{"id":"https://openalex.org/W2086170263","doi":"https://doi.org/10.1021/bi970805s","title":"Structure and Function of the Xenobiotic Substrate-Binding Site and Location of a Potential Non-Substrate-Binding Site in a Class \u03c0 Glutathione S-Transferase,","display_name":"Structure and Function of the Xenobiotic Substrate-Binding Site and Location of a Potential Non-Substrate-Binding Site in a Class \u03c0 Glutathione S-Transferase,","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2086170263","doi":"https://doi.org/10.1021/bi970805s","mag":"2086170263","pmid":"https://pubmed.ncbi.nlm.nih.gov/9245401"},"language":"en","primary_location":{"id":"doi:10.1021/bi970805s","doi":"https://doi.org/10.1021/bi970805s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi970805s","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069231811","display_name":"Xinhua Ji","orcid":"https://orcid.org/0000-0001-6942-1514","observed_orcids":["https://orcid.org/0000-0001-6942-1514"]},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinhua Ji","raw_affiliation_strings":["ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,","institution_ids":["https://openalex.org/I1321296531","https://openalex.org/I200719446","https://openalex.org/I4210140884","https://openalex.org/I4405261596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084386097","display_name":"M\u00e1ria Tordov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Tordova","raw_affiliation_strings":["ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,","institution_ids":["https://openalex.org/I1321296531","https://openalex.org/I200719446","https://openalex.org/I4210140884","https://openalex.org/I4405261596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017190155","display_name":"Rosemary O'Donnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosemary O'Donnell","raw_affiliation_strings":["ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,","institution_ids":["https://openalex.org/I1321296531","https://openalex.org/I200719446","https://openalex.org/I4210140884","https://openalex.org/I4405261596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109319006","display_name":"James F. Parsons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F. Parsons","raw_affiliation_strings":["ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,","institution_ids":["https://openalex.org/I1321296531","https://openalex.org/I200719446","https://openalex.org/I4210140884","https://openalex.org/I4405261596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000602748","display_name":"Janet B. Hayden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet B. Hayden","raw_affiliation_strings":["ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,","institution_ids":["https://openalex.org/I1321296531","https://openalex.org/I200719446","https://openalex.org/I4210140884","https://openalex.org/I4405261596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066462558","display_name":"Gary L. Gilliland","orcid":"https://orcid.org/0000-0001-7394-1846","observed_orcids":["https://orcid.org/0000-0001-7394-1846"]},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary L. Gilliland","raw_affiliation_strings":["ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,","institution_ids":["https://openalex.org/I1321296531","https://openalex.org/I200719446","https://openalex.org/I4210140884","https://openalex.org/I4405261596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085958014","display_name":"Piotr Zimniak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piotr Zimniak","raw_affiliation_strings":["ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL-Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Departments of Medicine and of Biochemistry & Molecular Biology,","institution_ids":["https://openalex.org/I1321296531","https://openalex.org/I200719446","https://openalex.org/I4210140884","https://openalex.org/I4405261596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.6554,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.8400582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"36","issue":"32","first_page":"9690","last_page":"9702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substrate-binding-site","display_name":"substrate binding site","score":0.7960000038146973},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7120000123977661},{"id":"https://openalex.org/keywords/hydrogen-bond-network","display_name":"hydrogen bond network","score":0.8029999732971191},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.968999981880188},{"id":"https://openalex.org/keywords/epoxide-hydrolysis","display_name":"epoxide hydrolysis","score":0.6259999871253967},{"id":"https://openalex.org/keywords/glutathione-conjugation","display_name":"glutathione conjugation","score":0.5350000262260437},{"id":"https://openalex.org/keywords/enzyme-active-site","display_name":"enzyme active