{"id":"https://openalex.org/W2086237232","doi":"https://doi.org/10.1046/j.1365-2249.2003.02171.x","title":"A marked difference in pathogenesis and immune response induced by differentMycobacterium tuberculosisgenotypes","display_name":"A marked difference in pathogenesis and immune response induced by differentMycobacterium tuberculosisgenotypes","publication_year":2003,"publication_date":"2003-06-24","ids":{"openalex":"https://openalex.org/W2086237232","doi":"https://doi.org/10.1046/j.1365-2249.2003.02171.x","mag":"2086237232","pmid":"https://pubmed.ncbi.nlm.nih.gov/12823275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1808750"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2249.2003.02171.x","doi":"https://doi.org/10.1046/j.1365-2249.2003.02171.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.2003.02171.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1808750/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103038877","display_name":"Beatriz L\u00f3pez","orcid":"https://orcid.org/0000-0003-1212-7810","observed_orcids":["https://orcid.org/0000-0003-1212-7810"]},"institutions":[{"id":"https://openalex.org/I4210113115","display_name":"Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud","ror":"https://ror.org/024hqjk04","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210113115"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"B L\u00d3PEZ","raw_affiliation_strings":["National Institute for Infectious Diseases, National Administration of Health Laboratories and Institutes \u2018Carlos G. Malbr\u00e1n\u2019, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Infectious Diseases, National Administration of Health Laboratories and Institutes \u2018Carlos G. Malbr\u00e1n\u2019, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210113115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067905785","display_name":"D Aguilar","orcid":"https://orcid.org/0009-0001-7055-6376","observed_orcids":["https://orcid.org/0009-0001-7055-6376"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"D AGUILAR","raw_affiliation_strings":["Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e1n\u2019, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e1n\u2019, M\u00e9xico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H OROZCO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"H OROZCO","raw_affiliation_strings":["Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e1n\u2019, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e1n\u2019, M\u00e9xico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109934670","display_name":"Marion Burger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M BURGER","raw_affiliation_strings":["Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012260420","display_name":"Clara Espitia","orcid":"https://orcid.org/0000-0001-7731-4049","observed_orcids":["https://orcid.org/0000-0001-7731-4049"]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"C ESPITIA","raw_affiliation_strings":["Department of Immunology, Biomedical Research Institute, National University of Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Biomedical Research Institute, National University of Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072620092","display_name":"Viviana Ritacco","orcid":"https://orcid.org/0000-0003-1217-0229","observed_orcids":["https://orcid.org/0000-0003-1217-0229"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]},{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]},{"id":"https://openalex.org/I4210113115","display_name":"Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud","ror":"https://ror.org/024hqjk04","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210113115"]},{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["AR","MX","NL"],"is_corresponding":false,"raw_author_name":"V RITACCO","raw_affiliation_strings":["Department of Immunology, Biomedical Research Institute, National University of Mexico","Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e1n\u2019, M\u00e9xico","Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands","National Council for Scientific Research, Argentina","National Institute for Infectious Diseases, National Administration of Health Laboratories and Institutes \u2018Carlos G. Malbr\u00e1n\u2019, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Biomedical Research Institute, National University of Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e1n\u2019, M\u00e9xico","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands","institution_ids":["https://openalex.org/I4210104433"]},{"raw_affiliation_string":"National Council for Scientific Research, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"National Institute for Infectious Diseases, National Administration of Health Laboratories and Institutes \u2018Carlos G. Malbr\u00e1n\u2019, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210113115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011491521","display_name":"Laura Yuritzi Barroso Barrera","orcid":"https://orcid.org/0009-0005-3777-5461","observed_orcids":["https://orcid.org/0009-0005-3777-5461"]},"institutions":[{"id":"https://openalex.org/I4210113115","display_name":"Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud","ror":"https://ror.org/024hqjk04","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210113115"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"L