{"id":"https://openalex.org/W2084860101","doi":"https://doi.org/10.1021/ac1019914","title":"Quantitative Determination of Sarcosine and Related Compounds in Urinary Samples by Liquid Chromatography with Tandem Mass Spectrometry","display_name":"Quantitative Determination of Sarcosine and Related Compounds in Urinary Samples by Liquid Chromatography with Tandem Mass Spectrometry","publication_year":2010,"publication_date":"2010-10-12","ids":{"openalex":"https://openalex.org/W2084860101","doi":"https://doi.org/10.1021/ac1019914","mag":"2084860101","pmid":"https://pubmed.ncbi.nlm.nih.gov/20939533"},"language":"en","primary_location":{"id":"doi:10.1021/ac1019914","doi":"https://doi.org/10.1021/ac1019914","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac1019914","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059672503","display_name":"Yongqing Jiang","orcid":"https://orcid.org/0000-0003-1678-9002","observed_orcids":["https://orcid.org/0000-0003-1678-9002"]},"institutions":[{"id":"https://openalex.org/I20382870","display_name":"Missouri University of Science and Technology","ror":"https://ror.org/00scwqd12","country_code":"US","type":"education","lineage":["https://openalex.org/I20382870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongqing Jiang","raw_affiliation_strings":["Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, Missouri 65409, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, Missouri 65409, United States","institution_ids":["https://openalex.org/I20382870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007476647","display_name":"Xiaoliang Cheng","orcid":"https://orcid.org/0000-0003-4236-290X","observed_orcids":["https://orcid.org/0000-0003-4236-290X"]},"institutions":[{"id":"https://openalex.org/I20382870","display_name":"Missouri University of Science and Technology","ror":"https://ror.org/00scwqd12","country_code":"US","type":"education","lineage":["https://openalex.org/I20382870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoliang Cheng","raw_affiliation_strings":["Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, Missouri 65409, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, Missouri 65409, United States","institution_ids":["https://openalex.org/I20382870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033753269","display_name":"Chuan Wang","orcid":"https://orcid.org/0000-0002-9219-1785","observed_orcids":["https://orcid.org/0000-0002-9219-1785"]},"institutions":[{"id":"https://openalex.org/I20382870","display_name":"Missouri University of Science and Technology","ror":"https://ror.org/00scwqd12","country_code":"US","type":"education","lineage":["https://openalex.org/I20382870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuan Wang","raw_affiliation_strings":["Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, Missouri 65409, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, Missouri 65409, United States","institution_ids":["https://openalex.org/I20382870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081352482","display_name":"Yinfa Ma","orcid":"https://orcid.org/0000-0002-9719-8345","observed_orcids":["https://orcid.org/0000-0002-9719-8345"]},"institutions":[{"id":"https://openalex.org/I20382870","display_name":"Missouri University of Science and Technology","ror":"https://ror.org/00scwqd12","country_code":"US","type":"education","lineage":["https://openalex.org/I20382870"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yinfa Ma","raw_affiliation_strings":["Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, Missouri 65409, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Environmental Research Center, Missouri University of Science and Technology, Rolla, Missouri 65409, United States","institution_ids":["https://openalex.org/I20382870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081352482"],"corresponding_institution_ids":["https://openalex.org/I20382870"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.3846,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.93262266,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"82","issue":"21","first_page":"9022","last_page":"9027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcosine","display_name":"sarcosine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proline","display_name":"proline","score":0.7360000014305115},{"id":"https://openalex.org/keywords/kynurenine","display_name":"kynurenine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/uracil","display_name":"uracil","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glycerol-3-phosphate","display_name":"glycerol-3-phosphate","score":0.9639999866485596},{"id":"https://openalex.org/keywords/urinary-metabolites","display_name":"urinary metabolites","score":0.8180000185966492},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6489999890327454},{"id":"https://openalex.org/keywords/early-cancer-screening","display_name":"early cancer screening","score":0.781000018119812},{"id":"https://openalex.org/keywords/multiple-reaction-monitoring","display_name":"multiple reaction monitoring","score":0.6620000004768372},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.718999981880188},{"id":"https://openalex.org/keywords/liquid-chromatography","display_name":"liquid