{"id":"https://openalex.org/W2084530852","doi":"https://doi.org/10.1210/jc.2009-2077","title":"Implication of Genetic Variants Near NEGR1 , SEC16B , TMEM18 , ETV5/DGKG , GNPDA2 , LIN7C/BDNF , MTCH2 , BCDIN3D/FAIM2 , SH2B1 , FTO , MC4R , and KCTD15 with Obesity and Type 2 Diabetes in 7705 Chinese","display_name":"Implication of Genetic Variants Near NEGR1 , SEC16B , TMEM18 , ETV5/DGKG , GNPDA2 , LIN7C/BDNF , MTCH2 , BCDIN3D/FAIM2 , SH2B1 , FTO , MC4R , and KCTD15 with Obesity and Type 2 Diabetes in 7705 Chinese","publication_year":2010,"publication_date":"2010-03-09","ids":{"openalex":"https://openalex.org/W2084530852","doi":"https://doi.org/10.1210/jc.2009-2077","mag":"2084530852","pmid":"https://pubmed.ncbi.nlm.nih.gov/20215397"},"language":"he","primary_location":{"id":"doi:10.1210/jc.2009-2077","doi":"https://doi.org/10.1210/jc.2009-2077","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2009-2077","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034303175","display_name":"Maggie C.Y. Ng","orcid":"https://orcid.org/0000-0002-4133-2007","observed_orcids":["https://orcid.org/0000-0002-4133-2007"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["CN","HK","US"],"is_corresponding":false,"raw_author_name":"Maggie C. Y. Ng","raw_affiliation_strings":["Center for Human Genomics (M.C.Y.N.), Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","Department of Pediatrics (M.C.Y.N.), Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","Section on Medical Genetics, Center for Diabetes Research (M.C.Y.N.), Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genomics (M.C.Y.N.), Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]},{"raw_affiliation_string":"Department of Pediatrics (M.C.Y.N.), Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Section on Medical Genetics, Center for Diabetes Research (M.C.Y.N.), Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009105983","display_name":"Claudia H.T. Tam","orcid":"https://orcid.org/0000-0002-9169-0013","observed_orcids":["https://orcid.org/0000-0002-9169-0013"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Claudia H. T. Tam","raw_affiliation_strings":["Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064838541","display_name":"Wing Yee So","orcid":"https://orcid.org/0000-0001-8078-7402","observed_orcids":["https://orcid.org/0000-0001-8078-7402"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Wing Yee So","raw_affiliation_strings":["Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113754705","display_name":"Janice S. K. Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Janice S. K. Ho","raw_affiliation_strings":["Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103462717","display_name":"Alfred W.H. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Alfred W. Chan","raw_affiliation_strings":["Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021394512","display_name":"Heung Man Lee","orcid":"https://orcid.org/0000-0002-5199-1778","observed_orcids":["https://orcid.org/0000-0002-5199-1778"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Heung Man Lee","raw_affiliation_strings":["Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108746587","display_name":"Vincent Kwok Lim Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Vincent K. L. Lam","raw_affiliation_strings":["Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091832416","display_name":"Juliana C.N. Chan","orcid":"https://orcid.org/0000-0003-1325-1194","observed_orcids":["https://orcid.org/0000-0003-1325-1194"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Juliana C. N. Chan","raw_affiliation_strings":["Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","Hong Kong Institute of Diabetes and Obesity (J.C.N.C.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","Li Ka Shing Institute of Health Sciences (J.C.N.C.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]},{"raw_affiliation_string":"Hong Kong Institute of Diabetes and Obesity (J.C.N.C.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]},{"raw_affiliation_string":"Li Ka Shing Institute of Health Sciences (J.C.N.C.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100447655","display_name":"Ronald C.W.","orcid":"https://orcid.org/0000-0002-1227-803X","observed_orcids":["https://orcid.org/0000-0002-1227-803X"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Ronald C. W. Ma","raw_affiliation_strings":["Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics (M.C.Y.N., C.H.T.T., W.Y.S., J.S.K.H., A.W.C., H.M.L., Y.W., V.K.L.L., J.C.N.C., R.C.W.M.), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100447655"],"corresponding_institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":8.4446,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.98393007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"95","issue":"5","first_page":"2418","last_page":"2425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.925000011920929},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6449999809265137},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gnpda2","display_name":"GNPDA2","score":0.7360000014305115},{"id":"https://openalex.org/keywords/sh2b1","display_name":"SH2B1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fto-gene","display_name":"FTO","score":0.996999979019165},{"id":"https://openalex.org/keywords/kctd15","display_name":"KCTD15","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9860000014305115},{"id":"https://openalex.org/keywords/waist-circumference","display_name":"waist