{"id":"https://openalex.org/W2085106911","doi":"https://doi.org/10.1021/bi026980c","title":"Domain Substructure of HPV E6 Oncoprotein: Biophysical Characterization of the E6 C-Terminal DNA-Binding Domain","display_name":"Domain Substructure of HPV E6 Oncoprotein: Biophysical Characterization of the E6 C-Terminal DNA-Binding Domain","publication_year":2003,"publication_date":"2003-04-08","ids":{"openalex":"https://openalex.org/W2085106911","doi":"https://doi.org/10.1021/bi026980c","mag":"2085106911","pmid":"https://pubmed.ncbi.nlm.nih.gov/12718532"},"language":"en","primary_location":{"id":"doi:10.1021/bi026980c","doi":"https://doi.org/10.1021/bi026980c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi026980c","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055646809","display_name":"Yves Nomin\u00e9","orcid":"https://orcid.org/0000-0002-2912-116X","observed_orcids":["https://orcid.org/0000-0002-2912-116X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Nomin\u00e9","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071670208","display_name":"S\u00e9bastian Charbonnier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastian Charbonnier","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066642384","display_name":"Tutik Ristriani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Tutik Ristriani","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013194285","display_name":"G\u00fcnter Stier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210087042","display_name":"Max Planck Institute for Medical Research","ror":"https://ror.org/000bxzc63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210087042"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Gunter Stier","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]},{"raw_affiliation_string":"Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210087042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033973847","display_name":"Murielle Masson","orcid":"https://orcid.org/0000-0002-7254-9962","observed_orcids":["https://orcid.org/0000-0002-7254-9962"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Murielle Masson","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021300113","display_name":"N\u00fckhet Cavusoglu","orcid":"https://orcid.org/0000-0001-9350-5312","observed_orcids":["https://orcid.org/0000-0001-9350-5312"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nukhet Cavusoglu","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110137088","display_name":"Alain VAN DORSSELAER","orcid":"https://orcid.org/0000-0002-8008-8377","observed_orcids":["https://orcid.org/0000-0002-8008-8377"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Van Dorsselaer","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074622303","display_name":"\u00c9tienne Weiss","orcid":"https://orcid.org/0000-0001-6622-6377","observed_orcids":["https://orcid.org/0000-0001-6622-6377"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"\u00c9tienne Weiss","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089366249","display_name":"Bruno Kieffer","orcid":"https://orcid.org/0000-0002-2033-4679","observed_orcids":["https://orcid.org/0000-0002-2033-4679"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Kieffer","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031768698","display_name":"Gilles Trav\u00e9","orcid":"https://orcid.org/0000-0002-4160-4121","observed_orcids":["https://orcid.org/0000-0002-4160-4121"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210143948","display_name":"\u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg","ror":"https://ror.org/05eyymj94","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143948"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gilles Trav\u00e9","raw_affiliation_strings":["Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunotechnologie, UMR CNRS 7100, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany, Laboratoire de RMN, UMR CNRS 7104, \u00c9cole Sup\u00e9rieure de Biotechnologie de Strasbourg, 67400 Illkirch, France, and Laboratoire de Spectrom\u00e9trie de Masse Bio-Organique, UMR CNRS 7509, Facult\u00e9 de Chimie, 67087 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086872","https://openalex.org/I4210143948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.1232,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.86845208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"42","issue":"17","first_page":"4909","last_page":"4917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-e6","display_name":"E6 oncoprotein","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.8989999890327454},{"id":"https://openalex.org/keywords/protein-domain-structure","display_name":"protein domain structure","score":0.6660000085830688},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6790000200271606},{"id":"https://openalex.org/keywords/secondary-structure","display_name":"secondary structure","score":0.8399999737739563},{"id":"https://openalex.org/keywords/monomeric-protein","display_name":"monomeric