{"id":"https://openalex.org/W2086359262","doi":"https://doi.org/10.1089/scd.2007.0260","title":"Mouse Hematopoietic Stem Cells, Unlike Human and Mouse Embryonic Stem Cells, Exhibit Checkpoint\u2013Apoptosis Coupling","display_name":"Mouse Hematopoietic Stem Cells, Unlike Human and Mouse Embryonic Stem Cells, Exhibit Checkpoint\u2013Apoptosis Coupling","publication_year":2008,"publication_date":"2008-09-14","ids":{"openalex":"https://openalex.org/W2086359262","doi":"https://doi.org/10.1089/scd.2007.0260","mag":"2086359262","pmid":"https://pubmed.ncbi.nlm.nih.gov/18788999","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2818989"},"language":"en","primary_location":{"id":"doi:10.1089/scd.2007.0260","doi":"https://doi.org/10.1089/scd.2007.0260","is_oa":false,"landing_page_url":"https://doi.org/10.1089/scd.2007.0260","pdf_url":null,"source":{"id":"https://openalex.org/S120158623","display_name":"Stem Cells and Development","issn_l":"1525-8165","issn":["1525-8165","1547-3287","1557-8534","2168-6580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2818989","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016526206","display_name":"Sara Rohrabaugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Rohrabaugh","raw_affiliation_strings":["Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana","Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031468426","display_name":"Charlie Mantel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlie Mantel","raw_affiliation_strings":["Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana","Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038161052","display_name":"Hal E. Broxmeyer","orcid":"https://orcid.org/0000-0001-6575-0476","observed_orcids":["https://orcid.org/0000-0001-6575-0476"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hal E. Broxmeyer","raw_affiliation_strings":["Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana","Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038161052"],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":null,"apc_paid":null,"fwci":0.2893,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.59650673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"17","issue":"5","first_page":"1017","last_page":"1020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.13899999856948853,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.9639999866485596},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lsk-cells","display_name":"LSK cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.6919999718666077},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hypodiploidy","display_name":"hypodiploidy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hsc-expansion","display_name":"HSC expansion","score":0.6489999890327454},{"id":"https://openalex.org/keywords/microtubule-depolymerization","display_name":"microtubule depolymerization","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8329671621322632},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7377715110778809},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6790415048599243},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.644086480140686},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5834898352622986},{"id":"https://openalex.org/C175732170","wikidata":"https://www.wikidata.org/wiki/Q9064829","display_name":"Spindle checkpoint","level":5,"score":0.5574227571487427},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4904131591320038},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4505848288536072},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.42039650678634644},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.41605454683303833},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.22777295112609863},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.19618940353393555},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18310168385505676},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1088813841342926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015739","descriptor_name":"Nocodazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/scd.2007.0260","doi":"https://doi.org/10.1089/scd.2007.0260","is_oa":false,"landing_page_url":"https://doi.org/10.1089/scd.2007.0260","pdf_url":null,"source":{"id":"https://openalex.org/S120158623","display_name":"Stem Cells and Development","issn_l":"1525-8165","issn":["1525-8165","1547-3287","1557-8534","2168-6580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells and Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2818989","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2818989","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Dev","raw_type":"Text"},{"id":"pmid:18788999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18788999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells and development","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2818989","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2818989","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Dev","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1093411735","display_name":"Mechanisms of Synergistic Regulation of Stem/Progenitors","funder_award_id":"R01HL056416","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3747627319","display_name":"Cytokine Enhancement of Myeloid Progenitor Cell Survival","funder_award_id":"R01HL067384","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5868952424","display_name":"Cancer Biology Training Program","funder_award_id":"T32CA111198","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5915159656","display_name":"Gene Replacement Therapy in Hematopoietic Stem Cells","funder_award_id":"P01HL053586","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W81837624","https://openalex.org/W1593569677","https://openalex.org/W1985495313","https://openalex.org/W1991116680","https://openalex.org/W1999334134","https://openalex.org/W2027035820","https://openalex.org/W2048109276","https://openalex.org/W2070082629","https://openalex.org/W2077278757","https://openalex.org/W2078358000","https://openalex.org/W2089124709","https://openalex.org/W2139718226","https://openalex.org/W2140656629","https://openalex.org/W3021649819"],"related_works":["https://openalex.org/W2089124709","https://openalex.org/W79461703","https://openalex.org/W2593159245","https://openalex.org/W2558068896","https://openalex.org/W2549844572","https://openalex.org/W2218386934","https://openalex.org/W2765686515","https://openalex.org/W2985968797","https://openalex.org/W2001578274","https://openalex.org/W2027801293"],"abstract_inverted_index":{"Previously,":[0],"we":[1,57,93],"reported":[2],"that":[3,153,173,190],"the":[4,41,60,87,95,119,135,180],"spindle":[5,97],"assembly":[6],"checkpoint":[7,98],"(SAC),":[8],"which":[9],"is":[10,15,43],"coupled":[11],"in":[12,19,102,110,137,193,195],"somatic":[13,70,158],"cells,":[14,106,114],"uncoupled":[16],"from":[17],"apoptosis-initiation":[18],"mouse":[20,88,174],"and":[21,33,85,145,198],"human":[22,201],"embryonic":[23],"stem":[24,52],"cells":[25,71,139,159],"(ESCs).":[26],"This":[27],"condition":[28],"allows":[29],"ESCs":[30,68,162],"to":[31,45,74,83,99,165,179],"tolerate":[32],"proliferate":[34],"as":[35,125,140,186],"polyploidy/aneuploid":[36],"cells.":[37],"Proper":[38],"function":[39],"of":[40,118,134,148,161,183,200],"SAC":[42,120,136],"vital":[44],"prevent":[46],"polyploidy/aneuploidy":[47],"during":[48],"ex":[49],"vivo":[50],"hematopoietic":[51,112],"cell":[53,80,168],"(HSC)":[54],"expansion.":[55],"Here":[56],"address,":[58],"for":[59,208],"first":[61],"time,":[62],"whether":[63],"HSCs":[64,127,154,175],"are":[65,176,187],"more":[66,156],"like":[67,157],"or":[69,204],"with":[72,163],"respect":[73,164],"SAC-apoptosis":[75],"coupling.":[76],"Using":[77],"multiparametric":[78],"permeablized":[79],"flow-cytometric":[81],"analysis":[82],"identify":[84],"analyze":[86],"sca":[89],"1(+)/c-kit(+)/lin(-)":[90],"(LSK)":[91],"population,":[92],"found":[94],"mitotic":[96],"be":[100],"functional":[101],"primary":[103],"murine":[104],"LSK":[105,138],"a":[107],"population":[108],"enriched":[109],"primitive":[111],"stem/progenitor":[113],"after":[115,132],"prolonged":[116],"activation":[117,133],"by":[121,142],"microtubule-depolymerizing":[122],"agents":[123],"such":[124],"nocodazole.":[126],"can":[128],"efficiently":[129],"initiate":[130],"apoptosis":[131],"indicated":[141],"increased":[143,146],"hypodiploidy":[144],"levels":[147],"activated":[149],"caspase":[150],"3,":[151],"suggesting":[152],"behave":[155],"instead":[160],"this":[166],"important":[167],"cycle":[169],"checkpoint.":[170],"We":[171],"conclude":[172],"not":[177],"subject":[178],"same":[181],"kinds":[182],"chromosomal":[184],"instability":[185],"ESCs,":[188],"knowledge":[189],"might":[191],"aid":[192],"optimizing":[194],"vitro":[196],"culture":[197],"expansion":[199],"bone":[202],"marrow":[203],"cord":[205],"blood":[206],"HSC":[207],"clinical":[209],"applications.":[210]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
