb04872.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1976.tb04872.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2086433172.pdf","grobid_xml":"https://content.openalex.org/works/W2086433172.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1512826705","https://openalex.org/W1972414343","https://openalex.org/W1980031031","https://openalex.org/W1983084712","https://openalex.org/W1988938430","https://openalex.org/W1995589311","https://openalex.org/W2004121480","https://openalex.org/W2004348581","https://openalex.org/W2022302291","https://openalex.org/W2045304133","https://openalex.org/W2076817261","https://openalex.org/W4299412079"],"related_works":["https://openalex.org/W2053199465","https://openalex.org/W1983847998","https://openalex.org/W2071666651","https://openalex.org/W1950021871","https://openalex.org/W4299412079","https://openalex.org/W2003405064","https://openalex.org/W2075309563","https://openalex.org/W2050057350","https://openalex.org/W1963875914","https://openalex.org/W2046176020"],"abstract_inverted_index":{"The":[0,46,129,146],"effect":[1,47,59],"of":[2,19,41,48,55,60,89,115,151,158,172,204,218,237,253,260],"diazepam":[3,49,95,261],"(5":[4],"mg":[5,12,105,139],"and":[6,9,13,35,43,69,101,106,122,140,148,179,262,264,277],"10":[7],"mg),":[8,15],"fosazepam":[10,61,103,137,166,192,238,266],"(60":[11,104,138],"80":[14,107,141],"a":[16],"soluble":[17],"derivative":[18],"diazepam,":[20],"on":[21,80,215,245],"sleep":[22,33,44,72,82,117,161,175,187,207,275],"was":[23,50,62,134,181,223,229],"studied":[24],"in":[25,184],"six":[26],"healthy":[27],"adult":[28],"males":[29],"using":[30],"electroencephalography":[31],"for":[32,38,73,274],"measures,":[34],"analogue":[36],"scales":[37],"subjective":[39,278],"assessments":[40],"well-being":[42,254],"quality.":[45],"limited":[51,85],"to":[52,65,86,131,198],"the":[53,58,66,87,113,155,169,199,216,232,256],"night":[54,68,88,114,201,234],"ingestion,":[56],"but":[57,165,221],"carried":[63],"over":[64,196],"next":[67,200],"so":[70],"modified":[71],"about":[74],"30":[75],"h":[76],"after":[77,235,258],"ingestion.":[78,90],"Effects":[79],"total":[81],"time":[83],"were":[84,92,120,124,194,212,243,272],"There":[91,211],"increases":[93],"with":[94,102,202,265],"(10":[96],"mg)":[97,108,142],"(P":[98,109,143,162,176,188,208],"=":[99,110,144,163,177,189,209],"0.05),":[100],"0.001).":[111],"For":[112],"ingestion":[116,236,259],"onset":[118],"latencies":[119],"shortened,":[121],"awakenings":[123],"reduced":[125,154,168,230],"by":[126,136],"both":[127],"drugs.":[128],"latency":[130],"stage":[132,159,173,185,205,219,226],"3":[133],"shortened":[135],"0.05).":[145,210],"low":[147],"high":[149],"dose":[150],"each":[152],"drug":[153],"duration":[156,170,217],"(min)":[157,171],"0":[160],"0.01),":[164],"also":[167],"1":[174,206],"0.001),":[178],"there":[180,193,222],"an":[182,250],"increase":[183],"2":[186],"0.01).":[190],"With":[191],"carry":[195],"effects":[197,214,242],"reduction":[203],"no":[213],"3,":[220],"evidence":[224],"that":[225],"4":[227],"activity":[228],"during":[231,255],"recovery":[233],"(80":[239],"mg).":[240],"No":[241],"observed":[244],"REM":[246],"sleep.":[247,270],"Subjects":[248],"reported":[249,268],"improved":[251,269],"sense":[252],"day":[257],"fosazepam,":[263],"they":[267],"Correlations":[271],"calculated":[273],"measures":[276],"assessments.":[279]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}