{"id":"https://openalex.org/W2086407828","doi":"https://doi.org/10.1089/met.2012.0135","title":"UP780, a Chromone-Enriched Aloe Composition Improves Insulin Sensitivity","display_name":"UP780, a Chromone-Enriched Aloe Composition Improves Insulin Sensitivity","publication_year":2013,"publication_date":"2013-04-10","ids":{"openalex":"https://openalex.org/W2086407828","doi":"https://doi.org/10.1089/met.2012.0135","mag":"2086407828","pmid":"https://pubmed.ncbi.nlm.nih.gov/23573999"},"language":"en","primary_location":{"id":"doi:10.1089/met.2012.0135","doi":"https://doi.org/10.1089/met.2012.0135","is_oa":false,"landing_page_url":"https://doi.org/10.1089/met.2012.0135","pdf_url":null,"source":{"id":"https://openalex.org/S61453932","display_name":"Metabolic Syndrome and Related Disorders","issn_l":"1540-4196","issn":["1540-4196","1557-8518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Syndrome and Related Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001659235","display_name":"Mesfin Yimam","orcid":"https://orcid.org/0000-0001-5009-1586","observed_orcids":["https://orcid.org/0000-0001-5009-1586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mesfin Yimam","raw_affiliation_strings":["Unigen, Inc., Seattle, Washington","Unigen, Inc., Seattle, WA 98121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unigen, Inc., Seattle, Washington","institution_ids":[]},{"raw_affiliation_string":"Unigen, Inc., Seattle, WA 98121, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113649829","display_name":"Jifu Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jifu Zhao","raw_affiliation_strings":["Unigen, Inc., Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unigen, Inc., Seattle, Washington","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059646950","display_name":"Brandon Corneliusen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brandon Corneliusen","raw_affiliation_strings":["Unigen, Inc., Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unigen, Inc., Seattle, Washington","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091141570","display_name":"Mandee Pantier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mandee Pantier","raw_affiliation_strings":["Unigen, Inc., Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unigen, Inc., Seattle, Washington","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000973850","display_name":"Lidia Alfaro Brownell","orcid":"https://orcid.org/0000-0002-5328-0152","observed_orcids":["https://orcid.org/0000-0002-5328-0152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lidia Alfaro Brownell","raw_affiliation_strings":["Unigen, Inc., Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unigen, Inc., Seattle, Washington","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Qi Jia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Jia","raw_affiliation_strings":["Unigen, Inc., Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unigen, Inc., Seattle, Washington","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7469,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.92598336,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"4","first_page":"267","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.4341000020503998,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aloesin","display_name":"aloesin","score":0.949999988079071},{"id":"https://openalex.org/keywords/aloe-vera-polysaccharide","display_name":"Aloe vera polysaccharide","score":0.8339999914169312},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.972000002861023},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.8809999823570251},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8330000042915344},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.6340000033378601},{"id":"https://openalex.org/keywords/fasting-triglycerides","display_name":"fasting triglycerides","score":0.7089999914169312},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C2779326954","wikidata":"https://www.wikidata.org/wiki/Q420156","display_name":"Chromone","level":2,"score":0.758531391620636},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.6903223991394043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6810107827186584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6695853471755981},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6457166075706482},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6201456785202026},{"id":"https://openalex.org/C2779404486","wikidata":"https://www.wikidata.org/wiki/Q80079","display_name":"Aloe vera","level":2,"score":0.6199407577514648},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5406692624092102},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4532308876514435},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.4343385100364685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18027344346046448},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.16573581099510193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1508222222328186},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.08736765384674072},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000504","descriptor_name":"Aloe","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001577","descriptor_name":"Benzophenones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/met.2012.0135","doi":"https://doi.org/10.1089/met.2012.0135","is_oa":false,"landing_page_url":"https://doi.org/10.1089/met.2012.0135","pdf_url":null,"source":{"id":"https://openalex.org/S61453932","display_name":"Metabolic