{"id":"https://openalex.org/W2085950211","doi":"https://doi.org/10.1002/smll.201201098","title":"Microfabricated Nanotopological Surfaces for Study of Adhesion\u2010Dependent Cell Mechanosensitivity","display_name":"Microfabricated Nanotopological Surfaces for Study of Adhesion\u2010Dependent Cell Mechanosensitivity","publication_year":2012,"publication_date":"2012-08-07","ids":{"openalex":"https://openalex.org/W2085950211","doi":"https://doi.org/10.1002/smll.201201098","mag":"2085950211","pmid":"https://pubmed.ncbi.nlm.nih.gov/22887768","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4113413"},"language":"en","primary_location":{"id":"doi:10.1002/smll.201201098","doi":"https://doi.org/10.1002/smll.201201098","is_oa":false,"landing_page_url":"https://doi.org/10.1002/smll.201201098","pdf_url":null,"source":{"id":"https://openalex.org/S94619837","display_name":"Small","issn_l":"1613-6810","issn":["1613-6810","1613-6829"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4113413","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100739315","display_name":"Weiqiang Chen","orcid":"https://orcid.org/0000-0002-9469-8328","observed_orcids":["https://orcid.org/0000-0002-9469-8328"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiqiang Chen","raw_affiliation_strings":["Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48105, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021469738","display_name":"Yubing Sun","orcid":"https://orcid.org/0000-0002-6831-3383","observed_orcids":["https://orcid.org/0000-0002-6831-3383"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yubing Sun","raw_affiliation_strings":["Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48105, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063240874","display_name":"Jianping Fu","orcid":"https://orcid.org/0000-0001-9629-6739","observed_orcids":["https://orcid.org/0000-0001-9629-6739"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jianping Fu","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA","Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Integrated Biosystems and Biomechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48105, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063240874"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":1.513,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.79569292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"81","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11737","display_name":"Advanced Materials and Mechanics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanotopography","display_name":"nanotopography","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.675000011920929},{"id":"https://openalex.org/keywords/reactive-ion-etching","display_name":"reactive ion etching","score":0.925000011920929},{"id":"https://openalex.org/keywords/photolithography","display_name":"photolithography","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nih-3t3-cells","display_name":"NIH3T3 cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":1.0},{"id":"https://openalex.org/keywords/biomaterials","display_name":"biomaterials","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C2777803738","wikidata":"https://www.wikidata.org/wiki/Q17146922","display_name":"Nanotopography","level":2,"score":0.8629308938980103},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7281113862991333},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.6640877723693848},{"id":"https://openalex.org/C527607","wikidata":"https://www.wikidata.org/wiki/Q175538","display_name":"Microfabrication","level":4,"score":0.6560053825378418},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.635384202003479},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6329160928726196},{"id":"https://openalex.org/C25479853","wikidata":"https://www.wikidata.org/wiki/Q12228614","display_name":"Nanopillar","level":3,"score":0.6105582118034363},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5980387330055237},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5876017808914185},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5522725582122803},{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.44518396258354187},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4233555793762207},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3230125308036804},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3071763515472412},{"id":"https://openalex.org/C186187911","wikidata":"https://www.wikidata.org/wiki/Q1093894","display_name":"Nanostructure","level":2,"score":0.1900148093700409},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13900750875473022},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0745340883731842},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008858","descriptor_name":"Microscopy, Phase-Contrast","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/smll.201201098","doi":"https://doi.org/10.1002/smll.201201098","is_oa":false,"landing_page_url":"https://doi.org/10.1002/smll.201201098","pdf_url":null,"source":{"id":"https://openalex.org/S94619837","display_name":"Small","issn_l":"1613-6810","issn":["1613-6810","1613-6829"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small","raw_type":"journal-article"},{"id":"pmid:22887768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22887768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3080750","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4113413","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4113413","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4113413","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Small","raw_type":"Text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/96422","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2027.42/96422","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3080750","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4113413","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6335250796","display_name":"SPORE in Prostate Cancer","funder_award_id":"P50CA069568","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1965933207","https://openalex.org/W1969929083","https://openalex.org/W1972081276","https://openalex.org/W1978485964","https://openalex.org/W1982769493","https://openalex.org/W1993006648","https://openalex.org/W1997974665","https://openalex.org/W2014015638","https://openalex.org/W2015979204","https://openalex.org/W2022735988","https://openalex.org/W2027820520","https://openalex.org/W2054598075","https://openalex.org/W2054635074","https://openalex.org/W2065223500","https://openalex.org/W2066276903","https://openalex.org/W2072827131","https://openalex.org/W2079921510","https://openalex.org/W2081418737","https://openalex.org/W2082917270","https://openalex.org/W2086243374","https://openalex.org/W2090056458","https://openalex.org/W2093126111","https://openalex.org/W2106639911","https://openalex.org/W2108405037","https://openalex.org/W2110148884","https://openalex.org/W2113641476","https://openalex.org/W2134208433","https://openalex.org/W2159060295","https://openalex.org/W4297907671"],"related_works":["https://openalex.org/W2009880018","https://openalex.org/W2079606989","https://openalex.org/W2249852767","https://openalex.org/W415489050","https://openalex.org/W2039973857","https://openalex.org/W3005850586","https://openalex.org/W1987051011","https://openalex.org/W2127421666","https://openalex.org/W2913110707","https://openalex.org/W3179500390"],"abstract_inverted_index":{"Cells":[0],"exhibit":[1],"high":[2],"sensitivity":[3],"and":[4,28,41,72,79],"diverse":[5,60],"responses":[6,83],"to":[7,77,84],"the":[8,12,32],"intrinsic":[9],"nanotopography":[10],"of":[11,31,62],"extracellular":[13],"matrix":[14],"through":[15],"their":[16],"nanoscale":[17],"cellular":[18,82],"sensing":[19],"machinery.":[20],"A":[21],"simple":[22],"microfabrication":[23],"method":[24],"for":[25,90,98],"precise":[26],"control":[27,78],"spatial":[29],"patterning":[30],"local":[33,51],"nanoroughness":[34,52,85],"on":[35],"glass":[36],"surfaces":[37],"by":[38],"using":[39],"photolithography":[40],"reactive":[42],"ion":[43],"etching":[44],"is":[45,48],"reported.":[46],"It":[47],"demonstrated":[49],"that":[50],"as":[53],"a":[54,59],"biophysical":[55],"cue":[56],"could":[57],"regulate":[58],"array":[61],"NIH/3T3":[63],"fibroblast":[64],"behaviors,":[65],"including":[66],"cell":[67],"morphology,":[68],"adhesion,":[69],"proliferation,":[70],"migration,":[71],"cytoskeleton":[73],"contractility.":[74],"The":[75],"capability":[76],"further":[80],"predict":[81],"might":[86],"suggest":[87],"novel":[88],"methods":[89],"developing":[91],"biomaterials":[92],"mimicking":[93],"nanotopographic":[94],"structures":[95],"in":[96],"vivo":[97],"functional":[99],"tissue":[100],"engineering.":[101]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
