{"id":"https://openalex.org/W2085354593","doi":"https://doi.org/10.1002/art.22262","title":"Genetic association between the PRKCH gene encoding protein kinase C\u03b7 isozyme and rheumatoid arthritis in the Japanese population","display_name":"Genetic association between the PRKCH gene encoding protein kinase C\u03b7 isozyme and rheumatoid arthritis in the Japanese population","publication_year":2006,"publication_date":"2006-12-28","ids":{"openalex":"https://openalex.org/W2085354593","doi":"https://doi.org/10.1002/art.22262","mag":"2085354593","pmid":"https://pubmed.ncbi.nlm.nih.gov/17195206"},"language":"en","primary_location":{"id":"doi:10.1002/art.22262","doi":"https://doi.org/10.1002/art.22262","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.22262","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017092579","display_name":"Yoichiro Takata","orcid":"https://orcid.org/0000-0002-8579-4043","observed_orcids":["https://orcid.org/0000-0002-8579-4043"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichiro Takata","raw_affiliation_strings":["The University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031108054","display_name":"Daisuke Hamada","orcid":"https://orcid.org/0000-0001-7868-6733","observed_orcids":["https://orcid.org/0000-0001-7868-6733"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Hamada","raw_affiliation_strings":["The University of Tokushima, Tokushima, , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Tokushima, , Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067837972","display_name":"Katsutoshi Miyatake","orcid":"https://orcid.org/0000-0002-2635-7310","observed_orcids":["https://orcid.org/0000-0002-2635-7310"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsutoshi Miyatake","raw_affiliation_strings":["The University of Tokushima, Tokushima, , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Tokushima, , Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103026001","display_name":"Shunji Nakano","orcid":"https://orcid.org/0000-0003-4909-1137","observed_orcids":["https://orcid.org/0000-0003-4909-1137"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunji Nakano","raw_affiliation_strings":["The University of Tokushima, Tokushima, , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Tokushima, , Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040651228","display_name":"Fumio Shinomiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumio Shinomiya","raw_affiliation_strings":["Mima Hospital, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mima Hospital, Tokushima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013746768","display_name":"Charles Scafe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles R. Scafe","raw_affiliation_strings":["Applied Biosystems Foster City California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Biosystems Foster City California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016536335","display_name":"Vincent M. Reeve","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent M. Reeve","raw_affiliation_strings":["Applied Biosystems Foster City California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Biosystems Foster City California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015105492","display_name":"Dai Osabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104082","display_name":"Japan Biological Informatics Consortium","ror":"https://ror.org/01astg473","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210104082"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Dai Osabe","raw_affiliation_strings":["Japan Biological Information Consortium, and Fujitsu, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Biological Information Consortium, and Fujitsu, Tokyo, Japan","institution_ids":["https://openalex.org/I4210104082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050287016","display_name":"Maki Moritani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maki Moritani","raw_affiliation_strings":["The University of Tokushima, Tokushima, , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Tokushima, , Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081191461","display_name":"Kiyoshi Kunika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Kunika","raw_affiliation_strings":["The University of Tokushima, Tokushima, , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Tokushima, , Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109144333","display_name":"Naoyuki Kamatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoyuki Kamatani","raw_affiliation_strings":["Tokyo Women's Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Women's Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006787725","display_name":"Hiroshi