{"id":"https://openalex.org/W2085680979","doi":null,"title":"Farmakologiczna modulacja funkcji i \u017cywotno\u015bci astrocyt\u00f3w jako nowa strategia neuroprotekcji po niedokrwieniu","display_name":"Farmakologiczna modulacja funkcji i \u017cywotno\u015bci astrocyt\u00f3w jako nowa strategia neuroprotekcji po niedokrwieniu","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2085680979","mag":"2085680979"},"language":"pl","primary_location":{"id":"mag:2085680979","doi":null,"is_oa":false,"landing_page_url":"https://kosmos.ptpk.org/index.php/Kosmos/article/view/294","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Kosmos","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029224222","display_name":"Kinga Szyd\u0142owska","orcid":"https://orcid.org/0000-0001-9019-7676","observed_orcids":["https://orcid.org/0000-0001-9019-7676"]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Kinga Szyd\u0142owska","raw_affiliation_strings":["Instytut Biologii Doswiadczalnej im.M.Nenckiego PAN, ul.Pasteura 3, 02-093 Warszawa"],"raw_orcid":"https://orcid.org/0000-0001-9019-7676","affiliations":[{"raw_affiliation_string":"Instytut Biologii Doswiadczalnej im.M.Nenckiego PAN, ul.Pasteura 3, 02-093 Warszawa","institution_ids":["https://openalex.org/I16778253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029224222"],"corresponding_institution_ids":["https://openalex.org/I16778253"],"apc_list":null,"apc_paid":null,"fwci":0.2092,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57584588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"57","issue":null,"first_page":"315","last_page":"329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.3628000020980835,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8669999837875366},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.8510000109672546},{"id":"https://openalex.org/keywords/calcineurin-inhibition","display_name":"calcineurin inhibition","score":0.9459999799728394},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/astrocyte-apoptosis","display_name":"astrocyte apoptosis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/neuron-astrocyte-interactions","display_name":"astrocyte-neuron interaction","score":0.8500000238418579},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.6179999709129333},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8173083066940308},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.733162522315979},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7190633416175842},{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.6814125776290894},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.6367701292037964},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5839266777038574},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5212381482124329},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.520193338394165},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.49326151609420776},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4373885989189148},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.41795897483825684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40313997864723206},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.37990105152130127},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34437626600265503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34074288606643677},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2992105782032013},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21212172508239746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18205499649047852},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09325456619262695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06168285012245178},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2085680979","doi":null,"is_oa":false,"landing_page_url":"https://kosmos.ptpk.org/index.php/Kosmos/article/view/294","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Kosmos","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W14148946","https://openalex.org/W129973106","https://openalex.org/W956232093","https://openalex.org/W1483485226","https://openalex.org/W1515334051","https://openalex.org/W1528505919","https://openalex.org/W1837631563","https://openalex.org/W1896952141","https://openalex.org/W1927904330","https://openalex.org/W1933803939","https://openalex.org/W1966343462","https://openalex.org/W1969305530","https://openalex.org/W1969530182","https://openalex.org/W1969612832","https://openalex.org/W1970842110","https://openalex.org/W1970918690","https://openalex.org/W1973198505","https://openalex.org/W1973351637","https://openalex.org/W1973587217","https://openalex.org/W1974720828","https://openalex.org/W1974892577","https://openalex.org/W1975111111","https://openalex.org/W1978171275","https://openalex.org/W1978876632","https://openalex.org/W1978896829","https://openalex.org/W1979031928","https://openalex.org/W1980180348","https://openalex.org/W1981196417","https://openalex.org/W1983836947","https://openalex.org/W1984506820","https://openalex.org/W1989639507","https://openalex.org/W1990216374","https://openalex.org/W2000075190","https://openalex.org/W2001537648