{"id":"https://openalex.org/W2085196145","doi":"https://doi.org/10.1002/ijc.1217","title":"Detection and enrichment of disseminated renal carcinoma cells from peripheral blood by immunomagnetic cell separation","display_name":"Detection and enrichment of disseminated renal carcinoma cells from peripheral blood by immunomagnetic cell separation","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2085196145","doi":"https://doi.org/10.1002/ijc.1217","mag":"2085196145","pmid":"https://pubmed.ncbi.nlm.nih.gov/11304694"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.1217","doi":"https://doi.org/10.1002/ijc.1217","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.1217","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067122522","display_name":"Udo Bilkenroth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Udo Bilkenroth","raw_affiliation_strings":["Institute of Pathology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany. udo.bilkenroth@medizin.uni-halle.de","Institute of Pathology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany. udo.bilkenroth@medizin.uni-halle.de","institution_ids":["https://openalex.org/I68956291"]},{"raw_affiliation_string":"Institute of Pathology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016256104","display_name":"Helge W. Taubert","orcid":"https://orcid.org/0000-0002-9077-1727","observed_orcids":["https://orcid.org/0000-0002-9077-1727"]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helge Taubert","raw_affiliation_strings":["Institute of Pathology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045940276","display_name":"Dagmar Riemann","orcid":"https://orcid.org/0000-0002-7989-6262","observed_orcids":["https://orcid.org/0000-0002-7989-6262"]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dagmar Riemann","raw_affiliation_strings":["Institute of Medical Immunology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Immunology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018146967","display_name":"Udo Rebmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Udo Rebmann","raw_affiliation_strings":["Clinic of Urology, Diakonissenanstalt, Dessau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Urology, Diakonissenanstalt, Dessau, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018573703","display_name":"Hans Heynemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans Heynemann","raw_affiliation_strings":["Clinic of Urology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Urology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109102851","display_name":"Axel Meye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel Meye","raw_affiliation_strings":["Clinic of Urology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany","Institute of Pathology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Urology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany","institution_ids":["https://openalex.org/I68956291"]},{"raw_affiliation_string":"Institute of Pathology, Faculty of Medicine, University Halle-Wittenberg, Halle/Saale, Germany","institution_ids":["https://openalex.org/I68956291"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067122522"],"corresponding_institution_ids":["https://openalex.org/I68956291"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.8095,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.84432491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"92","issue":"4","first_page":"577","last_page":"582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.12839999794960022,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/disseminated-tumor-cells","display_name":"disseminated tumor cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/magnetic-activated-cell-sorting","display_name":"magnetic cell separation","score":0.902999997138977},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.859000027179718},{"id":"https://openalex.org/keywords/leukodepletion","display_name":"leukocyte depletion","score":0.847000002861023},{"id":"https://openalex.org/keywords/tumor-grading","display_name":"tumor grading","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tumor-cell-detection","display_name":"cancer cell detection","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2781053203","wikidata":"https://www.wikidata.org/wiki/Q1660182","display_name":"Immunomagnetic separation","level":2,"score":0.7159560918807983},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6594411134719849},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.5992547273635864},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.5938186049461365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5621107816696167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4879550337791443},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.4846065938472748},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.4442508816719055},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43138980865478516},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.429563969373703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29799479246139526},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.267558753490448},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2603176236152649},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24897083640098572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.194114089012146},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.15461257100105286},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.1534656584262848},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.137843519449234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008280","descriptor_name":"Magnetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.1217","doi":"https://doi.org/10.1002/ijc.1217","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.1217","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:11304694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11304694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W40946240","https://openalex.org/W45166849","https://openalex.org/W64015674","https://openalex.org/W181147267","https://openalex.org/W1517713996","https://openalex.org/W1558034062","https://openalex.org/W1834558432","https://openalex.org/W1841872817","https://openalex.org/W1974442923","https://openalex.org/W1989215251","https://openalex.org/W1998324431","https://openalex.org/W2015415136","https://openalex.org/W2016693266","https://openalex.org/W2020072428","https://openalex.org/W2022511140","https://openalex.org/W2024838908","https://openalex.org/W2033041545","https://openalex.org/W2040540105","https://openalex.org/W2065958501","https://openalex.org/W2074174486","https://openalex.org/W2075222049","https://openalex.org/W2075329621","https://openalex.org/W2080273889","https://openalex.org/W2091167042","https://openalex.org/W2092862540","https://openalex.org/W2096446731","https://openalex.org/W2101818435","https://openalex.org/W2104041484","https://openalex.org/W2126735047","https://openalex.org/W2172225180","https://openalex.org/W2402303020","https://openalex.org/W2411598209","https://openalex.org/W2414576374","https://openalex.org/W2414686049","https://openalex.org/W2414878878","https://openalex.org/W2418082780","https://openalex.org/W2437881491","https://openalex.org/W2475161369","https://openalex.org/W2481787462","https://openalex.org/W4249422966","https://openalex.org/W7100946731"],"related_works":["https://openalex.org/W2094618536","https://openalex.org/W7099608804","https://openalex.org/W2411598209","https://openalex.org/W2332420851","https://openalex.org/W2374022424","https://openalex.org/W2353842867","https://openalex.org/W2083600983","https://openalex.org/W2110425935","https://openalex.org/W1972187428","https://openalex.org/W1991933103"],"abstract_inverted_index":{"We":[0],"have":[1],"established":[2],"an":[3,52,141,155],"immunomagnetic":[4],"separation":[5],"procedure":[6],"for":[7,87,121],"the":[8,15,20,111,122],"detection":[9],"of":[10,42,56,58,82,97,113,144],"circulating":[11],"tumor":[12,46,59,88,107,132,149,161],"cells":[13,34,47,60,89,108,117,162],"in":[14,28,79,110,163],"peripheral":[16,38,67,98,164],"blood":[17,50,68,99],"based":[18],"on":[19,90],"magnetic":[21],"cell":[22,133],"sorting":[23],"(MACS)":[24],"technique.":[25],"In":[26,40,63],"previous":[27],"vitro":[29],"experiments,":[30],"renal-cell":[31],"carcinoma":[32,73],"(RCC)":[33],"were":[35,75],"mixed":[36],"with":[37,147],"blood.":[39,165],"dilutions":[41],"1:200":[43],"to":[44,115,153,158],"1:107":[45],"per":[48,100],"mononuclear":[49],"cells,":[51],"average":[53],"recovery":[54],"rate":[55],"84%":[57],"was":[61],"determined.":[62],"our":[64],"study,":[65],"104":[66],"samples":[69],"from":[70],"59":[71],"renal":[72],"patients":[74,104,146],"analyzed.":[76],"MACS":[77,151],"resulted":[78],"significant":[80],"depletion":[81],"leukocytes,":[83],"permitting":[84],"a":[85,129],"search":[86],"just":[91],"1":[92,114],"slide.":[93],"Analyzing":[94],"8":[95],"ml":[96],"patient,":[101],"19/59":[102],"RCC":[103],"carried":[105],"disseminated":[106,160],"(32%)":[109],"range":[112],"38":[116],"(median":[118],"8).":[119],"Interestingly,":[120],"cytokeratin-positive":[123],"(CK+)":[124],"patient":[125],"group,":[126],"we":[127],"found":[128],"correlation":[130],"between":[131],"number":[134,143],"and":[135,140],"grading":[136],"(G2":[137],"vs.":[138],"G3)":[139],"increased":[142],"CK+":[145],"advanced":[148],"stage.":[150],"appears":[152],"be":[154],"efficient":[156],"technique":[157],"detect":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
