{"id":"https://openalex.org/W2085480583","doi":"https://doi.org/10.1002/1097-0142(19900901)66:5<862::aid-cncr2820660509>3.0.co;2-r","title":"Randomized comparison of doxorubicin and vindesine to doxorubicin for patients with metastatic soft-tissue sarcomas","display_name":"Randomized comparison of doxorubicin and vindesine to doxorubicin for patients with metastatic soft-tissue sarcomas","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W2085480583","doi":"https://doi.org/10.1002/1097-0142(19900901)66:5<862::aid-cncr2820660509>3.0.co;2-r","mag":"2085480583","pmid":"https://pubmed.ncbi.nlm.nih.gov/2201431"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19900901)66:5<862::aid-cncr2820660509>3.0.co;2-r","doi":"https://doi.org/10.1002/1097-0142(19900901)66:5<862::aid-cncr2820660509>3.0.co;2-r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900901)66:5<862::aid-cncr2820660509>3.0.co;2-r","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112252438","display_name":"Ernest C. Borden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ernest C. Borden","raw_affiliation_strings":["University of Wisconsin Clinical Cancer Center, Madison","Univ. of Wisconsin Clinical Cancer Center, Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin Clinical Cancer Center, Madison","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Univ. of Wisconsin Clinical Cancer Center, Madison","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106083321","display_name":"David A. Amato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Amato","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113540901","display_name":"John H. Edmonson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Edmonson","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057163122","display_name":"Paul S. Ritch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S. Ritch","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069559501","display_name":"Masanori Shiraki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Shiraki","raw_affiliation_strings":["Tufts New England Medical Center Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts New England Medical Center Hospital, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5112252438"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.2308,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.82333161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"66","issue":"5","first_page":"862","last_page":"867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-soft-tissue-sarcoma","display_name":"metastatic soft tissue sarcoma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vindesine","display_name":"vindesine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.8379999995231628},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8840000033378601},{"id":"https://openalex.org/keywords/histopathological-diagnosis","display_name":"histopathological diagnosis","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2779321808","wikidata":"https://www.wikidata.org/wiki/Q416660","display_name":"Vindesine","level":5,"score":0.9864434003829956},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8982771039009094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.863871693611145},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.7545791864395142},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5431804060935974},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.5314288139343262},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.497266560792923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4737813472747803},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4434043765068054},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3770372271537781},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3681798577308655},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32861781120300293},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.32195448875427246},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2560889422893524},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.10538095235824585},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.058484792709350586}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D014751","descriptor_name":"Vindesine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014751","descriptor_name":"Vindesine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014751","descriptor_name":"Vindesine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19900901)66:5<862::aid-cncr2820660509>3.0.co;2-r","doi":"https://doi.org/10.1002/1097-0142(19900901)66:5<862::aid-cncr2820660509>3.0.co;2-r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900901)66:5<862::aid-cncr2820660509>3.0.co;2-r","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:2201431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2201431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G6796618889","display_name":"Eastern Cooperative Oncology Group","funder_award_id":"U10CA013650","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7912900346","display_name":"EASTERN COOPERATIVE ONCOLOGY GROUP - WISCONSIN STUDIES","funder_award_id":"U10CA021076","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8112161023","display_name":"ECOG Statistical Office","funder_award_id":"U10CA023318","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1495571942","https://openalex.org/W1911517772","https://openalex.org/W1943427806","https://openalex.org/W1969965083","https://openalex.org/W2015052490","https://openalex.org/W2025639667","https://openalex.org/W2034328882","https://openalex.org/W2083438316","https://openalex.org/W2083668859","https://openalex.org/W2153365867","https://openalex.org/W2470214478","https://openalex.org/W4244729508","https://openalex.org/W4285719527","https://openalex.org/W6671026427"],"related_works":["https://openalex.org/W2401702182","https://openalex.org/W2909803018","https://openalex.org/W2126540415","https://openalex.org/W2161378536","https://openalex.org/W1882650898","https://openalex.org/W4254190769","https://openalex.org/W1856885090","https://openalex.org/W2104336706","https://openalex.org/W1496021054","https://openalex.org/W2752560124"],"abstract_inverted_index":{"Two":[0],"treatment":[1,147],"regimens":[2],"for":[3,107,110,119,123,174],"metastatic":[4,175],"soft-tissue":[5,44,176],"sarcomas":[6],"were":[7,54],"compared":[8],"in":[9,13,27,72,103,159],"a":[10,141],"randomized":[11],"trial":[12],"the":[14,30,37,41,161,168],"cooperative":[15],"group":[16],"setting.":[17],"Histopathologic":[18],"diagnosis":[19,42],"was":[20],"affirmed":[21,40],"by":[22],"pathology":[23],"reference":[24,38],"panel":[25,39],"review":[26],"72%":[28],"of":[29,35,43,52,74,83,129,146,156,167,170],"347":[31],"patients.":[32],"In":[33],"21%":[34],"patients,":[36],"sarcoma":[45],"but":[46],"disagreed":[47],"as":[48],"to":[49,76,85],"type;":[50],"7%":[51],"patients":[53,62,75,84,131],"ineligible":[55],"based":[56],"upon":[57],"cell":[58],"type.":[59],"Of":[60],"298":[61],"evaluable,":[63],"measurable":[64],"tumor":[65],"regression":[66],"(partial":[67],"or":[68,114,143],"complete":[69,104],"response)":[70],"occurred":[71],"17%":[73],"doxorubicin":[77,86,111,124,133,139,171],"(70":[78,87],"mg/m2":[79,88,93],"intravenously)":[80,89],"and":[81,90,112,125,134,136,154,172],"18%":[82],"vindesine":[91,135,173],"(3":[92],"intravenously),":[94],"each":[95],"given":[96],"every":[97],"3":[98],"weeks.":[99],"No":[100],"difference":[101],"existed":[102],"response":[105],"(4%":[106],"doxorubicin,":[108,120],"6%":[109],"vindesine)":[113],"median":[115],"survival":[116],"(9.4":[117],"months":[118,122],"9.9":[121],"vindesine).":[126],"Overall,":[127],"60%":[128],"those":[130],"on":[132,138],"46%":[137],"experienced":[140],"severe":[142],"worse":[144],"toxicity":[145,153],"(P":[148],"=":[149],"0.01).":[150],"With":[151],"greater":[152],"lack":[155],"any":[157],"gains":[158],"efficacy,":[160],"results":[162],"do":[163],"not":[164],"support":[165],"use":[166],"combination":[169],"sarcomas.":[177]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
