{"id":"https://openalex.org/W2084844932","doi":"https://doi.org/10.1177/107155760000700506","title":"Periovulatory and Interleukin (IL)-1\u2014Dependent Reglation of IL-6 in the Immature Rat Ovary: A Specific IL-1 Receptor-Mediated Eicosanoid-Dependent Effect","display_name":"Periovulatory and Interleukin (IL)-1\u2014Dependent Reglation of IL-6 in the Immature Rat Ovary: A Specific IL-1 Receptor-Mediated Eicosanoid-Dependent Effect","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2084844932","doi":"https://doi.org/10.1177/107155760000700506","mag":"2084844932","pmid":"https://pubmed.ncbi.nlm.nih.gov/11035283"},"language":"en","primary_location":{"id":"doi:10.1177/107155760000700506","doi":"https://doi.org/10.1177/107155760000700506","is_oa":false,"landing_page_url":"https://doi.org/10.1177/107155760000700506","pdf_url":null,"source":{"id":"https://openalex.org/S142156365","display_name":"Journal of the Society for Gynecologic Investigation","issn_l":"1071-5576","issn":["1071-5576","1556-7117"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Society for Gynecologic Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108514299","display_name":"Ki Wook Chung","orcid":"https://orcid.org/0000-0002-4418-1857","observed_orcids":["https://orcid.org/0000-0002-4418-1857"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ki Wook Chung","raw_affiliation_strings":["Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113598127","display_name":"Motomu Ando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I190930483","display_name":"Kyorin University","ror":"https://ror.org/0188yz413","country_code":"JP","type":"education","lineage":["https://openalex.org/I190930483"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Motomu Ando","raw_affiliation_strings":["Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah","Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Tokyo 181, Japan","Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Tokyo 181, Japan","institution_ids":["https://openalex.org/I190930483"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086044543","display_name":"Eli Y. Adashi","orcid":"https://orcid.org/0000-0001-7730-1192","observed_orcids":["https://orcid.org/0000-0001-7730-1192"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eli Y. Adashi","raw_affiliation_strings":["Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland; Division of Reproeuctive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah;","Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland; Division of Reproeuctive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah;","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I223532165"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086044543"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":0.3911,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.69871847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"5","first_page":"301","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9879999756813049},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/ovary","display_name":"ovary","score":0.5759999752044678},{"id":"https://openalex.org/keywords/ovulation","display_name":"ovulation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/il-1-receptor","display_name":"IL-1 receptor","score":0.800000011920929},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.9319999814033508},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8600000143051147},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.8159999847412109},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/aminoguanidine","display_name":"aminoguanidine","score":0.925000011920929},{"id":"https://openalex.org/keywords/immature-rat-ovary","display_name":"immature rat ovary","score":0.6179999709129333},{"id":"https://openalex.org/keywords/il-6-mrna-expression","display_name":"IL-6 mRNA expression","score":0.6669999957084656},{"id":"https://openalex.org/keywords/follicular-rupture","display_name":"follicle rupture","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.7328357696533203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6816601157188416},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6702112555503845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5971192717552185},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.5937714576721191},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5346578359603882},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.46829524636268616},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.4619728624820709},{"id":"https://openalex.org/C2776352991","wikidata":"https://www.wikidata.org/wiki/Q407680","display_name":"Eicosanoid","level":4,"score":0.4482467770576477},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41781723499298096},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4170985221862793},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.34155377745628357},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2979925870895386},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.25664985179901123},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22982171177864075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15043047070503235},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10107755661010742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004971","descriptor_name":"Estrus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006064","descriptor_name":"Gonadotropins, Equine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010060","descriptor_name":"Ovulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015777","descriptor_name":"Eicosanoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/107155760000700506","doi":"https://doi.org/10.1177/107155760000700506","is_oa":false,"landing_page_url":"https://doi.org/10.1177/107155760000700506","pdf_url":null,"source":{"id":"https://openalex.org/S142156365","display_name":"Journal of the Society for Gynecologic Investigation","issn_l":"1071-5576","issn":["1071-5576","1556-7117"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Society for Gynecologic Investigation","raw_type":"journal-article"},{"id":"pmid:11035283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11035283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Society for Gynecologic Investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.7099999785423279}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1570420775","display_name":null,"funder_award_id":"HD-30288","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3941151206","display_name":"INTERLEUKIN-1:  AN INTERMEDIARY IN OVULATION","funder_award_id":"5r01hd030288-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1488573278","https://openalex.org/W1964920982","https://openalex.org/W1967413976","https://openalex.org/W1983392326","https://openalex.org/W1999376129","https://openalex.org/W2019518112","https://openalex.org/W2021679367","https://openalex.org/W2028516288","https://openalex.org/W2029294144","https://openalex.org/W2045963295","https://openalex.org/W2048899274","https://openalex.org/W2052857449","https://openalex.org/W2061574494","https://openalex.org/W2069753865","https://openalex.org/W2070361140","https://openalex.org/W2072790320","https://openalex.org/W2073604350","https://openalex.org/W2077551460","https://openalex.org/W2077937947","https://openalex.org/W2078231415","https://openalex.org/W2078413454","https://openalex.org/W2079136292","https://openalex.org/W2082868572","https://openalex.org/W2085707821","https://openalex.org/W2092868076","https://openalex.org/W2115342920","https://openalex.org/W2125499492","https://openalex.org/W2129888466","https://openalex.org/W2145203144","https://openalex.org/W2155409158","https://openalex.org/W2158494565","https://openalex.org/W2161965230","https://openalex.org/W2162445820","https://openalex.org/W2166546992","https://openalex.org/W2181497251","https://openalex.org/W2408732553"],"related_works":["https://openalex.org/W4235615025","https://openalex.org/W2161965230","https://openalex.org/W2073856259","https://openalex.org/W2318850148","https://openalex.org/W2039771290","https://openalex.org/W2078231415","https://openalex.org/W2189465872","https://openalex.org/W4249068732","https://openalex.org/W4247291143","https://openalex.org/W2166546992"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}