{"id":"https://openalex.org/W2085568366","doi":"https://doi.org/10.1111/j.1464-410x.2008.08239.x","title":"Invasion of renal sinus fat is not an independent predictor of survival in pT3a renal cell carcinoma","display_name":"Invasion of renal sinus fat is not an independent predictor of survival in pT3a renal cell carcinoma","publication_year":2008,"publication_date":"2008-12-22","ids":{"openalex":"https://openalex.org/W2085568366","doi":"https://doi.org/10.1111/j.1464-410x.2008.08239.x","mag":"2085568366","pmid":"https://pubmed.ncbi.nlm.nih.gov/19154464"},"language":"en","primary_location":{"id":"doi:10.1111/j.1464-410x.2008.08239.x","doi":"https://doi.org/10.1111/j.1464-410x.2008.08239.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.2008.08239.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020201256","display_name":"Stephen A. Poon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen A. Poon","raw_affiliation_strings":["Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. sap2003@columbia.edu","Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. sap2003@columbia.edu","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081165230","display_name":"Joshua R Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua R. Gonzalez","raw_affiliation_strings":["Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011642832","display_name":"Mitchell C. Benson","orcid":"https://orcid.org/0000-0003-4018-5970","observed_orcids":["https://orcid.org/0000-0003-4018-5970"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell C. Benson","raw_affiliation_strings":["Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":null,"display_name":"James M. McKiernan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. McKiernan","raw_affiliation_strings":["Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020201256"],"corresponding_institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"],"apc_list":{"value":4770,"currency":"USD","value_usd":4770},"apc_paid":null,"fwci":0.7359,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.72910796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"103","issue":"12","first_page":"1622","last_page":"1625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/perirenal-fat-invasion","display_name":"perirenal fat invasion","score":0.996999979019165},{"id":"https://openalex.org/keywords/disease-specific-survival","display_name":"disease-specific survival","score":0.8659999966621399},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/nuclear-grade","display_name":"nuclear grade","score":0.8740000128746033},{"id":"https://openalex.org/keywords/surgical-margin-status","display_name":"surgical margin status","score":0.7490000128746033},{"id":"https://openalex.org/keywords/systemic-metastases","display_name":"systemic metastases","score":0.828000009059906},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2781428559","wikidata":"https://www.wikidata.org/wiki/Q4120208","display_name":"Renal sinus","level":4,"score":0.902895450592041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.793926477432251},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.7223975658416748},{"id":"https://openalex.org/C26254459","wikidata":"https://www.wikidata.org/wiki/Q577238","display_name":"Adipose capsule of kidney","level":3,"score":0.6729885339736938},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.6721877455711365},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6531016230583191},{"id":"https://openalex.org/C2778913397","wikidata":"https://www.wikidata.org/wiki/Q7646216","display_name":"Surgical margin","level":3,"score":0.5390609502792358},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.533224880695343},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5117852091789246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49497050046920776},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.45456674695014954},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.43460705876350403},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3869480490684509},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3102007508277893},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2942514419555664},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.2885228991508484},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.06453609466552734}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004812","descriptor_name":"Epidemiologic Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D007682","descriptor_name":"Kidney Pelvis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1464-410x.2008.08239.x","doi":"https://doi.org/10.1111/j.1464-410x.2008.08239.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.2008.08239.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},{"id":"pmid:19154464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19154464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1968203559","https://openalex.org/W2016988907","https://openalex.org/W2068938579","https://openalex.org/W2071794510","https://openalex.org/W2085085017","https://openalex.org/W2086739500","https://openalex.org/W2093703462","https://openalex.org/W2124466255","https://openalex.org/W2167466850","https://openalex.org/W2199488029","https://openalex.org/W4239180165"],"related_works":["https://openalex.org/W2068938579","https://openalex.org/W2277479031","https://openalex.org/W2086739500","https://openalex.org/W3132148108","https://openalex.org/W2795497192","https://openalex.org/W1988977486","https://openalex.org/W2163362861","https://openalex.org/W2969248622","https://openalex.org/W2911848461","https://openalex.org/W2796402460"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"clarify":[2],"the":[3,6,19,39,48,53,123,149,233,236],"significance":[4],"of":[5,8,12,115,130,238,245],"location":[7],"extrarenal":[9],"tumour":[10],"extension":[11],"renal":[13,49,92,216],"cell":[14],"carcinoma":[15],"(RCC)":[16],"as":[17,97],"in":[18,136,232],"2002":[20],"Tumour-Nodes-Metastasis":[21],"classification.":[22],"Renal":[23],"cortical":[24],"tumours":[25,42,217],"with":[26,43,81,90,143,152,215,218,229],"perirenal":[27],"fat":[28,33],"invasion":[29,34],"(PFI)":[30],"or":[31,100],"sinus":[32],"(SFI)":[35],"are":[36,45,68,220],"consolidated":[37],"within":[38],"pT3a":[40,91],"grouping;":[41],"SFI":[44,133,219,239],"close":[46],"to":[47,85,87,112,223],"veins,":[50],"lymphatics":[51],"and":[52,70,104,140,183,205],"collecting":[54],"system.":[55],"This":[56],"might":[57],"carry":[58],"a":[59,127,144,193],"worse":[60,145],"prognosis":[61],"for":[62,190],"disease-specific":[63],"survival":[64],"(DSS),":[65],"but":[66],"reports":[67],"limited":[69],"contradictory.":[71],"PATIENTS":[72],"AND":[73],"METHODS:":[74],"We":[75],"retrospectively":[76],"reviewed":[77],"1244":[78],"patients":[79,89,120,139,235],"treated":[80],"nephrectomy":[82],"from":[83,225],"1988":[84],"2007,":[86],"identify":[88],"tumours.":[93],"They":[94],"were":[95,110,188,210],"classified":[96],"having":[98],"PFI":[99,153],"SFI.":[101],"Kaplan-Meier":[102],"analysis":[103],"Cox":[105],"proportional":[106],"hazards":[107],"regression":[108],"models":[109],"used":[111],"assess":[113],"predictors":[114],"survival.":[116],"RESULTS:":[117],"The":[118],"230":[119],"who":[121],"met":[122],"inclusion":[124],"criteria":[125],"had":[126],"median":[128],"follow-up":[129],"24":[131],"months.":[132],"was":[134,141,240],"found":[135],"63":[137],"(27.4%)":[138],"associated":[142],"5-year":[146],"DSS":[147],"than":[148,227],"167":[150],"(72.6%)":[151],"(62.5%":[154],"vs":[155],"75.0%;":[156],"log":[157],"rank":[158],"P":[159],"=":[160],"0.022).":[161],"On":[162],"univariate":[163],"analysis,":[164],"diameter":[165],"(hazard":[166],"ratio,":[167],"HR":[168],"1.1),":[169],"nuclear":[170,197],"grade":[171,198],"(HR":[172,176,181,186,199,203,208],"4.5),":[173],"margin":[174,201],"status":[175,202],"5.8),":[177],"lymph":[178],"node":[179],"metastases":[180,185,207],"6.4),":[182],"systemic":[184,206],"15.4)":[187],"significant":[189],"DSS.":[191,246],"In":[192],"multivariate":[194],"model,":[195],"only":[196],"3.1),":[200],"8.9)":[204],"9.8)":[209],"independent":[211,243],"predictors.":[212],"CONCLUSION:":[213],"Patients":[214],"more":[221],"likely":[222],"die":[224],"RCC":[226],"those":[228],"PFI.":[230],"However,":[231],"present":[234],"presence":[237],"not":[241],"an":[242],"predictor":[244]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}