{"id":"https://openalex.org/W2085233103","doi":"https://doi.org/10.1111/j.1471-0528.1993.tb15108.x","title":"Anti\u2010D concentrations in fetal and maternal serum and amniotic fluid in rhesus allo\u2010immunised pregnancies","display_name":"Anti\u2010D concentrations in fetal and maternal serum and amniotic fluid in rhesus allo\u2010immunised pregnancies","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W2085233103","doi":"https://doi.org/10.1111/j.1471-0528.1993.tb15108.x","mag":"2085233103","pmid":"https://pubmed.ncbi.nlm.nih.gov/8217975"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-0528.1993.tb15108.x","doi":"https://doi.org/10.1111/j.1471-0528.1993.tb15108.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-0528.1993.tb15108.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210173111","display_name":"BJOG An International Journal of Obstetrics & Gynaecology","issn_l":"0306-5456","issn":["0306-5456","1365-215X","1470-0328","1471-0528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJOG: An International Journal of Obstetrics &amp; Gynaecology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111575517","display_name":"D. L. Economides","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Demetrios L. Economides","raw_affiliation_strings":["Oxford Rhesus Therapy Unit, John Radcliffe Hospital, London, UK","Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Rhesus Therapy Unit, John Radcliffe Hospital, London, UK","institution_ids":["https://openalex.org/I2802742124"]},{"raw_affiliation_string":"Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108448317","display_name":"Peter J. Bowell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter J. Bowell","raw_affiliation_strings":["Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001494727","display_name":"MARK SELINGER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Selinger","raw_affiliation_strings":["Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010809106","display_name":"G.A. Pratt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geoffrey A. Pratt","raw_affiliation_strings":["Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jane Ferguson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jane Ferguson","raw_affiliation_strings":["Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109247227","display_name":"I.Z. MacKenzie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. Z. Mackenzie","raw_affiliation_strings":["Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Rhesus Therapy Unit, John Radcliffe Hospital, Oxford","institution_ids":["https://openalex.org/I2802742124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111575517"],"corresponding_institution_ids":["https://openalex.org/I2802742124"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.9076,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73737916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"100","issue":"10","first_page":"923","last_page":"926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-d-antibodies","display_name":"anti-D antibodies","score":0.7919999957084656},{"id":"https://openalex.org/keywords/rh-isoimmunization","display_name":"Rh isoimmunization","score":0.7149999737739563},{"id":"https://openalex.org/keywords/fetal-anemia","display_name":"fetal anemia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/amniotic-fluid","display_name":"amniotic fluid","score":0.8510000109672546},{"id":"https://openalex.org/keywords/fetal-serum","display_name":"fetal serum","score":0.8830000162124634},{"id":"https://openalex.org/keywords/maternal-serum","display_name":"maternal serum","score":0.9100000262260437},{"id":"https://openalex.org/keywords/placental-permeability","display_name":"placental permeability","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.6079999804496765},{"id":"https://openalex.org/keywords/rhesus-monkey-model","display_name":"rhesus monkey model","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.879517674446106},{"id":"https://openalex.org/C2778194526","wikidata":"https://www.wikidata.org/wiki/Q901674","display_name":"Amniotic fluid","level":4,"score":0.8254036903381348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7333675622940063},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.6892269849777222},{"id":"https://openalex.org/C2777966818","wikidata":"https://www.wikidata.org/wiki/Q473768","display_name":"Amniocentesis","level":5,"score":0.6477664709091187},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5672533512115479},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5132038593292236},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.44734737277030945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3332253694534302},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32206106185913086},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.2611369490623474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10942515730857849},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000653","descriptor_name":"Amniotic Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007518","descriptor_name":"Isoantibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012203","descriptor_name":"Rh