chromatography","score":0.5770000219345093},{"id":"https://openalex.org/keywords/creatinine","display_name":"creatinine","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9292460680007935},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8690770864486694},{"id":"https://openalex.org/C2779943223","wikidata":"https://www.wikidata.org/wiki/Q414157","display_name":"Sarcosine","level":4,"score":0.7449421882629395},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6850826740264893},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.6714425683021545},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6556712985038757},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.5861715078353882},{"id":"https://openalex.org/C2777379063","wikidata":"https://www.wikidata.org/wiki/Q161233","display_name":"Formic acid","level":2,"score":0.5671255588531494},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.497510701417923},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.46890509128570557},{"id":"https://openalex.org/C71043704","wikidata":"https://www.wikidata.org/wiki/Q17144692","display_name":"Selected reaction monitoring","level":4,"score":0.46380260586738586},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4585864245891571},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.09545454382896423},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.07812106609344482},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06431901454925537}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003401","descriptor_name":"Creatine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003401","descriptor_name":"Creatine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012521","descriptor_name":"Sarcosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012521","descriptor_name":"Sarcosine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016482","descriptor_name":"Urinalysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac1019914","doi":"https://doi.org/10.1021/ac1019914","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac1019914","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:20939533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20939533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1549690016","https://openalex.org/W1971606140","https://openalex.org/W1978461542","https://openalex.org/W1993229728","https://openalex.org/W1998526226","https://openalex.org/W2009863844","https://openalex.org/W2030926866","https://openalex.org/W2050235247","https://openalex.org/W2055761634","https://openalex.org/W2060559335","https://openalex.org/W2066172349","https://openalex.org/W2079573964","https://openalex.org/W2087424236","https://openalex.org/W2088546724","https://openalex.org/W2123230901","https://openalex.org/W2155680682","https://openalex.org/W2162923066","https://openalex.org/W2162978625","https://openalex.org/W2418800106","https://openalex.org/W4211024301"],"related_works":["https://openalex.org/W2084925449","https://openalex.org/W2324976654","https://openalex.org/W2591008484","https://openalex.org/W1972716867","https://openalex.org/W2163133337","https://openalex.org/W2560038361","https://openalex.org/W3028916844","https://openalex.org/W2316299880","https://openalex.org/W1984740654","https://openalex.org/W2027554102"],"abstract_inverted_index":{"The":[0,20,145,160,172,193,213],"current":[1],"prostate":[2,56,74],"cancer":[3,57,75,240],"(PCa)":[4],"diagnosis,":[5],"based":[6],"on":[7],"the":[8,123,151,157,164,183,196,201],"blood":[9],"prostate-specific":[10],"antigen":[11],"(PSA)":[12],"level":[13],"measurement,":[14],"is":[15,81,219],"not":[16],"a":[17,97,129,142],"precise":[18],"science.":[19],"widely":[21],"used":[22,228],"PSA":[23],"biomarker":[24],"for":[25,85,229,237],"PCa":[26],"has":[27],"poor":[28],"sensitivity":[29],"and":[30,32,37,46,104,138,182,198,207,223],"specificity":[31],"often":[33],"leads":[34],"to":[35,72,102,169,179,190],"false-negative":[36],"false-positive":[38],"test":[39],"results.":[40],"Recently,":[41],"sarcosine,":[42],"proline,":[43],"kynurenine,":[44],"uracil,":[45],"glycerol":[47],"3-phosphate":[48],"were":[49,125,148,210],"found":[50],"in":[51,54,91,111,136,150,216,234],"higher":[52],"concentrations":[53],"metastatic":[55],"urine":[58,92,112,235],"samples.":[59,93],"By":[60],"measuring":[61],"all":[62],"five":[63],"of":[64,88,122,163,174,185,200],"these":[65,89,231],"metabolites,":[66,203],"doctors":[67],"may":[68],"be":[69,227],"better":[70],"able":[71],"diagnose":[73],"with":[76,132,156],"high":[77],"accuracy.":[78],"However,":[79],"there":[80],"no":[82],"method":[83,99],"reported":[84],"simultaneous":[86],"detection":[87,175],"compounds":[90],"In":[94],"this":[95,217],"study,":[96],"novel":[98],"was":[100,166,176],"developed":[101,215],"separate":[103],"quantify":[105],"six":[106,146,202,232],"urinary":[107],"metabolites":[108,147,233],"including":[109],"creatinine":[110],"samples":[113,236],"by":[114],"using":[115,128],"liquid":[116],"chromatography/tandem":[117],"mass":[118],"spectrometry.":[119],"Chromatographic":[120],"separations":[121],"analytes":[124,165],"carried":[126],"out":[127],"phenyl-hexyl":[130],"column":[131],"0.1%":[133],"formic":[134],"acid":[135],"water":[137],"acetonitrile,":[139],"respectively,":[140],"under":[141],"gradient":[143],"program.":[144],"detected":[149],"multiple":[152],"reaction":[153],"monitoring":[154],"modes":[155],"ESI-positive":[158],"mode.":[159],"linear":[161],"range":[162],"from":[167,177,188],"0.003":[168],"40":[170],"\u03bcmol/L.":[171],"limit":[173,184],"0.05":[178],"4":[180],"nmol/L,":[181],"quantification":[186,199],"ranged":[187],"3":[189],"20":[191],"nmol/L.":[192],"factors":[194],"affecting":[195],"separation":[197],"such":[204],"as":[205],"mobile-phase":[206],"MS":[208],"conditions,":[209],"also":[211],"investigated.":[212],"technique":[214],"study":[218],"simple,":[220],"fast,":[221],"sensitive,":[222],"selective.":[224],"It":[225],"can":[226],"quantifying":[230],"potential":[238],"early":[239],"screening.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
