{"id":"https://openalex.org/W2084827367","doi":"https://doi.org/10.1097/mbc.0b013e328352e90e","title":"Predicting prothrombotic tendencies in sepsis using spatial clot growth dynamics","display_name":"Predicting prothrombotic tendencies in sepsis using spatial clot growth dynamics","publication_year":2012,"publication_date":"2012-06-08","ids":{"openalex":"https://openalex.org/W2084827367","doi":"https://doi.org/10.1097/mbc.0b013e328352e90e","mag":"2084827367","pmid":"https://pubmed.ncbi.nlm.nih.gov/22688554"},"language":"en","primary_location":{"id":"doi:10.1097/mbc.0b013e328352e90e","doi":"https://doi.org/10.1097/mbc.0b013e328352e90e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mbc.0b013e328352e90e","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation &amp; Fibrinolysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064531118","display_name":"Natalia P. Soshitova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia P. Soshitova","raw_affiliation_strings":["HemaCore LLC, Moscow, Russia","HemaCore LLC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HemaCore LLC, Moscow, Russia","institution_ids":[]},{"raw_affiliation_string":"HemaCore LLC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036354833","display_name":"Sergey S. Karamzin","orcid":"https://orcid.org/0000-0002-1347-8463","observed_orcids":["https://orcid.org/0000-0002-1347-8463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergey S. Karamzin","raw_affiliation_strings":["HemaCore LLC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HemaCore LLC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065753585","display_name":"Anna N. Balandina","orcid":"https://orcid.org/0000-0002-7032-695X","observed_orcids":["https://orcid.org/0000-0002-7032-695X"]},"institutions":[{"id":"https://openalex.org/I4210122842","display_name":"Center for Theoretical Problems of Physicochemical Pharmacology","ror":"https://ror.org/02ncvqp37","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210115279","https://openalex.org/I4210122842"]},{"id":"https://openalex.org/I4210127411","display_name":"Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology","ror":"https://ror.org/02h8dsx08","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210127411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna N. Balandina","raw_affiliation_strings":["Center for Theoretical Problems of Physicochemical Pharmacology","Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia","Center for Theoretical Problems of Physicochemical Pharmacology; Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Problems of Physicochemical Pharmacology","institution_ids":["https://openalex.org/I4210122842"]},{"raw_affiliation_string":"Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia","institution_ids":[]},{"raw_affiliation_string":"Center for Theoretical Problems of Physicochemical Pharmacology; Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia","institution_ids":["https://openalex.org/I4210122842","https://openalex.org/I4210127411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043244387","display_name":"Olga A. Fadeeva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olga A. Fadeeva","raw_affiliation_strings":["HemaCore LLC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HemaCore LLC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024872737","display_name":"\u0410 \u0412 \u041a\u0440\u0435\u0447\u0435\u0442\u043e\u0432\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100648","display_name":"National Medical Research Center for Hematology","ror":"https://ror.org/015fskz95","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100648","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna V. Kretchetova","raw_affiliation_strings":["National Research Center for Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Center for Hematology","institution_ids":["https://openalex.org/I4210100648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051655365","display_name":"\u0413 \u041c \u0413\u0430\u043b\u0441\u0442\u044f\u043d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100648","display_name":"National Medical Research Center for Hematology","ror":"https://ror.org/015fskz95","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100648","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Gennadiy M. Galstian","raw_affiliation_strings":["National Research Center for Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Center for Hematology","institution_ids":["https://openalex.org/I4210100648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058001042","display_name":"Mikhail Aleksandrovich Panteleev","orcid":"https://orcid.org/0000-0002-8128-7757","observed_orcids":["https://orcid.org/0000-0002-8128-7757"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210100648","display_name":"National Medical Research Center for Hematology","ror":"https://ror.org/015fskz95","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100648","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210122842","display_name":"Center