protein","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.7603636980056763},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6010836958885193},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5789262056350708},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5785256028175354},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5077880024909973},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.4962199330329895},{"id":"https://openalex.org/C57711820","wikidata":"https://www.wikidata.org/wiki/Q310425","display_name":"C-terminus","level":3,"score":0.46667802333831787},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.45173248648643494},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.4355873167514801},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4316330850124359},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3865607976913452},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3747156262397766},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3349851369857788},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2800809144973755},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22109192609786987},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1695205271244049},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11402928829193115},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1021/bi026980c","doi":"https://doi.org/10.1021/bi026980c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi026980c","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:12718532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12718532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03406433v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03406433","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry, 2003, 42 (17), pp.4909-4917. ⟨10.1021/bi026980c⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:edoc.mpg.de:567830","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/567830","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry, v.42, 4909-4917 (2003)","raw_type":"Article"},{"id":"pmh:oai:escidoc.org:escidoc:1996953","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0019-9E3F-4","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088280","host_organization_name":"Max Planck Digital Library","host_organization_lineage":["https://openalex.org/I4210088280"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:escidoc.org:escidoc:2532938","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0000-3C91-9","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088280","host_organization_name":"Max Planck Digital Library","host_organization_lineage":["https://openalex.org/I4210088280"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2532938","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0000-3C91-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W153439827","https://openalex.org/W198220135","https://openalex.org/W1529610039","https://openalex.org/W1529992354","https://openalex.org/W1763110138","https://openalex.org/W1782055207","https://openalex.org/W1968084203","https://openalex.org/W1972459558","https://openalex.org/W1984343058","https://openalex.org/W1991221143","https://openalex.org/W2004204418","https://openalex.org/W2036716199","https://openalex.org/W2056515323","https://openalex.org/W2080876082","https://openalex.org/W2092515268","https://openalex.org/W2098766103","https://openalex.org/W2108720228","https://openalex.org/W2138027990","https://openalex.org/W2140035539","https://openalex.org/W2145224950","https://openalex.org/W2160393299","https://openalex.org/W2169168530","https://openalex.org/W2169821755"],"related_works":["https://openalex.org/W2028551015","https://openalex.org/W2056515323","https://openalex.org/W1968309894","https://openalex.org/W2039430313","https://openalex.org/W2013241714","https://openalex.org/W2137790471","https://openalex.org/W2050845585","https://openalex.org/W3044950387","https://openalex.org/W1967508492","https://openalex.org/W7095843475"],"abstract_inverted_index":{"E6":[0,45,48,64,111],"is":[1,129],"a":[2,38],"viral":[3],"oncoprotein":[4],"implicated":[5],"in":[6],"cervical":[7],"cancers,":[8],"produced":[9],"by":[10],"high-risk":[11],"human":[12],"papillomaviruses":[13],"(HPVs).":[14],"Structural":[15],"data":[16],"concerning":[17],"this":[18,57],"protein":[19],"are":[20],"scarce":[21],"due":[22],"to":[23],"the":[24,33,53,101,109,127],"difficulty":[25],"of":[26,37,56,62,82,108,137],"producing":[27],"recombinant":[28],"E6.":[29,59],"Recently,":[30],"we":[31,51,124],"described":[32],"expression":[34],"and":[35,41,70,76,88,120,132,139],"purification":[36],"stable,":[39],"folded,":[40],"biologically":[42],"active":[43],"HPV16":[44],"mutant":[46],"called":[47],"6C/6S.":[49],"Here,":[50],"analyzed":[52],"domain":[54,99],"substructure":[55],"mutated":[58],"Nonspecific":[60],"proteolysis":[61],"full-length":[63,110],"6C/6S":[65],"(158":[66],"residues)":[67],"yielded":[68],"N-terminal":[69],"C-terminal":[71,80],"fragments":[72],"encompassing":[73],"residues":[74,83],"7-83":[75],"87-158,":[77],"respectively.":[78],"The":[79,97],"fragment":[81],"87-158":[84],"was":[85],"cloned,":[86],"overexpressed,":[87],"purified":[89,98],"at":[90],"concentrations":[91],"as":[92,94],"high":[93],"1":[95],"mM.":[96],"retains":[100],"selective":[102],"four-way":[103],"DNA":[104],"junction":[105],"recognition":[106],"activity":[107],"protein.":[112],"Using":[113],"UV":[114,116],"absorption,":[115],"fluorescence,":[117],"circular":[118],"dichroism,":[119],"nuclear":[121],"magnetic":[122],"resonance,":[123],"show":[125],"that":[126],"peptide":[128],"primarily":[130],"monomeric":[131],"folded":[133],"with":[134],"equal":[135],"proportions":[136],"alpha-helix":[138],"beta-sheet":[140],"secondary":[141],"structure.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}