{"id":"https://openalex.org/W2085487669","doi":"https://doi.org/10.1097/00003246-200203000-00003","title":"l-Arginine supplementation in hyperdynamic endotoxemic pigs: Effect on nitric oxide synthesis by the different organs*","display_name":"l-Arginine supplementation in hyperdynamic endotoxemic pigs: Effect on nitric oxide synthesis by the different organs*","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2085487669","doi":"https://doi.org/10.1097/00003246-200203000-00003","mag":"2085487669","pmid":"https://pubmed.ncbi.nlm.nih.gov/11990907"},"language":"en","primary_location":{"id":"doi:10.1097/00003246-200203000-00003","doi":"https://doi.org/10.1097/00003246-200203000-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-200203000-00003","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045806298","display_name":"Maaike J. Bruins","orcid":"https://orcid.org/0000-0001-9517-4617","observed_orcids":["https://orcid.org/0000-0001-9517-4617"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maaike J. Bruins","raw_affiliation_strings":["Department of Surgery, Maastricht University, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Maastricht University, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022058638","display_name":"Peter B. Soeters","orcid":"https://orcid.org/0000-0003-1340-5042","observed_orcids":["https://orcid.org/0000-0003-1340-5042"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter B. Soeters","raw_affiliation_strings":["From the Department of Surgery (MJB, PBS, NEPD), Maastricht University, Maastricht, The Netherlands","and the Departments of Anatomy & Embryology (WHL) and Biochemistry (AJM), University of Amsterdam, Amsterdam, the Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery (MJB, PBS, NEPD), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"and the Departments of Anatomy & Embryology (WHL) and Biochemistry (AJM), University of Amsterdam, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052827329","display_name":"Wouter H. Lamers","orcid":"https://orcid.org/0000-0003-3032-7824","observed_orcids":["https://orcid.org/0000-0003-3032-7824"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wouter H. Lamers","raw_affiliation_strings":["From the Department of Surgery (MJB, PBS, NEPD), Maastricht University, Maastricht, The Netherlands","and the Departments of Anatomy & Embryology (WHL) and Biochemistry (AJM), University of Amsterdam, Amsterdam, the Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery (MJB, PBS, NEPD), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"and the Departments of Anatomy & Embryology (WHL) and Biochemistry (AJM), University of Amsterdam, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111797872","display_name":"Alfred J. Meijer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alfred J. Meijer","raw_affiliation_strings":["From the Department of Surgery (MJB, PBS, NEPD), Maastricht University, Maastricht, The Netherlands","and the Departments of Anatomy & Embryology (WHL) and Biochemistry (AJM), University of Amsterdam, Amsterdam, the Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery (MJB, PBS, NEPD), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"and the Departments of Anatomy & Embryology (WHL) and Biochemistry (AJM), University of Amsterdam, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073459667","display_name":"Nicolaas E.P. Deutz","orcid":"https://orcid.org/0000-0001-5845-6447","observed_orcids":["https://orcid.org/0000-0001-5845-6447"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nicolaas E. P. Deutz","raw_affiliation_strings":["From the Department of Surgery (MJB, PBS, NEPD), Maastricht University, Maastricht, The Netherlands","and the Departments of Anatomy & Embryology (WHL) and Biochemistry (AJM), University of Amsterdam, Amsterdam, the Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery (MJB, PBS, NEPD), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"and the Departments of Anatomy & Embryology (WHL) and Biochemistry (AJM), University of Amsterdam, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.9739,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.96642588,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"30","issue":"3","first_page":"508","last_page":"517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.30979999899864197,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine-supplementation","display_name":"arginine supplementation","score":0.996999979019165},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.9290000200271606},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.9340000152587891},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/escherichia-coli-endotoxin","display_name":"Escherichia coli endotoxin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hyperdynamic-circulation","display_name":"hyperdynamic circulation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.7590000033378601},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5899999737739563},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.8109999895095825},{"id":"https://openalex.org/keywords/portal-drained-viscera","display_name":"portal-drained viscera","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hindquarter-muscle","display_name":"hindquarter muscle","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.933276891708374},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.7530314922332764},{"id":"https://openalex.org/C2776179834","wikidata":"https://www.wikidata.org/wiki/Q72158415","display_name":"Nitrite","level":3,"score":0.6996808052062988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6220279932022095},{"id":"https://openalex.org/C2776384668","wikidata":"https://www.wikidata.org/wiki/Q182168","display_name":"Nitrate","level":2,"score":0.4639676809310913},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4489525854587555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42725110054016113},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3444731533527374},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34331831336021423},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3200604021549225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25044864416122437},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.19411006569862366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19228726625442505},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.06572440266609192}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004750","descriptor_name":"Enteral