circumference","score":0.968999981880188},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.7419999837875366},{"id":"https://openalex.org/keywords/negr1","display_name":"NEGR1","score":0.5389999747276306},{"id":"https://openalex.org/keywords/sec16b","display_name":"SEC16B","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tmem18","display_name":"TMEM18","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mtch2","display_name":"MTCH2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5828993916511536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5353586673736572},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4941714107990265},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.48324283957481384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4728206396102905},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.41328197717666626},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.31924158334732056},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.223942369222641},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1423945128917694},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.09641999006271362},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071516","descriptor_name":"Alpha-Ketoglutarate-Dependent Dioxygenase FTO","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015816","descriptor_name":"Cell Adhesion Molecules, Neuronal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019704","descriptor_name":"Protein Disulfide-Isomerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044105","descriptor_name":"Receptor, Melanocortin, Type 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2009-2077","doi":"https://doi.org/10.1210/jc.2009-2077","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2009-2077","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:20215397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20215397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1572982878","https://openalex.org/W1994014704","https://openalex.org/W2001423848","https://openalex.org/W2003629248","https://openalex.org/W2017158337","https://openalex.org/W2020593578","https://openalex.org/W2022016342","https://openalex.org/W2028335133","https://openalex.org/W2043068094","https://openalex.org/W2055160461","https://openalex.org/W2058032165","https://openalex.org/W2068394933","https://openalex.org/W2076450470","https://openalex.org/W2080341828","https://openalex.org/W2092207134","https://openalex.org/W2092280887","https://openalex.org/W2092640467","https://openalex.org/W2095359724","https://openalex.org/W2097660065","https://openalex.org/W2098161436","https://openalex.org/W2110678911","https://openalex.org/W2126718294","https://openalex.org/W2129150286","https://openalex.org/W2133972493","https://openalex.org/W2140609764","https://openalex.org/W2156789874","https://openalex.org/W2161262764","https://openalex.org/W2161633633","https://openalex.org/W2163144326","https://openalex.org/W2166431807","https://openalex.org/W2169884611"],"related_works":["https://openalex.org/W1479880455","https://openalex.org/W1975882857","https://openalex.org/W3014013325","https://openalex.org/W2017641001","https://openalex.org/W2464875409","https://openalex.org/W2149921190","https://openalex.org/W2104513338","https://openalex.org/W2065812817","https://openalex.org/W2170423840","https://openalex.org/W2245147265"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Recent":[1],"genome-wide":[2],"association":[3],"studies":[4],"have":[5],"identified":[6],"multiple":[7],"novel":[8],"loci":[9,45,80,126,174],"associated":[10,23,40,90,134],"with":[11,24,91,135,184],"obesity":[12,25,107],"in":[13,31,59,119,158,182,210,216,221],"Europeans.":[14],"We":[15,37],"hypothesized":[16],"that":[17],"these":[18],"genetic":[19],"variants":[20],"may":[21],"be":[22],"and":[26,57,66,86,208],"type":[27],"2":[28],"diabetes":[29],"(T2D)":[30],"Chinese.":[32,222],"RESEARCH":[33],"DESIGN":[34],"AND":[35],"METHODS:":[36],"examined":[38],"14":[39],"single-nucleotide":[41],"polymorphisms":[42],"at":[43,78],"12":[44],"(NEGR1,":[46],"SEC16B,":[47],"TMEM18,":[48],"ETV5/DGKG,":[49],"GNPDA2,":[50,82,204],"LIN7C/BDNF,":[51],"MTCH2,":[52],"BCDIN3D/FAIM2,":[53,83,205],"SH2B1,":[54,84,206],"FTO,":[55,85,207],"MC4R,":[56],"KCTD15)":[58],"605":[60],"healthy":[61,64],"adults,":[62],"1087":[63],"adolescents":[65],"6013":[67],"T2D":[68,136,159,219],"patients":[69],"from":[70],"Hong":[71],"Kong.":[72],"RESULTS:":[73],"The":[74,123],"European":[75],"at-risk":[76,189],"alleles":[77],"five":[79,172],"including":[81],"KCTD15":[87,209],"were":[88,131,149],"significantly":[89],"increased":[92],"body":[93],"mass":[94],"index":[95],"(BMI),":[96],"waist":[97],"circumference":[98],"(4.5":[99],"x":[100,113,194],"10(-8)":[101],"<":[102,104,115,117,142,144],"P":[103,116,143],"0.024),":[105],"and/or":[106],"risk":[108,137,160,220],"(odds":[109,138],"ratio":[110,139],"1.14-1.22,":[111],"2.0":[112],"10(-5)":[114],"0.002)":[118],"our":[120],"Chinese":[121],"populations.":[122],"former":[124],"four":[125],"as":[127,129],"well":[128],"LIN7C/BDNF":[130],"also":[132],"modestly":[133],"1.09-1.22,":[140],"0.008":[141],"0.041),":[145],"but":[146],"the":[147,171,200,211],"associations":[148],"lost":[150],"after":[151],"adjustment":[152],"for":[153],"BMI,":[154],"suggesting":[155],"their":[156],"roles":[157],"are":[161],"mediated":[162],"through":[163],"modulation":[164],"of":[165,170,178,188,203,213],"adiposity.":[166],"Joint":[167],"effect":[168],"analyses":[169],"adiposity":[173],"revealed":[175],"an":[176],"increase":[177],"about":[179],"0.29":[180],"kg/m(2)":[181],"BMI":[183],"each":[185],"additional":[186],"copy":[187],"allele":[190],"(P(trend)":[191],"=":[192],"4.2":[193],"10(-12)).":[195],"CONCLUSIONS:":[196],"Our":[197],"findings":[198],"support":[199],"important":[201],"contribution":[202],"regulation":[212],"adiposity,":[214],"which":[215],"turn":[217],"affects":[218]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":16}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