BARRERA","raw_affiliation_strings":["National Institute for Infectious Diseases, National Administration of Health Laboratories and Institutes \u2018Carlos G. Malbr\u00e1n\u2019, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Infectious Diseases, National Administration of Health Laboratories and Institutes \u2018Carlos G. Malbr\u00e1n\u2019, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210113115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009745059","display_name":"Kristin Kremer","orcid":"https://orcid.org/0009-0004-1729-5463","observed_orcids":["https://orcid.org/0009-0004-1729-5463"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"K KREMER","raw_affiliation_strings":["Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016385354","display_name":"Rog\u00e9lio Hern\u00e1ndez\u2010Pando","orcid":"https://orcid.org/0000-0003-1292-3833","observed_orcids":["https://orcid.org/0000-0003-1292-3833"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"R HERNANDEZ-PANDO","raw_affiliation_strings":["Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e1n\u2019, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e1n\u2019, M\u00e9xico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045879589","display_name":"Kris Huygen","orcid":"https://orcid.org/0000-0001-7808-0512","observed_orcids":["https://orcid.org/0000-0001-7808-0512"]},"institutions":[{"id":"https://openalex.org/I4405271293","display_name":"Les Amis des Instituts Pasteur \u00e0 Bruxelles","ror":"https://ror.org/026wyqd33","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4405271293"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"K HUYGEN","raw_affiliation_strings":["Mycobacterial Immunology, Pasteur Institute of Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycobacterial Immunology, Pasteur Institute of Brussels, Belgium","institution_ids":["https://openalex.org/I4405271293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025754154","display_name":"Dick van Soolingen","orcid":"https://orcid.org/0000-0003-0767-6161","observed_orcids":["https://orcid.org/0000-0003-0767-6161"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D VAN SOOLINGEN","raw_affiliation_strings":["Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5016385354"],"corresponding_institution_ids":["https://openalex.org/I4210097900"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":14.9412,"has_fulltext":false,"cited_by_count":454,"citation_normalized_percentile":{"value":0.99387122,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"133","issue":"1","first_page":"30","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.609000027179718},{"id":"https://openalex.org/keywords/beijing-genotype","display_name":"Beijing genotype","score":0.6980000138282776},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis-h37rv","display_name":"Mycobacterium tuberculosis H37Rv","score":0.8870000243186951},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.6579999923706055},{"id":"https://openalex.org/keywords/bcg-vaccination","display_name":"BCG vaccination","score":0.5899999737739563},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.49799999594688416},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.968999981880188},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.718999981880188},{"id":"https://openalex.org/keywords/mouse-model-of-tuberculosis","display_name":"mouse model of tuberculosis","score":0.5529999732971191},{"id":"https://openalex.org/keywords/tuberculosis-vaccine-development","display_name":"tuberculosis vaccine development","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7217958569526672},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7085504531860352},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6942003965377808},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6486000418663025},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6024558544158936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5997248291969299},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5123001337051392},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.47241154313087463},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4600275754928589},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40033239126205444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15327900648117065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14805370569229126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14793679118156433},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05849045515060425}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001500","descriptor_name":"BCG Vaccine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1046/j.1365-2249.2003.02171.x","doi":"https://doi.org/10.1046/j.1365-2249.2003.02171.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.2003.02171.