for Theoretical Problems of Physicochemical Pharmacology","ror":"https://ror.org/02ncvqp37","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210115279","https://openalex.org/I4210122842"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Mikhail A. Panteleev","raw_affiliation_strings":["to Mikhail A. Panteleev, National Research Center for Hematology, 4 Novyi Zykovskii Pr, Moscow 125167, RussiaTel: +7 495 612 3522; fax: +7 495 612-8870; e-mail: [email\u00a0protected]","Center for Theoretical Problems of Physicochemical Pharmacology; Department of Physics, Moscow State University; HemaCore LLC; National Research Center for Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"to Mikhail A. Panteleev, National Research Center for Hematology, 4 Novyi Zykovskii Pr, Moscow 125167, RussiaTel: +7 495 612 3522; fax: +7 495 612-8870; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I4210100648"]},{"raw_affiliation_string":"Center for Theoretical Problems of Physicochemical Pharmacology; Department of Physics, Moscow State University; HemaCore LLC; National Research Center for Hematology","institution_ids":["https://openalex.org/I19880235","https://openalex.org/I4210122842"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080077871","display_name":"\u0424\u0430\u0437\u043e\u0438\u043b \u0418. \u0410\u0442\u0430\u0443\u043b\u043b\u0430\u0445\u0430\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-6668-0948","observed_orcids":["https://orcid.org/0000-0002-6668-0948","https://orcid.org/0000-0002-8805-1499"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210122842","display_name":"Center for Theoretical Problems of Physicochemical Pharmacology","ror":"https://ror.org/02ncvqp37","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210115279","https://openalex.org/I4210122842"]},{"id":"https://openalex.org/I4210127411","display_name":"Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology","ror":"https://ror.org/02h8dsx08","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210127411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Fazoil I. Ataullakhanov","raw_affiliation_strings":["Center for Theoretical Problems of Physicochemical Pharmacology; Department of Physics, Moscow State University; Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia; HemaCore LLC; National Research Center for Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Problems of Physicochemical Pharmacology; Department of Physics, Moscow State University; Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia; HemaCore LLC; National Research Center for Hematology","institution_ids":["https://openalex.org/I19880235","https://openalex.org/I4210122842","https://openalex.org/I4210127411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058001042"],"corresponding_institution_ids":["https://openalex.org/I19880235","https://openalex.org/I4210100648","https://openalex.org/I4210122842"],"apc_list":null,"apc_paid":null,"fwci":4.9066,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.95707274,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"6","first_page":"498","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.44119998812675476,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.44119998812675476,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.36719998717308044,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0868000015616417,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.996999979019165},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.7929999828338623},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.6880000233650208},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/thrombodynamics","display_name":"thrombodynamics","score":0.9670000076293945},{"id":"https://openalex.org/keywords/fibrin-clot-formation","display_name":"fibrin clot formation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.847000002861023},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/thromboelastography","display_name":"thromboelastography","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hypocoagulability","display_name":"hypocoagulability","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2777664302","wikidata":"https://www.wikidata.org/wiki/Q4463725","display_name":"Thromboelastography","level":3,"score":0.7759582996368408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7230169773101807},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7046438455581665},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.6879419088363647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5607403516769409},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.4743337035179138},{"id":"https://openalex.org/C2779519742","wikidata":"https://www.wikidata.org/wiki/Q198526","display_name":"D-dimer","level":2,"score":0.46710506081581116},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4517400562763214},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43390440940856934},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4216860234737396},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3755284547805786},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2544713616371155}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/mbc.0b013e328352e90e","doi":"https://doi.org/10.1097/mbc.0b013e328352e90e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mbc.0b013e328352e90e","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation &amp; Fibrinolysis","raw_type":"journal-article"},{"id":"pmid:22688554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22688554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334801","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1562986705","https://openalex.org/W1965833894","https://openalex.org/W1993041144","https://openalex.org/W1998233400","https://openalex.org/W2014764322","https://openalex.org/W2017739615","https://openalex.org/W2020902823","https://openalex.org/W2034975785","https://openalex.org/W2037887416","https://openalex.org/W2038759408","https://openalex.org/W2043112537","https://openalex.org/W2081858385","https://openalex.org/W2082764820","https://openalex.org/W2086544626","https://openalex.org/W2088598503","https://openalex.org/W2110971703","https://openalex.org/W2120474997","https://openalex.org/W2120677427","https://openalex.org/W2120722937","https://openalex.org/W2120823353","https://openalex.org/W2122934196","https://openalex.org/W2124321287","https://openalex.org/W2126655081","https://openalex.org/W2128042853","https://openalex.org/W2132984496","https://openalex.org/W2135492318","https://openalex.org/W2156287996","https://openalex.org/W2161021257","https://openalex.org/W2167741910","https://openalex.org/W2168183582","https://openalex.org/W2168454493","https://openalex.org/W2173025320","https://openalex.org/W2332156797","https://openalex.org/W2396194974","https://openalex.org/W2405481495"],"related_works":["https://openalex.org/W3017363899","https://openalex.org/W1541739792","https://openalex.org/W2903575404","https://openalex.org/W3099050267","https://openalex.org/W2397400882","https://openalex.org/W1989780640","https://openalex.org/W2884179177","https://openalex.org/W2589794737","https://openalex.org/W2972633124","https://openalex.org/W2997981835"],"abstract_inverted_index":{"Inflammation":[0],"in":[1,25,35,77,100,127,136,142,220,225],"sepsis":[2,74],"is":[3,31],"associated":[4],"with":[5,62,70],"hypercoagulation":[6,126],"that":[7],"may":[8],"lead":[9],"to":[10,22,32,55],"thrombosis":[11,135],"and":[12,54,73,222],"disseminated":[13],"intravascular":[14],"coagulation.":[15],"Conventional":[16],"diagnostic":[17,234],"assays":[18,118],"are":[19],"poorly":[20],"sensitive":[21],"procoagulant":[23],"changes":[24,34],"sepsis.":[26],"Objectives":[27],"of":[28,38,52,59,65,105,144,239],"the":[29,50,57,63,78,89,158,169,205,237],"article":[30],"study":[33],"hemostatic":[36],"state":[37],"septic":[39],"patients":[40,69,81,199],"using":[41],"spatial":[42,152,163,228],"clot":[43,93,98,123,153,164,216,229],"growth":[44,94,124,154,165,217,230],"assay":[45,95,166],"(currently":[46],"being":[47],"developed":[48],"under":[49],"trademark":[51],"thrombodynamics)":[53],"compare":[56],"sensitivity":[58,64],"this":[60,208],"method":[61],"conventional":[66],"methods.":[67],"Sixteen":[68],"hematological":[71],"malignancies":[72],"were":[75,119],"enrolled":[76],"study.":[79],"All":[80],"had":[82,200],"been":[83],"surveyed":[84],"for":[85,193,236],"a":[86,101,178],"month":[87],"following":[88],"infection":[90],"onset.":[91],"Spatial":[92,122,215],"monitors":[96],"fibrin":[97],"development":[99],"nonstirred":[102],"thin":[103],"layer":[104],"platelet-free":[106],"plasma":[107],"activated":[108],"by":[109],"immobilized":[110],"tissue":[111],"factor.":[112],"Clotting":[113],"time":[114,160],"tests,":[115],"thromboelastography,":[116],"D-dimer":[117,130,146,171,202],"also":[120],"performed.":[121],"revealed":[125],"six":[128],"patients.":[129],"levels":[131,147,203],"increase":[132,150],"(with":[133],"vein":[134],"one":[137],"case)":[138],"was":[139,155,173,189],"subsequently":[140],"observed":[141],"five":[143],"them.":[145],"did":[148],"not":[149],"when":[151],"normal.":[156],"At":[157],"next":[159],"point,":[161],"after":[162,177],"showed":[167,218],"hypercoagulation,":[168],"mean":[170],"concentration":[172],"significantly":[174],"higher":[175],"than":[176],"normal":[179],"analysis":[180],"(457":[181],"versus":[182],"234":[183],"\u03bcg/l;":[184],"P":[185],"<":[186],"0.05);":[187],"there":[188],"no":[190],"such":[191],"correlation":[192],"other":[194],"assays.":[195],"The":[196],"remaining":[197],"10":[198],"elevated":[201],"on":[204],"first":[206],"day;":[207],"either":[209],"decreased":[210],"gradually":[211],"or":[212],"remained":[213],"elevated.":[214],"normalization":[219],"survivors":[221],"growing":[223],"hypocoagulation":[224],"nonsurvivors.":[226],"Measuring":[227],"dynamics":[231],"has":[232],"potential":[233],"utility":[235],"evaluation":[238],"thrombotic":[240],"risk.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}