{"id":"https://openalex.org/W2085640002","doi":"https://doi.org/10.1161/01.cir.85.4.1364","title":"Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.","display_name":"Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W2085640002","doi":"https://doi.org/10.1161/01.cir.85.4.1364","mag":"2085640002","pmid":"https://pubmed.ncbi.nlm.nih.gov/1555280"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.85.4.1364","doi":"https://doi.org/10.1161/01.cir.85.4.1364","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.85.4.1364","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013091913","display_name":"DONNA M. MANCINI","orcid":"https://orcid.org/0000-0002-6050-1785","observed_orcids":["https://orcid.org/0000-0002-6050-1785"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D M Mancini","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Walter","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003217797","display_name":"Nathaniel Reichek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Reichek","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086139759","display_name":"Robert E. Lenkinski","orcid":"https://orcid.org/0000-0001-7371-5048","observed_orcids":["https://orcid.org/0000-0001-7371-5048"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Lenkinski","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043375829","display_name":"Kevin K. McCully","orcid":"https://orcid.org/0000-0001-9850-487X","observed_orcids":["https://orcid.org/0000-0001-9850-487X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K K McCully","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111513798","display_name":"J L Mullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Mullen","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":null,"display_name":"J R Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J R Wilson","raw_affiliation_strings":["Department of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":57.2303,"has_fulltext":false,"cited_by_count":735,"citation_normalized_percentile":{"value":0.99975056,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"85","issue":"4","first_page":"1364","last_page":"1373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.06109999865293503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9950000047683716},{"id":"https://openalex.org/keywords/exercise-intolerance","display_name":"exercise intolerance","score":1.0},{"id":"https://openalex.org/keywords/muscle-metabolism","display_name":"muscle metabolism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.847000002861023},{"id":"https://openalex.org/keywords/phosphocreatine","display_name":"phosphocreatine","score":0.7940000295639038},{"id":"https://openalex.org/keywords/inorganic-phosphorus","display_name":"inorganic phosphorus","score":0.8140000104904175},{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.9649999737739563},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5580000281333923},{"id":"https://openalex.org/keywords/peak-oxygen-uptake","display_name":"peak oxygen uptake","score":0.6380000114440918},{"id":"https://openalex.org/keywords/fat-stores","display_name":"fat stores","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9106858968734741},{"id":"https://openalex.org/C2777321227","wikidata":"https://www.wikidata.org/wiki/Q5420062","display_name":"Exercise intolerance","level":3,"score":0.8436750173568726},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6923072934150696},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6918439269065857},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6755106449127197},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.5148093104362488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48865798115730286},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.4249803125858307},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4232522249221802},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.41287919878959656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37011247873306274}],"mesh":[{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010725","descriptor_name":"Phosphocreatine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010725","descriptor_name":"Phosphocreatine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010725","descriptor_name":"Phosphocreatine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010758","descriptor_name":"Phosphorus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010758","descriptor_name":"Phosphorus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010758","descriptor_name":"Phosphorus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.85.4.1364","doi":"https://doi.org/10.1161/01.cir.85.4.1364","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.85.4.1364","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:1555280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1555280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W143547166","https://openalex.org/W