{"id":"https://openalex.org/W2085643863","doi":"https://doi.org/10.1128/jvi.00006-15","title":"Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8 + T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression","display_name":"Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8 + T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression","publication_year":2015,"publication_date":"2015-01-22","ids":{"openalex":"https://openalex.org/W2085643863","doi":"https://doi.org/10.1128/jvi.00006-15","mag":"2085643863","pmid":"https://pubmed.ncbi.nlm.nih.gov/25609823"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00006-15","doi":"https://doi.org/10.1128/jvi.00006-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00006-15","pdf_url":"https://jvi.asm.org/content/jvi/89/7/3723.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/89/7/3723.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055075685","display_name":"Kiera Clayton","orcid":"https://orcid.org/0009-0006-9398-0651","observed_orcids":["https://orcid.org/0009-0006-9398-0651"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kiera L. Clayton","raw_affiliation_strings":["Department of Immunology, University of Toronto, Toronto, Ontario, Canada","aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087280144","display_name":"Matthew B. Douglas-Vail","orcid":"https://orcid.org/0000-0003-3084-5760","observed_orcids":["https://orcid.org/0000-0003-3084-5760"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew B. Douglas-Vail","raw_affiliation_strings":["Department of Immunology, University of Toronto, Toronto, Ontario, Canada","aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103648521","display_name":"A. K. M. Nur-ur Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. K. M. Nur-ur Rahman","raw_affiliation_strings":["Department of Immunology, University of Toronto, Toronto, Ontario, Canada","aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060483216","display_name":"Karyn E. Medcalf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Karyn E. Medcalf","raw_affiliation_strings":["Department of Immunology, University of Toronto, Toronto, Ontario, Canada","aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052680621","display_name":"Irene Y. Xie","orcid":"https://orcid.org/0000-0002-4911-1364","observed_orcids":["https://orcid.org/0000-0002-4911-1364"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Irene Y. Xie","raw_affiliation_strings":["Department of Immunology, University of Toronto, Toronto, Ontario, Canada","aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022635622","display_name":"Glen M. Chew","orcid":"https://orcid.org/0000-0001-6186-4353","observed_orcids":["https://orcid.org/0000-0001-6186-4353"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glen M. Chew","raw_affiliation_strings":["Hawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA","bHawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"bHawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023005377","display_name":"Ravi Tandon","orcid":"https://orcid.org/0000-0003-3267-896X","observed_orcids":["https://orcid.org/0000-0003-3267-896X"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Tandon","raw_affiliation_strings":["Hawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA","bHawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"bHawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067188451","display_name":"Marion C. Lanteri","orcid":"https://orcid.org/0000-0002-4213-5013","observed_orcids":["https://orcid.org/0000-0002-4213-5013","https://orcid.org/0009-0003-0855-7487"]},"institutions":[{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marion C. Lanteri","raw_affiliation_strings":["Blood Systems Research Institute, San Francisco, California, USA","eBlood Systems Research Institute, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Systems Research Institute, San Francisco, California, USA","institution_ids":["https://openalex.org/I4210093991"]},{"raw_affiliation_string":"eBlood Systems Research Institute, San Francisco, California, USA","institution_ids":["https://openalex.org/I4210093991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051080788","display_name":"Philip J. Norris","orcid":"https://orcid.org/0000-0003-0526-2088","observed_orcids":["https://orcid.org/0000-0003-0526-2088"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. Norris","raw_affiliation_strings":["Blood Systems Research Institute, San Francisco, California, USA","Department of Laboratory Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA","HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francsico, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Systems Research Institute, San Francisco, California, USA","institution_ids":["https://openalex.org/I4210093991"]},{"raw_affiliation_string":"Department of Laboratory Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]},{"raw_affiliation_string":"HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francsico, California, USA","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063704053","display_name":"Steven