{"id":"https://openalex.org/W2085105486","doi":"https://doi.org/10.2174/157339907779802094","title":"Role of Endogenous Androgen Against Insulin Resistance and Athero-sclerosis in Men with Type 2 Diabetes","display_name":"Role of Endogenous Androgen Against Insulin Resistance and Athero-sclerosis in Men with Type 2 Diabetes","publication_year":2007,"publication_date":"2007-02-01","ids":{"openalex":"https://openalex.org/W2085105486","doi":"https://doi.org/10.2174/157339907779802094","mag":"2085105486","pmid":"https://pubmed.ncbi.nlm.nih.gov/18220653"},"language":"en","primary_location":{"id":"doi:10.2174/157339907779802094","doi":"https://doi.org/10.2174/157339907779802094","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157339907779802094","pdf_url":null,"source":{"id":"https://openalex.org/S204739293","display_name":"Current Diabetes Reviews","issn_l":"1573-3998","issn":["1573-3998","1875-6417"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Diabetes Reviews","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090866721","display_name":"Michiaki Fukui","orcid":"https://orcid.org/0000-0003-0903-1797","observed_orcids":["https://orcid.org/0000-0003-0903-1797"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiaki Fukui","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. sayarinapm@hotmail.com","Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. sayarinapm@hotmail.com","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022519339","display_name":"Yoshihiro Kitagawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiro Kitagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066117605","display_name":"Hiroyuki Ose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Ose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032780268","display_name":"Goji Hasegawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Goji Hasegawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108522725","display_name":"Toshikazu Yoshikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshikazu Yoshikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101796079","display_name":"Naoto Nakamura","orcid":"https://orcid.org/0000-0002-9029-3462","observed_orcids":["https://orcid.org/0000-0002-9029-3462"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Nakamura","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji,Kamigyo-ku, Kyoto 602-8566, Japan.,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji,Kamigyo-ku, Kyoto 602-8566, Japan.,Japan","institution_ids":["https://openalex.org/I40677808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6539,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.8950495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"3","issue":"1","first_page":"25","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endogenous-androgens","display_name":"endogenous androgens","score":0.9819999933242798},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.7829999923706055},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.781000018119812},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/testosterone-deficiency","display_name":"androgen deficiency","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hypogonadism","display_name":"hypogonadism","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dehydroepiandrosterone-sulfate","display_name":"dehydroepiandrosterone sulfate","score":0.9240000247955322},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.7379999756813049},{"id":"https://openalex.org/keywords/castration","display_name":"castration","score":0.8159999847412109},{"id":"https://openalex.org/keywords/testosterone-supplementation","display_name":"testosterone supplementation","score":0.921999990940094},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7419999837875366},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.6389999985694885},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8418694734573364},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8094576597213745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8076367378234863},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7807302474975586},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6743494272232056},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6293618083000183},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5705624222755432},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5079744458198547},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.19222566485404968}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019314","descriptor_name":"Dehydroepiandrosterone Sulfate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019314","descriptor_name":"Dehydroepiandrosterone Sulfate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2174/157339907779802094","doi":"https://doi.org/10.2174/157339907779802094","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157339907779802094","pdf_url":null,"source":{"id":"https://openalex.org/S204739293","display_name":"Current Diabetes Reviews","issn_l":"1573-3998","issn":["1573-3998","1875-6417"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Diabetes Reviews","raw_type":"journal-article"},{"id":"pmid:18220653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18220653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current diabetes reviews","raw_type":"Evaluation Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.313.3830","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.313.3830","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.benthamscience.com/cdr/samples/cdr3-1/D0004D.