Syndrome and Related Disorders","issn_l":"1540-4196","issn":["1540-4196","1557-8518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Syndrome and Related Disorders","raw_type":"journal-article"},{"id":"pmid:23573999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23573999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic syndrome and related disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W11307833","https://openalex.org/W60427499","https://openalex.org/W1979515186","https://openalex.org/W1981261500","https://openalex.org/W1983864692","https://openalex.org/W1986721386","https://openalex.org/W1990365809","https://openalex.org/W1991736265","https://openalex.org/W1999835438","https://openalex.org/W2027107698","https://openalex.org/W2027459237","https://openalex.org/W2040365189","https://openalex.org/W2047622876","https://openalex.org/W2051820078","https://openalex.org/W2057329096","https://openalex.org/W2065940350","https://openalex.org/W2066909002","https://openalex.org/W2078838901","https://openalex.org/W2079379175","https://openalex.org/W2080424087","https://openalex.org/W2089595695","https://openalex.org/W2095307176","https://openalex.org/W2095763488","https://openalex.org/W2096773810","https://openalex.org/W2102951314","https://openalex.org/W2113328569","https://openalex.org/W2126521413","https://openalex.org/W2126545477","https://openalex.org/W2127934772","https://openalex.org/W2135050619","https://openalex.org/W2135173562","https://openalex.org/W2139714284","https://openalex.org/W2145490597","https://openalex.org/W2146724216","https://openalex.org/W2162413992","https://openalex.org/W2164284551","https://openalex.org/W2164340474","https://openalex.org/W2184991825","https://openalex.org/W2201697664","https://openalex.org/W2416781424"],"related_works":["https://openalex.org/W2127740814","https://openalex.org/W2045586684","https://openalex.org/W7100199235","https://openalex.org/W300748121","https://openalex.org/W2023801929","https://openalex.org/W56359458","https://openalex.org/W2100017297","https://openalex.org/W7098841942","https://openalex.org/W2142964025","https://openalex.org/W2138259877"],"abstract_inverted_index":{"BACKGROUND:":[0],"Diabetic":[1,183],"individuals":[2],"experience":[3],"elevated":[4],"fasting":[5,170,199],"glucose,":[6],"glycosylated":[7],"hemoglobin":[8],"(HbA1c),":[9],"and":[10,13,54,63,110,143,147,166,172,203],"plasma":[11,137,173,208],"insulin":[12,24,50,138],"impaired":[14],"glucose":[15,174,201,222,250],"tolerance.":[16],"Adiponectin":[17],"is":[18],"a":[19,78,99,115,125,164,195,204,216,230,239],"hormone":[20],"inversely":[21],"correlated":[22],"with":[23,43,87,186],"resistance.":[25],"Here":[26],"we":[27],"describe":[28],"the":[29,49,153,245],"activity":[30,76],"of":[31,74,104,132,134,179,189,247],"aloesin,":[32],"an":[33,44,88],"aloe":[34,45,60,157,161],"chromone":[35],"that":[36,228],"increases":[37],"adiponectin":[38,70],"production":[39],"and,":[40],"when":[41],"formulated":[42,86],"polysaccharide":[46,95],"composition,":[47,233],"improves":[48],"sensitivity":[51],"in":[52,67,77,108,169,198,207,220],"db/db":[53,111,151],"diet-induced":[55],"obese-diabetic":[56],"mice.":[57],"METHODS:":[58],"Two":[59],"chromones,":[61],"aloesin":[62,84,146],"aloesinol,":[64,148],"were":[65,140],"tested":[66],"vitro":[68],"for":[69,191],"production.":[71],"Following":[72],"confirmation":[73],"glucose-lowering":[75],"high-fat":[79],"diet":[80],"(HFD)-induced":[81],"mouse":[82,112],"model,":[83],"was":[85,106,122],"Aloe":[89],"vera":[90],"inner":[91],"leaf":[92],"gel":[93],"powder":[94],"preparation":[96],"to":[97,243],"yield":[98],"composition":[100,162],"designated":[101],"UP780.":[102],"Efficacy":[103],"UP780":[105,160,190,214],"evaluated":[107],"HDF-induced":[109,135],"models.":[113],"GW1929,":[114],"synthetic":[116],"peroxisome":[117],"proliferator-activated":[118],"receptor-\u03b3":[119],"(PPAR\u03b3)":[120],"agonist,":[121],"used":[123,237],"as":[124,238],"positive":[126],"control.":[127],"RESULTS:":[128],"After":[129],"3":[130],"weeks":[131,178,193],"treatment":[133],"mice,":[136,152],"levels":[139,175,202],"decreased":[141],"37.9%":[142],"46.7%":[144],"by":[145],"respectively.":[149,182],"In":[150,210],"chromone-":[154],"(2%":[155],"chromone:98%":[156],"polysaccharide)":[158],"enriched":[159],"showed":[163,194,215],"33.7%":[165],"46.0%":[167],"decrease":[168,197],"triglyceride":[171],"after":[176],"10":[177,192],"oral":[180],"treatment,":[181],"mice":[184],"gavaged":[185],"200":[187],"mg/kg":[188],"30.3%":[196],"blood":[200,221,249],"32.2%":[205],"reduction":[206],"insulin.":[209],"both":[211],"animal":[212],"models,":[213],"statistically":[217],"significant":[218],"improvement":[219],"clearance.":[223],"CONCLUSION:":[224],"These":[225],"findings":[226],"indicate":[227],"UP780,":[229],"chromone-standardized,":[231],"aloe-based":[232],"could":[234],"potentially":[235],"be":[236],"natural":[240],"product":[241],"option":[242],"facilitate":[244],"maintenance":[246],"healthy":[248],"levels.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
