{"id":"https://openalex.org/W2084644792","doi":"https://doi.org/10.1016/0928-0987(95)00028-5","title":"Drug transport to the brain: comparison between in vitro and in vivo models of the blood-brain barrier","display_name":"Drug transport to the brain: comparison between in vitro and in vivo models of the blood-brain barrier","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2084644792","doi":"https://doi.org/10.1016/0928-0987(95)00028-5","mag":"2084644792"},"language":"en","primary_location":{"id":"doi:10.1016/0928-0987(95)00028-5","doi":"https://doi.org/10.1016/0928-0987(95)00028-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0928-0987(95)00028-5","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102978132","display_name":"Marie\u2010Pierre Dehouck","orcid":"https://orcid.org/0000-0002-9217-3202","observed_orcids":["https://orcid.org/0000-0002-9217-3202"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"M.P. Dehouck","raw_affiliation_strings":["U325 INSERM, Institut Pasteur, 1 rue Calmette, 59019 Lille Ce\u00b4dex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U325 INSERM, Institut Pasteur, 1 rue Calmette, 59019 Lille Ce\u00b4dex, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110001161","display_name":"B. Dehouck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4210098046","display_name":"Centre de Recherche Jean Pierre Aubert","ror":"https://ror.org/00x76wb44","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210098046"]},{"id":"https://openalex.org/I4387155073","display_name":"Lille Neurosciences & Cognition","ror":"https://ror.org/04p94ax69","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4387155073"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Dehouck","raw_affiliation_strings":["U325 INSERM, Institut Pasteur, 1 rue Calmette, 59019 Lille Ce\u00b4dex, France","Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U325 INSERM, Institut Pasteur, 1 rue Calmette, 59019 Lille Ce\u00b4dex, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573"]},{"raw_affiliation_string":"Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210098046","https://openalex.org/I4387155073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076241271","display_name":"C. Schluep","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891806","display_name":"Sandoz Group AG (Switzerland)","ror":"https://ror.org/02rse7p59","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4388891806"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"C. Schluep","raw_affiliation_strings":["Drug Safety Assessment, Sandoz Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Assessment, Sandoz Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I4388891806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018370030","display_name":"Michel Lemaire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891806","display_name":"Sandoz Group AG (Switzerland)","ror":"https://ror.org/02rse7p59","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4388891806"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Lemaire","raw_affiliation_strings":["Drug Safety Assessment, Sandoz Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Assessment, Sandoz Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I4388891806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109294156","display_name":"Rom\u00e9o Cecchelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R. Cecchelli","raw_affiliation_strings":["U325 INSERM, Institut Pasteur, 1 rue Calmette, 59019 Lille Ce\u00b4dex, France","Universite\u00b4de Lille I, 59650 Villeneuve d'Ascq Ce\u00b4dex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U325 INSERM, Institut Pasteur, 1 rue Calmette, 59019 Lille Ce\u00b4dex, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573"]},{"raw_affiliation_string":"Universite\u00b4de Lille I, 59650 Villeneuve d'Ascq Ce\u00b4dex, France","institution_ids":["https://openalex.org/I2279609970"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102978132"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573"],"apc_list":{"value":3070,"currency":"USD","value_usd":3070},"apc_paid":null,"fwci":1.3732,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.80882353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"3","issue":"6","first_page":"357","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drug-transport","display_name":"drug transport","score":0.8579999804496765},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/in-vitro-model","display_name":"in vitro model","score":0.5630000233650208},{"id":"https://openalex.org/keywords/extraction-ratio","display_name":"extraction ratio","score":0.6740000247955322},{"id":"https://openalex.org/keywords/permeability-coefficient","display_name":"permeability coefficient","score":0.9559999704360962},{"id":"https://openalex.org/keywords/lipid-solubility","display_name":"lipid solubility","score":0.9539999961853027},{"id":"https://openalex.org/keywords/forecasting-model-comparison","display_name":"forecasting model comparison","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8715020418167114},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7470213174819946},{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.7120928168296814},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.6222282648086548},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4738619327545166},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.42579177021980286},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41141754388809204},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32305383682250977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28079816699028015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2519732713699341},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15153545141220093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14084863662719727},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1282830536365509},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.07750195264816284},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/0928-0987(95)00028-5","doi":"https://doi.org/10.1016/0928-0987(95)00028-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0928-0987(95)00028-5","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:HAL:hal-00530648v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00530648","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Pharmaceutical Sciences, 1995, p. 357-365","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W48848062","https://openalex.org/W59744083","https://openalex.org/W1252895163","https://openalex.org/W1606372460","https://openalex.org/W1819219928","https://openalex.org/W1855437336","https://openalex.org/W1896856524","https://openalex.org/W1978518128","https://openalex.org/W1979409628","https://openalex.org/W1986402630","https://openalex.org/W2010868948","https://openalex.org/W2013456954","https://openalex.org/W2014795764","https://openalex.org/W2027568211","https://openalex.org/W2045304765","https://openalex.org/W2053557534","https://openalex.org/W2055137108","https://openalex.org/W2067223842","https://openalex.org/W2084595515","https://openalex.org/W2085322430","https://openalex.org/W2104698368","https://openalex.org/W2105301861","https://openalex.org/W2117697959","https://openalex.org/W2136372031","https://openalex.org/W2159464926","https://openalex.org/W2470246832"],"related_works":["https://openalex.org/W4241652298","https://openalex.org/W1896856524","https://openalex.org/W2009081910","https://openalex.org/W1581321319","https://openalex.org/W1988474837","https://openalex.org/W2085322430","https://openalex.org/W2042001901","https://openalex.org/W2063022473","https://openalex.org/W2088261937","https://openalex.org/W4231937766"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2016-06-24T00:00:00"}
