{"id":"https://openalex.org/W2084969487","doi":"https://doi.org/10.1021/tx030039s","title":"Detection of Nitrated Benzene Metabolites in Bone Marrow of B6C3F1 Mice Treated with Benzene","display_name":"Detection of Nitrated Benzene Metabolites in Bone Marrow of B6C3F1 Mice Treated with Benzene","publication_year":2004,"publication_date":"2004-01-30","ids":{"openalex":"https://openalex.org/W2084969487","doi":"https://doi.org/10.1021/tx030039s","mag":"2084969487","pmid":"https://pubmed.ncbi.nlm.nih.gov/15025507"},"language":"en","primary_location":{"id":"doi:10.1021/tx030039s","doi":"https://doi.org/10.1021/tx030039s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx030039s","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029558674","display_name":"K.-M. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.-M. Chen","raw_affiliation_strings":["Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080527856","display_name":"Karam El\u2010Bayoumy","orcid":"https://orcid.org/0000-0002-4198-0696","observed_orcids":["https://orcid.org/0000-0002-4198-0696"]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. El-Bayoumy","raw_affiliation_strings":["Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Cunningham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Cunningham","raw_affiliation_strings":["Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018954418","display_name":"Cesar A. Aliaga","orcid":"https://orcid.org/0009-0003-0370-9875","observed_orcids":["https://orcid.org/0009-0003-0370-9875"]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Aliaga","raw_affiliation_strings":["Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081254150","display_name":"Haofeng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Li","raw_affiliation_strings":["Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071395886","display_name":"Assieh A. Melikian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. A. Melikian","raw_affiliation_strings":["Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, New York, 10595","institution_ids":["https://openalex.org/I4210167017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210167017"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2662,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.56260598,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":"3","first_page":"370","last_page":"377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzene","display_name":"benzene","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nitrobenzene","display_name":"nitrobenzene","score":0.7609999775886536},{"id":"https://openalex.org/keywords/nitrophenol-isomers","display_name":"nitrophenol isomers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6669999957084656},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.9200000166893005},{"id":"https://openalex.org/keywords/benzene-metabolites","display_name":"benzene metabolites","score":0.7639999985694885},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9860000014305115},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/fenton-reaction","display_name":"Fenton reaction","score":0.8460000157356262},{"id":"https://openalex.org/keywords/b6c3f1-mice","display_name":"B6C3F1 mice","score":0.7559999823570251},{"id":"https://openalex.org/keywords/redox-cycling","display_name":"redox cycling","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2777691172","wikidata":"https://www.wikidata.org/wiki/Q2270","display_name":"Benzene","level":2,"score":0.8546026945114136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8388001918792725},{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.7469908595085144},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.582797646522522},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5536313652992249},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5274945497512817},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5258222818374634},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.4308352470397949},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.4227529466152191},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.40611377358436584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3721911907196045},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3317492604255676},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.27103888988494873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1804429292678833},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17473691701889038},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001554","descriptor_name":"Benzene","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001554","descriptor_name":"Benzene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009566","descriptor_name":"Nitrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015538","descriptor_name":"Nitrosation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030421","descriptor_name":"Peroxynitrous Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/tx030039s","doi":"https://doi.org/10.1021/tx030039s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx030039s","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},{"id":"pmid:15025507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15025507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical research in toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7097651146","display_name":"CANCER CENTER SUPPORT GRANT","funder_award_id":"P30CA017613","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7516135604","display_name":"Tobacco Carcinogenesis and Chemoprevention","funder_award_id":"P01CA070972","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1539674192","https://openalex.org/W1991233596","https://openalex.org/W2005127542","https://openalex.org/W2020032922","https://openalex.org/W2052350481","https://openalex.org/W2084615137","https://openalex.org/W2106532850","https://openalex.org/W2113482820","https://openalex.org/W2155936162","https://openalex.org/W2400663273"],"related_works":["https://openalex.org/W2106532850","https://openalex.org/W1997156925","https://openalex.org/W2006782025","https://openalex.org/W2048480497","https://openalex.org/W7101182598","https://openalex.org/W2056497212","https://openalex.org/W2415288917","https://openalex.org/W2376128825","https://openalex.org/W2124261966","https://openalex.org/W2022381623"],"abstract_inverted_index":{"Benzene,":[0],"a":[1,7,147,287],"constituent":[2],"of":[3,17,29,49,82,89,102,112,121,137,143,151,163,197,206,227,233,250,259],"cigarette":[4],"smoke,":[5],"is":[6,20,44,286],"human":[8],"leukemogen":[9],"and":[10,169,195,241,292],"induces":[11],"bone":[12,34,87,191,248,277,303],"marrow":[13,35,88,249,304],"toxicity.":[14,305],"The":[15,119,179],"mechanism":[16],"benzene-induced":[18],"toxicity":[19],"not":[21,267],"well-established.":[22],"We":[23],"hypothesized":[24],"that":[25,43,274,283,297],"relatively":[26],"high":[27],"levels":[28],"nitric":[30,284],"oxide":[31,285],"formed":[32,85,99,133,275],"in":[33,86,104,107,115,134,166,246,262,276,299],"can":[36,63,131,293],"react":[37],"with":[38,92,200,216],"oxygen":[39],"and/or":[40],"superoxide":[41],"anion":[42],"generated":[45],"during":[46,100],"redox":[47],"cycling":[48],"ring-hydroxylated":[50],"benzene":[51,83,103,165,256,290],"metabolites":[52,189,221],"to":[53,126,231,289],"yield":[54],"peroxynitrite":[55],"as":[56,58],"well":[57],"other":[59,263],"NO-derived":[60],"intermediates.":[61],"Peroxynitrite":[62],"either":[64,266],"directly":[65],"damage":[66],"cellular":[67],"macromolecules":[68],"or":[69,110,159,175,269],"form":[70,294],"nitrated":[71,295],"toxic":[72],"metabolites.":[73],"Toward":[74],"this":[75],"end,":[76],"we":[77,95],"investigated":[78],"whether":[79,128],"nitro":[80,260],"derivatives":[81,261,296],"are":[84],"mice":[90,171,198,252],"treated":[91,199],"benzene.":[93],"First,":[94],"have":[96],"characterized":[97,224],"products":[98,130],"activation":[101],"Fenton's":[105],"system":[106],"the":[108,170,247,251],"absence":[109],"presence":[111],"NO-releasing":[113],"compound":[114],"vitro":[116],"by":[117,204,225],"GC/MS.":[118],"result":[120],"above":[122],"experiment":[123],"prompted":[124],"us":[125],"determine":[127],"similar":[129],"be":[132],"vivo.":[135],"Groups":[136],"B6C3F1":[138],"male":[139],"mice,":[140],"eight":[141],"weeks":[142],"age,":[144],"were":[145,172,202,222,244],"given":[146],"single":[148],"intraperitoneal":[149],"dose":[150,162],"[14C]benzene":[152,201],"(400":[153],"mg/kg":[154],"body":[155],"wt,":[156],"9.7":[157],"mCi/mmol)":[158],"an":[160],"equal":[161],"unlabeled":[164],"corn":[167],"oil,":[168],"killed":[173],"0.5":[174],"1":[176,253],"h":[177,254],"posttreatment.":[178],"control":[180],"group":[181],"received":[182],"only":[183],"vehicle":[184],"injections.":[185],"Organic":[186],"solvent":[187],"extractable":[188],"from":[190],"marrow,":[192],"liver,":[193],"lungs,":[194],"blood":[196],"identified":[203],"comparison":[205,226],"their":[207,228],"respective":[208],"retention":[209],"times":[210],"under":[211],"two":[212],"different":[213],"HPLC":[214],"conditions":[215],"authentic":[217],"standard":[218],"samples.":[219],"These":[220],"further":[223],"GC/MS":[229],"properties":[230],"those":[232],"reference":[234],"standards.":[235],"Nitro":[236],"metabolites,":[237],"namely,":[238],"nitrobenzene,":[239],"nitrobiphenyl,":[240],"nitrophenol":[242],"isomers,":[243],"detected":[245],"after":[255],"treatment.":[257],"Formation":[258],"tissues":[264],"was":[265,270],"observed":[268],"significantly":[271],"less":[272],"than":[273],"marrow.":[278],"This":[279],"study":[280],"clearly":[281],"demonstrates":[282],"contributor":[288],"metabolism":[291],"may,":[298],"part,":[300],"account":[301],"for":[302]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}