{"id":"https://openalex.org/W2085447458","doi":"https://doi.org/10.1002/eji.1830261251","title":"Cell division in the compartment of naive and memory T lymphocytes","display_name":"Cell division in the compartment of naive and memory T lymphocytes","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2085447458","doi":"https://doi.org/10.1002/eji.1830261251","mag":"2085447458","pmid":"https://pubmed.ncbi.nlm.nih.gov/8977320"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830261251","doi":"https://doi.org/10.1002/eji.1830261251","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830261251","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111835749","display_name":"Ludovica Bruno","orcid":"https://orcid.org/0009-0006-8042-3370","observed_orcids":["https://orcid.org/0009-0006-8042-3370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ludovica Bruno","raw_affiliation_strings":["Basel Institute for Immunology, Switzerland","\u2020Basel Institute for Immunology, Basel, Switzerland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basel Institute for Immunology, Switzerland","institution_ids":[]},{"raw_affiliation_string":"\u2020Basel Institute for Immunology, Basel, Switzerland;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012087369","display_name":"Harald von Boehmer","orcid":"https://orcid.org/0000-0002-9714-1613","observed_orcids":["https://orcid.org/0000-0002-9714-1613"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Harald von Boehmer","raw_affiliation_strings":["Institute Necker, INSERM 373, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Necker, INSERM 373, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089755489","display_name":"J\u00f6rg Kirberg","orcid":"https://orcid.org/0009-0009-3635-0137","observed_orcids":["https://orcid.org/0009-0009-3635-0137"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J\u00f6rg Kirberg","raw_affiliation_strings":["Basel Institute for Immunology, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basel Institute for Immunology, Basel, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089755489"],"corresponding_institution_ids":[],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":3.2847,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.92619847,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"26","issue":"12","first_page":"3179","last_page":"3184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-division","display_name":"T cell division","score":0.7099999785423279},{"id":"https://openalex.org/keywords/t-cell-receptor-transgenic-mice","display_name":"T cell receptor transgenic mice","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/t-cell-activation-markers","display_name":"T cell activation markers","score":0.6600000262260437},{"id":"https://openalex.org/keywords/lymphokines","display_name":"lymphokines","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7384412288665771},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7021279335021973},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5918838381767273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5505670309066772},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5265745520591736},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.5049107670783997},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5047818422317505},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.4738236665725708},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.46882838010787964},{"id":"https://openalex.org/C8840205","wikidata":"https://www.wikidata.org/wiki/Q7623301","display_name":"Streptamer","level":5,"score":0.46421435475349426},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.4540659785270691},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.4157026410102844},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.40567129850387573},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3598994016647339},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35730648040771484},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1824626326560974},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15081074833869934},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.11645433306694031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09607407450675964}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013934","descriptor_name":"Thymectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.1830261251","doi":"https://doi.org/10.1002/eji.1830261251","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830261251","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:8977320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8977320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1968273066","https://openalex.org/W1976673695","https://openalex.org/W1979116835","https://openalex.org/W1986356667","https://openalex.org/W1998724551","https://openalex.org/W2006981670","https://openalex.org/W2014924137","https://openalex.org/W2019638830","https://openalex.org/W2025336339","https://openalex.org/W2026891958","https://openalex.org/W2037367542","https://openalex.org/W2041061869","https://openalex.org/W2044163622","https://openalex.org/W2045887180","https://openalex.org/W2049998759","https://openalex.org/W2061140050","https://openalex.org/W2092095871","https://openalex.org/W2096325339","https://openalex.org/W2097863314","https://openalex.org/W2133703099","https://openalex.org/W2145700827","https://openalex.org/W2162508156"],"related_works":["https://openalex.org/W1998724551","https://openalex.org/W2017149270","https://openalex.org/W2315798836","https://openalex.org/W7095080516","https://openalex.org/W2146446831","https://openalex.org/W2137384756","https://openalex.org/W2001036909","https://openalex.org/W2133074450","https://openalex.org/W1509377852","https://openalex.org/W1982148376"],"abstract_inverted_index":{"Expression":[0],"of":[1,16,33,52,93,99,122,157,170,180],"activation":[2,169],"markers":[3],"and":[4,12,45],"proliferative":[5],"status":[6],"were":[7,57,69,82,128],"measured":[8],"in":[9,72,84,96],"peripheral":[10],"CD4+":[11,36],"CD8+":[13],"T":[14,18,37,62,66,125,133,172,203],"cells":[15,38,47,67,80,95,126,134,173,204],"various":[17],"cell":[19],"receptor":[20],"(TCR)-transgenic":[21],"mice":[22,208],"either":[23],"before":[24],"or":[25,42,163],"after":[26,77,88,147],"intentional":[27,34,100],"antigenic":[28,101,137],"stimulation.":[29],"In":[30,118],"the":[31,50,91,97,158,178,187,198],"absence":[32,98],"immunization,":[35],"persisted":[39,209],"as":[40],"resting":[41],"partially":[43],"activated":[44,124],"cycling":[46,71],"depending":[48],"on":[49,192],"specificity":[51],"their":[53],"TCR.":[54],"Similar":[55],"results":[56],"obtained":[58],"following":[59],"transfer":[60,148],"into":[61,149],"cell-deficient":[63],"recipients,":[64],"i.e.":[65],"that":[68,81,109,127,152,165,186],"not":[70,75,111,154,167,190],"situ":[73,85],"did":[74,153],"cycle":[76,141],"transfer,":[78],"whereas":[79],"proliferating":[83],"also":[86],"cycled":[87],"transfer.":[89],"Thus,":[90,161],"TCR":[92,195],"some":[94,106],"stimulation":[102,138],"may":[103,174],"bind":[104],"to":[105,140,210],"unidentified":[107],"ligand":[108],"does":[110,189],"induce":[112,155,168],"tolerance,":[113],"but":[114],"rather":[115],"slow":[116],"expansion.":[117],"a":[119,144,193,211],"different":[120],"sort":[121],"experiment,":[123],"derived":[129],"from":[130,205],"noncycling":[131],"naive":[132,159,171],"by":[135,197],"deliberate":[136],"continued":[139],"slowly":[142],"even":[143],"long":[145],"time":[146],"antigen-free":[150],"recipients":[151],"proliferation":[156],"cells.":[160,182],"lymphokines":[162],"ligands":[164],"do":[166],"be":[175],"responsible":[176],"for":[177],"maintenance":[179],"memory":[181,199,202],"Our":[183],"experiments":[184],"show":[185],"latter":[188],"depend":[191],"second":[194],"expressed":[196],"cells,":[200],"since":[201],"RAG-2(-/-)":[206],"TCR-transgenic":[207],"similar":[212],"extent.":[213]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}