{"id":"https://openalex.org/W2085645088","doi":"https://doi.org/10.1016/j.juro.2014.02.1102","title":"MP49-01 SUBCLONAL ORIGIN OF PROSTATE CANCER METASTASIS WITH MUTATOR PHENOTYPE FROM A NOVEL MSH2 GENE FUSION","display_name":"MP49-01 SUBCLONAL ORIGIN OF PROSTATE CANCER METASTASIS WITH MUTATOR PHENOTYPE FROM A NOVEL MSH2 GENE FUSION","publication_year":2014,"publication_date":"2014-03-28","ids":{"openalex":"https://openalex.org/W2085645088","doi":"https://doi.org/10.1016/j.juro.2014.02.1102","mag":"2085645088"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2014.02.1102","doi":"https://doi.org/10.1016/j.juro.2014.02.1102","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2014.02.1102","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026263135","display_name":"Matthew K. H. Hong","orcid":"https://orcid.org/0000-0002-0727-2848","observed_orcids":["https://orcid.org/0000-0002-0727-2848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Hong","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048069780","display_name":"Geoff Macintyre","orcid":"https://orcid.org/0000-0003-3906-467X","observed_orcids":["https://orcid.org/0000-0003-3906-467X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoff Macintyre","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013083229","display_name":"Clare Sloggett","orcid":"https://orcid.org/0000-0001-8409-6705","observed_orcids":["https://orcid.org/0000-0001-8409-6705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clare Sloggett","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023110316","display_name":"Marek Cmero","orcid":"https://orcid.org/0000-0001-7783-5530","observed_orcids":["https://orcid.org/0000-0001-7783-5530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marek Cmero","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021677313","display_name":"Andrew J. Lonie","orcid":"https://orcid.org/0000-0002-2006-3856","observed_orcids":["https://orcid.org/0000-0002-2006-3856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Lonie","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049644716","display_name":"Haroon Naeem","orcid":"https://orcid.org/0000-0001-9019-8345","observed_orcids":["https://orcid.org/0000-0001-9019-8345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haroon Naeem","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004776968","display_name":"David C. Wedge","orcid":"https://orcid.org/0000-0002-7572-3196","observed_orcids":["https://orcid.org/0000-0002-7572-3196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Wedge","raw_affiliation_strings":["Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079808888","display_name":"Peter Van Loo","orcid":"https://orcid.org/0000-0003-0292-1949","observed_orcids":["https://orcid.org/0000-0003-0292-1949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter van Loo","raw_affiliation_strings":["Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080997789","display_name":"Ludmil B. Alexandrov","orcid":"https://orcid.org/0000-0003-3596-4515","observed_orcids":["https://orcid.org/0000-0003-3596-4515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ludmil Alexandrov","raw_affiliation_strings":["Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082727924","display_name":"Nikhil Sapre","orcid":"https://orcid.org/0000-0003-0648-3747","observed_orcids":["https://orcid.org/0000-0003-0648-3747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikhil Sapre","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062061938","display_name":"Pramit M. Phal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pramit Phal","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031792625","display_name":"Xiaowen Chin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaowen Chin","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013449537","display_name":"Michael Kerger","orcid":"https://orcid.org/0000-0002-9745-728X","observed_orcids":["https://orcid.org/0000-0002-9745-728X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Kerger","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109088330","display_name":"John Pedersen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Pedersen","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Ryan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Ryan","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040379508","display_name":"Anthony J. Costello","orcid":"https://orcid.org/0000-0003-3083-1799","observed_orcids":["https://orcid.org/0000-0003-3083-1799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony Costello","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080415325","display_name":"Ultan