{"id":"https://openalex.org/W2084715465","doi":"https://doi.org/10.2165/00003088-199630050-00004","title":"Clinical Pharmacokinetics of Molsidomine","display_name":"Clinical Pharmacokinetics of Molsidomine","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2084715465","doi":"https://doi.org/10.2165/00003088-199630050-00004","mag":"2084715465","pmid":"https://pubmed.ncbi.nlm.nih.gov/8743336"},"language":"en","primary_location":{"id":"doi:10.2165/00003088-199630050-00004","doi":"https://doi.org/10.2165/00003088-199630050-00004","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00003088-199630050-00004","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058578660","display_name":"Bernd Rosenkranz","orcid":"https://orcid.org/0000-0002-9867-8826","observed_orcids":["https://orcid.org/0000-0002-9867-8826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernd Rosenkranz","raw_affiliation_strings":["Hoechst AG, Frankfurt am Main, Germany","Clinical Research, Hoechst AG, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoechst AG, Frankfurt am Main, Germany","institution_ids":[]},{"raw_affiliation_string":"Clinical Research, Hoechst AG, Frankfurt am Main, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110026750","display_name":"Bernhard Rudolf Winkelmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernhard R. Winkelmann","raw_affiliation_strings":["Clinical Research, Hoechst AG, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research, Hoechst AG, Frankfurt am Main, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017526919","display_name":"Michael John Parnham","orcid":"https://orcid.org/0000-0002-7098-8451","observed_orcids":["https://orcid.org/0000-0002-7098-8451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Parnham","raw_affiliation_strings":["Bonn and Institute of Pharmacology for Life Scientists, PAS, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bonn and Institute of Pharmacology for Life Scientists, PAS, Frankfurt am Main, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":2.2968,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.86346587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"30","issue":"5","first_page":"372","last_page":"384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.06840000301599503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molsidomine","display_name":"molsidomine","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sin-1","display_name":"SIN-1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/nitric-oxide-prodrug","display_name":"nitric oxide prodrug","score":0.8190000057220459},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9190000295639038},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8320000171661377},{"id":"https://openalex.org/keywords/first-pass-metabolism","display_name":"first-pass metabolism","score":0.6800000071525574},{"id":"https://openalex.org/keywords/hepatic-clearance","display_name":"hepatic clearance","score":0.5720000267028809},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.5019999742507935},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.6690000295639038},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9860000014305115},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/angina","display_name":"angina pectoris","score":0.921999990940094},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5070000290870667},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.49300000071525574},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5730000138282776},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.40299999713897705},{"id":"https://openalex.org/keywords/vasodilators","display_name":"vasodilators","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2780773033","wikidata":"https://www.wikidata.org/wiki/Q408132","display_name":"Molsidomine","level":3,"score":0.8344202041625977},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6783831119537354},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.60652756690979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.556525707244873},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5069146752357483},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4556853771209717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28374749422073364},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008981","descriptor_name":"Molsidomine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008981","descriptor_name":"Molsidomine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2165/00003088-199630050-00004","doi":"https://doi.org/10.2165/00003088-199630050-00004","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00003088-199630050-00004","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},{"id":"pmid:8743336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8743336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacokinetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1983914778","https://openalex.org/W1986899686","https://openalex.org/W1997299907","https://openalex.org/W2007737411","https://openalex.org/W2007833655","https://openalex.org/W2009841863","https://openalex.org/W2011390424","https://openalex.org/W2031631012","https://openalex.org/W2040852689","https://openalex.org/W2043242169","https://openalex.org/W2053916409","https://openalex.org/W2059821606","https://openalex.org/W2068721639","https://openalex.org/W2080040682","https://openalex.org/W2092145002","https://openalex.org/W2118910022","https://openalex.org/W2143286554","https://openalex.org/W2145388082","https://openalex.org/W2276584107","https://openalex.org/W2311802513","https://openalex.org/W2329131996","https://openalex.org/W2396377173","https://openalex.org/W2411609753","https://openalex.org/W2416051622","https://openalex.org/W2416257392","https://openalex.org/W2438075260","https://openalex.org/W2473707841"],"related_works":["https://openalex.org/W2045168984","https://openalex.org/W33133350","https://openalex.org/W2066967967","https://openalex.org/W2009841863","https://openalex.org/W2118910022","https://openalex.org/W2145388082","https://openalex.org/W2311802513","https://openalex.org/W2276584107","https://openalex.org/W7074210016","https://openalex.org/W124549987"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}