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmid:12823275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12823275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1808750","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1808750/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmh:oai:rivm.openrepository.com:10029/639707","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/639707","pdf_url":null,"source":{"id":"https://openalex.org/S4306401814","display_name":"Rivm Repository (Netherlands National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1808750","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1808750/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W37545008","https://openalex.org/W56036994","https://openalex.org/W192637436","https://openalex.org/W1516537577","https://openalex.org/W1554398145","https://openalex.org/W1841196254","https://openalex.org/W1884882993","https://openalex.org/W1945178855","https://openalex.org/W1970910747","https://openalex.org/W1974477626","https://openalex.org/W1975045527","https://openalex.org/W1987733838","https://openalex.org/W1994580619","https://openalex.org/W1994971990","https://openalex.org/W2007531693","https://openalex.org/W2017021222","https://openalex.org/W2017519798","https://openalex.org/W2035579424","https://openalex.org/W2045867063","https://openalex.org/W2048597976","https://openalex.org/W2065217848","https://openalex.org/W2100887397","https://openalex.org/W2106462617","https://openalex.org/W2109484445","https://openalex.org/W2113395588","https://openalex.org/W2117034387","https://openalex.org/W2125140731","https://openalex.org/W2134990166","https://openalex.org/W2135717170","https://openalex.org/W2142147087","https://openalex.org/W2147955285","https://openalex.org/W2149200346","https://openalex.org/W2153092680","https://openalex.org/W2153742459","https://openalex.org/W2155432507","https://openalex.org/W2166413103","https://openalex.org/W2170586454","https://openalex.org/W2242770549","https://openalex.org/W2276833683","https://openalex.org/W2410325834","https://openalex.org/W6602307319"],"related_works":["https://openalex.org/W2072695164","https://openalex.org/W7214912775","https://openalex.org/W2585160258","https://openalex.org/W2129536819","https://openalex.org/W4310117088","https://openalex.org/W2039368794","https://openalex.org/W2074325829","https://openalex.org/W2066086624","https://openalex.org/W4244542613","https://openalex.org/W2166376682"],"abstract_inverted_index":{"In":[0,175],"the":[1,54,60,78,145,148,172,189,197,209],"last":[2],"decade,":[3],"an":[4],"unprecedented":[5],"genetic":[6],"diversity":[7,58],"has":[8],"been":[9],"disclosed":[10],"among":[11],"Mycobacterium":[12],"tuberculosis":[13,67,180,226],"strains":[14,99,128,169,181],"found":[15,74],"worldwide.":[16],"However,":[17],"well-conserved":[18],"genotypes":[19,227],"seem":[20],"to":[21,35,42,85],"prevail":[22],"in":[23,137,194,205],"areas":[24],"with":[25,94,97,167,188],"high":[26],"incidence":[27],"of":[28,56,62,115,144,157,224],"tuberculosis.":[29],"As":[30],"this":[31],"may":[32],"be":[33],"related":[34],"selective":[36],"advantages,":[37],"such":[38],"as":[39],"advanced":[40],"mechanisms":[41],"circumvent":[43],"[M.":[44],"bovis":[45],"Bacille":[46],"Calmette-Guerin":[47],"(BCG)-induced]":[48],"host":[49],"defence":[50],"mechanisms,":[51],"we":[52],"investigated":[53],"influence":[55],"strain":[57,80],"on":[59,216],"course":[61],"experimental":[63],"disease.":[64],"Twelve":[65],"M.":[66,179,225],"strains,":[68],"representing":[69],"four":[70],"major":[71],"genotype":[72,150],"families":[73,151],"worldwide":[75],"today,":[76],"and":[77,112,121,134,139,147,196,207],"laboratory":[79,232],"H37Rv":[81,173],"were":[82,100,208],"each":[83],"used":[84],"infect":[86],"BALB/c":[87],"mice":[88,206],"by":[89,102],"direct":[90],"intratracheal":[91],"injection.":[92],"Compared":[93],"H37Rv,":[95],"infections":[96],"Beijng":[98],"characterized":[101],"extensive":[103],"pneumonia,":[104,131],"early":[105],"but":[106],"ephemeral":[107],"tumour":[108],"necrosis":[109],"factor-alpha":[110],"(TNF-alpha)":[111],"inducible":[113],"isoform":[114],"nitric":[116],"oxide":[117],"synthetase":[118],"(iNOS)":[119],"expression,":[120],"significantly":[122],"higher":[123],"earlier":[124],"mortality.":[125],"Conversely,":[126],"Canetti":[127],"induced":[129],"limited":[130],"sustained":[132],"TNF-alpha":[133],"iNOS":[135],"expression":[136],"lungs,":[138],"almost":[140],"100%":[141],"survival.":[142,158],"Strains":[143],"Somali":[146],"Haarlem":[149],"displayed":[152],"less":[153,163],"homogeneous,":[154],"intermediate":[155],"rates":[156],"Previous":[159],"BCG":[160],"vaccination":[161],"protected":[162],"effectively":[164],"against":[165,171],"infection":[166],"Beijing":[168,190],"than":[170,229],"strain.":[174],"conclusion,":[176],"genetically":[177],"different":[178,184],"evoked":[182],"markedly":[183],"immunopathological":[185],"events.":[186],"Bacteria":[187],"genotype,":[191],"highly":[192],"prevalent":[193],"Asia":[195],"former":[198],"USSR,":[199],"elicited":[200],"a":[201,221,230],"non-protective":[202],"immune":[203],"response":[204],"most":[210],"virulent.":[211],"Future":[212],"immunological":[213],"research,":[214],"particularly":[215],"candidate":[217],"vaccines,":[218],"should":[219],"include":[220],"broad":[222],"spectrum":[223],"rather":[228],"few":[231],"strains.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":35},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}