{"id":"https://openalex.org/W2084786304","doi":"https://doi.org/10.1300/j092v13n01_03","title":"Unexplained Prolonged Fatigue in Primary Care","display_name":"Unexplained Prolonged Fatigue in Primary Care","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2084786304","doi":"https://doi.org/10.1300/j092v13n01_03","mag":"2084786304"},"language":"en","primary_location":{"id":"doi:10.1300/j092v13n01_03","doi":"https://doi.org/10.1300/j092v13n01_03","is_oa":false,"landing_page_url":"https://doi.org/10.1300/j092v13n01_03","pdf_url":null,"source":{"id":"https://openalex.org/S202174029","display_name":"Journal of Chronic Fatigue Syndrome","issn_l":"1057-3321","issn":["1057-3321","1547-0660"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chronic Fatigue Syndrome","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108490040","display_name":"Horng-Shiuann Wu","orcid":"https://orcid.org/0000-0001-7859-1742","observed_orcids":["https://orcid.org/0000-0001-7859-1742"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Horng-Shiuann Wu","raw_affiliation_strings":["Saint Louis University, Community and Family Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Louis University, Community and Family Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084793954","display_name":"Mark B. Mengel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark B. Mengel","raw_affiliation_strings":["Saint Louis University, Community and Family Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Louis University, Community and Family Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108490040"],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.19684365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"1","first_page":"15","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11334","display_name":"Psychosomatic Disorders and Their Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-fatigue-syndrome","display_name":"chronic fatigue syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/case-definition","display_name":"case definition","score":0.7409999966621399},{"id":"https://openalex.org/keywords/diagnostic-criteria","display_name":"diagnostic criteria","score":0.7149999737739563},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.6470000147819519},{"id":"https://openalex.org/keywords/physician-patient-relationship","display_name":"physician-patient relationship","score":0.7889999747276306},{"id":"https://openalex.org/keywords/functional-disability","display_name":"functional disability","score":0.6399999856948853},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9079999923706055},{"id":"https://openalex.org/keywords/psychosocial-factors","display_name":"psychosocial factors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/laboratory-testing","display_name":"laboratory testing","score":0.578000009059906},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.4059999883174896},{"id":"https://openalex.org/keywords/fatigue-management","display_name":"fatigue management","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.7678797841072083},{"id":"https://openalex.org/C2779566273","wikidata":"https://www.wikidata.org/wiki/Q209733","display_name":"Chronic fatigue syndrome","level":2,"score":0.7185623645782471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7155860662460327},{"id":"https://openalex.org/C3020395016","wikidata":"https://www.wikidata.org/wiki/Q5113974","display_name":"Chronic fatigue","level":3,"score":0.6158511638641357},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.5429077744483948},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5005314350128174},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.46376535296440125},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4554654061794281},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.30011242628097534},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.24597859382629395},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.11903390288352966},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1300/j092v13n01_03","doi":"https://doi.org/10.1300/j092v13n01_03","is_oa":false,"landing_page_url":"https://doi.org/10.1300/j092v13n01_03","pdf_url":null,"source":{"id":"https://openalex.org/S202174029","display_name":"Journal