{"id":"https://openalex.org/W2084718186","doi":"https://doi.org/10.1117/12.469353","title":"Clinical studies of photodynamic therapy for malignant brain tumors: Karnofsky score and neurological score in patients with recurrent gloms treated with Photofrin PDT","display_name":"Clinical studies of photodynamic therapy for malignant brain tumors: Karnofsky score and neurological score in patients with recurrent gloms treated with Photofrin PDT","publication_year":2002,"publication_date":"2002-06-06","ids":{"openalex":"https://openalex.org/W2084718186","doi":"https://doi.org/10.1117/12.469353","mag":"2084718186"},"language":"en","primary_location":{"id":"doi:10.1117/12.469353","doi":"https://doi.org/10.1117/12.469353","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.469353","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068019570","display_name":"Paul J. M\u00fcller","orcid":"https://orcid.org/0000-0002-3804-9630","observed_orcids":["https://orcid.org/0000-0002-3804-9630"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paul J. Muller","raw_affiliation_strings":["St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080602355","display_name":"Brian C. Wilson","orcid":"https://orcid.org/0000-0001-5543-666X","observed_orcids":["https://orcid.org/0000-0001-5543-666X"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brian C. Wilson","raw_affiliation_strings":["St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014618519","display_name":"Lothar D. Lilge","orcid":"https://orcid.org/0000-0001-5533-0005","observed_orcids":["https://orcid.org/0000-0001-5533-0005"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lothar D. Lilge","raw_affiliation_strings":["St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071954573","display_name":"Victor X. D. Yang","orcid":"https://orcid.org/0000-0002-1166-8271","observed_orcids":["https://orcid.org/0000-0002-1166-8271"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Victor X. Yang","raw_affiliation_strings":["St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070886832","display_name":"Abhay K. Varma","orcid":"https://orcid.org/0000-0001-5481-004X","observed_orcids":["https://orcid.org/0000-0001-5481-004X"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Abhay Varma","raw_affiliation_strings":["St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083069028","display_name":"Arjen Bogaards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Arjen Bogaards","raw_affiliation_strings":["St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Michael's Hospital and Princess Margaret Hospital/Univ. of Toronto (Canada)","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035760028","display_name":"Fred W. Hetzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred W. Hetzel","raw_affiliation_strings":["Swedish Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Ctr. (United States)","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336659","display_name":"Qun Chen","orcid":"https://orcid.org/0000-0001-5159-8100","observed_orcids":["https://orcid.org/0000-0001-5159-8100"]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qun Chen","raw_affiliation_strings":["Swedish Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Ctr. (United States)","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027161588","display_name":"Tim Fullagar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim Fullagar","raw_affiliation_strings":["Swedish Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Ctr. (United States)","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053202206","display_name":"Robert Alan Fenstermaker","orcid":"https://orcid.org/0000-0003-0309-8130","observed_orcids":["https://orcid.org/0000-0003-0309-8130"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Fenstermaker","raw_affiliation_strings":["Roswell Park Cancer Institute (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute (United States)","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028078923","display_name":"Robert G. Selker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799629232","display_name":"Western Pennsylvania Hospital","ror":"https://ror.org/02yhx1447","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799629232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Selker","raw_affiliation_strings":["Western Pennsylvania Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Pennsylvania Hospital (United States)","institution_ids":["https://openalex.org/I2799629232"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016774003","display_name":"Judith Abrams","orcid":"https://orcid.org/0000-0001-9171-6458","observed_orcids":["https://orcid.org/0000-0001-9171-6458"]},"institutions":[{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Abrams","raw_affiliation_strings":["Karmanos Cancer Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karmanos Cancer Ctr. (United States)","institution_ids":["https://openalex.org/I4210090317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8256,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.88801453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4612","issue":null,"first_page":"40","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.08060000091791153,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.7590000033378601},{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/photofrin","display_name":"Photofrin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/karnofsky-performance-status","display_name":"Karnofsky performance status","score":0.7749999761581421},{"id":"https://openalex.org/keywords/neurological-function","display_name":"neurological function","score":0.7670000195503235},{"id":"https://openalex.org/keywords/light-dose","display_name":"light dose","score":0.5979999899864197},{"id":"https://openalex.org/keywords/astrocytic-tumors","display_name":"astrocytic tumors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.460999995470047},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.48399999737739563},{"id":"https://openalex.org/keywords/visual-field","display_name":"visual