{"id":"https://openalex.org/W2085604902","doi":"https://doi.org/10.4078/jkra.2007.14.4.322","title":"The Blocking of TNF-alpha by RNA Interference and Its Influence on Synovial Fibroblast and Chondrocytes","display_name":"The Blocking of TNF-alpha by RNA Interference and Its Influence on Synovial Fibroblast and Chondrocytes","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2085604902","doi":"https://doi.org/10.4078/jkra.2007.14.4.322","mag":"2085604902"},"language":"en","primary_location":{"id":"doi:10.4078/jkra.2007.14.4.322","doi":"https://doi.org/10.4078/jkra.2007.14.4.322","is_oa":true,"landing_page_url":"https://doi.org/10.4078/jkra.2007.14.4.322","pdf_url":"https://synapse.koreamed.org/upload/SynapseData/PDFData/0010jkra/jkra-14-322.pdf","source":{"id":"https://openalex.org/S4210189126","display_name":"Journal of Rheumatic Diseases","issn_l":"1226-8070","issn":["1226-8070","2093-940X","2233-4718"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","kci-registered","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Korean Rheumatism Association","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://synapse.koreamed.org/upload/SynapseData/PDFData/0010jkra/jkra-14-322.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100759951","display_name":"Hyun Ah Kim","orcid":"https://orcid.org/0000-0002-9318-7446","observed_orcids":["https://orcid.org/0000-0002-9318-7446","https://orcid.org/0000-0002-9125-7156","https://orcid.org/0000-0001-6568-2469"]},"institutions":[{"id":"https://openalex.org/I4210159787","display_name":"Hallym University Sacred Heart Hospital","ror":"https://ror.org/04ngysf93","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210159787","https://openalex.org/I4210167048"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyun Ah Kim","raw_affiliation_strings":["Department of Intenal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intenal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea","institution_ids":["https://openalex.org/I4210159787"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100759951"],"corresponding_institution_ids":["https://openalex.org/I4210159787"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21077989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"4","first_page":"322","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tnf-receptor-1","display_name":"TNF receptor 1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.703000009059906},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.9470000267028809},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.9490000009536743},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.6539999842643738},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.7192744016647339},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6182659864425659},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.545663058757782},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5242550373077393},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.513247013092041},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4958127439022064},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.48277178406715393},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4155856966972351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24022656679153442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22564667463302612},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19445249438285828},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14450132846832275},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09592300653457642},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07800856232643127},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0760829746723175},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.05161431431770325},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4078/jkra.2007.14.4.322","doi":"https://doi.org/10.4078/jkra.2007.14.4.322","is_oa":true,"landing_page_url":"https://doi.org/10.4078/jkra.2007.14.4.322","pdf_url":"https://synapse.koreamed.org/upload/SynapseData/PDFData/0010jkra/jkra-14-322.pdf","source":{"id":"https://openalex.org/S4210189126","display_name":"Journal of Rheumatic Diseases","issn_l":"1226-8070","issn":["1226-8070","2093-940X","2233-4718"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","kci-registered","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Korean Rheumatism Association","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.876.8987","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.876.8987","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://synapse.koreamed.org/Synapse/Data/PDFData/0010JKRA/jkra-14-322.pdf","raw_type":"text"},{"id":"mag:3181723683","doi":null,"is_oa":false,"landing_page_url":"http://dspace.kci.go.kr/handle/kci/1532309","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.4078/jkra.2007.14.4.322","doi":"https://doi.org/10.4078/jkra.2007.14.4.322","is_oa":true,"landing_page_url":"https://doi.org/10.4078/jkra.2007.14.4.322","pdf_url":"https://synapse.koreamed.org/upload/SynapseData/PDFData/0010jkra/jkra-14-322.pdf","source":{"id":"https://openalex.org/S4210189126","display_name":"Journal of Rheumatic Diseases","issn_l":"1226-8070","issn":["1226-8070","2093-940X","2233-4718"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","kci-registered","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Korean Rheumatism Association","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2085604902.pdf","grobid_xml":"https://content.openalex.org/works/W2085604902.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1611419331","https://openalex.org/W1977564820","https://openalex.org/W1978870867","https://openalex.org/W2051001095","https://openalex.org/W2059864468","https://openalex.org/W2066868344","https://openalex.org/W2072629836","https://openalex.org/W2086973294","https://openalex.org/W2092357477","https://openalex.org/W2098100188","https://openalex.org/W2117991391","https://openalex.org/W2130485280","https://openalex.org/W2134414575","https://openalex.org/W2314052274","https://openalex.org/W2319957449","https://openalex.org/W2336588424","https://openalex.org/W4211039187","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7096736051","https://openalex.org/W2583606085","https://openalex.org/W3165783167","https://openalex.org/W4250077778","https://openalex.org/W4252268912","https://openalex.org/W2915657040","https://openalex.org/W2095394617","https://openalex.org/W4214926223","https://openalex.org/W1976066154","https://openalex.org/W2901842757"],"abstract_inverted_index":{"Objective:":[0],"Small":[1],"interfering":[2],"RNA":[3,6],"(siRNA)":[4],"triggers":[5],"interference":[7],"in":[8,17,42,84,117],"mammalian":[9],"somatic":[10],"cells.TNF-\u03b1":[11],"is":[12],"a":[13],"proinflammatory":[14],"cytokine":[15],"implicated":[16],"the":[18,38,78,110,137],"pathogenesis":[19],"of":[20,81,90,99,112,142],"inflammatory":[21],"arthritis":[22,25],"including":[23],"rheumatoid":[24],"(RA).This":[26],"study":[27],"was":[28,53,94,127],"to":[29,36,76],"use":[30],"TNF":[31],"receptor":[32],"1":[33,101],"(TNFRI)specific":[34],"siRNA":[35,52,83,108,134],"inhibit":[37,136],"TNF-\u03b1":[39,91,126],"mediated":[40,92],"signaling":[41,93,140],"RA":[43,119],"fibroblast":[44],"like":[45],"synoviocytes":[46],"(FLS)":[47],"and":[48,64,71,87,115,121,139],"chondrocytes.Methods:":[49],"TNFRI":[50,82,107,113,131,133,143],"specific":[51],"produced":[54],"by":[55,96,104,125,130],"targeting":[56],"3":[57],"nucleotide":[58],"sequences":[59],"at":[60],"474\u223c":[61],"494,":[62],"562\u223c582":[63],"668\u223c688.Reverse":[65],"transcriptase":[66],"polymerase":[67],"chain":[68],"reaction":[69],"(RT-PCR)":[70],"Western":[72],"blot":[73],"were":[74],"performed":[75],"optimize":[77],"silencing":[79],"effects":[80],"cultured":[85],"FLS":[86,120],"chondrocytes.The":[88],"inhibition":[89],"determined":[95],"ELISA":[97],"assay":[98],"metalloproteinase":[100],"secretion":[102,123],"induced":[103,124],"TNF-\u03b1.":[105],"Results:The":[106],"inhibited":[109],"expression":[111,138],"mRNA":[114],"protein":[116],"both":[118],"chondrocytes.MMP-1":[122],"significantly":[128],"downregulated":[129],"siRNA.Conclusion:":[132],"can":[135],"downstream":[141]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}