{"id":"https://openalex.org/W2084752736","doi":"https://doi.org/10.1097/00054725-200401000-00001","title":"Regulation of Gene Expression in Inflammatory Bowel Disease and Correlation with IBD Drugs: Screening by DNA Microarrays","display_name":"Regulation of Gene Expression in Inflammatory Bowel Disease and Correlation with IBD Drugs: Screening by DNA Microarrays","publication_year":2003,"publication_date":"2003-12-15","ids":{"openalex":"https://openalex.org/W2084752736","doi":"https://doi.org/10.1097/00054725-200401000-00001","mag":"2084752736","pmid":"https://pubmed.ncbi.nlm.nih.gov/15058520"},"language":"en","primary_location":{"id":"doi:10.1097/00054725-200401000-00001","doi":"https://doi.org/10.1097/00054725-200401000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00054725-200401000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004674117","display_name":"Thomas P. Dooley","orcid":"https://orcid.org/0000-0002-3057-4756","observed_orcids":["https://orcid.org/0000-0002-3057-4756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas P. Dooley","raw_affiliation_strings":["IntegriDerm Inc., Birmingham, Alabama 35211, USA. dooley@integiderm.com","IntegriDerm Inc., Birmingham Alabama, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IntegriDerm Inc., Birmingham, Alabama 35211, USA. dooley@integiderm.com","institution_ids":[]},{"raw_affiliation_string":"IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030918526","display_name":"Ernest V. Curto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernest V. Curto","raw_affiliation_strings":["From IntegriDerm Inc., Birmingham Alabama, U.S.A","IntegriDerm Inc., Birmingham Alabama, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]},{"raw_affiliation_string":"IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109323081","display_name":"Shanker P. Reddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanker P. Reddy","raw_affiliation_strings":["From IntegriDerm Inc., Birmingham Alabama, U.S.A","IntegriDerm Inc., Birmingham Alabama, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]},{"raw_affiliation_string":"IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard L. Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard L. Davis","raw_affiliation_strings":["From IntegriDerm Inc., Birmingham Alabama, U.S.A","IntegriDerm Inc., Birmingham Alabama, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]},{"raw_affiliation_string":"IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035468246","display_name":"Glenna W. Lambert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenna W. Lambert","raw_affiliation_strings":["From IntegriDerm Inc., Birmingham Alabama, U.S.A","IntegriDerm Inc., Birmingham Alabama, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]},{"raw_affiliation_string":"IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072622157","display_name":"Teresa W. Wilborn","orcid":"https://orcid.org/0000-0003-4835-4951","observed_orcids":["https://orcid.org/0000-0003-4835-4951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa W. Wilborn","raw_affiliation_strings":["From IntegriDerm Inc., Birmingham Alabama, U.S.A","IntegriDerm Inc., Birmingham Alabama, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]},{"raw_affiliation_string":"IntegriDerm Inc., Birmingham Alabama, U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016132909","display_name":"Charles O. Elson","orcid":"https://orcid.org/0000-0001-8873-1534","observed_orcids":["https://orcid.org/0000-0001-8873-1534"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles O. Elson","raw_affiliation_strings":["Gastroenterology and Hepatology, University of Alabama at Birmingham School of Medicine, Birmingham Alabama, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Hepatology, University of Alabama at Birmingham School of Medicine, Birmingham Alabama, U.S.A","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3862,"currency":"USD","value_usd":3862},"apc_paid":null,"fwci":3.7286,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.93014508,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9700000286102295},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7584309577941895},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.7328575849533081},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7233458757400513},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5932937860488892},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4867143929004669},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45354264974594116},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4480031430721283},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44354817271232605},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4251415729522705},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4072641134262085},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39809197187423706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3755257725715637},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33726489543914795},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.265234112739563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24065381288528442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07594531774520874}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00054725-200401000-00001","doi":"https://doi.org/10.1097/00054725-200401000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00054725-200401000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},{"id":"pmid:15058520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15058520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory bowel diseases","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3191419845","display_name":"SULFOTRANSFERASE EXPRESSION IN EPITHELIA AND CARCINOMAS","funder_award_id":"R01GM061399","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7743525561","display_name":"DNA Microarray for Gastroenterology Research","funder_award_id":"R43DK060290","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1522580416","https://openalex.org/W1565683301","https://openalex.org/W1642457845","https://openalex.org/W1670573097","https://openalex.org/W1963967547","https://openalex.org/W1977750903","https://openalex.org/W1978270674","https://openalex.org/W2000074410","https://openalex.org/W2000842925","https://openalex.org/W2009187729","https://openalex.org/W2015904374","https://openalex.org/W2021446933","https://openalex.org/W2029841402","https://openalex.org/W2036805379","https://openalex.org/W2037685537","https://openalex.org/W2043658624","https://openalex.org/W2054990195","https://openalex.org/W2076445114","https://openalex.org/W2078781304","https://openalex.org/W2118203814","https://openalex.org/W2128791737","https://openalex.org/W2129199356","https://openalex.org/W2133410753","https://openalex.org/W2139631902","https://openalex.org/W2145330633","https://openalex.org/W2169170236","https://openalex.org/W2232026888","https://openalex.org/W2291431313","https://openalex.org/W2435483321"],"related_works":["https://openalex.org/W566648924","https://openalex.org/W2100273400","https://openalex.org/W2981125949","https://openalex.org/W2077219920","https://openalex.org/W2005983819","https://openalex.org/W2060231484","https://openalex.org/W2761976365","https://openalex.org/W4376254297","https://openalex.org/W2187384145","https://openalex.org/W2616096611"],"abstract_inverted_index":{"Potential":[0,87],"biomarkers":[1,88,161],"for":[2,81,89,103,162,225],"Crohn's":[3],"disease":[4,61,196],"(CD)":[5],"and":[6,22,51,65,84,114,134,169,185,230],"ulcerative":[7],"colitis":[8],"(UC)":[9],"were":[10,39,116,179],"identified":[11,118],"from":[12,119],"two":[13],"sets":[14],"of":[15,35,195,228],"full":[16],"thickness":[17],"pathologic":[18],"samples":[19,64,184,198],"utilizing":[20],"DermArray":[21],"PharmArray":[23],"DNA":[24],"microarrays":[25],"relative":[26],"to":[27,74,127],"uninvolved":[28],"(Un)":[29],"colon":[30],"or":[31,188,214],"normal":[32],"colon.":[33],"Seven":[34],"the":[36,139],"over-expressed":[37],"genes":[38,80],"verified":[40],"using":[41],"quantitative":[42],"RT-PCR":[43],"(i.e.,":[44],"TMPT,":[45],"FABP1,":[46],"IFI27,":[47],"LCN2,":[48],"COL11A2,":[49],"HXB,":[50],"metallothionein).":[52],"By":[53],"correlating":[54],"gene":[55,176],"expression":[56,124],"profiles":[57],"between":[58,182],"inflammatory":[59],"bowel":[60],"(IBD)":[62],"tissue":[63,197],"IBD":[66,82,183,229],"drug-treated":[67,202],"cell":[68,91,203],"cultures":[69,204],"it":[70],"might":[71,159,172,207],"be":[72,128,160],"possible":[73],"identify":[75],"new":[76,152,209],"candidate":[77],"molecular":[78],"target":[79],"therapy":[83,164],"drug":[85,216],"discovery.":[86],"CaCo2":[90,132,191],"cultures,":[92],"which":[93],"are":[94],"routinely":[95],"used":[96],"as":[97],"a":[98],"GI":[99],"tract":[100],"surrogate":[101],"model":[102],"in":[104,130,138,144,165,167,199,205,220],"vitro":[105,206,221],"pharmacokinetic":[106],"studies,":[107],"treated":[108],"with":[109],"azathioprine,":[110],"5-aminosalicylic":[111,189],"acid,":[112],"metronidazole,":[113],"prednisone":[115],"also":[117,180],"another":[120],"experiment.":[121],"Metallothionein":[122],"mRNA":[123],"was":[125,135],"found":[126],"down-regulated":[129],"azathioprine-treated":[131],"cells,":[133],"coincidentally":[136],"up-regulated":[137],"CD":[140],"sample,":[141],"thus":[142],"resulting":[143],"an":[145],"anti-correlation.":[146],"These":[147],"results":[148],"suggest":[149],"that":[150,157,170],"this":[151],"screening":[153],"methodology":[154,222],"is":[155,223],"feasible,":[156],"metallothioneins":[158],"azathioprine":[163,171],"vivo":[166,200],"CD,":[168],"mechanistically":[173],"down-regulate":[174],"metallothionein":[175],"expression.":[177],"Correlations":[178],"observed":[181],"either":[186],"metronidazole-":[187],"acid-treated":[190],"cells.":[192],"Similar":[193],"comparisons":[194],"vs":[201],"reveal":[208],"mechanistic":[210],"insights":[211],"concerning":[212],"established":[213],"experimental":[215],"therapies.":[217],"This":[218],"affordable":[219],"promising":[224],"expanded":[226],"studies":[227],"other":[231],"diseases.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}