{"id":"https://openalex.org/W2085969237","doi":"https://doi.org/10.1016/s0165-5728(98)00132-5","title":"Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death","display_name":"Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W2085969237","doi":"https://doi.org/10.1016/s0165-5728(98)00132-5","mag":"2085969237","pmid":"https://pubmed.ncbi.nlm.nih.gov/9726836"},"language":"en","primary_location":{"id":"doi:10.1016/s0165-5728(98)00132-5","doi":"https://doi.org/10.1016/s0165-5728(98)00132-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-5728(98)00132-5","pdf_url":null,"source":{"id":"https://openalex.org/S137419829","display_name":"Journal of Neuroimmunology","issn_l":"0165-5728","issn":["0165-5728","1872-8421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108673916","display_name":"Lap Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lap Ho","raw_affiliation_strings":["Neuroinflammation Research Centre, Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029-6574, USA","Neuroinflammation Research Centre, Department of Psychiatry and Brookdale Center for Molecular Biology and Fishberg Center for Neurobiology, Box 1229, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroinflammation Research Centre, Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029-6574, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Neuroinflammation Research Centre, Department of Psychiatry and Brookdale Center for Molecular Biology and Fishberg Center for Neurobiology, Box 1229, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Osaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroshi Osaka","raw_affiliation_strings":["Neuroinflammation Research Centre, Department of Psychiatry and Brookdale Center for Molecular Biology and Fishberg Center for Neurobiology, Box 1229, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroinflammation Research Centre, Department of Psychiatry and Brookdale Center for Molecular Biology and Fishberg Center for Neurobiology, Box 1229, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108408168","display_name":"Paul S. S. Aisen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S Aisen","raw_affiliation_strings":["Neuroinflammation Research Centre, Department of Psychiatry and Brookdale Center for Molecular Biology and Fishberg Center for Neurobiology, Box 1229, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroinflammation Research Centre, Department of Psychiatry and Brookdale Center for Molecular Biology and Fishberg Center for Neurobiology, Box 1229, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048364336","display_name":"Giulio Maria Pasinetti","orcid":"https://orcid.org/0000-0002-1524-5196","observed_orcids":["https://orcid.org/0000-0002-1524-5196"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Giulio Maria Pasinetti","raw_affiliation_strings":["Neuroinflammation Research Centre, Department of Psychiatry and Brookdale Center for Molecular Biology and Fishberg Center for Neurobiology, Box 1229, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroinflammation Research Centre, Department of Psychiatry and Brookdale Center for Molecular Biology and Fishberg Center for Neurobiology, Box 1229, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048364336"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":5.1286,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.95759325,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"89","issue":"1-2","first_page":"142","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cox-2-mrna-expression","display_name":"COX-2 mRNA expression","score":0.765999972820282},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8379999995231628},{"id":"https://openalex.org/keywords/dentate-granule-cells","display_name":"dentate gyrus granule cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/p19-cells","display_name":"P19 cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8583908677101135},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6445664167404175},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5503156781196594},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.544920802116394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4898378551006317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48967745900154114},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4295499622821808},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4280718266963959},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4170725345611572},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.40504786372184753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2186679244041443},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16657423973083496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07987171411514282},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07154965400695801},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05865022540092468}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0165-5728(98)00132-5","doi":"https://doi.org/10.1016/s0165-5728(98)00132-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-5728(98)00132-5","pdf_url":null,"source":{"id":"https://openalex.org/S137419829","display_name":"Journal of Neuroimmunology","issn_l":"0165-5728","issn":["0165-5728","1872-8421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmunology","raw_type":"journal-article"},{"id":"pmid:9726836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9726836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroimmunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G32991890","display_name":null,"funder_award_id":"AG 05138","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3550458066","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005138","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4769657527","display_name":"INFLAMMATION IN AGING AND ALZHEIMERS DISEASE","funder_award_id":"1r03ag014239-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6083021773","display_name":null,"funder_award_id":"AG-13799","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8115219665","display_name":"COMPLEMENT AND NEUROPROTECTION:  ALZHEIMER'S DISEASE","funder_award_id":"R01AG013799","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G931492282","display_name":null,"funder_award_id":"AG14239","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1485442945","https://openalex.org/W1836761553","https://openalex.org/W1964089588","https://openalex.org/W1983479763","https://openalex.org/W1987469323","https://openalex.org/W1988939737","https://openalex.org/W1993459259","https://openalex.org/W1995198341","https://openalex.org/W2006878154","https://openalex.org/W2008424322","https://openalex.org/W2032166908","https://openalex.org/W2038091854","https://openalex.org/W2039453997","https://openalex.org/W2043707891","https://openalex.org/W2045733321","https://openalex.org/W2046454316","https://openalex.org/W2047649942","https://openalex.org/W2064729669","https://openalex.org/W2068477037","https://openalex.org/W2075078491","https://openalex.org/W2085680573","https://openalex.org/W2088519917","https://openalex.org/W2089964041","https://openalex.org/W2093731034","https://openalex.org/W2097997344","https://openalex.org/W2107359522","https://openalex.org/W2147710510","https://openalex.org/W2415888850","https://openalex.org/W6716286290"],"related_works":["https://openalex.org/W1995198341","https://openalex.org/W2123107307","https://openalex.org/W2039908421","https://openalex.org/W2164144995","https://openalex.org/W2031313156","https://openalex.org/W2048786608","https://openalex.org/W2338562269","https://openalex.org/W2005675676","https://openalex.org/W2162319448","https://openalex.org/W1978517176"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}