{"id":"https://openalex.org/W2085648819","doi":"https://doi.org/10.7150/ijms.8577","title":"Effects of Ang II Receptor Blocker Irbesartan on Adipose Tissue Function in Mice with Metabolic Disorders","display_name":"Effects of Ang II Receptor Blocker Irbesartan on Adipose Tissue Function in Mice with Metabolic Disorders","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2085648819","doi":"https://doi.org/10.7150/ijms.8577","mag":"2085648819","pmid":"https://pubmed.ncbi.nlm.nih.gov/24834011"},"language":"en","primary_location":{"id":"doi:10.7150/ijms.8577","doi":"https://doi.org/10.7150/ijms.8577","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijms.8577","pdf_url":"https://www.medsci.org/v11p0646.pdf","source":{"id":"https://openalex.org/S46225466","display_name":"International Journal of Medical Sciences","issn_l":"1449-1907","issn":["1449-1907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.medsci.org/v11p0646.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011507465","display_name":"Akinobu Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinobu Maeda","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063566174","display_name":"Kouichi Tamura","orcid":"https://orcid.org/0000-0002-0660-5372","observed_orcids":["https://orcid.org/0000-0002-0660-5372"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kouichi Tamura","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028819689","display_name":"Hiromichi Wakui","orcid":"https://orcid.org/0000-0001-8023-922X","observed_orcids":["https://orcid.org/0000-0001-8023-922X","https://orcid.org/0000-0002-9748-5811"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromichi Wakui","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004675936","display_name":"Masato Ohsawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Ohsawa","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044044075","display_name":"Kengo Azushima","orcid":"https://orcid.org/0000-0002-5136-0730","observed_orcids":["https://orcid.org/0000-0002-5136-0730"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kengo Azushima","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081793444","display_name":"Kazushi Uneda","orcid":"https://orcid.org/0000-0002-9660-142X","observed_orcids":["https://orcid.org/0000-0002-9660-142X"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazushi Uneda","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102860389","display_name":"Ryu Kobayashi","orcid":"https://orcid.org/0000-0003-1075-2372","observed_orcids":["https://orcid.org/0000-0003-1075-2372"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryu Kobayashi","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032452130","display_name":"Yuko Tsurumi\u2010Ikeya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Tsurumi-Ikeya","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051340028","display_name":"Tomohiko Kanaoka","orcid":"https://orcid.org/0000-0001-5267-3790","observed_orcids":["https://orcid.org/0000-0001-5267-3790"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiko Kanaoka","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007035912","display_name":"Toru Dejima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Dejima","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059892780","display_name":"Koji Ohki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Ohki","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047613165","display_name":"Sona Haku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sona Haku","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065349837","display_name":"Akio Yamashita","orcid":"https://orcid.org/0000-0001-7095-4473","observed_orcids":["https://orcid.org/0000-0001-7095-4473"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Yamashita","raw_affiliation_strings":["2. Department of Molecular Biology, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2. Department of Molecular Biology, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111708707","display_name":"Satoshi Umemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Umemura","raw_affiliation_strings":["1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate Scholl of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan","institution_ids":["https://openalex.org/I89630735"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063566174"],"corresponding_institution_ids":["https://openalex.org/I89630735"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":1.4785,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.84054767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"6","first_page":"646","last_page":"651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irbesartan","display_name":"irbesartan","score":1.0},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9309999942779541},{"id":"https://openalex.org/keywords/kk-ay-mice","display_name":"KK-Ay mice","score":0.765999972820282},{"id":"https://openalex.org/keywords/genetic-obesity","display_name":"genetic obesity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8059999942779541},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8349999785423279},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9760000109672546},{"id":"https://openalex.org/keywords/atrap","display_name":"ATRAP","score":0.9129999876022339},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7400000095367432},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.6830000281333923},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2780259554","wikidata":"https://www.wikidata.org/wiki/Q947266","display_name":"Irbesartan","level":3,"score":0.9734726548194885},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.9147286415100098},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8438944816589355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8041846752166748},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6758109927177429},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6369948387145996},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4913412630558014},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.44522824883461},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.44196605682373047},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.44077083468437195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3516097664833069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3201258182525635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26543471217155457},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.23836886882781982},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.17452356219291687}],"mesh":[{"descriptor_ui":"D000077405","descriptor_name":"Irbesartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077405","descriptor_name":"Irbesartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077405","descriptor_name":"Irbesartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.7150/ijms.8577","doi":"https://doi.org/10.7150/ijms.8577","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijms.8577","pdf_url":"https://www.medsci.org/v11p0646.pdf","source":{"id":"https://openalex.org/S46225466","display_name":"International