{"id":"https://openalex.org/W2085713554","doi":"https://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","title":"Control of C3b and C5b deposition by CD46 (membrane cofactor protein) after alternative but not classical complement activation","display_name":"Control of C3b and C5b deposition by CD46 (membrane cofactor protein) after alternative but not classical complement activation","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2085713554","doi":"https://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","mag":"2085713554","pmid":"https://pubmed.ncbi.nlm.nih.gov/10092084"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199903%2929%3A03%3C815%3A%3AAID-IMMU815%3E3.0.CO%3B2-8","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199903%2929%3A03%3C815%3A%3AAID-IMMU815%3E3.0.CO%3B2-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041207966","display_name":"Patricia Devaux","orcid":"https://orcid.org/0000-0002-5345-8336","observed_orcids":["https://orcid.org/0000-0002-5345-8336"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patricia Devaux","raw_affiliation_strings":["Immunit\u00e9 & Infections Virales, IVMC, CNRS-UCBL UMR 5537, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunit\u00e9 & Infections Virales, IVMC, CNRS-UCBL UMR 5537, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070473478","display_name":"Dale Christiansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dale Christiansen","raw_affiliation_strings":["Immunite\u0301 & Infections Virales I.V.M.C., CNRS-UCBL UMR 5537, Lyon, France","Immunit\u00e9 & Infections Virales I.V.M.C., CNRS-UCBL UMR 5537, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunite\u0301 & Infections Virales I.V.M.C., CNRS-UCBL UMR 5537, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Immunit\u00e9 & Infections Virales I.V.M.C., CNRS-UCBL UMR 5537, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040108125","display_name":"Marc Fontaine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Fontaine","raw_affiliation_strings":["INSERM U78, Faculte\u0301 mixte de Me\u0301decine et Pharmacie, Rouen, France","INSERM U78, Facult\u00e9 mixte de M\u00e9decine et Pharmacie, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U78, Faculte\u0301 mixte de Me\u0301decine et Pharmacie, Rouen, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U78, Facult\u00e9 mixte de M\u00e9decine et Pharmacie, Rouen, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076173260","display_name":"Denis Gerlier","orcid":"https://orcid.org/0000-0001-5539-456X","observed_orcids":["https://orcid.org/0000-0001-5539-456X"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denis Gerlier","raw_affiliation_strings":["Immunite\u0301 & Infections Virales I.V.M.C., CNRS-UCBL UMR 5537, Lyon, France","Immunit\u00e9 & Infections Virales I.V.M.C., CNRS-UCBL UMR 5537, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunite\u0301 & Infections Virales I.V.M.C., CNRS-UCBL UMR 5537, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Immunit\u00e9 & Infections Virales I.V.M.C., CNRS-UCBL UMR 5537, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":1.5966,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.83070648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"29","issue":"03","first_page":"815","last_page":"822"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd46","display_name":"CD46","score":0.949999988079071},{"id":"https://openalex.org/keywords/membrane-cofactor-protein","display_name":"membrane cofactor protein","score":0.9909999966621399},{"id":"https://openalex.org/keywords/complement-regulation","display_name":"complement regulation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/c3b-deposition","display_name":"C3b deposition","score":0.875},{"id":"https://openalex.org/keywords/alternative-complement-pathway","display_name":"alternative complement pathway","score":0.9879999756813049},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.9959999918937683},{"id":"https://openalex.org/keywords/c3-convertase","display_name":"C3 convertase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/c5-convertase","display_name":"C5 convertase","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.9216197729110718},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.7853842973709106},{"id":"https://openalex.org/C92731135","wikidata":"https://www.wikidata.org/wiki/Q4035579","display_name":"CD46","level":4,"score":0.7265028953552246},{"id":"https://openalex.org/C9478725","wikidata":"https://www.wikidata.org/wiki/Q5008114","display_name":"C3-convertase","level":5,"score":0.7092612385749817},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.604409396648407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5528087019920349},{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.508562445640564},{"id":"https://openalex.org/C64297162","wikidata":"https://www.wikidata.org/wiki/Q1987070","display_name":"Deposition (geology)","level":3,"score":0.4861904978752136},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.38711702823638916},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3787177801132202},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3543626070022583},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3337162733078003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33148401975631714},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.163998544216156},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15617966651916504},{"id":"https://openalex.org/C2816523","wikidata":"https://www.wikidata.org/wiki/Q180184","display_name":"Sediment","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003169","descriptor_name":"Complement