G. Deeks","orcid":"https://orcid.org/0000-0001-6371-747X","observed_orcids":["https://orcid.org/0000-0001-6371-747X"]},"institutions":[{"id":"https://openalex.org/I1295908608","display_name":"San Francisco General Hospital","ror":"https://ror.org/05j8x4n38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295908608"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven G. Deeks","raw_affiliation_strings":["HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francsico, California, USA","cHIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francsico, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francsico, California, USA","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]},{"raw_affiliation_string":"cHIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francsico, California, USA","institution_ids":["https://openalex.org/I1295908608","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000604059","display_name":"Lishomwa C. Ndhlovu","orcid":"https://orcid.org/0000-0001-5427-4187","observed_orcids":["https://orcid.org/0000-0001-5427-4187"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lishomwa C. Ndhlovu","raw_affiliation_strings":["Hawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA","bHawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"bHawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064409926","display_name":"Mario Ostrowski","orcid":"https://orcid.org/0000-0002-7369-1936","observed_orcids":["https://orcid.org/0000-0002-7369-1936"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4210130040","display_name":"Maple Leaf Medical Clinic","ror":"https://ror.org/03qq7fj62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210130040"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mario A. Ostrowski","raw_affiliation_strings":["Department of Immunology, University of Toronto, Toronto, Ontario, Canada","Department of Medicine, University of Toronto, Toronto, Ontario, Canada","Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada","Maple Leaf Clinic, Toronto, Ontario, Canada","aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1297363086"]},{"raw_affiliation_string":"Maple Leaf Clinic, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210130040"]},{"raw_affiliation_string":"aDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8343,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.91182439,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"89","issue":"7","first_page":"3723","last_page":"3736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-tim-3","display_name":"soluble TIM-3","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cd8-t-cell-exhaustion","display_name":"CD8+ T cell exhaustion","score":0.847000002861023},{"id":"https://openalex.org/keywords/adam10","display_name":"ADAM10","score":0.843999981880188},{"id":"https://openalex.org/keywords/hiv-disease-progression","display_name":"HIV disease progression","score":0.7889999747276306},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.7639999985694885},{"id":"https://openalex.org/keywords/galectin-9","display_name":"galectin-9","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hiv-specific-t-cell-responses","display_name":"HIV-specific T cell responses","score":0.5220000147819519},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.6759999990463257},{"id":"https://openalex.org/keywords/hiv-viral-load","display_name":"HIV viral load","score":0.6499999761581421},{"id":"https://openalex.org/keywords/chronic-immune-activation","display_name":"chronic immune activation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/hiv-controllers","display_name":"HIV controllers","score":0.4620000123977661},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7937308549880981},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6400830149650574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5930781960487366},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5888357758522034},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5555133819580078},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.47081002593040466},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.46185481548309326},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43285876512527466},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3588590919971466},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13650834560394287},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07376083731651306}],"mesh":[{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072597","descriptor_name":"Hepatitis A Virus Cellular Receptor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072597","descriptor_name":"Hepatitis A Virus Cellular Receptor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072597","descriptor_name":"Hepatitis A Virus Cellular Receptor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.00006-15","doi":"https://doi.org/10.1128/jvi.00006-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00006-15","pdf_url":"https://jvi.asm.org/content/jvi/89/7/3723.