{"id":"https://openalex.org/W2084863754","doi":"https://doi.org/10.1016/0165-6147(89)90206-x","title":"The signal transduction system of the leukotriene D4 receptor","display_name":"The signal transduction system of the leukotriene D4 receptor","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W2084863754","doi":"https://doi.org/10.1016/0165-6147(89)90206-x","mag":"2084863754","pmid":"https://pubmed.ncbi.nlm.nih.gov/2556821"},"language":"en","primary_location":{"id":"doi:10.1016/0165-6147(89)90206-x","doi":"https://doi.org/10.1016/0165-6147(89)90206-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-6147(89)90206-x","pdf_url":null,"source":{"id":"https://openalex.org/S31167473","display_name":"Trends in Pharmacological Sciences","issn_l":"0165-6147","issn":["0165-6147","1873-3735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077755519","display_name":"Stanley T. Crooke","orcid":"https://orcid.org/0000-0002-4260-1520","observed_orcids":["https://orcid.org/0000-0002-4260-1520"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley T. Crooke","raw_affiliation_strings":["Stanley T. Crooke is Professor of Pharmacology at Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley T. Crooke is Professor of Pharmacology at Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064849804","display_name":"Mike Mattern","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mike Mattern","raw_affiliation_strings":["Mike Mattem is a Senior Investigator at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mike Mattem is a Senior Investigator at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007588400","display_name":"Henry M. Sarau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry M. Sarau","raw_affiliation_strings":["Henry M. Sarau is Assistant Director at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Sarau is Assistant Director at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103703982","display_name":"James D. Winkler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Winkler","raw_affiliation_strings":["James D. Winkler, Joanna Balcarek, Angela Wong and C. Frank Bennett are Associate Senior Investigators at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James D. Winkler, Joanna Balcarek, Angela Wong and C. Frank Bennett are Associate Senior Investigators at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039244613","display_name":"Joanna M. Balcarek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna Balcarek","raw_affiliation_strings":["James D. Winkler, Joanna Balcarek, Angela Wong and C. Frank Bennett are Associate Senior Investigators at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James D. Winkler, Joanna Balcarek, Angela Wong and C. Frank Bennett are Associate Senior Investigators at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027181810","display_name":"Angela Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Wong","raw_affiliation_strings":["James D. Winkler, Joanna Balcarek, Angela Wong and C. Frank Bennett are Associate Senior Investigators at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James D. Winkler, Joanna Balcarek, Angela Wong and C. Frank Bennett are Associate Senior Investigators at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083296071","display_name":"C. Frank Bennett","orcid":"https://orcid.org/0000-0001-9887-6251","observed_orcids":["https://orcid.org/0000-0001-9887-6251"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Frank Bennett","raw_affiliation_strings":["James D. Winkler, Joanna Balcarek, Angela Wong and C. Frank Bennett are Associate Senior Investigators at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James D. Winkler, Joanna Balcarek, Angela Wong and C. Frank Bennett are Associate Senior Investigators at Smith Kline and French Laboratories, 709 Swedeland Road, Swedeland, PA 19479, USA","institution_ids":["https://openalex.org/I4210114143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.2083,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.78186597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"10","issue":"3","first_page":"103","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.1200999990105629,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukotriene-d4-receptor","display_name":"leukotriene D4 receptor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/leukotriene-e4","display_name":"leukotriene E4","score":0.7400000095367432},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9139999747276306},{"id":"https://openalex.org/keywords/partial-agonism","display_name":"partial agonism","score":0.7369999885559082},{"id":"https://openalex.org/keywords/receptor-cloning","display_name":"receptor cloning","score":0.7149999737739563},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.7914050817489624},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7052266597747803},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5379052758216858},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5319400429725647},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4885190725326538},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.47489872574806213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.451852023601532},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.4184829294681549},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24014809727668762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12458539009094238}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018077","descriptor_name":"Receptors, Leukotriene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0165-6147(89)90206-x","doi":"https://doi.org/10.1016/0165-6147(89)90206-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-6147(89)90206-x","pdf_url":null,"source":{"id":"https://openalex.org/S31167473","display_name":"Trends in Pharmacological Sciences","issn_l":"0165-6147","issn":["0165-6147","1873-3735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:2556821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2556821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in pharmacological sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W628280147","https://openalex.org/W1509351410","https://openalex.org/W1544535182","https://openalex.org/W1546244903","https://openalex.org/W1776295853","https://openalex.org/W1810077778","https://openalex.org/W1930532000","https://openalex.org/W1938196075","https://openalex.org/W1964302399","https://openalex.org/W1969299547","https://openalex.org/W1988865472","https://openalex.org/W1993741794","https://openalex.org/W2008981686","https://openalex.org/W2031428812","https://openalex.org/W2042446681","https://openalex.org/W2074349548","https://openalex.org/W2076704773","https://openalex.org/W2082241918","https://openalex.org/W2086608397","https://openalex.org/W2094890838","https://openalex.org/W2130045854","https://openalex.org/W2131744664","https://openalex.org/W2146033738","https://openalex.org/W2263895214","https://openalex.org/W2265043649","https://openalex.org/W2269742582","https://openalex.org/W2413771143","https://openalex.org/W2419338956","https://openalex.org/W2463424128","https://openalex.org/W4256608107"],"related_works":["https://openalex.org/W62089526","https://openalex.org/W2416717033","https://openalex.org/W2327914283","https://openalex.org/W2022913193","https://openalex.org/W195919601","https://openalex.org/W1829571684","https://openalex.org/W1496438795","https://openalex.org/W2052355511","https://openalex.org/W1602800967","https://openalex.org/W2131032941"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