Inactivator Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003179","descriptor_name":"Complement C3b","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003182","descriptor_name":"Complement C5","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050776","descriptor_name":"Complement C5b","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051916","descriptor_name":"Membrane Cofactor Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199903%2929%3A03%3C815%3A%3AAID-IMMU815%3E3.0.CO%3B2-8","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.3.co;2-#","doi":"https://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.3.co;2-#","is_oa":false,"landing_page_url":"http://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.3.co;2-#","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:10092084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10092084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02475186v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02475186","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Immunology, 1999, 29 (3), pp.815-822. &#x27E8;10.1002/(SICI)1521-4141(199903)29:033.0.CO;2-8&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","doi":"https://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1521-4141(199903)29:03<815::aid-immu815>3.0.co;2-8","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291521-4141%28199903%2929%3A03%3C815%3A%3AAID-IMMU815%3E3.0.CO%3B2-8","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322891","display_name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Sup\u00e9rieur et de la Recherche","ror":"https://ror.org/03sjk9a61"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2085713554.pdf","grobid_xml":"https://content.openalex.org/works/W2085713554.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W345313747","https://openalex.org/W1541628337","https://openalex.org/W1596122825","https://openalex.org/W1604210437","https://openalex.org/W1630187190","https://openalex.org/W1812697829","https://openalex.org/W1831186908","https://openalex.org/W1906351552","https://openalex.org/W1970946495","https://openalex.org/W1985261073","https://openalex.org/W2001342707","https://openalex.org/W2019176700","https://openalex.org/W2043116254","https://openalex.org/W2055978589","https://openalex.org/W2058954337","https://openalex.org/W2076086679","https://openalex.org/W2097222143","https://openalex.org/W2109323320","https://openalex.org/W2129071590","https://openalex.org/W2140971592","https://openalex.org/W2144106231","https://openalex.org/W2146816086","https://openalex.org/W2152020672","https://openalex.org/W2152070428","https://openalex.org/W2188704141","https://openalex.org/W2585732487"],"related_works":["https://openalex.org/W1550517269","https://openalex.org/W2079596700","https://openalex.org/W2097250023","https://openalex.org/W2095322182","https://openalex.org/W2144106231","https://openalex.org/W2017209826","https://openalex.org/W1590533130","https://openalex.org/W2152020672","https://openalex.org/W2161682867","https://openalex.org/W2414505813"],"abstract_inverted_index":{"C3b":[0,36,61,67,83,95,141,167,194],"and":[1,7,23,125,133,213],"C5b":[2,100,148],"deposition":[3,37,62,68,84,96,101,142,149,168,195],"following":[4,112,154],"complement":[5],"activation,":[6],"its":[8],"regulation":[9,146],"by":[10,55,150,172],"CD46":[11,75,151,164,188],"were":[12,85],"studied":[13],"using":[14,128],"xenogenic":[15],"Chinese":[16],"hamster":[17],"ovary":[18],"(CHO)":[19],"cells":[20,111],"as":[21],"targets":[22],"cytofluorometry.":[24],"Following":[25],"activation":[26,113,155],"of":[27,35,48,60,82,91,114,119,147,156,182,200,208],"the":[28,80,89,92,115,120,157,166,173,180,183,191,198,201,206,209],"alternative":[29,116,174,184,202],"pathway,":[30],"an":[31],"initial":[32],"low":[33],"level":[34,59],"was":[38,53,69,76,97,102,152],"observed":[39,104],"on":[40,105,109,123],"CHO":[41,106,124],"cell":[42],"surfaces":[43],"after":[44],"a":[45,56,64],"lag":[46],"time":[47],"approximately":[49],"4":[50],"min.":[51,73],"This":[52],"followed":[54],"secondary":[57,93],"high":[58,94],"with":[63],"slower":[65],"rate.":[66],"maximal":[70],"within":[71],"15":[72],"When":[74],"expressed":[77],"(B2":[78],"isoform),":[79],"kinetics":[81],"essentially":[86],"unchanged,":[87],"but":[88,107],"onset":[90],"fully":[98],"prevented.":[99],"also":[103],"not":[108],"CHO.CD46":[110,126],"pathway.":[117,159],"Activation":[118],"classical":[121,158,211],"pathway":[122],"cells,":[127],"factor":[129],"B-depleted":[130],"human":[131],"serum":[132],"anti-CHO":[134],"antibodies,":[135],"resulted":[136],"in":[137],"almost":[138],"identical":[139],"single-peak":[140],"profiles.":[143],"Accordingly,":[144],"no":[145],"evident":[153],"These":[160],"data":[161],"indicate":[162],"that":[163],"prevents":[165,189],"amplification":[169],"loop":[170],"mediated":[171],"C3":[175,203,212],"convertase":[176,204],"and,":[177],"consequently,":[178],"inhibits":[179],"formation":[181,199,207],"C5":[185,214],"convertase.":[186],"But":[187],"neither":[190],"spontaneous":[192],"tick-over":[193],"leading":[196],"to":[197],"nor":[205],"functional":[210],"convertases.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}