{"id":"https://openalex.org/W2085506563","doi":"https://doi.org/10.1016/j.neulet.2005.01.053","title":"Degeneration of dopaminergic neurons in the substantia nigra of zitter mutant rat and protection by chronic intake of Vitamin E","display_name":"Degeneration of dopaminergic neurons in the substantia nigra of zitter mutant rat and protection by chronic intake of Vitamin E","publication_year":2005,"publication_date":"2005-02-11","ids":{"openalex":"https://openalex.org/W2085506563","doi":"https://doi.org/10.1016/j.neulet.2005.01.053","mag":"2085506563","pmid":"https://pubmed.ncbi.nlm.nih.gov/15862896"},"language":"en","primary_location":{"id":"doi:10.1016/j.neulet.2005.01.053","doi":"https://doi.org/10.1016/j.neulet.2005.01.053","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2005.01.053","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101691617","display_name":"Shuichi Ueda","orcid":"https://orcid.org/0000-0002-7105-102X","observed_orcids":["https://orcid.org/0000-0002-7105-102X"]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shuichi Ueda","raw_affiliation_strings":["Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan. shu-ueda@dokkyomed.ac.jp","Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan. shu-ueda@dokkyomed.ac.jp","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]},{"raw_affiliation_string":"Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I4210086780","https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025454325","display_name":"Shin\u2010ichi Sakakibara","orcid":"https://orcid.org/0000-0001-8983-2249","observed_orcids":["https://orcid.org/0000-0001-8983-2249"]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-ichi Sakakibara","raw_affiliation_strings":["Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I4210086780","https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039231233","display_name":"Kazuhiko Nakadate","orcid":"https://orcid.org/0000-0001-6717-7167","observed_orcids":["https://orcid.org/0000-0001-6717-7167"]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Nakadate","raw_affiliation_strings":["Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I4210086780","https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053943034","display_name":"Takahiro Noda","orcid":"https://orcid.org/0000-0002-6844-384X","observed_orcids":["https://orcid.org/0000-0002-6844-384X"]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Noda","raw_affiliation_strings":["Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Neurobiology, JST/RISTEX, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I4210086780","https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007232861","display_name":"Motoo Shinoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoo Shinoda","raw_affiliation_strings":["Laboratory Animal Research Center, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Research Center, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014426745","display_name":"Jeffrey N. Joyce","orcid":"https://orcid.org/0000-0002-0131-0946","observed_orcids":["https://orcid.org/0000-0002-0131-0946"]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey N. Joyce","raw_affiliation_strings":["Tomas H. Christopher Center for Parkinson's Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tomas H. Christopher Center for Parkinson's Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA","institution_ids":["https://openalex.org/I4210145600"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101691617"],"corresponding_institution_ids":["https://openalex.org/I109009565","https://openalex.org/I4210086780","https://openalex.org/I78274823"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":1.7104,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.81798053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"380","issue":"3","first_page":"252","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.9309999942779541},{"id":"https://openalex.org/keywords/substantia-nigra-pars-compacta","display_name":"substantia nigra pars compacta","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.5440000295639038},{"id":"https://openalex.org/keywords/antioxidant-rich-diet","display_name":"antioxidant diet","score":0.6850000023841858},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7789999842643738},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.8830159902572632},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.858464241027832},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6713710427284241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6590778231620789},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.5729113221168518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5083164572715759},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.449052631855011},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3227723240852356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19175389409065247}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011922","descriptor_name":"Rats, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neulet.2005.01.053","doi":"https://doi.org/10.1016/j.neulet.2005.01.053","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2005.01.053","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:15862896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15862896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1480022284","https://openalex.org/W1910298002","https://openalex.org/W1960561004","https://openalex.org/W1968847638","https://openalex.org/W1974898145","https://openalex.org/W1977776486","https://openalex.org/W1985827408","https://openalex.org/W1989350751","https://openalex.org/W1996374049","https://openalex.org/W2000217055","https://openalex.org/W2001289566","https://openalex.org/W2012331523","https://openalex.org/W2015727009","https://openalex.org/W2018290969","https://openalex.org/W2023562568","https://openalex.org/W2027194955","https://openalex.org/W2030013648","https://openalex.org/W2034071775","https://openalex.org/W2036572840","https://openalex.org/W2058186282","https://openalex.org/W2081844190","https://openalex.org/W2089873014","https://openalex.org/W2094507987","https://openalex.org/W2095323303","https://openalex.org/W2096990903","https://openalex.org/W2129902275","https://openalex.org/W2155149688","https://openalex.org/W2416219844"],"related_works":["https://openalex.org/W1993219522","https://openalex.org/W2094507987","https://openalex.org/W2804470624","https://openalex.org/W561864700","https://openalex.org/W2089873014","https://openalex.org/W2050877473","https://openalex.org/W2014585682","https://openalex.org/W1985827408","https://openalex.org/W1982204714","https://openalex.org/W2088011543"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}