Journal of Medical Sciences","issn_l":"1449-1907","issn":["1449-1907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmid:24834011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24834011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2998804","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4021097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4021097","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4021097","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Med Sci","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.687.5974","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.687.5974","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.medsci.org/v11p0646.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.7150/ijms.8577","doi":"https://doi.org/10.7150/ijms.8577","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijms.8577","pdf_url":"https://www.medsci.org/v11p0646.pdf","source":{"id":"https://openalex.org/S46225466","display_name":"International Journal of Medical Sciences","issn_l":"1449-1907","issn":["1449-1907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1094133083","display_name":null,"funder_award_id":"JKFB13-17","funder_id":"https://openalex.org/F4320311436","funder_display_name":"Salt Science Research Foundation"},{"id":"https://openalex.org/G3642819018","display_name":null,"funder_award_id":"JKFB13-17","funder_id":"https://openalex.org/F4320324576","funder_display_name":"Kidney Foundation, Japan"},{"id":"https://openalex.org/G5216726371","display_name":"Receptor-based modulation of cardiovascular disease in the process of aging","funder_award_id":"25460906","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5604646807","display_name":"Research on receptor binding molecule in hypertension and organ injury","funder_award_id":"24591233","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5742921741","display_name":"Development of the high blood pressure medical treatment by angiotensin receptor binding molecule","funder_award_id":"24790950","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311436","display_name":"Salt Science Research Foundation","ror":"https://ror.org/05th9sq46"},{"id":"https://openalex.org/F4320321627","display_name":"Dainippon Sumitomo Pharma","ror":"https://ror.org/04sapgw72"},{"id":"https://openalex.org/F4320324576","display_name":"Kidney Foundation, Japan","ror":"https://ror.org/04dnmj419"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2085648819.pdf","grobid_xml":"https://content.openalex.org/works/W2085648819.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1587875569","https://openalex.org/W1898391394","https://openalex.org/W1964425253","https://openalex.org/W1971277314","https://openalex.org/W1978955123","https://openalex.org/W1996713062","https://openalex.org/W1998416080","https://openalex.org/W1999229158","https://openalex.org/W2007414597","https://openalex.org/W2009590767","https://openalex.org/W2017863220","https://openalex.org/W2039912643","https://openalex.org/W2041089635","https://openalex.org/W2045907417","https://openalex.org/W2060266516","https://openalex.org/W2060376980","https://openalex.org/W2063832381","https://openalex.org/W2069465345","https://openalex.org/W2081455569","https://openalex.org/W2090500556","https://openalex.org/W2092984930","https://openalex.org/W2094498915","https://openalex.org/W2100784798","https://openalex.org/W2102897116","https://openalex.org/W2112914472","https://openalex.org/W2154993634","https://openalex.org/W2165843485","https://openalex.org/W2166156812","https://openalex.org/W2168580426","https://openalex.org/W2169211336","https://openalex.org/W2171157803","https://openalex.org/W2171172775","https://openalex.org/W2171390260","https://openalex.org/W2172142004","https://openalex.org/W4251240516"],"related_works":["https://openalex.org/W2149410839","https://openalex.org/W2149661529","https://openalex.org/W2038563245","https://openalex.org/W2744890335","https://openalex.org/W2350886079","https://openalex.org/W2126797993","https://openalex.org/W2162471541","https://openalex.org/W1966128948","https://openalex.org/W2118736985","https://openalex.org/W2132612653"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"indicate":[2],"that":[3,154],"the":[4,11,21,27,66,74,101,114,123,155,161,165,180],"functional":[5],"renin-angiotensin":[6],"system":[7],"(RAS)":[8],"exists":[9],"in":[10,20,46,90,93,113,164,168],"adipose":[12,15,75,102,115,124,146,166,181],"tissue.":[13,76],"The":[14,77],"tissue":[16,116,136,147,167],"RAS":[17],"is":[18,171],"proposed":[19],"pathophysiology":[22],"of":[23,34,54,71,117,127,135,143,145,177,179,186,189],"metabolic":[24,56],"disorders.":[25],"In":[26,96],"present":[28],"study,":[29],"we":[30],"examined":[31],"therapeutic":[32],"effects":[33,188],"irbesartan,":[35],"an":[36,131],"angiotensin":[37],"II":[38],"(Ang":[39],"II)":[40],"type":[41],"1":[42],"receptor":[43],"(AT1R)-specific":[44],"blocker,":[45],"genetically":[47],"obese":[48],"diabetic":[49],"KKAy":[50,94,118,169],"mice,":[51],"a":[52,87,140,175],"model":[53],"human":[55],"disorders":[57],"without":[58],"any":[59],"dietary":[60],"loading,":[61],"with":[62,79,86,139],"our":[63],"focus":[64],"on":[65,68,73,160],"analysis":[67],"possible":[69],"effect":[70,159],"irbesartan":[72,80,98,121],"treatment":[78],"significantly":[81,99],"lowered":[82],"systolic":[83],"blood":[84],"pressure":[85],"concomitant":[88,141],"decrease":[89,109],"body":[91],"weight":[92],"mice.":[95,119],"addition,":[97],"decreased":[100],"leptin":[103],"mRNA":[104,111],"expression":[105,112,126],"and":[106],"tended":[107],"to":[108],"IL-6":[110],"Furthermore":[120],"preserved":[122],"gene":[125],"AT1R-associated":[128],"protein":[129],"(ATRAP),":[130],"endogenous":[132],"inhibitory":[133],"molecule":[134],"AT1R":[137],"signaling,":[138],"tendency":[142],"up-regulation":[144,178],"ATRAP/AT1R":[148,182],"ratio.":[149],"Collectively,":[150],"these":[151],"results":[152],"suggest":[153],"irbesartan-induced":[156],"beneficial":[157],"suppressive":[158],"leptin-IL-6":[162],"axis":[163],"mice":[170],"partly":[172],"mediated":[173],"by":[174],"trend":[176],"ratio":[183],"as":[184],"one":[185],"pleiotropic":[187],"irbesartan.":[190]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