field","score":0.5239999890327454},{"id":"https://openalex.org/keywords/speech-function","display_name":"speech function","score":0.6850000023841858},{"id":"https://openalex.org/keywords/gait","display_name":"gait","score":0.6850000023841858},{"id":"https://openalex.org/keywords/postoperative-mortality","display_name":"postoperative mortality","score":0.460999995470047},{"id":"https://openalex.org/keywords/newly-diagnosed-glioma","display_name":"newly diagnosed glioma","score":0.6859999895095825},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8667938709259033},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7886618375778198},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.6029199361801147},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5167638659477234},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5123437643051147},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.46786049008369446},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.469353","doi":"https://doi.org/10.1117/12.469353","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.469353","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W40813847","https://openalex.org/W1748218710","https://openalex.org/W1968143941","https://openalex.org/W1985110931","https://openalex.org/W1994460634","https://openalex.org/W2002956495","https://openalex.org/W2010304397","https://openalex.org/W2012104150","https://openalex.org/W2032090704","https://openalex.org/W2036560693","https://openalex.org/W2040243935","https://openalex.org/W2042172629","https://openalex.org/W2073224867","https://openalex.org/W2113012900","https://openalex.org/W2117322456","https://openalex.org/W2405318500","https://openalex.org/W2419034284","https://openalex.org/W2896024265"],"related_works":["https://openalex.org/W2027844255","https://openalex.org/W1980073077","https://openalex.org/W2090876421","https://openalex.org/W4234803579","https://openalex.org/W2042172629","https://openalex.org/W2349414290","https://openalex.org/W1489278279","https://openalex.org/W2589621250","https://openalex.org/W2118342895","https://openalex.org/W1982303278"],"abstract_inverted_index":{"In":[0,50,159],"our":[1,382],"previous":[2,383],"phase":[3],"II":[4],"studies":[5,393],"we":[6,164],"treated":[7],"112":[8],"patients":[9,29,52,101,130,139,206,296],"with":[10,14,30,102,131,207,373],"malignant":[11,36,105,133,149],"brain":[12,386],"tumors":[13],"2-mg/kg":[15],"Photofrin":[16],"i.v.":[17],"and":[18,41,108,152,169,183,216,222,237,282,325,333],"intra-operative":[19],"cavitary":[20],"PDT.":[21],"We":[22,73],"concluded":[23],"that":[24,385],"PDT":[25,89,117,126,388],"was":[26,58,67,235,264,268,340,358,389],"safe":[27],"in":[28,129,202,230,254,271,279,289,305,319,345,355,361,396],"newly":[31,103,147],"diagnosed":[32,104,148],"or":[33],"recurrent":[34,132,156,161,208,363],"supratentorial":[35],"gliomas.":[37],"Pathology,":[38],"performance":[39],"grade":[40],"light":[42,56,115,124],"dose":[43,57,116,125],"were":[44,194,210,219,316,329],"significantly":[45],"related":[46],"to":[47,83,90,111,122,145,154,185,249],"survival":[48,60,99],"time.":[49],"selected":[51],"when":[53],"an":[54],"adequate":[55],"used":[59],"time":[61],"improved.":[62],"The":[63,192,200,212,227,242,251,314,391],"surgical":[64],"mortality":[65],"rate":[66],"less":[68],"than":[69,286],"3%.":[70],"[spie":[71],"2000]":[72],"have":[74,140],"initiated":[75],"two":[76],"randomized":[77],"prospective":[78,378],"trials":[79],"-":[80,143],"the":[81,86,98,109,146,155,160,166,172,186,323,346],"first,":[82],"determine":[84,112],"if":[85],"addition":[87],"of":[88,100,171,204,238,261,276,293,301,322,370],"standard":[91],"therapy":[92],"[surgery,":[93],"radiation":[94],"and/or":[95],"chemotherapy]":[96],"prolongs":[97],"astrocytic":[106,134],"tumors;":[107],"second,":[110],"whether":[113],"high":[114],"[120":[118],"J/cm2]":[119,128],"is":[120],"superior":[121],"low":[123],"[40":[127],"tumors.":[135],"To":[136],"date,":[137],"158":[138],"been":[141],"recruited":[142],"72":[144],"glioma":[150,157,162],"study":[151,163],"86":[153,203],"study.":[158],"compared":[165,195,334],"pre-operative":[167],"KS":[168,201,218,252],"elements":[170],"neurological":[173,327,347],"examination":[174,182,328],"[speech":[175],"function,":[176,180],"visual":[177],"fields,":[178],"cognitive":[179],"sensory":[181],"gait]":[184],"post-operative":[187,217,258],"examinations":[188],"at":[189],"hospital":[190,367],"discharge.":[191],"means":[193],"by":[196,284,335,398,403],"paired":[197,337],"student-t":[198],"test.":[199],"88":[205],"gliomas":[209],"assessable.":[211],"mean":[213,228],"[s.d.]":[214],"preoperative":[215,312,324],"82+/-":[220],"14":[221],"79+/-":[223],"17,":[224],"respectively":[225],"[p=0.003].":[226],"decline":[229,275,300,354],"KS,":[231],"although":[232],"statistically":[233,342,352],"significant,":[234],"small":[236,350],"no":[239,269],"clinical":[240,379,392],"importance.":[241],"median":[243],"Karnofsky":[244,356,375],"score":[245,332,357],"changed":[246],"from":[247],"90":[248],"80.":[250],"improved":[253,304],"8":[255],"patients;":[256],"their":[257,311],"average":[259,368],"length":[260,369],"stay":[262,371],"(alos)":[263],"=9.7":[265],"days.":[266],"There":[267,339],"change":[270],"47":[272],"[alos=8.3],":[273],"a":[274,299,331,336,341],"10":[277,287],"points":[278,288,303],"24":[280],"[aloc=13.4]":[281],"declined":[283],"more":[285],"7":[290,295],"[alos=23.3].":[291],"Three":[292],"these":[294,362],"who":[297],"had":[298],">10":[302],"follow-up":[306],"but":[307,351],"did":[308],"not":[309,317],"reach":[310],"KS.":[313],"data":[315],"available":[318],"2.":[320],"Elements":[321],"discharge":[326],"assigned":[330],"t-test.":[338],"insignificant":[343],"improvement":[344],"score.":[348,376],"A":[349],"significant":[353],"identified":[359],"post-operatively":[360],"tumor":[364,387],"patients.":[365],"Their":[366],"increased":[372],"declining":[374],"These":[377],"observations":[380],"confirmed":[381],"conclusion":[384],"safe.":[390],"are":[394],"supported":[395],"part":[397],"grant":[399],"CA":[400],"43892":[401],"awarded":[402],"DHHS/NIH/NCI.":[404]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}