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1554762746","https://openalex.org/W1579561821","https://openalex.org/W1585897597","https://openalex.org/W1930338481","https://openalex.org/W1965551000","https://openalex.org/W1969632703","https://openalex.org/W1975334977","https://openalex.org/W1983659537","https://openalex.org/W1984770458","https://openalex.org/W1998106197","https://openalex.org/W1999997178","https://openalex.org/W2015512055","https://openalex.org/W2016392921","https://openalex.org/W2017020170","https://openalex.org/W2019233350","https://openalex.org/W2027923074","https://openalex.org/W2033327841","https://openalex.org/W2035676300","https://openalex.org/W2035853598","https://openalex.org/W2038898844","https://openalex.org/W2039884430","https://openalex.org/W2043234947","https://openalex.org/W2044526379","https://openalex.org/W2045402270","https://openalex.org/W2045724757","https://openalex.org/W2050834111","https://openalex.org/W2050953803","https://openalex.org/W2051508338","https://openalex.org/W2052234617","https://openalex.org/W2053566663","https://openalex.org/W2054755175","https://openalex.org/W2056996743","https://openalex.org/W2058414979","https://openalex.org/W2062764979","https://openalex.org/W2067587030","https://openalex.org/W2072655745","https://openalex.org/W2074640427","https://openalex.org/W2075047759","https://openalex.org/W2082448317","https://openalex.org/W2085368059","https://openalex.org/W2086247313","https://openalex.org/W2087471461","https://openalex.org/W2089396531","https://openalex.org/W2089583049","https://openalex.org/W2091187697","https://openalex.org/W2093994334","https://openalex.org/W2094263259","https://openalex.org/W2094493191","https://openalex.org/W2103884661","https://openalex.org/W2104778698","https://openalex.org/W2106834461","https://openalex.org/W2107034706","https://openalex.org/W2107732097","https://openalex.org/W2110825938","https://openalex.org/W2113576333","https://openalex.org/W2118047070","https://openalex.org/W2118723360","https://openalex.org/W2118778938","https://openalex.org/W2122493686","https://openalex.org/W2123651897","https://openalex.org/W2126739686","https://openalex.org/W2127274100","https://openalex.org/W2130501906","https://openalex.org/W2133251189","https://openalex.org/W2133506496","https://openalex.org/W2134451964","https://openalex.org/W2139598955","https://openalex.org/W2148162359","https://openalex.org/W2148746144","https://openalex.org/W2154888535","https://openalex.org/W2156645392","https://openalex.org/W2157613085","https://openalex.org/W2159631329","https://openalex.org/W2162632293","https://openalex.org/W2163199704","https://openalex.org/W2163371302","https://openalex.org/W2165035590","https://openalex.org/W2165678874","https://openalex.org/W2165913105","https://openalex.org/W2168352496","https://openalex.org/W2214528734","https://openalex.org/W2319047836","https://openalex.org/W2321613759","https://openalex.org/W2333783346","https://openalex.org/W3143276943","https://openalex.org/W4231706664","https://openalex.org/W4249227027"],"related_works":["https://openalex.org/W7096151433","https://openalex.org/W2137783284","https://openalex.org/W2070295872","https://openalex.org/W2275719766","https://openalex.org/W2050263294","https://openalex.org/W2146316448","https://openalex.org/W2379263998","https://openalex.org/W2076650872","https://openalex.org/W4322713632","https://openalex.org/W2052683314"],"abstract_inverted_index":{"Age-related":[0],"decline":[1],"in":[2,10,65,97,112],"serum":[3,72,143],"testosterone":[4,95,157],"and":[5,39,63,108,130,145,164],"dehydroepiandrosterone":[6],"sulfate":[7],"concentrations":[8,13,73],"occur":[9],"men.":[11,54],"Low":[12,71],"of":[14,74,117,128],"these":[15],"endogenous":[16,75],"androgens":[17,76],"have":[18,47,154],"been":[19],"linked":[20],"with":[21,45,67,79,102,126,150],"insulin":[22,61,92,141,162],"resistance,":[23,93,142],"which":[24],"is":[25],"an":[26],"important":[27],"upstream":[28],"driver":[29],"for":[30],"metabolic":[31],"abnormalities":[32],"such":[33],"as":[34],"hyperglycemia,":[35],"hypertension,":[36],"or":[37],"hyperlipidemia,":[38],"increased":[40],"cardiovascular":[41],"risk.":[42],"Moreover,":[43],"men":[44,66,101,149],"diabetes":[46,153],"significantly":[48],"less":[49],"circulating":[50],"androgen":[51,59,103,118],"than":[52],"nondiabetic":[53],"Here,":[55],"we":[56],"summarize":[57],"how":[58],"affects":[60],"resistance":[62,163],"atherosclerosis":[64,129],"type":[68,98,151],"2":[69,99,152],"diabetes.":[70],"are":[77],"associated":[78],"visceral":[80,110],"fat":[81],"accumulation.":[82],"Androgen":[83,123],"deprivation":[84],"by":[85],"castration":[86],"to":[87,114],"treat":[88],"prostate":[89],"cancer":[90],"increases":[91],"while":[94],"administration":[96],"diabetic":[100],"deficiency":[104,119],"improves":[105],"glucose":[106],"homeostasis":[107],"decreases":[109],"fat,":[111],"addition":[113],"alleviating":[115],"symptoms":[116],"including":[120],"erectile":[121],"dysfunction.":[122],"correlates":[124],"inversely":[125],"severity":[127],"has":[131],"beneficial":[132],"effects":[133],"upon":[134],"vascular":[135],"reactivity,":[136],"inflammatory":[137],"cytokine,":[138],"adhesion":[139],"molecules,":[140],"lipids,":[144],"hemostatic":[146],"factors.":[147],"Because":[148],"relative":[155],"hypogonadism,":[156],"supplementation":[158],"could":[159],"decrease":[160],"both":[161],"atherosclerosis.":[165]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}