{"id":"https://openalex.org/W2084701385","doi":"https://doi.org/10.1111/j.1349-7006.1998.tb03288.x","title":"Chemoprevention of N\u2010Nitroso\u2010N\u2010methylurea\u2010induced Rat Mammary Cancer by Miso and Tamoxifen, Alone and in Combination","display_name":"Chemoprevention of N\u2010Nitroso\u2010N\u2010methylurea\u2010induced Rat Mammary Cancer by Miso and Tamoxifen, Alone and in Combination","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2084701385","doi":"https://doi.org/10.1111/j.1349-7006.1998.tb03288.x","mag":"2084701385","pmid":"https://pubmed.ncbi.nlm.nih.gov/9685851","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5921843"},"language":"en","primary_location":{"id":"doi:10.1111/j.1349-7006.1998.tb03288.x","doi":"https://doi.org/10.1111/j.1349-7006.1998.tb03288.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1998.tb03288.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.1998.tb03288.x","source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.1998.tb03288.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103692436","display_name":"Takahiko Gotoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405287266","display_name":"Research Institute for Radiation Biology and Medicine, Hiroshima University","ror":"https://ror.org/04mfv5z87","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiko Gotoh","raw_affiliation_strings":["Department of Cancer Research, Hiroshima University","Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University","Department of Surgery, Gotoh Hospital, 1-8-20 Higashi-chuo, Kure, Hiroshima 737-0052"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Hiroshima University","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]},{"raw_affiliation_string":"Department of Surgery, Gotoh Hospital, 1-8-20 Higashi-chuo, Kure, Hiroshima 737-0052","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043155011","display_name":"Kazumasa Yamada","orcid":"https://orcid.org/0000-0002-7884-9050","observed_orcids":["https://orcid.org/0000-0002-7884-9050","https://orcid.org/0009-0009-5406-6981"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405287266","display_name":"Research Institute for Radiation Biology and Medicine, Hiroshima University","ror":"https://ror.org/04mfv5z87","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumasa Yamada","raw_affiliation_strings":["Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020597801","display_name":"Akihiro Ito","orcid":"https://orcid.org/0000-0001-7224-1100","observed_orcids":["https://orcid.org/0000-0001-7224-1100"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405287266","display_name":"Research Institute for Radiation Biology and Medicine, Hiroshima University","ror":"https://ror.org/04mfv5z87","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akihiro Ito","raw_affiliation_strings":["Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101514349","display_name":"Hong Xia Yin","orcid":"https://orcid.org/0000-0003-4518-4635","observed_orcids":["https://orcid.org/0000-0003-4518-4635"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405287266","display_name":"Research Institute for Radiation Biology and Medicine, Hiroshima University","ror":"https://ror.org/04mfv5z87","country_code":"JP","type":"facility","lineage":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hong Yin","raw_affiliation_strings":["Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405287266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000204553","display_name":"Tsuyoshi Kataoka","orcid":"https://orcid.org/0000-0002-7687-4121","observed_orcids":["https://orcid.org/0000-0002-7687-4121"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Kataoka","raw_affiliation_strings":["Second Department of Surgery, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112656456","display_name":"Kiyohiko Dohi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyohiko Dohi","raw_affiliation_strings":["Second Department of Surgery, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020597801"],"corresponding_institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405287266"],"apc_list":null,"apc_paid":null,"fwci":2.9587,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.90941413,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"89","issue":"5","first_page":"487","last_page":"495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.20720000565052032,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.05689999833703041,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/miso","display_name":"miso","score":0.890999972820282},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/n-nitroso-n-methylurea","display_name":"N-nitroso-N-methylurea","score":0.9269999861717224},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fermented-soybean","display_name":"fermented soybean","score":0.8230000138282776},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-multiplicity","display_name":"tumor multiplicity","score":0.6650000214576721},{"id":"https://openalex.org/keywords/tumor-shrinkage","display_name":"tumor shrinkage","score":0.6669999957084656},{"id":"https://openalex.org/keywords/rat-mammary-tumors","display_name":"rat mammary tumors","score":0.625}],"concepts":[{"id":"https://openalex.org/C2776067312","wikidata":"https://www.wikidata.org/wiki/Q50429983","display_name":"Antiestrogen","level":5,"score":0.6869052052497864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6623943448066711},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.6479498147964478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.552882969379425},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5410981774330139},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.5156387090682983},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.5016322135925293},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3984679579734802},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3126367926597595}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008770","descriptor_name":"Methylnitrosourea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013025","descriptor_name":"Glycine max","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1349-7006.1998.tb03288.x","doi":"https://doi.org/10.1111/j.1349-7006.1998.tb03288.