","https://openalex.org/W2007910408","https://openalex.org/W2012454384","https://openalex.org/W2013763910","https://openalex.org/W2014178477","https://openalex.org/W2015079240","https://openalex.org/W2015463429","https://openalex.org/W2018819897","https://openalex.org/W2019890311","https://openalex.org/W2023375612","https://openalex.org/W2024547006","https://openalex.org/W2025461456","https://openalex.org/W2026289215","https://openalex.org/W2029624481","https://openalex.org/W2031273428","https://openalex.org/W2031644015","https://openalex.org/W2035493973","https://openalex.org/W2037337146","https://openalex.org/W2039686824","https://openalex.org/W2039721791","https://openalex.org/W2041356239","https://openalex.org/W2042095676","https://openalex.org/W2046578258","https://openalex.org/W2047687479","https://openalex.org/W2048841941","https://openalex.org/W2050525685","https://openalex.org/W2052045439","https://openalex.org/W2052672438","https://openalex.org/W2056959062","https://openalex.org/W2058708999","https://openalex.org/W2061668138","https://openalex.org/W2062148496","https://openalex.org/W2063272984","https://openalex.org/W2066036370","https://openalex.org/W2074057272","https://openalex.org/W2074187719","https://openalex.org/W2076052606","https://openalex.org/W2077704809","https://openalex.org/W2080636088","https://openalex.org/W2087798692","https://openalex.org/W2088139813","https://openalex.org/W2094022748","https://openalex.org/W2096978860","https://openalex.org/W2103456224","https://openalex.org/W2109917609","https://openalex.org/W2116552938","https://openalex.org/W2121376151","https://openalex.org/W2127338217","https://openalex.org/W2128249118","https://openalex.org/W2128772172","https://openalex.org/W2134733089","https://openalex.org/W2137911312","https://openalex.org/W2140175924","https://openalex.org/W2143302994","https://openalex.org/W2148980073","https://openalex.org/W2149382113","https://openalex.org/W2158500293","https://openalex.org/W2158972964","https://openalex.org/W2159119513","https://openalex.org/W2162943360","https://openalex.org/W2166014740","https://openalex.org/W2167596663","https://openalex.org/W2169079203","https://openalex.org/W2782175582"],"related_works":["https://openalex.org/W1978896829","https://openalex.org/W1977541339","https://openalex.org/W2056959062","https://openalex.org/W2019360814","https://openalex.org/W2124549591","https://openalex.org/W1984506820","https://openalex.org/W2134733089","https://openalex.org/W4386274190","https://openalex.org/W2598700789","https://openalex.org/W1989639507"],"abstract_inverted_index":{"Neuron-astrocyte":[0],"interactions":[1],"are":[2,80],"critical":[3],"for":[4],"signalling,":[5],"energy":[6],"metabolism,":[7],"extracellular":[8],"ion":[9],"and":[10,15,31,39,55,61,70,110,124,137,163,171,179,192],"glutamate":[11,29,105],"homeostasis,":[12],"volume":[13],"regulation":[14],"neuroprotection":[16],"in":[17,50,75,93,116,129,149,166,177,180,196,204],"the":[18,76],"central":[19],"nervous":[20],"system.":[21],"Glutamate":[22],"uptake":[23],"by":[24],"astrocytes":[25,79,103,176],"may":[26,198],"prevent":[27],"excitotoxic":[28],"elevation":[30],"determine":[32],"neuronal":[33,158],"survival.":[34],"However,":[35],"activation":[36],"of":[37,52,72,96,100,122,132,169,175,189],"astrogliosis":[38],"brain":[40,47,97,164],"inflammation":[41,165],"during":[42],"cerebral":[43],"ischemia":[44],"exacerbates":[45],"primary":[46],"damage,":[48],"resulting":[49],"upregulation":[51],"cytotoxic/infammatory":[53],"cytokines":[54],"mediators,":[56],"that":[57,187],"alter":[58],"blood":[59],"flow":[60],"increase":[62],"vascular":[63],"permeability,":[64],"thus":[65],"leading":[66],"to":[67,85,104],"secondary":[68],"damage":[69],"accumulation":[71],"immune":[73],"cells":[74],"brain.":[77,118,182],"Although,":[78],"more":[81],"resistant":[82],"than":[83],"neurons":[84,155],"ischemic":[86,117,181],"injury,":[87],"astrocyte":[88,190],"death":[89,109,195],"have":[90],"been":[91],"demonstrated":[92],"animal":[94,130,167],"models":[95,131,168],"ischemia.":[98,139],"Exposure":[99],"cultured":[101],"cortical":[102],"induces":[106],"apoptotic":[107],"cell":[108,159],"similar":[111],"events":[112],"can":[113],"be":[114,199],"detected":[115],"FK506,":[119],"an":[120],"inhibitor":[121],"calcineurin":[123],"immunosuppressive":[125],"drug,":[126],"is":[127],"neuroprotective":[128],"neurologic":[133],"diseases,":[134],"including":[135],"focal":[136],"global":[138],"FK506":[140],"exerts":[141],"a":[142,200],"complex":[143],"action":[144],"on":[145],"many":[146],"processes":[147],"ongoing":[148],"pathological":[150],"brain:":[151],"it":[152],"directly":[153],"protects":[154],"from":[156],"glutamate-induced":[157],"death,":[160],"reduces":[161],"gliosis":[162],"stroke,":[170],"inhibits":[172],"Glu-induced":[173],"apoptosis":[174],"vitro":[178],"Altogether,":[183],"recent":[184],"findings":[185],"suggest":[186],"modulation":[188],"functions":[191],"astrocytic":[193],"survival/cell":[194],"neurodegeneration":[197],"novel":[201],"therapeutic":[202],"strategy":[203],"neurological":[205],"disorders.":[206]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}