site","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7718443870544434},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7245349884033203},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.7070921063423157},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.6177374124526978},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5946951508522034},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5936936736106873},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5257590413093567},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5183359384536743},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.47533583641052246},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.4544459283351898},{"id":"https://openalex.org/C2776376580","wikidata":"https://www.wikidata.org/wiki/Q407355","display_name":"Transferase","level":3,"score":0.44668257236480713},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.43671706318855286},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.36110997200012207},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27468204498291016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13791126012802124},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0947158932685852},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06877312064170837},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006531","descriptor_name":"HEPES","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi970805s","doi":"https://doi.org/10.1021/bi970805s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi970805s","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:9245401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9245401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1986634057","display_name":null,"funder_award_id":"ES 07804","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2065805718","display_name":"Glutathione transferases and oxidative stress toxicology","funder_award_id":"R01ES007804","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3894001105","display_name":"Chemistry, Structure and Biology of Thiol Transferases","funder_award_id":"R01GM030910","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W193935746","https://openalex.org/W206306583","https://openalex.org/W337892304","https://openalex.org/W1489526459","https://openalex.org/W1520933788","https://openalex.org/W1792325685","https://openalex.org/W1842899761","https://openalex.org/W1881840670","https://openalex.org/W1966041739","https://openalex.org/W1986191025","https://openalex.org/W2001641653","https://openalex.org/W2019596708","https://openalex.org/W2021223798","https://openalex.org/W2028231353","https://openalex.org/W2034038760","https://openalex.org/W2044082153","https://openalex.org/W2072594030","https://openalex.org/W2074461690","https://openalex.org/W2075356247","https://openalex.org/W2078057889","https://openalex.org/W2079178286","https://openalex.org/W2080476827","https://openalex.org/W2081502357","https://openalex.org/W2084140341","https://openalex.org/W2088761341","https://openalex.org/W2099388173","https://openalex.org/W2154011403","https://openalex.org/W4238638020"],"related_works":["https://openalex.org/W2112440852","https://openalex.org/W2079178286","https://openalex.org/W2157623058","https://openalex.org/W1992528871","https://openalex.org/W2048414704","https://openalex.org/W2119998716","https://openalex.org/W2049246523","https://openalex.org/W2011128626","https://openalex.org/W2043188811","https://openalex.org/W2328379975"],"abstract_inverted_index":{"Complex":[0],"structures":[1,35],"of":[2,7,27,74,102,129,140,146,160,166,178,200,209,231,246],"a":[3,46,66,141,169,183,236],"naturally":[4],"occurring":[5],"variant":[6],"human":[8],"class":[9,53],"pi":[10],"glutathione":[11,210],"S-transferase":[12],"1-1":[13,56],"(hGSTP1-1)":[14],"with":[15,174],"either":[16],"S-hexylglutathione":[17],"or":[18],"(9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,":[19],"10-dihydrophenanthrene":[20],"[(9R,10R)-GSPhen]":[21],"have":[22],"been":[23],"determined":[24],"at":[25,45],"resolutions":[26],"1.8":[28],"and":[29,82,92,95,110,112,125,131,155,192,225,229],"1.9":[30],"A,":[31],"respectively.":[32],"The":[33,163,227],"crystal":[34],"reveal":[36],"that":[37,50,137,240],"the":[38,63,71,86,99,121,126,138,147,151,157,161,175,179,197,207,221,247],"xenobiotic":[39],"substrate-binding":[40,158],"site":[41,234,239],"(H-site)":[42],"is":[43,65,88,96,134,182,218,241],"located":[44],"position":[47],"similar":[48],"to":[49,211],"observed":[51],"in":[52,206,220,243],"mu":[54],"GST":[55],"from":[57],"rat":[58],"liver":[59],"(rGSTM1-1).":[60],"In":[61,84],"rGSTM1-1,":[62],"H-site":[64,152],"hydrophobic":[67,91],"cavity":[68,87,222],"defined":[69,97],"by":[70,98],"side":[72,100,127],"chains":[73,101,128],"Y6,":[75],"W7,":[76],"V9,":[77],"L12,":[78],"I111,":[79],"Y115,":[80],"F208,":[81],"S209.":[83],"hGSTP1-1,":[85],"approximately":[89],"half":[90,93],"hydrophilic":[94],"Y7,":[103],"F8,":[104],"V10,":[105],"R13,":[106],"V104,":[107],"Y108,":[108],"N204,":[109],"G205":[111],"five":[113,122],"water":[114,123,153],"molecules.":[115],"A":[116],"hydrogen":[117,170,185],"bond":[118,171,186],"network":[119],"connects":[120],"molecules":[124],"R13":[130],"N204.":[132],"V104":[133],"positioned":[135],"such":[136],"introduction":[139],"methyl":[142],"group":[143,165,199],"(the":[144],"result":[145],"V104I":[148],"mutation)":[149],"disturbs":[150],"structure":[154],"alters":[156],"properties":[159,230],"isozyme.":[162],"hydroxyl":[164,198],"Y7":[167],"forms":[168],"(3.2":[172],"A)":[173,188],"sulfur":[176],"atom":[177],"product.":[180],"There":[181],"short":[184],"(2.5":[187],"between":[189,223],"Y108":[190,201],"(OH)":[191],"(9R,":[193],"10R)-GSPhen":[194],"(O5),":[195],"indicating":[196],"as":[202],"an":[203],"electrophilic":[204],"participant":[205],"addition":[208],"epoxides.":[212],"An":[213],"N-(2-hydroxethyl)piperazine-N'-2-ethanesulfonic":[214],"acid":[215],"(HEPES)":[216],"molecule":[217],"found":[219],"beta2":[224],"alphaI.":[226],"location":[228],"this":[232],"HEPES-binding":[233],"fit":[235],"possible":[237],"non-substrate-binding":[238],"involved":[242],"noncompetitive":[244],"inhibition":[245],"enzyme.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