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1998.tb03288.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.1998.tb03288.x","source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4864500","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5921843","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5921843","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5921843","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jpn J Cancer Res","raw_type":"Text"},{"id":"pmid:9685851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9685851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1349-7006.1998.tb03288.x","doi":"https://doi.org/10.1111/j.1349-7006.1998.tb03288.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1998.tb03288.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.1998.tb03288.x","source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6735000014305115}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2084701385.pdf"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1232084907","https://openalex.org/W1576830910","https://openalex.org/W1581174886","https://openalex.org/W1656644300","https://openalex.org/W1752892371","https://openalex.org/W1810933484","https://openalex.org/W1850198354","https://openalex.org/W1917273054","https://openalex.org/W1954528307","https://openalex.org/W1959428162","https://openalex.org/W1984036546","https://openalex.org/W1985403541","https://openalex.org/W1985831869","https://openalex.org/W1986570252","https://openalex.org/W1989073112","https://openalex.org/W1997756416","https://openalex.org/W1998732486","https://openalex.org/W1998890155","https://openalex.org/W2000106013","https://openalex.org/W2001163687","https://openalex.org/W2008972850","https://openalex.org/W2011308345","https://openalex.org/W2012197470","https://openalex.org/W2014646550","https://openalex.org/W2016386722","https://openalex.org/W2021892056","https://openalex.org/W2025807806","https://openalex.org/W2035982626","https://openalex.org/W2047456504","https://openalex.org/W2054432873","https://openalex.org/W2059886775","https://openalex.org/W2063947339","https://openalex.org/W2069701115","https://openalex.org/W2083922824","https://openalex.org/W2086158585","https://openalex.org/W2087530999","https://openalex.org/W2094218531","https://openalex.org/W2098640833","https://openalex.org/W2112834309","https://openalex.org/W2119772691","https://openalex.org/W2133028092","https://openalex.org/W2137741674","https://openalex.org/W2151432955","https://openalex.org/W2155800082","https://openalex.org/W2165099479","https://openalex.org/W2168414916","https://openalex.org/W2170845683","https://openalex.org/W2271524825","https://openalex.org/W2323539697","https://openalex.org/W2342010475","https://openalex.org/W2399911188","https://openalex.org/W2406317904","https://openalex.org/W2409367583","https://openalex.org/W2411447623","https://openalex.org/W3020816940","https://openalex.org/W4407364781","https://openalex.org/W6640026979"],"related_works":["https://openalex.org/W2025807806","https://openalex.org/W1999310308","https://openalex.org/W2071848515","https://openalex.org/W2473906936","https://openalex.org/W3041616778","https://openalex.org/W2078006490","https://openalex.org/W2165099479","https://openalex.org/W1973497823","https://openalex.org/W2290511833","https://openalex.org/W2070061206"],"abstract_inverted_index":{"We":[0],"examined":[1],"the":[2,43,71,79,114,123,133,149,156,159,162,176,187,211,215,220,230,239,245,258],"effects":[3],"of":[4,37,41,73,98,106,161,164,213,229,236,238,247],"a":[5,29,234,290],"Japanese":[6],"fermented":[7],"soybean":[8],"product,":[9],"miso,":[10],"and":[11,15,60,102,111,117,128,136,143,166,201,222,227,249,251,260,266,283],"tamoxifen":[12],"(TAM),":[13],"alone":[14],"in":[16,70,113,122,132,148,219,278,297],"combination,":[17],"on":[18,168],"N-nitroso-N-methylurea":[19],"(MNU)-induced":[20],"rat":[21,170],"mammary":[22,107,171,177,281],"cancer.":[23],"Seven-week-old":[24],"female":[25],"CD/Crj":[26],"rats":[27,44,87,99,188],"received":[28],"single":[30],"i.v.":[31],"dose":[32],"(50":[33],"mg/kg":[34],"body":[35],"weight)":[36],"MNU.":[38],"After":[39],"administration":[40],"MNU,":[42],"were":[45,88,109,189],"divided":[46,190],"into":[47,191],"4":[48],"groups:":[49,194],"regular":[50,56,195,197],"diet":[51,57,63,198,204],"(control),":[52],"10%":[53,61,124,137,150,202],"miso":[54,62,125,151,165,203,248,275],"diet,":[55,196],"+":[58,64,152,199,205],"TAM,":[59,200,250],"TAM.":[65,206,300],"TAM":[66,134,153,167,223,261],"was":[67,84,173,225,242,253],"implanted":[68],"s.c.":[69],"form":[72],"pellets":[74],"containing":[75],"2.5":[76],"mg":[77],"at":[78],"same":[80],"time":[81],"as":[82],"MNU":[83,94,181],"administered.":[85],"All":[86],"observed":[89],"for":[90],"18":[91],"weeks":[92,209],"after":[93,210],"administration.":[95],"Incidence":[96],"(percentage":[97],"with":[100,299],"tumors)":[101],"multiplicity":[103],"(mean":[104],"tumors/rat)":[105],"tumors":[108,172,178],"91%":[110],"4.5":[112],"control,":[115],"77%":[116],"2.4":[118],"(P":[119,130,138,145,263],"<":[120,139,146,264,268],"0.05)":[121],"group,":[126,135],"68%":[127],"1.4":[129],"<0.01)":[131],"0.0001":[140],"or":[141],"less)":[142],"0.2":[144],"0.0001)":[147],"group.":[154],"In":[155],"second":[157],"experiment,":[158],"effect":[160],"combination":[163,246,298],"established":[169],"investigated.":[174],"When":[175],"induced":[179],"by":[180,244],"reached":[182],"10":[183],"to":[184,288],"25":[185],"mm,":[186],"3":[192],"treatment":[193],"At":[207],"6":[208],"start":[212],"treatment,":[214],"mean":[216],"tumor":[217],"size":[218],"control":[221,259],"groups":[224,262],"160%":[226],"141%":[228],"pretreatment":[231,240],"value,":[232],"but":[233],"decrease":[235],"85%":[237],"value":[241],"produced":[243],"this":[252],"significantly":[254],"different":[255],"from":[256],"both":[257],"0.01)":[265],"P":[267],"0.05,":[269],"respectively).":[270],"These":[271],"results":[272],"indicate":[273],"that":[274],"is":[276],"useful":[277],"protecting":[279],"against":[280],"cancer":[282],"it":[284],"can":[285],"be":[286],"expected":[287],"have":[289],"potent":[291],"antitumor":[292],"effect,":[293],"especially":[294],"when":[295],"used":[296]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}