Inoue","orcid":"https://orcid.org/0000-0002-7724-6637","observed_orcids":["https://orcid.org/0000-0002-7724-6637"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Inoue","raw_affiliation_strings":["The University of Tokushima, Tokushima, , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Tokushima, , Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112145053","display_name":"Natsuo Yasui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsuo Yasui","raw_affiliation_strings":["The University of Tokushima, Tokushima, , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Tokushima, , Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045658450","display_name":"Mitsuo Itakura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104082","display_name":"Japan Biological Informatics Consortium","ror":"https://ror.org/01astg473","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210104082"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuo Itakura","raw_affiliation_strings":["The University of Tokushima, Tokushima, and Japan Biological Information Consortium, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Tokushima, and Japan Biological Information Consortium, Tokyo, Japan","institution_ids":["https://openalex.org/I4210104082","https://openalex.org/I922474255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.724,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.83950914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"56","issue":"1","first_page":"30","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/protein-kinase-c-eta","display_name":"protein kinase C eta","score":0.9629999995231628},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8420000076293945},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9549999833106995},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8550000190734863},{"id":"https://openalex.org/keywords/haplotype-blocks","display_name":"haplotype blocks","score":0.9409999847412109},{"id":"https://openalex.org/keywords/atp-binding-site","display_name":"ATP binding site","score":0.8050000071525574},{"id":"https://openalex.org/keywords/t-cell-expression","display_name":"T cell expression","score":0.5350000262260437},{"id":"https://openalex.org/keywords/lymphocyte-gene-expression","display_name":"lymphocyte gene expression","score":0.7009999752044678},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.45100000500679016},{"id":"https://openalex.org/keywords/japanese-population","display_name":"Japanese population","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7747706174850464},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.7091518640518188},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6701183319091797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6449124813079834},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5996044278144836},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.48815780878067017},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.46297189593315125},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4519280791282654},{"id":"https://openalex.org/C55060382","wikidata":"https://www.wikidata.org/wiki/Q7675093","display_name":"Tag SNP","level":5,"score":0.4385780692100525},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.42859724164009094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42624393105506897},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.3556824326515198},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3425869941711426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15069183707237244},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099293","descriptor_name":"Protein Kinase C-lambda","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002883","descriptor_name":"Chromosomes, Human, Pair 14","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/art.22262","doi":"https://doi.org/10.1002/art.22262","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.22262","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},{"id":"pmid:17195206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17195206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.537.8441","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.537.8441","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.genome.tokushima-u.ac.jp/dgi/JAPDGI/images/publicarion PDF/2007/Arthritis Rheum. 2007.