of Chronic Fatigue Syndrome","issn_l":"1057-3321","issn":["1057-3321","1547-0660"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chronic Fatigue Syndrome","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W61113570","https://openalex.org/W1538919177","https://openalex.org/W2029139790","https://openalex.org/W2039706959","https://openalex.org/W2052784041","https://openalex.org/W2062979773","https://openalex.org/W2073780967","https://openalex.org/W2098287790","https://openalex.org/W2108984301","https://openalex.org/W2117739653","https://openalex.org/W2145991000","https://openalex.org/W2149374445","https://openalex.org/W2150264985","https://openalex.org/W2153707102","https://openalex.org/W2210652714"],"related_works":["https://openalex.org/W2503816092","https://openalex.org/W2185519652","https://openalex.org/W1485337293","https://openalex.org/W2164136802","https://openalex.org/W2911398575","https://openalex.org/W2099981377","https://openalex.org/W1974271005","https://openalex.org/W7126283933","https://openalex.org/W4317926690","https://openalex.org/W154273314"],"abstract_inverted_index":{"Background:":[0],"Unexplained":[1],"prolonged":[2],"fatigue":[3,127,149,217],"(UPF)":[4],"is":[5,16,44,99,106,111],"one":[6],"of":[7,21,58,65,73,97,102,118,132,186,226,233],"the":[8,39,71,82,87,93,115,122,156,167,184,203,234],"most":[9,123],"common":[10],"complaints":[11],"in":[12,201,215],"primary":[13,88],"care.":[14],"UPF":[15,28,66,98,119,227],"difficult":[17],"to":[18,68,91],"manage":[19],"because":[20],"its":[22],"nonspecific":[23],"nature":[24],"and":[25,34,49,67,154,170,174,189,194,196,206,223,239],"unknown":[26],"mechanism.":[27],"frequently":[29],"frustrates":[30],"health":[31],"care":[32],"professionals":[33],"has":[35],"negative":[36],"impacts":[37],"on":[38],"physician-patient":[40],"relationship.":[41],"Although":[42],"it":[43],"nonfatal,":[45],"fatigue-associated":[46],"functional":[47],"impairments":[48],"economic":[50],"consequences":[51,225],"are":[52,145,162,179,199,245],"substantial,":[53],"negatively":[54],"impacting":[55],"patients'":[56],"quality":[57],"life.Objectives:":[59],"To":[60],"evaluate":[61],"current":[62,168],"knowledge":[63],"development":[64],"help":[69],"focus":[70],"direction":[72],"future":[74],"investigations.Methods:":[75],"A":[76],"literature":[77],"review":[78],"was":[79],"undertaken":[80],"with":[81,138,183],"MEDLINE":[83],"databases":[84],"chosen":[85],"as":[86,150],"electronic":[89],"resources":[90],"retrieve":[92],"literature.Results:":[94],"Current":[95],"understanding":[96],"limited.":[100],"Lack":[101],"consistent":[103],"scientific":[104],"language":[105],"a":[107,151,240],"major":[108],"problem.":[109],"There":[110],"no":[112],"consensus":[113],"about":[114,147],"case":[116],"definition":[117],"even":[120],"for":[121,242],"widely":[124],"studied":[125],"chronic":[126],"syndrome":[128],"(CFS).":[129],"Various":[130],"sets":[131],"classification":[133],"have":[134],"been":[135],"developed,":[136],"each":[137],"similar":[139],"but":[140,212],"not":[141,180],"identical":[142],"criteria.":[143,158],"Clinicians":[144],"dubious":[146],"perceiving":[148],"clinical":[152],"entity":[153],"ignore":[155],"diagnosis":[157],"Many":[159],"more":[160,229],"patients":[161],"excluded":[163],"than":[164],"included":[165],"from":[166],"classifications":[169],"lack":[171],"appropriate":[172],"evaluation":[173],"treatment.":[175],"The":[176,219],"predisposing":[177],"factors":[178,208],"well":[181],"established":[182],"exception":[185],"being":[187],"female":[188],"relatively":[190],"young.":[191],"Laboratory":[192],"testing":[193],"immune":[195],"endocrine":[197],"abnormalities":[198],"inconsistent":[200],"determining":[202],"causes.":[204],"Psychological":[205],"social":[207],"play":[209],"an":[210],"important":[211],"inconclusive":[213],"role":[214],"mediating":[216],"status.Conclusions:":[218],"high":[220],"prevalence,":[221],"persistence,":[222],"disability-associated":[224],"warrant":[228],"attention.":[230],"Further":[231],"investigations":[232],"symptoms,":[235],"psychosocial-based":[236],"symptom":[237],"experiences,":[238],"search":[241],"effective":[243],"management":[244],"needed.":[246]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}