{"id":"https://openalex.org/W2085023948","doi":"https://doi.org/10.1097/fpc.0b013e32833428d0","title":"Development of a Pharmacogenetic Predictive Test in asthma: proof of concept","display_name":"Development of a Pharmacogenetic Predictive Test in asthma: proof of concept","publication_year":2010,"publication_date":"2010-01-20","ids":{"openalex":"https://openalex.org/W2085023948","doi":"https://doi.org/10.1097/fpc.0b013e32833428d0","mag":"2085023948","pmid":"https://pubmed.ncbi.nlm.nih.gov/20032818"},"language":"en","primary_location":{"id":"doi:10.1097/fpc.0b013e32833428d0","doi":"https://doi.org/10.1097/fpc.0b013e32833428d0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fpc.0b013e32833428d0","pdf_url":null,"source":{"id":"https://openalex.org/S192301155","display_name":"Pharmacogenetics and Genomics","issn_l":"1744-6872","issn":["1744-6872","1744-6880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654515","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064006702","display_name":"Ann Chen Wu","orcid":"https://orcid.org/0000-0003-0599-9063","observed_orcids":["https://orcid.org/0000-0003-0599-9063"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ann Chen Wu","raw_affiliation_strings":["Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215-5301, USA. ann.wu@childrens.harvard.edu","Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215-5301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215-5301, USA. ann.wu@childrens.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]},{"raw_affiliation_string":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215-5301, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021188210","display_name":"Blanca E. Himes","orcid":"https://orcid.org/0000-0002-2868-1333","observed_orcids":["https://orcid.org/0000-0002-2868-1333"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210092658","display_name":"Harvard\u2013MIT Division of Health Sciences and Technology","ror":"https://ror.org/00jjeh629","country_code":"US","type":"education","lineage":["https://openalex.org/I4210092658"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blanca E. Himes","raw_affiliation_strings":["Channing Laboratory, Brigham and Women's Hospital","Children's Hospital Informatics Program","Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Laboratory, Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Children's Hospital Informatics Program","institution_ids":[]},{"raw_affiliation_string":"Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4210092658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008569720","display_name":"Jessica Ann Lasky-Su","orcid":"https://orcid.org/0000-0001-6236-4705","observed_orcids":["https://orcid.org/0000-0001-6236-4705"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Lasky-Su","raw_affiliation_strings":["Channing Laboratory, Brigham and Women's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Laboratory, Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086120301","display_name":"Augusto A. Litonjua","orcid":"https://orcid.org/0000-0003-0422-5875","observed_orcids":["https://orcid.org/0000-0003-0422-5875"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Augusto Litonjua","raw_affiliation_strings":["Center for Genomic Medicine, Department of Medicine, Brigham and Women's Hospital","Channing Laboratory, Brigham and Women's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Department of Medicine, Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Channing Laboratory, Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443359","display_name":"Lingling Li","orcid":"https://orcid.org/0000-0003-3742-8548","observed_orcids":["https://orcid.org/0000-0003-3742-8548"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lingling Li","raw_affiliation_strings":["Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002736890","display_name":"Christoph Lange","orcid":"https://orcid.org/0000-0003-2620-1030","observed_orcids":["https://orcid.org/0000-0003-2620-1030"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph Lange","raw_affiliation_strings":["Harvard School of Public Health, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public Health, Boston","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108423726","display_name":"John J. Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086066","display_name":"Nemours Children\u2019s Clinic","ror":"https://ror.org/00f76x039","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086066","https://openalex.org/I4210108049"]},{"id":"https://openalex.org/I4210158181","display_name":"Nemours Children's Clinic","ror":"https://ror.org/050hscv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210108049","https://openalex.org/I4210158181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Lima","raw_affiliation_strings":["Nemours Children's Clinic, Centers for Clinical Pediatric Pharmacology & Pharmacogenetics, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nemours Children's Clinic, Centers for Clinical Pediatric Pharmacology & Pharmacogenetics, Jacksonville, Florida","institution_ids":["https://openalex.org/I4210086066","https://openalex.org/I4210158181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070636215","display_name":"Charles G. Irvin","orcid":"https://orcid.org/0000-0002-5721-2720","observed_orcids":["https://orcid.org/0000-0002-5721-2720"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles G. Irvin","raw_affiliation_strings":["Vermont Lung Center, University of Vermont, College of Medicine, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vermont Lung Center, University of Vermont, College of Medicine, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073763243","display_name":"Scott T. Weiss","orcid":"https://orcid.org/0000-0001-7196-303X","observed_orcids":["https://orcid.org/0000-0001-7196-303X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott T. Weiss","raw_affiliation_strings":["Center for Genomic Medicine, Department of Medicine, Brigham and Women's Hospital","Channing Laboratory, Brigham and Women's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Department of Medicine, Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Channing Laboratory, Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5064006702"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"],"apc_list":null,"apc_paid":null,"fwci":0.95,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.75796525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"2","first_page":"86","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bronchodilator-response","display_name":"bronchodilator response","score":0.843999981880188},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9070000052452087},{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.7950000166893005},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.796999990940094},{"id":"https://openalex.org/keywords/family-based-association","display_name":"family-based association","score":0.6729999780654907},{"id":"https://openalex.org/keywords/childhood-asthma-management-program","display_name":"Childhood Asthma Management Program","score":0.9309999942779541},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.7304708957672119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6801433563232422},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5361101031303406},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5310949087142944},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5146868824958801},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4734365940093994},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.4112406373023987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39778512716293335},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.18707683682441711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15969157218933105},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11842650175094604},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/fpc.0b013e32833428d0","doi":"https://doi.org/10.1097/fpc.0b013e32833428d0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fpc.0b013e32833428d0","pdf_url":null,"source":{"id":"https://openalex.org/S192301155","display_name":"Pharmacogenetics and Genomics","issn_l":"1744-6872","issn":["1744-6872","1744-6880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Genomics","raw_type":"journal-article"},{"id":"pmid:20032818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20032818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and genomics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2652681","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654515","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3654515","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654515","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacogenet Genomics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3654515","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654515","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacogenet Genomics","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/1","display_name":"No poverty","score":0.7799999713897705}],"study_designs":[],"awards":[{"id":"https://openalex.org/G162555452","display_name":null,"funder_award_id":"T32 HL07427","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1676747839","display_name":"LEUKOTRIENE POLYMORPHISMS &MONTELUKAST RESPONSE","funder_award_id":"R01HL071394","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1927670946","display_name":"Pharmacogenetics of Asthma Treatment","funder_award_id":"5u01hl065899-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2132094421","display_name":null,"funder_award_id":"HL071394","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2509796369","display_name":null,"funder_award_id":"T32HL007427","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2772107177","display_name":null,"funder_award_id":"U01HL075419","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G291751459","display_name":null,"funder_award_id":"U01-HL065899","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4037237974","display_name":null,"funder_award_id":"R01HL074755","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G409283166","display_name":"Effectiveness of Pharmacogenetic Testing in Asthma","funder_award_id":"K08HL088046","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6416256245","display_name":"Translational Genetics and Genomics of Airways Diseases","funder_award_id":"K12HL089990","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7725497064","display_name":"Genetics and Gene Expression Profiling in Asthma","funder_award_id":"R01HL086601","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7824598287","display_name":"Common