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:25609823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25609823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2283t3zq","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2283t3zq","pdf_url":"https://escholarship.org/content/qt2283t3zq/qt2283t3zq.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, vol 89, iss 7","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4403393","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4403393","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Virol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1128/jvi.00006-15","doi":"https://doi.org/10.1128/jvi.00006-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00006-15","pdf_url":"https://jvi.asm.org/content/jvi/89/7/3723.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1531094742","display_name":null,"funder_award_id":"R24-AI067039","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1651394900","display_name":"Clinical and Translational Science Institute","funder_award_id":"UL1RR024131","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1818305134","display_name":"Impact of HIV-associated inflammation on disease","funder_award_id":"K24AI069994","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2592733289","display_name":null,"funder_award_id":"RO1 AI087145","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3322721267","display_name":null,"funder_award_id":"RR024131","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3357657595","display_name":"DARE: Delaney AIDS Research Enterprise to find a cure.","funder_award_id":"U19AI096109","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G349814709","display_name":null,"funder_award_id":"R01 AI087145","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G378552126","display_name":null,"funder_award_id":"P30 AI 027757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3911225753","display_name":null,"funder_award_id":"P30 A1027763","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G3917235369","display_name":null,"funder_award_id":"AI067039","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4570650908","display_name":null,"funder_award_id":"P30A1027763","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G4831188122","display_name":null,"funder_award_id":"AI087145","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5934524914","display_name":null,"funder_award_id":"R24 AI067039","funder_id":"https://openalex.org/F4320332582","funder_display_name":"Center for AIDS Research, University of Washington"},{"id":"https://openalex.org/G6444951560","display_name":null,"funder_award_id":"AI096109","funder_id":"https://openalex.org/F4320309010","funder_display_name":"Delaney AIDS Research Enterprise"},{"id":"https://openalex.org/G6655413242","display_name":null,"funder_award_id":"AI096109","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G758528517","display_name":null,"funder_award_id":"UL1RR024131","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G9000877288","display_name":"CFAR Network of Integrated Clinical Systems (CNICS)","funder_award_id":"5r24ai067039-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G97119092","display_name":null,"funder_award_id":"P30 AI027763","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309010","display_name":"Delaney AIDS Research Enterprise","ror":"https://ror.org/040gxv777"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2085643863.pdf","grobid_xml":"https://content.openalex.org/works/W2085643863.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1490502914","https://openalex.org/W1498311899","https://openalex.org/W1968023042","https://openalex.org/W1970455281","https://openalex.org/W1976935171","https://openalex.org/W1977500561","https://openalex.org/W1978436252","https://openalex.org/W1978715924","https://openalex.org/W1981221499","https://openalex.org/W1982280354","https://openalex.org/W1985117788","https://openalex.org/W1985997449","https://openalex.org/W1991807494","https://openalex.org/W1993528700","https://openalex.org/W1996032846","https://openalex.org/W1997731331","https://openalex.org/W2010542459","https://openalex.org/W2012755158","https://openalex.org/W2013177587","https://openalex.org/W2014827330","https://openalex.org/W2021165507","https://openalex.org/W2021379322","https://openalex.org/W2027625151","https://openalex.org/W2040353461","https://openalex.org/W2043918194","https://openalex.org/W2049652679","https://openalex.org/W2053289663","https://openalex.org/W2055819944","https://openalex.org/W2060169824","https://openalex.org/W2070631889","https://openalex.org/W2072757837","https://openalex.org/W2072918899","https://openalex.org/W2077127521","https://openalex.org/W2082832891","https://openalex.org/W2091963767","https://openalex.org/W2104966044","https://openalex.org/W2105804574","https://openalex.org/W2108565475","