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1522588191","https://openalex.org/W1532445586","https://openalex.org/W1583477127","https://openalex.org/W1767727568","https://openalex.org/W1982733535","https://openalex.org/W1982772265","https://openalex.org/W1987055888","https://openalex.org/W1998067501","https://openalex.org/W2004729843","https://openalex.org/W2010061543","https://openalex.org/W2015865604","https://openalex.org/W2017314543","https://openalex.org/W2024938068","https://openalex.org/W2027007610","https://openalex.org/W2035249926","https://openalex.org/W2041326553","https://openalex.org/W2049362010","https://openalex.org/W2051906211","https://openalex.org/W2061672889","https://openalex.org/W2063014521","https://openalex.org/W2065419533","https://openalex.org/W2072651272","https://openalex.org/W2076186450","https://openalex.org/W2080817427","https://openalex.org/W2083878136","https://openalex.org/W2086755979","https://openalex.org/W2093120748","https://openalex.org/W2093503233","https://openalex.org/W2094190795","https://openalex.org/W2094282176","https://openalex.org/W2096536544","https://openalex.org/W2102079012","https://openalex.org/W2104502907","https://openalex.org/W2122004833","https://openalex.org/W2125759768","https://openalex.org/W2130309165","https://openalex.org/W2137299974","https://openalex.org/W2140126911","https://openalex.org/W2142890842","https://openalex.org/W2144911879","https://openalex.org/W2145937373","https://openalex.org/W2152348310","https://openalex.org/W2152664025","https://openalex.org/W2161381121","https://openalex.org/W2166570978","https://openalex.org/W2168651519","https://openalex.org/W2303094714","https://openalex.org/W2418402827","https://openalex.org/W4251621895","https://openalex.org/W7095892121"],"related_works":["https://openalex.org/W2276427651","https://openalex.org/W2169654055","https://openalex.org/W7095637230","https://openalex.org/W2998583118","https://openalex.org/W2167654128","https://openalex.org/W2033287763","https://openalex.org/W2016221087","https://openalex.org/W2027007610","https://openalex.org/W2140771611","https://openalex.org/W2092580244"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Analyses":[1],"of":[2,12,38,69,107,138,196,199,212,221],"families":[3],"with":[4,43],"rheumatoid":[5],"arthritis":[6],"(RA)":[7],"have":[8],"suggested":[9],"the":[10,62,66,79,118,139,147,197,208],"presence":[11],"a":[13,133,202],"putative":[14],"susceptibility":[15,203],"locus":[16],"on":[17],"chromosome":[18],"14q21-23.":[19],"This":[20],"large":[21],"population-based":[22],"genetic":[23],"association":[24,36],"study":[25,37],"was":[26,49,100,164,185],"undertaken":[27],"to":[28,103],"examine":[29],"this":[30],"region.":[31],"METHODS:":[32],"A":[33],"2-stage":[34],"case-control":[35],"950":[39,46],"unrelated":[40],"Japanese":[41,209],"patients":[42],"RA":[44,206,222],"and":[45,184],"healthy":[47],"controls":[48],"performed":[50],"using":[51],">400":[52],"gene-based":[53],"common":[54,135],"single-nucleotide":[55],"polymorphisms":[56],"(SNPs).":[57],"RESULTS:":[58],"Multiple":[59],"SNPs":[60,131],"in":[61,117,169,177,207],"PRKCH":[63,119,140,161,200],"gene":[64,120,204],"encoding":[65],"eta":[67],"isozyme":[68],"protein":[70],"kinase":[71],"C":[72],"(PKCeta)":[73],"showed":[74],"significant":[75,81],"single-locus":[76],"disease":[77,128],"associations,":[78],"most":[80],"being":[82],"SNP":[83,99],"c.427+8134C>T":[84],"(odds":[85],"ratio":[86],"0.72,":[87],"95%":[88],"confidence":[89],"interval":[90],"0.62-0.83,":[91],"P":[92],"=":[93],"5.9":[94],"x":[95],"10(-5)).":[96],"Each":[97],"RA-associated":[98],"consistently":[101],"mapped":[102],"3":[104],"distinct":[105],"regions":[106],"strong":[108],"linkage":[109,112],"disequilibrium":[110,113],"(i.e.,":[111],"or":[114,174,181],"haplotype":[115],"blocks)":[116],"locus,":[121],"suggesting":[122],"that":[123,150],"multiple":[124],"causal":[125],"variants":[126],"influence":[127],"susceptibility.":[129],"Significant":[130],"included":[132],"novel":[134],"missense":[136],"polymorphism":[137],"gene,":[141],"V374I":[142],"(rs2230500),":[143],"which":[144],"lies":[145],"within":[146],"ATP-binding":[148],"site":[149],"is":[151],"highly":[152],"conserved":[153],"among":[154],"PKC":[155],"superfamily":[156],"members.":[157],"In":[158],"circulating":[159],"lymphocytes,":[160],"messenger":[162],"RNA":[163],"expressed":[165],"at":[166],"higher":[167],"levels":[168],"resting":[170],"T":[171,225],"cells":[172,179],"(CD4(+)":[173],"CD8(+))":[175],"than":[176],"B":[178],"(CD19(+))":[180],"monocytes":[182],"(CD14(+))":[183],"significantly":[186],"down-regulated":[187],"through":[188,223],"immune":[189],"responses.":[190,228],"CONCLUSION:":[191],"Our":[192],"results":[193],"provide":[194],"evidence":[195],"involvement":[198],"as":[201],"for":[205],"population.":[210],"Dysregulation":[211],"PKCeta":[213],"signal":[214],"transduction":[215],"pathway(s)":[216],"may":[217],"confer":[218],"increased":[219],"risk":[220],"aberrant":[224],"cell-mediated":[226],"autoimmune":[227]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}