McDermott","orcid":"https://orcid.org/0000-0001-9032-4700","observed_orcids":["https://orcid.org/0000-0001-9032-4700"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ultan McDermott","raw_affiliation_strings":["Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103118796","display_name":"Niall M. Corcoran","orcid":"https://orcid.org/0000-0003-4483-6945","observed_orcids":["https://orcid.org/0000-0003-4483-6945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niall Corcoran","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080995949","display_name":"Christopher M. Hovens","orcid":"https://orcid.org/0000-0002-0610-1289","observed_orcids":["https://orcid.org/0000-0002-0610-1289"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Hovens","raw_affiliation_strings":["Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melbourne, Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1762957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"191","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.25609999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer-metastasis","display_name":"prostate cancer metastasis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":0.7310000061988831},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mutator-phenotype","display_name":"mutator phenotype","score":0.8899999856948853},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6169999837875366},{"id":"https://openalex.org/keywords/somatic-copy-number-alterations","display_name":"somatic copy number alterations","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5079701542854309},{"id":"https://openalex.org/C74916050","wikidata":"https://www.wikidata.org/wiki/Q841090","display_name":"Classics","level":1,"score":0.35707807540893555},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.20497137308120728}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2014.02.1102","doi":"https://doi.org/10.1016/j.juro.2014.02.1102","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2014.02.1102","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6200000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"You":[0],"have":[1,614],"accessJournal":[2],"of":[3,262,293,318,345,361,402,485,493,537,541,572,579,588],"UrologyProstate":[4],"Cancer:":[5],"Basic":[6],"Research":[7],"IV1":[8],"Apr":[9],"2014MP49-01":[10],"SUBCLONAL":[11],"ORIGIN":[12],"OF":[13],"PROSTATE":[14],"CANCER":[15],"METASTASIS":[16],"WITH":[17],"MUTATOR":[18],"PHENOTYPE":[19],"FROM":[20],"A":[21,534],"NOVEL":[22],"MSH2":[23,280,529,582,622],"GENE":[24],"FUSION":[25],"Matthew":[26,66,643],"Hong,":[27],"Geoff":[28,75,650],"Macintyre,":[29],"Clare":[30,84,657],"Sloggett,":[31],"Marek":[32,93,664],"Cmero,":[33],"Andrew":[34,55,102,194,671,742],"Lonie,":[35],"Haroon":[36,111,678],"Naeem,":[37],"David":[38,120,685],"Wedge,":[39],"Peter":[40,129,692],"van":[41,130,132,693],"Loo,":[42],"Ludmil":[43,140,700],"Alexandrov,":[44],"Nikhil":[45,149,707],"Sapre,":[46],"Pramit":[47,158,714],"Phal,":[48],"Xiaowen":[49,167,721],"Chin,":[50],"Michael":[51,176,728],"Kerger,":[52],"John":[53,185,735],"Pedersen,":[54],"Ryan,":[56],"Anthony":[57,203,749],"Costello,":[58],"Ultan":[59,212,756],"McDermott,":[60],"Niall":[61,221,763],"Corcoran,":[62],"and":[63,230,251,295,307,323,354,398,414,425,428,443,467,516,532,543,546,599,602,605],"Christopher":[64,231,770],"Hovens":[65,233,771],"HongMatthew":[67],"Hong":[68,644],"More":[69,78,87,96,105,114,123,134,143,152,161,170,179,188,197,206,215,224,234,645,652,659,666,673,680,687,695,702,709,716,723,730,737,744,751,758,765,772],"articles":[70,79,88,97,106,115,124,135,144,153,162,171,180,189,198,207,216,225,235,646,653,660,667,674,681,688,696,703,710,717,724,731,738,745,752,759,766,773],"by":[71,80,89,98,107,116,125,136,145,154,163,172,181,190,199,208,217,226,236,418,647,654,661,668,675,682,689,697,704,711,718,725,732,739,746,753,760,767,774],"this":[72,81,90,99,108,117,126,137,146,155,164,173,182,191,200,209,218,227,237,648,655,662,669,676,683,690,698,705,712,719,726,733,740,747,754,761,768,775],"author":[73,82,91,100,109,118,127,138,147,156,165,174,183,192,201,210,219,228,238,649,656,663,670,677,684,691,699,706,713,720,727,734,741,748,755,762,769,776],",":[74,83,92,101,110,119,128,139,148,157,166,175,184,193,202,211,220,229],"MacintyreGeoff":[76],"Macintyre":[77,651],"SloggettClare":[85],"Sloggett":[86,658],"CmeroMarek":[94],"Cmero":[95,665],"LonieAndrew":[103],"Lonie":[104,672],"NaeemHaroon":[112],"Naeem":[113,679],"WedgeDavid":[121],"Wedge":[122,686],"LooPeter":[131],"Loo":[133,694],"AlexandrovLudmil":[141],"Alexandrov":[142,701],"SapreNikhil":[150],"Sapre":[151,708],"PhalPramit":[159],"Phal":[160,715],"ChinXiaowen":[168],"Chin":[169,722],"KergerMichael":[177],"Kerger":[178,729],"PedersenJohn":[186],"Pedersen":[187,736],"RyanAndrew":[195],"Ryan":