{"id":"https://openalex.org/W2086237673","doi":"https://doi.org/10.1097/01.shk.0000145936.31967.d7","title":"NEUTROPHIL ELASTASE, MIP-2, AND TLR-4 EXPRESSION DURING HUMAN AND EXPERIMENTAL SEPSIS","display_name":"NEUTROPHIL ELASTASE, MIP-2, AND TLR-4 EXPRESSION DURING HUMAN AND EXPERIMENTAL SEPSIS","publication_year":2004,"publication_date":"2004-12-17","ids":{"openalex":"https://openalex.org/W2086237673","doi":"https://doi.org/10.1097/01.shk.0000145936.31967.d7","mag":"2086237673","pmid":"https://pubmed.ncbi.nlm.nih.gov/15614130"},"language":"en","primary_location":{"id":"doi:10.1097/01.shk.0000145936.31967.d7","doi":"https://doi.org/10.1097/01.shk.0000145936.31967.d7","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.shk.0000145936.31967.d7","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045905510","display_name":"Hironori Tsujimoto","orcid":"https://orcid.org/0000-0002-2808-4723","observed_orcids":["https://orcid.org/0000-0002-2808-4723"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Hironori Tsujimoto","raw_affiliation_strings":["Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan. tsuijiflorida@aol.com","Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan","Department of Surgery, University of Florida College of Medicine, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan. tsuijiflorida@aol.com","institution_ids":["https://openalex.org/I53888640"]},{"raw_affiliation_string":"Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]},{"raw_affiliation_string":"Department of Surgery, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032872485","display_name":"Satoshi Ono","orcid":"https://orcid.org/0000-0002-9864-348X","observed_orcids":["https://orcid.org/0000-0002-9864-348X"]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoshi Ono","raw_affiliation_strings":["Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100557296","display_name":"Takashi Majima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Majima","raw_affiliation_strings":["Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068499112","display_name":"Nobuaki Kawarabayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Nobuaki Kawarabayashi","raw_affiliation_strings":["Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eiji Takayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiji Takayama","raw_affiliation_strings":["Department of Parasitology","Department of Parasitology, \u00a7Division of Basic Traumatology, and \u2225Department of Microbiology, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology","institution_ids":[]},{"raw_affiliation_string":"Department of Parasitology, \u00a7Division of Basic Traumatology, and \u2225Department of Microbiology, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076917742","display_name":"Manabu Kinoshita","orcid":"https://orcid.org/0000-0002-2750-3084","observed_orcids":["https://orcid.org/0000-0002-2750-3084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manabu Kinoshita","raw_affiliation_strings":["Division of Basic Traumatology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Traumatology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100843339","display_name":"Shuhji Seki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuhji Seki","raw_affiliation_strings":["Department of Microbiology, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051249520","display_name":"Hoshio Hiraide","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hoshio Hiraide","raw_affiliation_strings":["Division of Basic Traumatology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Traumatology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081164839","display_name":"Lyle L. Moldawer","orcid":"https://orcid.org/0000-0002-9041-9838","observed_orcids":["https://orcid.org/0000-0002-9041-9838"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lyle L Moldawer","raw_affiliation_strings":["Department of Surgery, University of Florida College of Medicine, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113576958","display_name":"Hidetaka Mochizuki","orcid":"https://orcid.org/0009-0006-0271-0171","observed_orcids":["https://orcid.org/0009-0006-0271-0171"]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hidetaka Mochizuki","raw_affiliation_strings":["Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032872485","https://openalex.org/A5045905510","https://openalex.org/A5068499112","https://openalex.org/A5100557296","https://openalex.org/A5113576958"],"corresponding_institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4210087193","https://openalex.org/I53888640"],"apc_list":null,"apc_paid":null,"fwci":2.8763,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.91159598,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"39","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.22599999606609344,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.179299995303154,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8330000042915344},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.9300000071525574},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.6200000047683716},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9200000166893005},{"id":"https://openalex.org/keywords/chemokine-production","display_name":"chemokine production","score":0.7429999709129333},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.9319999814033508},{"id":"https://openalex.org/keywords/positive-feedback-loop","display_name":"positive feedback loop","score":0.718999981880188},{"id":"https://openalex.org/keywords/neutrophil-elastase-inhibitor","display_name":"neutrophil elastase inhibitor","score":0.7879999876022339},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.800000011920929},{"id":"https://openalex.org/keywords/organ-damage","display_name":"organ damage","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.7751024961471558},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.68044513463974},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.6027233004570007},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5864194631576538},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.5766653418540955},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5643463134765625},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5574173927307129},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5231600999832153},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.5227475166320801},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.43325892090797424},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.41949397325515747},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.38742777705192566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38113927841186523},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28110066056251526},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015846","descriptor_name":"Monokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054360","descriptor_name":"Chemokine CXCL1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.shk.0000145936.31967.d7","doi":"https://doi.org/10.1097/01.shk.0000145936.31967.d7","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.shk.0000145936.31967.d7","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:15614130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15614130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3167766668","display_name":"Targeted IL-10 Gene Therapy in Sepsis Syndromes","funder_award_id":"R01GM063041","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6580640935","display_name":"CYTOKINE REGULATION IN SEPSIS/INFLAMMATION","funder_award_id":"R37GM040586","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W40001950","https://openalex.org/W1511030747","https://openalex.org/W1575059030","https://openalex.org/W1605072661","https://openalex.org/W1644456902","https://openalex.org/W1655860314","https://openalex.org/W1945510071","https://openalex.org/W1967774301","https://openalex.org/W1968134126","https://openalex.org/W1971521446","https://openalex.org/W1979213174","https://openalex.org/W2004999743","https://openalex.org/W2007502914","https://openalex.org/W2010047414","https://openalex.org/W2014745588","https://openalex.org/W2017390338","https://openalex.org/W2035655971","https://openalex.org/W2039697569","https://openalex.org/W2050413576","https://openalex.org/W2050946282","https://openalex.org/W2052648717","https://openalex.org/W2060222319","https://openalex.org/W2065248093","https://openalex.org/W2071637551","https://openalex.org/W2078012955","https://openalex.org/W2085107527","https://openalex.org/W2090071602","https://openalex.org/W2094776056","https://openalex.org/W2109594310","https://openalex.org/W2126191679","https://openalex.org/W2126659405","https://openalex.org/W2130827011","https://openalex.org/W2132347745","https://openalex.org/W2513246490","https://openalex.org/W2599527603","https://openalex.org/W2768146862","https://openalex.org/W4293242440"],"related_works":["https://openalex.org/W2066420604","https://openalex.org/W2034359425","https://openalex.org/W2056426731","https://openalex.org/W4404166919","https://openalex.org/W2130619285","https://openalex.org/W2687152040","https://openalex.org/W2026927834","https://openalex.org/W2050728089","https://openalex.org/W2074309896","https://openalex.org/W2085268252"],"abstract_inverted_index":{"Highly":[0],"activated":[1],"neutrophils":[2,182],"play":[3,21],"a":[4,137,147,211],"critical":[5,37],"role":[6,24],"in":[7,11,25,77,90,95,102,115,146,151,183,187],"mediating":[8],"organ":[9],"injury":[10],"sepsis":[12,57,79,93,184],"by":[13,108],"releasing":[14],"neutrophil":[15],"elastase":[16],"(NE).":[17],"Toll-like":[18],"receptors":[19],"(TLRs)":[20],"an":[22],"important":[23],"the":[26,39,42,46,52,68,129,216,220],"host":[27,53],"defense":[28,54],"against":[29],"invading":[30],"microbes,":[31],"and":[32,51,74,80,94,98,111,167,192],"their":[33,141],"signaling":[34],"pathway":[35],"is":[36],"to":[38,143,157],"activation":[40],"of":[41,128,181,195,205],"proinflammatory":[43],"response.":[44],"However,":[45],"relationship":[47],"between":[48],"TLR":[49],"expression":[50,76,85,172,194,204],"mechanism":[55],"during":[56],"has":[58],"not":[59],"been":[60],"fully":[61],"elucidated.":[62],"In":[63],"this":[64],"paper,":[65],"we":[66],"investigated":[67],"relationships":[69],"among":[70,219],"chemokine":[71,190],"(MIP-2),":[72],"TLR-4,":[73,207],"NE":[75,138,166,198],"human":[78,174],"murine":[81,96],"peritonitis":[82,97,118],"(CLP).":[83],"TLR-4":[84,163,171],"on":[86,173],"monocytes/macrophages":[87],"was":[88,99,119,155],"examined":[89],"patients":[91],"with":[92,117,124,136,162,202],"markedly":[100],"increased":[101,122,189,193,203],"both":[103,169],"populations.":[104,223],"LPS-induced":[105],"MIP-2":[106,152],"production":[107,191],"bronchoalveolar":[109],"cells":[110,114],"liver":[112],"mononuclear":[113],"mice":[116],"also":[120],"significantly":[121],"compared":[123],"sham-operated":[125],"mice.":[126],"Pretreatment":[127],"macrophage":[130],"cell":[131,222],"line,":[132],"RAW":[133],"264.7":[134],"cells,":[135],"inhibitor":[139],"before":[140],"exposure":[142],"LPS":[144,168],"resulted":[145],"significant":[148],"dose-dependent":[149],"decrease":[150],"production,":[153],"which":[154],"comparable":[156],"that":[158],"seen":[159],"following":[160],"pretreatment":[161],"antibody.":[164],"Furthermore,":[165],"up-regulated":[170],"peripheral":[175],"blood":[176],"monocytes.":[177],"Thus,":[178],"chemokine-induced":[179],"recruitment":[180],"may":[185,199],"result":[186],"further":[188],"TLR-4.":[196],"Neutrophil-derived":[197],"be":[200],"associated":[201],"monocyte/macrophage":[206],"thereby":[208],"serving":[209],"as":[210],"positive":[212],"feedback":[213],"loop":[214],"for":[215],"inflammatory":[217],"response":[218],"different":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}