{"id":"https://openalex.org/W2084795601","doi":"https://doi.org/10.1126/science.1165946","title":"Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1","display_name":"Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1","publication_year":2009,"publication_date":"2009-02-19","ids":{"openalex":"https://openalex.org/W2084795601","doi":"https://doi.org/10.1126/science.1165946","mag":"2084795601","pmid":"https://pubmed.ncbi.nlm.nih.gov/19229036","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429349"},"language":"en","primary_location":{"id":"doi:10.1126/science.1165946","doi":"https://doi.org/10.1126/science.1165946","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1165946","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429349","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090447990","display_name":"Sandy D. Westerheide","orcid":"https://orcid.org/0000-0003-4683-9648","observed_orcids":["https://orcid.org/0000-0003-4683-9648"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210140120","display_name":"Turku Centre for Biotechnology","ror":"https://ror.org/0421ba211","country_code":"FI","type":"facility","lineage":["https://openalex.org/I4210140120"]}],"countries":["FI","US"],"is_corresponding":true,"raw_author_name":"Sandy D. Westerheide","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I4210140120"]},{"raw_affiliation_string":"University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049287983","display_name":"Julius Anckar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210140120","display_name":"Turku Centre for Biotechnology","ror":"https://ror.org/0421ba211","country_code":"FI","type":"facility","lineage":["https://openalex.org/I4210140120"]}],"countries":["FI","US"],"is_corresponding":true,"raw_author_name":"Julius Anckar","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I4210140120"]},{"raw_affiliation_string":"University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066755414","display_name":"Stanley M. Stevens","orcid":"https://orcid.org/0000-0002-1399-0256","observed_orcids":["https://orcid.org/0000-0002-1399-0256"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210140120","display_name":"Turku Centre for Biotechnology","ror":"https://ror.org/0421ba211","country_code":"FI","type":"facility","lineage":["https://openalex.org/I4210140120"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Stanley M. Stevens","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I4210140120"]},{"raw_affiliation_string":"University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007027974","display_name":"Lea Sistonen","orcid":"https://orcid.org/0000-0003-1341-2867","observed_orcids":["https://orcid.org/0000-0003-1341-2867"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210140120","display_name":"Turku Centre for Biotechnology","ror":"https://ror.org/0421ba211","country_code":"FI","type":"facility","lineage":["https://openalex.org/I4210140120"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Lea Sistonen","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I4210140120"]},{"raw_affiliation_string":"University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004866198","display_name":"Richard I. Morimoto","orcid":"https://orcid.org/0000-0002-3431-445X","observed_orcids":["https://orcid.org/0000-0002-3431-445X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210140120","display_name":"Turku Centre for Biotechnology","ror":"https://ror.org/0421ba211","country_code":"FI","type":"facility","lineage":["https://openalex.org/I4210140120"]}],"countries":["FI","US"],"is_corresponding":true,"raw_author_name":"Richard I. Morimoto","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Biology, Turku Centre for Biotechnology, A\u030abo Akademi University, FI-20520 Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I4210140120"]},{"raw_affiliation_string":"University of Florida, Protein Chemistry Core Facility, Interdisciplinary Center for Biotechnology Research, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004866198","https://openalex.org/A5049287983","https://openalex.org/A5090447990"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I130217899","https://openalex.org/I33213144","https://openalex.org/I4210140120"],"apc_list":null,"apc_paid":null,"fwci":27.4829,"has_fulltext":false,"cited_by_count":718,"citation_normalized_percentile":{"value":0.9983617,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"323","issue":"5917","first_page":"1063","last_page":"1066"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-shock-factor-1","display_name":"heat shock factor 1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.984000027179718},{"id":"https://openalex.org/keywords/protein-acetylation","display_name":"protein acetylation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/deacetylation","display_name":"deacetylation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hsp70-promoter","display_name":"hsp70 promoter","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.7739999890327454},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8690000176429749},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.753000020980835},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2776667301","wikidata":"https://www.wikidata.org/wiki/Q18027324","display_name":"HSF1","level":5,"score":0.965631902217865},{"id":"https://openalex.org/C52981337","wikidata":"https://www.wikidata.org/wiki/Q24782817","display_name":"Heat shock