[196,743],"CostelloAnthony":[204],"Costello":[205,750],"McDermottUltan":[213],"McDermott":[214,757],"CorcoranNiall":[222],"Corcoran":[223,764],"HovensChristopher":[232],"View":[239],"All":[240,778],"Author":[241],"Informationhttps://doi.org/10.1016/j.juro.2014.02.1102AboutPDF":[242],"ToolsAdd":[243],"to":[244,302,309,341,350,355,422,440,446,607],"favoritesDownload":[245],"CitationsTrack":[246],"CitationsPermissionsReprints":[247],"ShareFacebookTwitterLinked":[248],"InEmail":[249],"Introduction":[250],"Objectives":[252],"There":[253],"has":[254],"been":[255],"recent":[256],"interest":[257],"in":[258,265,279,348,513,526,561,564,626],"the":[259,290,343,346,351,357,362,454,479,486,494,498,580,618],"elevated":[260],"risk":[261],"prostate":[263,320,376,628],"cancer":[264,321,353,377],"men":[266],"with":[267,330,373,539,549,577],"Lynch":[268],"syndrome,":[269],"where":[270],"a":[271,328,331,335,369,403,419,483,507,527,550],"DNA":[272,427,554],"mismatch":[273,336,555,619],"repair":[274,337,556,620],"gene":[275,530,621],"mutation":[276],"such":[277],"as":[278,301],"is":[281],"inherited.":[282],"These":[283],"cancers":[284,304],"may":[285,298,595,610,623],"possess":[286],"more":[287],"than":[288,497],"10-fold":[289],"usual":[291],"number":[292,536,568],"mutations":[294,538,545,560],"their":[296],"study":[297],"present":[299,313,512],"clues":[300],"how":[303,617],"evolve,":[305],"metastasise":[306],"respond":[308],"therapy.":[310],"Here":[311],"we":[312],"results":[314],"from":[315,327,393,482,553],"genome":[316,436],"sequencing":[317,437,445,505],"paired":[319],"metastasis":[322,347,405,480,589],"primary":[324,352,487,515,598],"tumour":[325,389,415,488],"samples":[326,390,411],"patient":[329,367],"mutator":[332,363,551],"phenotype":[333,552],"implicating":[334],"defect.":[338],"We":[339,613],"aimed":[340],"determine":[342],"clonality":[344],"relation":[349],"characterise":[356],"underlying":[358],"molecular":[359],"cause":[360],"phenotype.":[364],"Methods":[365],"Our":[366],"was":[368,438,461,557],"64":[370],"year-old":[371],"man":[372],"Gleason":[374],"9":[375],"who":[378],"developed":[379],"metastatic":[380,600],"disease":[381],"at":[382,399,406,574],"22":[383],"months":[384],"post-radical":[385],"prostatectomy.":[386],"Fresh":[387],"frozen":[388],"were":[391,412],"taken":[392],"his":[394],"original":[395],"prostatectomy":[396],"specimen":[397],"percutaneous":[400],"biopsy":[401],"bone":[404],"35":[407],"post-operative":[408],"months.":[409],"Tissue":[410],"cryosectioned":[413],"content":[416],"confirmed":[417,520],"pathologist":[420],"prior":[421],"mechanical":[423],"homogenisation":[424],"simultaneous":[426],"RNA":[429],"extraction":[430],"(Allprep":[431],"Micro":[432],"Kit,":[433],"Qiagen).":[434],"Whole":[435],"performed":[439],"40x":[441],"coverage":[442],"transcriptome":[444],"120":[447],"million":[448],"reads":[449],"per":[450],"sample":[451],"both":[452,514],"on":[453],"Illumina":[455],"HiSeq2000":[456],"platform.":[457],"Genome":[458],"Analysis":[459],"ToolKit":[460],"used":[462],"for":[463,490,502],"WGS":[464,518],"read":[465],"alignment":[466],"single":[468],"nucleotide":[469],"variants":[470],"called":[471],"using":[472],"MuTect.":[473],"Results":[474],"Subclonal":[475],"analysis":[476,569],"revealed":[477,506,570],"that":[478,591,608],"derived":[481],"subclone":[484,500],"accounting":[489,501],"just":[491],"30%":[492],"cells,":[495],"rather":[496],"dominant":[499],"70%.":[503],"Transcriptome":[504],"novel":[508],"MSH2-NRXN1":[509],"fusion":[510],"transcript":[511],"metastasis.":[517],"data":[519],"an":[521],"intrachromosomal":[522],"translocation":[523],"event":[524],"resulting":[525],"truncated":[528],"product":[531],"inactivation.":[533],"high":[535],"overrepresentation":[540],"C>T":[542],"T>C":[544],"indels":[547],"consistent":[548,576],"seen":[558],"(35,515":[559],"primary,":[562],"64,716":[563],"metastasis).":[565],"Allele-specific":[566],"copy":[567],"loss":[571,578],"heterozygosity":[573],"2p21,":[575],"other":[581],"allele.":[583],"Conclusions":[584],"The":[585],"subclonal":[586],"origin":[587],"suggests":[590],"different":[592],"selection":[593],"pressures":[594],"exist":[596],"between":[597],"sites":[601],"optimal":[603],"therapy":[604,609],"response":[606],"also":[611,616],"differ.":[612],"shown":[615],"be":[624],"inactivated":[625],"sporadic":[627],"cancer.":[629],"\u00a9":[630],"2014FiguresReferencesRelatedDetails":[631],"Volume":[632],"191Issue":[633],"4SApril":[634],"2014Page:":[635],"e502":[636],"Advertisement":[637,779,780],"Copyright":[638],"&":[639],"Permissions\u00a9":[640],"2014MetricsAuthor":[641],"Information":[642],"Expand":[777],"PDF":[781],"downloadLoading":[782],"...":[783]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