Genetic Determinants of Asthma and COPD-PROGRAM PROJECT","funder_award_id":"P01HL083069","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G821063702","display_name":null,"funder_award_id":"U01 HL65899","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G914722656","display_name":null,"funder_award_id":"HL074755","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320307154","display_name":"American Lung Association","ror":"https://ror.org/01p3rh655"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W19162607","https://openalex.org/W1971316893","https://openalex.org/W1971717194","https://openalex.org/W1975728475","https://openalex.org/W2009399774","https://openalex.org/W2015371796","https://openalex.org/W2015559766","https://openalex.org/W2019464839","https://openalex.org/W2019501962","https://openalex.org/W2022995367","https://openalex.org/W2029426756","https://openalex.org/W2030676726","https://openalex.org/W2037668591","https://openalex.org/W2042280647","https://openalex.org/W2043990114","https://openalex.org/W2057012029","https://openalex.org/W2065339174","https://openalex.org/W2068861734","https://openalex.org/W2080713361","https://openalex.org/W2087574085","https://openalex.org/W2094728439","https://openalex.org/W2098629594","https://openalex.org/W2104488513","https://openalex.org/W2104732389","https://openalex.org/W2108171492","https://openalex.org/W2119310256","https://openalex.org/W2127230663","https://openalex.org/W2141750609","https://openalex.org/W2151774137","https://openalex.org/W2152785448","https://openalex.org/W2157226274","https://openalex.org/W2168909179","https://openalex.org/W2328176404","https://openalex.org/W2471343115","https://openalex.org/W2587236239","https://openalex.org/W2594805288"],"related_works":["https://openalex.org/W1492804085","https://openalex.org/W4319602444","https://openalex.org/W2111535578","https://openalex.org/W2060187873","https://openalex.org/W2017531614","https://openalex.org/W2159383925","https://openalex.org/W4210925395","https://openalex.org/W1980009000","https://openalex.org/W2129618373","https://openalex.org/W1525772098"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1,163],"assess":[2,164],"the":[3,35,39,44,75,111,114,146,150,165,169,171,175,191,202,232,249,254,262,271,283],"feasibility":[4],"of":[5,15,38,85,113,123,134,156,168,204,216,229,282],"developing":[6],"a":[7,55,100,205,292],"Combined":[8,101,209,255],"Clinical":[9,80,102,192,210,256,272],"and":[10,41,50,99,103,117,152,211,238,243,257,261,278],"Pharmacogenetic":[11,76,104,212,258,263],"Predictive":[12,77,81,105,193,213,259,264,273],"Test,":[13],"comprised":[14,74,84,215],"multiple":[16,306],"single":[17],"nucleotide":[18],"polymorphisms":[19,218,290,308],"(SNPs)":[20],"that":[21,33,59,69,288,300],"is":[22,302],"associated":[23,71,296],"with":[24,72,226,291,297],"poor":[25,129,224],"bronchodilator":[26],"response":[27],"(BDR).":[28],"METHODS:":[29],"We":[30,94],"genotyped":[31],"SNPs":[32,61,68],"tagged":[34],"whole":[36],"genome":[37],"parents":[40],"children":[42,112,234],"in":[43,90,107,139,219,231,248,280,304],"Childhood":[45],"Asthma":[46],"Management":[47],"Program":[48],"(CAMP)":[49],"implemented":[51],"an":[52,227],"algorithm":[53],"using":[54,305],"family-based":[56],"association":[57],"test":[58],"ranked":[60],"by":[62],"statistical":[63],"power.":[64],"The":[65,79,187],"top":[66],"eight":[67],"were":[70,181,196,266],"BDR":[73,133,142,225,298],"Test.":[78],"Test":[82,106,194,214,260,265,274],"was":[83,128,143],"baseline":[86],"forced":[87],"expiratory":[88],"volume":[89],"1":[91],"s":[92],"(FEV1).":[93],"evaluated":[95],"these":[96],"predictive":[97,166],"tests":[98],"three":[108],"distinct":[109],"populations:":[110],"CAMP":[115,233],"trial":[116,121],"two":[118,250],"additional":[119],"clinical":[120,293],"populations":[122],"asthma.":[124],"Our":[125,208,286],"outcome":[126],"measure":[127],"BDR,":[130],"defined":[131],"as":[132,145],"less":[135],"than":[136,270],"20th":[137],"percentile":[138],"each":[140,184,281],"population.":[141,185],"calculated":[144,182],"percent":[147],"difference":[148],"between":[149,276],"prebronchodilator":[151],"postbronchodilator":[153],"(two":[154],"puffs":[155],"albuterol":[157],"at":[158],"180":[159],"microg/puff)":[160],"FEV1":[161,222],"value.":[162],"ability":[167],"test,":[170],"corresponding":[172],"area":[173],"under":[174],"receiver":[176],"operating":[177],"characteristic":[178],"curves":[179],"(AUROCs)":[180],"for":[183,190],"RESULTS:":[186],"AUROC":[188,203,228],"values":[189],"alone":[195],"not":[197],"significantly":[198,267],"different":[199],"from":[200],"0.50,":[201],"random":[206],"classifier.":[207],"genetic":[217,289,307],"addition":[220],"to":[221,310,316,319],"predicted":[223],"0.65":[230],"(n":[235,240,245],"=":[236,241,246],"422)":[237],"0.60":[239],"475)":[242],"0.63":[244],"235)":[247],"independent":[251],"populations.":[252,284],"Both":[253],"more":[268],"accurate":[269],"(AUROC":[275],"0.44":[277],"0.55)":[279],"CONCLUSION:":[285],"finding":[287],"trait":[294],"are":[295,314],"suggests":[299],"there":[301],"promise":[303],"simultaneously":[309],"predict":[311],"which":[312],"asthmatics":[313],"likely":[315],"respond":[317],"poorly":[318],"bronchodilators.":[320]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
