{"id":"https://openalex.org/W2084929520","doi":"https://doi.org/10.1016/0304-3835(83)90160-x","title":"Interferon potentiates cytotoxic effects of 5-fluorouracil on cell proliferation of established human cell lines originating from neoplastic tissues","display_name":"Interferon potentiates cytotoxic effects of 5-fluorouracil on cell proliferation of established human cell lines originating from neoplastic tissues","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2084929520","doi":"https://doi.org/10.1016/0304-3835(83)90160-x","mag":"2084929520","pmid":"https://pubmed.ncbi.nlm.nih.gov/6187435"},"language":"en","primary_location":{"id":"doi:10.1016/0304-3835(83)90160-x","doi":"https://doi.org/10.1016/0304-3835(83)90160-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3835(83)90160-x","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074665742","display_name":"Toshihiro Miyoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Miyoshi","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki 701-01 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki 701-01 Japan","institution_ids":["https://openalex.org/I189996419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090145685","display_name":"Shigeo Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeo Ogawa","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki 701-01 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kawasaki Medical School, Kurashiki 701-01 Japan","institution_ids":["https://openalex.org/I189996419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111794545","display_name":"Toshinori Kanamori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165085132","display_name":"Mochida Pharmaceutical (Japan)","ror":"https://ror.org/045p8e908","country_code":"JP","type":"company","lineage":["https://openalex.org/I165085132"]},{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshinori Kanamori","raw_affiliation_strings":["Department of Pathology, Kawasaki Medical School, Kurashiki 701-01 Japan","Mochida Pharmaceutical Co., Ltd., 1-1-1, Kamiya Tokyo 115 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kawasaki Medical School, Kurashiki 701-01 Japan","institution_ids":["https://openalex.org/I189996419"]},{"raw_affiliation_string":"Mochida Pharmaceutical Co., Ltd., 1-1-1, Kamiya Tokyo 115 Japan","institution_ids":["https://openalex.org/I165085132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074546199","display_name":"Masahiro Nobuhara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165085132","display_name":"Mochida Pharmaceutical (Japan)","ror":"https://ror.org/045p8e908","country_code":"JP","type":"company","lineage":["https://openalex.org/I165085132"]},{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Nobuhara","raw_affiliation_strings":["Department of Pathology, Kawasaki Medical School, Kurashiki 701-01 Japan","Mochida Pharmaceutical Co., Ltd., 1-1-1, Kamiya Tokyo 115 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kawasaki Medical School, Kurashiki 701-01 Japan","institution_ids":["https://openalex.org/I189996419"]},{"raw_affiliation_string":"Mochida Pharmaceutical Co., Ltd., 1-1-1, Kamiya Tokyo 115 Japan","institution_ids":["https://openalex.org/I165085132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109173342","display_name":"Masayoshi Namba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165085132","display_name":"Mochida Pharmaceutical (Japan)","ror":"https://ror.org/045p8e908","country_code":"JP","type":"company","lineage":["https://openalex.org/I165085132"]},{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayoshi Namba","raw_affiliation_strings":["Department of Pathology, Kawasaki Medical School, Kurashiki 701-01, Japan","Mochida Pharmaceutical Co., Ltd., 1-1-1, Kamiya Tokyo 115 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kawasaki Medical School, Kurashiki 701-01, Japan","institution_ids":["https://openalex.org/I189996419"]},{"raw_affiliation_string":"Mochida Pharmaceutical Co., Ltd., 1-1-1, Kamiya Tokyo 115 Japan","institution_ids":["https://openalex.org/I165085132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":null,"fwci":1.3771,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.81700157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"3","first_page":"239","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.9980000257492065},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":1.0},{"id":"https://openalex.org/keywords/drug-potentiation","display_name":"drug potentiation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/synergistic-cytotoxicity","display_name":"synergistic cytotoxicity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5260000228881836},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7369999885559082},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5289999842643738},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.8542256355285645},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.7763874530792236},{"id":"https://openalex.org/C16232356","wikidata":"https://www.wikidata.org/wiki/Q4215980","display_name":"Raji cell","level":3,"score":0.7557474374771118},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6063516139984131},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.594247043132782},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5490036010742188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47550779581069946},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4107885956764221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3777998089790344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3658550977706909},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30782538652420044},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24762409925460815},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13164764642715454},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/0304-3835(83)90160-x","doi":"https://doi.org/10.1016/0304-3835(83)90160-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0304-3835(83)90160-x","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:6187435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6187435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"},{"id":"mag:2239984566","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000069875?l=ja","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W5609089","https://openalex.org/W560642211","https://openalex.org/W1479960751","https://openalex.org/W1515227788","https://openalex.org/W1589608483","https://openalex.org/W1792686355","https://openalex.org/W1878265365","https://openalex.org/W1937824671","https://openalex.org/W1968912301","https://openalex.org/W1980253503","https://openalex.org/W1980476120","https://openalex.org/W1988899691","https://openalex.org/W1993585891","https://openalex.org/W2002673703","https://openalex.org/W2018162474","https://openalex.org/W2047330128","https://openalex.org/W2058301818","https://openalex.org/W2093657716","https://openalex.org/W2103885797","https://openalex.org/W2120553565","https://openalex.org/W2133705580","https://openalex.org/W2139040913","https://openalex.org/W2149581643","https://openalex.org/W2249028562","https://openalex.org/W2339778209","https://openalex.org/W2411281014","https://openalex.org/W3204395199","https://openalex.org/W3216705818","https://openalex.org/W6615611972","https://openalex.org/W6628710005","https://openalex.org/W6630757819","https://openalex.org/W6638208253","https://openalex.org/W6673591682","https://openalex.org/W6703781524"],"related_works":["https://openalex.org/W2415299230","https://openalex.org/W1640401641","https://openalex.org/W1967658581","https://openalex.org/W15914712","https://openalex.org/W1992689278","https://openalex.org/W2413167169","https://openalex.org/W1997695098","https://openalex.org/W1988828691","https://openalex.org/W1625444068","https://openalex.org/W2405398459"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}