factor","level":5,"score":0.6902331113815308},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.606624960899353},{"id":"https://openalex.org/C137984847","wikidata":"https://www.wikidata.org/wiki/Q1621258","display_name":"Heat shock","level":4,"score":0.5494581460952759},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.5256316065788269},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.48780062794685364},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.48544102907180786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42594215273857117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41259604692459106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25702738761901855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07985353469848633}],"mesh":[{"descriptor_ui":"D000076249","descriptor_name":"Heat Shock Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1126/science.1165946","doi":"https://doi.org/10.1126/science.1165946","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1165946","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:19229036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19229036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2429064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429349","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3429349","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429349","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/1d8080d7-3c08-43e9-a668-5cb57987ae9d","doi":null,"is_oa":false,"landing_page_url":"https://research.abo.fi/en/publications/1d8080d7-3c08-43e9-a668-5cb57987ae9d","pdf_url":null,"source":{"id":"https://openalex.org/S4406923060","display_name":"\u00c5bo Akademi University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Westerheide, S D, Anckar, J, Stevens, S M, Sistonen, L & Morimoto, R I 2009, 'Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1', Science, vol. 323, no. 5917, pp. 1063\u20131066. https://doi.org/10.1126/science.1165946","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2429064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429349","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4944879654","display_name":"C. Elegans Model for Neurodegenerative Diseases of Aging","funder_award_id":"R01AG026647","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5280339932","display_name":"A Systems Approach to Stress Biology and Proteostasis Networks","funder_award_id":"R01GM038109","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7437889387","display_name":"REGULATION AND EXPRESSION OF THE HSP70 GENE FAMILY","funder_award_id":"R37GM038109","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1479962123","https://openalex.org/W1523651119","https://openalex.org/W1563624749","https://openalex.org/W1797639751","https://openalex.org/W1912190980","https://openalex.org/W1972229641","https://openalex.org/W2023431124","https://openalex.org/W2023746083","https://openalex.org/W2050363846","https://openalex.org/W2054447845","https://openalex.org/W2064391294","https://openalex.org/W2088381487","https://openalex.org/W2097848886","https://openalex.org/W2097948853","https://openalex.org/W2116991275","https://openalex.org/W2119624960","https://openalex.org/W2124595934","https://openalex.org/W2124898423","https://openalex.org/W2129091231","https://openalex.org/W2140925956","https://openalex.org/W2141444248","https://openalex.org/W2152622809","https://openalex.org/W2167990179"],"related_works":["https://openalex.org/W2089878813","https://openalex.org/W2002852563","https://openalex.org/W1989635548","https://openalex.org/W7098996624","https://openalex.org/W2102824402","https://openalex.org/W2127475482","https://openalex.org/W1534285222","https://openalex.org/W2977775099","https://openalex.org/W2026152516","https://openalex.org/W2374764616"],"abstract_inverted_index":{"Heat":[0],"shock":[1,57,79],"factor":[2,49],"1":[3],"(HSF1)":[4],"is":[5,30],"essential":[6],"for":[7,97,112],"protecting":[8],"cells":[9],"from":[10,86],"protein-damaging":[11],"stress":[12],"associated":[13],"with":[14],"misfolded":[15],"proteins":[16],"and":[17,22,47,82,108,117],"regulates":[18,39],"the":[19,45,55,74,77,98,103,118],"insulin-signaling":[20],"pathway":[21],"aging.":[23],"Here,":[24],"we":[25],"show":[26],"that":[27,37],"human":[28],"HSF1":[29,52,62,85,101],"inducibly":[31],"acetylated":[32],"at":[33],"a":[34,64,94,110],"critical":[35],"residue":[36],"negatively":[38],"DNA":[40],"binding":[41,53],"activity.":[42],"Activation":[43],"of":[44,71,76,84,100,105],"deacetylase":[46],"longevity":[48],"SIRT1":[50,72,113],"prolonged":[51],"to":[54],"heat":[56,78],"promoter":[58,89],"Hsp70":[59],"by":[60],"maintaining":[61],"in":[63,102,114],"deacetylated,":[65],"DNA-binding":[66],"competent":[67],"state.":[68],"Conversely,":[69],"down-regulation":[70],"accelerated":[73],"attenuation":[75],"response":[80],"(HSR)":[81],"release":[83],"its":[87],"cognate":[88],"elements.":[90],"These":[91],"results":[92],"provide":[93],"mechanistic":[95],"basis":[96],"requirement":[99],"regulation":[104],"life":[106],"span":[107],"establish":[109],"role":[111],"protein":[115],"homeostasis":[116],"HSR.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":35},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":56},{"year":2015,"cited_by_count":42},{"year":2014,"cited_by_count":50},{"year":2013,"cited_by_count":59},{"year":2012,"cited_by_count":42}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}