https://openalex.org/W2112400160","https://openalex.org/W2115358608","https://openalex.org/W2119146367","https://openalex.org/W2121603793","https://openalex.org/W2122730216","https://openalex.org/W2123528481","https://openalex.org/W2130035794","https://openalex.org/W2130603879","https://openalex.org/W2133560683","https://openalex.org/W2134130131","https://openalex.org/W2136738141","https://openalex.org/W2145476394","https://openalex.org/W2145738273","https://openalex.org/W2146790197","https://openalex.org/W2149545956","https://openalex.org/W2159110897","https://openalex.org/W2163001100","https://openalex.org/W2167717479","https://openalex.org/W2170871835","https://openalex.org/W2592935721"],"related_works":["https://openalex.org/W2365906682","https://openalex.org/W2356836538","https://openalex.org/W3087470930","https://openalex.org/W2388744202","https://openalex.org/W2414729062","https://openalex.org/W2020684972","https://openalex.org/W2340237593","https://openalex.org/W3030597314","https://openalex.org/W1490833013","https://openalex.org/W1572148375"],"abstract_inverted_index":{"UNLABELLED:":[0],"Chronic":[1],"HIV":[2,61,127,159,173,220,324,360,369],"infection":[3,325],"results":[4],"in":[5,20,46,60,96,109,115,136,145,193,219,236,242,266,276,314,342],"a":[6,37,86,290,365],"loss":[7],"of":[8,40,75,89,105,189,195,208,217,234,257,269,293,307,317,331,349,368],"HIV-specific":[9],"CD8(+)":[10,77,190],"T":[11,27,78,191,249,294,308],"cell":[12,28,250,295],"effector":[13],"function,":[14],"termed":[15],"\"exhaustion,\"":[16],"which":[17],"is":[18,54,63,70,302,312,327,335,353],"mediated,":[19],"part,":[21],"by":[22,80],"the":[23,73,81,90,97,187,215,231,238,254,258,267,305,315,336],"membrane":[24],"coinhibitory":[25,91,298],"receptor":[26],"immunoglobulin":[29],"mucin":[30],"domain-3":[31],"(Tim-3).":[32],"Like":[33],"many":[34],"other":[35],"receptors,":[36],"soluble":[38,51,87,103,291],"form":[39,88,104,292],"this":[41,284],"protein":[42],"has":[43],"been":[44],"described":[45],"human":[47,116,343],"blood":[48],"plasma.":[49],"However,":[50],"Tim-3":[52,69,106,183],"(sTim-3)":[53],"poorly":[55],"characterized,":[56],"and":[57,118,124,161,248,271,326,347],"its":[58,345],"role":[59],"disease":[62,174,221,332,370],"unknown.":[64],"Here,":[65,286],"we":[66,179,287],"show":[67,288],"that":[68,181,289],"shed":[71,303],"from":[72,304],"surface":[74,306],"responding":[76],"cells":[79,192],"matrix":[82],"metalloproteinase":[83],"ADAM10,":[84],"producing":[85],"receptor.":[92],"Despite":[93,176,230],"previous":[94],"reports":[95],"mouse":[98],"model,":[99],"no":[100],"alternatively":[101],"spliced,":[102],"was":[107,113,119,131],"observed":[108],"humans.":[110],"Shed":[111],"sTim-3":[112,153,169,209,218,311,341,357,362],"found":[114,133,180],"plasma":[117,168,316],"significantly":[120],"elevated":[121,313],"during":[122],"early":[123],"chronic":[125,245,323],"untreated":[126],"infection,":[128],"but":[129],"it":[130,352],"not":[132,185],"differentially":[134],"modulated":[135],"highly":[137],"active":[138],"antiretroviral":[139],"therapy":[140],"(HAART)-treated":[141],"HIV-infected":[142,243],"subjects":[143,319],"or":[144,199,282,322],"elite":[146],"controllers":[147],"compared":[148],"to":[149,213,240,253,273,280,339,359],"HIV-uninfected":[150],"subjects.":[151],"Plasma":[152],"levels":[154],"were":[155],"positively":[156],"correlated":[157,163,171],"with":[158,164,172,223,278,320,329],"load":[160],"negatively":[162],"CD4":[165],"counts.":[166],"Thus,":[167],"shedding":[170,182],"progression.":[175,333,371],"these":[177,262],"correlations,":[178],"did":[184],"improve":[186],"function":[188,210],"terms":[194],"gamma":[196],"interferon":[197],"production":[198],"prevent":[200],"their":[201],"apoptosis":[202],"through":[203],"galectin-9.":[204],"Further":[205],"characterization":[206],"studies":[207],"are":[211],"needed":[212],"understand":[214],"contribution":[216],"pathogenesis,":[222,361],"implications":[224],"for":[225],"novel":[226],"therapeutic":[227],"interventions.":[228],"IMPORTANCE:":[229],"overall":[232],"success":[233],"HAART":[235,279],"slowing":[237],"progression":[239],"AIDS":[241],"subjects,":[244],"immune":[246,259],"activation":[247],"exhaustion":[251,296],"contribute":[252],"eventual":[255],"deterioration":[256],"system.":[260],"Understanding":[261],"processes":[263],"will":[264],"aid":[265],"development":[268],"interventions":[270],"therapeutics":[272],"be":[274],"used":[275],"combination":[277],"slow":[281],"reverse":[283],"deterioration.":[285],"associated":[297,328],"molecule":[299],"3,":[300],"sTim-3,":[301],"cells.":[309],"Furthermore,":[310],"treatment-naive":[318],"acute":[321],"markers":[330],"This":[334],"first":[337],"study":[338],"characterize":[340],"plasma,":[344],"source,":[346],"mechanism":[348],"production.":[350],"While":[351],"still":[354],"unclear":[355],"whether":[356],"contributes":[358],"may":[363],"represent":[364],"new":[366],"correlate":[367]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2016-06-24T00:00:00"}