182243634","https://openalex.org/W364005502","https://openalex.org/W647494760","https://openalex.org/W1532619623","https://openalex.org/W1759863294","https://openalex.org/W1885438205","https://openalex.org/W1971464765","https://openalex.org/W1977592054","https://openalex.org/W1977923285","https://openalex.org/W1988795044","https://openalex.org/W2003776648","https://openalex.org/W2009907972","https://openalex.org/W2018727310","https://openalex.org/W2019125365","https://openalex.org/W2022579740","https://openalex.org/W2045546826","https://openalex.org/W2048664109","https://openalex.org/W2058825984","https://openalex.org/W2061074878","https://openalex.org/W2064215488","https://openalex.org/W2066050658","https://openalex.org/W2071578047","https://openalex.org/W2086668012","https://openalex.org/W2101904341","https://openalex.org/W2121443655","https://openalex.org/W2125349482","https://openalex.org/W2132775851","https://openalex.org/W2133406706","https://openalex.org/W2144601461","https://openalex.org/W2149700345","https://openalex.org/W2165887549","https://openalex.org/W2174552657","https://openalex.org/W2175847409","https://openalex.org/W2186048555","https://openalex.org/W2220166263","https://openalex.org/W2287535885","https://openalex.org/W2324476825","https://openalex.org/W2366095704","https://openalex.org/W2460207057","https://openalex.org/W3008012472","https://openalex.org/W4239146293","https://openalex.org/W4298282028"],"related_works":["https://openalex.org/W3008363345","https://openalex.org/W1984832913","https://openalex.org/W3137012746","https://openalex.org/W2508547619","https://openalex.org/W4302291099","https://openalex.org/W1998631924","https://openalex.org/W3017811988","https://openalex.org/W2052379600","https://openalex.org/W2058023763","https://openalex.org/W2017549538"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,253],"purpose":[2],"of":[3,11,64,101,105,127,137,146,150,186,190,194,201],"this":[4],"study":[5],"was":[6,96,123,156],"to":[7,18,115,290],"investigate":[8],"the":[9,65,99,102,113,116,160,242,292],"prevalence":[10],"skeletal":[12,120,281],"muscle":[13,23,94,106,121,153,214,224,260,282,298],"atrophy":[14,283],"and":[15,21,46,61,74,83,90,211,222,284,296],"its":[16],"relation":[17],"exercise":[19,238,294],"intolerance":[20],"abnormal":[22],"metabolism":[24],"in":[25,50,69,107,125,134,159,198,241],"patients":[26,53,71,161,243,274],"with":[27,54,72,162,183,244,249,259,275],"heart":[28],"failure":[29],"(HF).":[30],"METHODS":[31],"AND":[32],"RESULTS:":[33],"Peak":[34],"VO2,":[35],"percent":[36],"ideal":[37],"body":[38],"weight":[39],"(%":[40],"IBW),":[41],"24-hour":[42],"urine":[43],"creatinine":[44],"(Cr),":[45],"anthropometrics":[47],"were":[48,67,86,180,206,239,256],"measured":[49,87],"62":[51],"ambulatory":[52],"HF.":[55],"31P":[56,234],"magnetic":[57],"resonance":[58],"spectroscopy":[59],"(MRS)":[60],"imaging":[62],"(MRI)":[63,155],"calf":[66,213],"performed":[68],"15":[70],"HF":[73,163,277],"10":[75],"control":[76],"subjects.":[77],"Inorganic":[78],"phosphorus":[79],"(Pi),":[80],"phosphocreatine":[81],"(PCr),":[82],"intracellular":[84],"pH":[85],"at":[88],"rest":[89],"during":[91,237],"exercise.":[92],"Calf":[93,152],"volume":[95,154,215,261],"determined":[97],"from":[98,112],"sum":[100],"integrated":[103],"area":[104,225],"1-cm-thick":[108],"contiguous":[109],"axial":[110],"images":[111],"patella":[114],"calcaneus.":[117],"A":[118],"reduced":[119,158,293],"mass":[122],"noted":[124],"68%":[126],"patients,":[128],"as":[129],"evidenced":[130],"by":[131],"a":[132],"decrease":[133],"Cr-to-height":[135],"ratio":[136],"less":[138,147,175,187,195,231,266],"than":[139,148,176,188,196,232,267],"7.4":[140],"mg/cm":[141],"and/or":[142,192],"upper":[143],"arm":[144],"circumference":[145],"5%":[149,189],"normal.":[151],"also":[157],"(controls,":[164],"675":[165],"+/-":[166,171],"84":[167],"cm3/m2;":[168,173],"HF,":[169,245],"567":[170],"112":[172],"p":[174,230,265],"0.05).":[177,233,268],"Fat":[178],"stores":[179],"largely":[181],"preserved":[182],"triceps":[184],"skinfold":[185],"normal":[191],"IBW":[193],"80%":[197],"only":[199],"8%":[200],"patients.":[202],"Modest":[203],"linear":[204],"correlations":[205],"observed":[207,240],"between":[208],"peak":[209],"VO2":[210],"both":[212,291],"per":[216],"meter":[217],"squared":[218],"(r":[219,226,262],"=":[220,227,263],"0.48)":[221],"midarm":[223],"0.36)":[228],"(both":[229],"metabolic":[235,254,285],"abnormalities":[236],"which":[246],"is":[247],"consistent":[248],"intrinsic":[250],"oxidative":[251],"abnormalities.":[252,286],"changes":[255],"weakly":[257],"correlated":[258],"-0.42,":[264],"CONCLUSIONS:":[269],"These":[270],"findings":[271],"indicate":[272],"that":[273],"chronic":[276],"frequently":[278],"develop":[279],"significant":[280],"Atrophy":[287],"contributes":[288],"modestly":[289],"capacity":[295],"altered":[297],"metabolism.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":26}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}