{"id":"https://openalex.org/W2084863149","doi":"https://doi.org/10.1016/s0957-4166(00)00349-9","title":"Rapid access to enantiopure bupropion and its major metabolite by stereospecific nucleophilic substitution on an \u03b1-ketotriflate","display_name":"Rapid access to enantiopure bupropion and its major metabolite by stereospecific nucleophilic substitution on an \u03b1-ketotriflate","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2084863149","doi":"https://doi.org/10.1016/s0957-4166(00)00349-9","mag":"2084863149"},"language":"en","primary_location":{"id":"doi:10.1016/s0957-4166(00)00349-9","doi":"https://doi.org/10.1016/s0957-4166(00)00349-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0957-4166(00)00349-9","pdf_url":null,"source":{"id":"https://openalex.org/S88152556","display_name":"Tetrahedron Asymmetry","issn_l":"0957-4166","issn":["0957-4166","1362-511X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron: Asymmetry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073677677","display_name":"Q. Kevin Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qun K Fang","raw_affiliation_strings":["Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037011841","display_name":"Zhengxu S. Han","orcid":"https://orcid.org/0000-0001-8386-1356","observed_orcids":["https://orcid.org/0000-0001-8386-1356"]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengxu Han","raw_affiliation_strings":["Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022035478","display_name":"Paul T. Grover","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Grover","raw_affiliation_strings":["Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003612461","display_name":"Donald W. Kessler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Kessler","raw_affiliation_strings":["Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015397568","display_name":"Chris H. Senanayake","orcid":"https://orcid.org/0009-0009-3170-0687","observed_orcids":["https://orcid.org/0009-0009-3170-0687"]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris H Senanayake*","raw_affiliation_strings":["Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023791089","display_name":"Stephen A. Wald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen A Wald","raw_affiliation_strings":["Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Sepracor Inc., 111 Locke Drive, Marlborough, MA 01752, USA","institution_ids":["https://openalex.org/I4210122020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073677677"],"corresponding_institution_ids":["https://openalex.org/I4210122020"],"apc_list":null,"apc_paid":null,"fwci":1.114,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.7279731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"18","first_page":"3659","last_page":"3663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12527","display_name":"Chemistry and Stereochemistry Studies","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bupropion","display_name":"bupropion","score":0.9950000047683716},{"id":"https://openalex.org/keywords/enantiopure-synthesis","display_name":"enantiopure synthesis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/stereospecific-synthesis","display_name":"stereospecific synthesis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nucleophilic-substitution","display_name":"nucleophilic substitution","score":0.9290000200271606},{"id":"https://openalex.org/keywords/alpha-amino-ketones","display_name":"\u03b1-amino ketones","score":0.8669999837875366},{"id":"https://openalex.org/keywords/alpha-hydroxy-ketones","display_name":"\u03b1-hydroxy ketones","score":0.9179999828338623},{"id":"https://openalex.org/keywords/chiral-pool-synthesis","display_name":"chiral pool synthesis","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C93237805","wikidata":"https://www.wikidata.org/wiki/Q5375227","display_name":"Enantiopure drug","level":4,"score":0.9524443745613098},{"id":"https://openalex.org/C187921627","wikidata":"https://www.wikidata.org/wiki/Q2469470","display_name":"Stereospecificity","level":3,"score":0.8429018259048462},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7656388282775879},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6476348042488098},{"id":"https://openalex.org/C2777738585","wikidata":"https://www.wikidata.org/wiki/Q170744","display_name":"Ketone","level":2,"score":0.6350144743919373},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5477336645126343},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.5472388863563538},{"id":"https://openalex.org/C21774173","wikidata":"https://www.wikidata.org/wiki/Q2462024","display_name":"Trifluoromethanesulfonate","level":3,"score":0.5325766205787659},{"id":"https://openalex.org/C2778498671","wikidata":"https://www.wikidata.org/wiki/Q2843448","display_name":"Aminoketone","level":2,"score":0.45248016715049744},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23618045449256897},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.19597700238227844},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.12622720003128052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08608397841453552}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0957-4166(00)00349-9","doi":"https://doi.org/10.1016/s0957-4166(00)00349-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0957-4166(00)00349-9","pdf_url":null,"source":{"id":"https://openalex.org/S88152556","display_name":"Tetrahedron Asymmetry","issn_l":"0957-4166","issn":["0957-4166","1362-511X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron: Asymmetry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W588500352","https://openalex.org/W1975729750","https://openalex.org/W2073694391","https://openalex.org/W2073940796","https://openalex.org/W2116124049","https://openalex.org/W2951187886","https://openalex.org/W2953164589","https://openalex.org/W2953384556"],"related_works":["https://openalex.org/W2949332335","https://openalex.org/W2315423682","https://openalex.org/W2052293296","https://openalex.org/W1995528440","https://openalex.org/W2058784496","https://openalex.org/W1997985772","https://openalex.org/W2941675326","https://openalex.org/W2098318107","https://openalex.org/W6989550904","https://openalex.org/W2082839300"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