Nutrition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014781","descriptor_name":"Viscera","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1097/00003246-200203000-00003","doi":"https://doi.org/10.1097/00003246-200203000-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-200203000-00003","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:11990907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11990907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/1d5a35d8-d0bf-4c3d-87b1-a2c6a12a8404","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/1d5a35d8-d0bf-4c3d-87b1-a2c6a12a8404","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bruins, M J, Soeters, P B, Lamers, W H, Meijer, A J & Deutz, N E P 2002, 'L-arginine supplementation in hyperdynamic endotoxemic pigs: effect on nitric oxide synthesis by the different organs', Critical Care Medicine, vol. 30, no. 3, pp. 508-517. https://doi.org/10.1097/00003246-200203000-00003","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/a3d8f04e-5f6e-4fbb-afe3-cf9dfed16f89","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/larginine-supplementation-in-hyperdynamic-endotoxemic-pigs-effect-on-nitric-oxide-synthesis-by-the-different-organs(a3d8f04e-5f6e-4fbb-afe3-cf9dfed16f89).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical care medicine, 30(3), 508 - 517. Lippincott Williams and Wilkins","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/12d7a6de-70c1-4aa0-94cd-8cc975391172","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/12d7a6de-70c1-4aa0-94cd-8cc975391172","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bruins, M J, Soeters, P B, Lamers, W H, Meijer, A J & Deutz, N E P 2002, 'L-arginine supplementation in hyperdynamic endotoxemic pigs: effect on nitric oxide synthesis by the different organs', Critical care medicine, vol. 30, no. 3, pp. 508-517. https://doi.org/10.1097/00003246-200203000-00003","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/1d5a35d8-d0bf-4c3d-87b1-a2c6a12a8404","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/1d5a35d8-d0bf-4c3d-87b1-a2c6a12a8404","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care Medicine, 30(3), 508 - 517. LIPPINCOTT WILLIAMS & WILKINS","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W578069077","https://openalex.org/W1585106310","https://openalex.org/W1929009802","https://openalex.org/W1969714386","https://openalex.org/W1972836643","https://openalex.org/W2007462231","https://openalex.org/W2012602663","https://openalex.org/W2019451160","https://openalex.org/W2020173969","https://openalex.org/W2022664194","https://openalex.org/W2040534043","https://openalex.org/W2054445986","https://openalex.org/W2060591452","https://openalex.org/W2067768584","https://openalex.org/W2078339353","https://openalex.org/W2134033609","https://openalex.org/W2144302244","https://openalex.org/W2145232867","https://openalex.org/W2155791167","https://openalex.org/W2160032995","https://openalex.org/W2175016966","https://openalex.org/W2210121124","https://openalex.org/W2239157081","https://openalex.org/W2338245682","https://openalex.org/W2338292609","https://openalex.org/W2343786794","https://openalex.org/W2407859649","https://openalex.org/W2412469902"],"related_works":["https://openalex.org/W1993126816","https://openalex.org/W2136448020","https://openalex.org/W1998001366","https://openalex.org/W2429069628","https://openalex.org/W1972157068","https://openalex.org/W2022959515","https://openalex.org/W1983169185","https://openalex.org/W2126211536","https://openalex.org/W2147251066","https://openalex.org/W1994874971"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Under":[1],"septic":[2],"conditions,":[3],"the":[4,11,98,116,146,149,152,155,174],"protective":[5],"role":[6],"of":[7,19,25,28,81,103,108,138,202,214],"nitric":[8,43,112,170,184,217],"oxide":[9,44,113,171,185,218],"in":[10,142,181,220],"organs":[12],"may":[13],"become":[14],"compromised":[15],"at":[16],"a":[17,23,38,79,124],"time":[18],"increased":[20,169],"demand":[21],"as":[22,37],"result":[24],"decreased":[26],"availability":[27],"L-arginine.":[29],"It":[30],"remains":[31],"unknown":[32],"whether":[33],"supplementation":[34,110],"with":[35,49,64,88,118,123],"L-arginine,":[36],"substrate,":[39],"can":[40],"modulate":[41],"organ":[42,130],"production.":[45],"DESIGN:":[46],"Controlled":[47],"study":[48],"laboratory":[50],"animals.":[51],"SETTING:":[52],"University":[53],"research":[54],"laboratory.":[55],"SUBJECTS:":[56],"Female":[57],"crossbred":[58],"pigs.":[59],"INTERVENTION:":[60],"Pigs":[61,85],"were":[62,86,121,135],"challenged":[63],"Escherichia":[65],"coli":[66],"endotoxin":[67,95,104],"(intravenously)":[68],"and":[69,96,115,154,178,189],"received":[70],"intravenous":[71],"fluid":[72],"resuscitation":[73],"for":[74],"24":[75],"hrs":[76],"to":[77,199],"reproduce":[78],"model":[80],"long-lasting":[82],"hyperdynamic":[83],"endotoxemia.":[84],"infused":[87],"either":[89],"L-arginine":[90,109,166,215],"or":[91],"L-alanine":[92],"intravenously":[93],"during":[94],"via":[97],"intragastric":[99],"route":[100],"after":[101],"cessation":[102],"infusion.":[105],"The":[106,160],"effects":[107],"on":[111],"synthesis":[114,186,219],"relationships":[117],"arginine":[119],"metabolism":[120],"determined":[122],"stable":[125],"isotope":[126,161],"infusion":[127],"protocol.":[128],"Also,":[129],"nitrite":[131,193],"plus":[132,194],"nitrate":[133,195],"fluxes":[134,196],"measured.":[136],"Implantation":[137],"multiple":[139],"catheters":[140],"enabled":[141],"vivo":[143],"measurements":[144],"across":[145],"hindquarter":[147],"muscle,":[148],"portal-drained":[150,175],"viscera,":[151,176],"liver,":[153,177],"kidneys.":[156],"MEASUREMENTS":[157],"AND":[158],"RESULTS:":[159],"conversion":[162],"method":[163],"showed":[164],"that":[165],"intervention":[167],"significantly":[168],"production":[172],"by":[173],"kidneys,":[179],"resulting":[180],"elevated":[182],"whole-body":[183],"under":[187],"endotoxemic":[188],"postendotoxemic":[190],"conditions.":[191],"Organ":[192],"only":[197],"tended":[198],"increase":[200],"because":[201],"high":[203],"variance":[204],"among":[205],"data.":[206],"CONCLUSIONS:":[207],"In":[208],"this":[209],"endotoxemia":[210],"model,":[211],"supplemental":[212],"use":[213],"favored":[216],"various":[221],"organs.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}