Isoimmunization","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012203","descriptor_name":"Rh Isoimmunization","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018029","descriptor_name":"Rho(D) Immune Globulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-0528.1993.tb15108.x","doi":"https://doi.org/10.1111/j.1471-0528.1993.tb15108.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-0528.1993.tb15108.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210173111","display_name":"BJOG An International Journal of Obstetrics & Gynaecology","issn_l":"0306-5456","issn":["0306-5456","1365-215X","1470-0328","1471-0528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJOG: An International Journal of Obstetrics &amp; Gynaecology","raw_type":"journal-article"},{"id":"pmid:8217975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8217975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of obstetrics and gynaecology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W615686096","https://openalex.org/W1984553308","https://openalex.org/W2024022434","https://openalex.org/W2026354769","https://openalex.org/W2040908059","https://openalex.org/W2063293076","https://openalex.org/W2089165523","https://openalex.org/W2153944808","https://openalex.org/W2257823050","https://openalex.org/W2484423436"],"related_works":["https://openalex.org/W2024022434","https://openalex.org/W2015541482","https://openalex.org/W2083872718","https://openalex.org/W2080352384","https://openalex.org/W2104372694","https://openalex.org/W2153944808","https://openalex.org/W1981431876","https://openalex.org/W2016858815","https://openalex.org/W2084100988","https://openalex.org/W2137906861"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,17,53,73,124,138],"relation":[4],"between":[5,102],"anti-D":[6,94,110,127,140,171,201,231,242],"concentrations":[7,172,213],"in":[8,149,214,229,238],"maternal":[9,103,166,215],"serum,":[10,104,216],"fetal":[11,20,37,47,79,85,105,159,199,217,225],"serum":[12,106,126,167,200,218],"and":[13,16,26,49,88,90,107,116,168,219],"amniotic":[14,108,169,220],"fluid,":[15],"development":[18],"of":[19,55,93,113,123,158],"anaemia.":[21,226],"DESIGN:":[22],"Observational":[23],"cross":[24,117],"sectional":[25,118],"longitudinal":[27,115],"study.":[28],"SETTING:":[29],"Regional":[30],"referral":[31],"centre.":[32],"SUBJECTS:":[33],"Sixty-one":[34],"women":[35],"undergoing":[36],"blood":[38,48,80,86],"sampling":[39,87],"at":[40],"19":[41],"to":[42,77],"36":[43],"weeks'":[44],"gestation":[45,234],"for":[46,52,241],"haematocrit":[50],"estimation":[51],"management":[54],"Rh":[56,64,134,152],"(D)":[57,65,135,153],"allo-immunisation.":[58],"Thirty-eight":[59],"pregnancies":[60,132],"(7":[61],"with":[62,129,133,151,165,198,224,233,243],"an":[63,236],"negative":[66,136],"fetus)":[67],"were":[68,99],"tested":[69],"only":[70],"once":[71],"but":[72,192],"rest":[74],"had":[75],"two":[76],"five":[78],"samplings.":[81],"INTERVENTIONS:":[82],"Ultrasound":[83],"guided":[84],"amniocentesis,":[89],"automated":[91],"analysis":[92],"antibody":[95],"quantitation.":[96],"RESULTS:":[97],"There":[98],"strong":[100],"correlations":[101],"fluid":[109,170,221],"concentrations.":[111],"Analyses":[112],"both":[114],"data":[119],"demonstrated":[120],"a":[121,195],"decrease":[122,228],"maternal/fetal":[125,139,230],"ratio":[128,141,232],"gestation.":[130],"In":[131],"fetuses":[137],"was":[142,163,194],"significantly":[143],"lower":[144],"(P":[145],"<":[146,180,189,209],"0.0001)":[147],"than":[148],"those":[150],"positive":[154],"fetuses.":[155],"The":[156,227],"degree":[157],"anaemia":[160],"(delta":[161],"haematocrit)":[162],"correlated":[164,223],"(r":[173,202],"=":[174,177,183,186,203,206],"-0.55,":[175],"n":[176,185,205],"54,":[178,207],"P":[179,188,208],"0.0001;":[181],"r":[182],"-0.57,":[184],"44,":[187],"0.0001,":[190],"respectively)":[191],"there":[193],"weaker":[196],"correlation":[197],"0.37,":[204],"0.01).":[210],"CONCLUSION:":[211],"Anti-D":[212],"are":[222],"suggests":[235],"increase":[237],"placental":[239],"permeability":[240],"advancing":[244],"pregnancy.":[245]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}