{"id":"https://openalex.org/W2084480171","doi":"https://doi.org/10.1158/1538-7445.am10-4340","title":"Abstract 4340: Development of short peptide probe to detect ovarian tumors in mouse xenograph model","display_name":"Abstract 4340: Development of short peptide probe to detect ovarian tumors in mouse xenograph model","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2084480171","doi":"https://doi.org/10.1158/1538-7445.am10-4340","mag":"2084480171"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-4340","doi":"https://doi.org/10.1158/1538-7445.am10-4340","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-4340","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048709122","display_name":"Chung-Wein Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446363","display_name":"Purdue University in Indianapolis","ror":"https://ror.org/0482ksk80","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219","https://openalex.org/I4388446363"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung-Wein Lee","raw_affiliation_strings":["1Purdue University, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Purdue University, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446363","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lili Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lili Guo","raw_affiliation_strings":["2Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010543493","display_name":"Keith M. Stantz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith M. Stantz","raw_affiliation_strings":["3Purdue University, School of Health Science, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Purdue University, School of Health Science, Indianapolis, IN","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"4340","last_page":"4340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fsh-receptor","display_name":"FSH receptor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/near-infrared-fluorescence-imaging","display_name":"near-infrared fluorescence imaging","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tumor-detection","display_name":"tumor detection","score":0.6809999942779541},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.8080000281333923},{"id":"https://openalex.org/keywords/ovcar-3-cells","display_name":"OVCAR-3 cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/borderline-ovarian-tumors","display_name":"borderline ovarian tumors","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.72846919298172},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.5718051195144653},{"id":"https://openalex.org/C29390026","wikidata":"https://www.wikidata.org/wiki/Q14904760","display_name":"Follicle-stimulating hormone receptor","level":5,"score":0.5672522187232971},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.5515178442001343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5481732487678528},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5449364185333252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49597105383872986},{"id":"https://openalex.org/C2780084626","wikidata":"https://www.wikidata.org/wiki/Q11793790","display_name":"Ovarian tumor","level":4,"score":0.49471303820610046},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4375855028629303},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.40018633008003235},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37412816286087036},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37133899331092834},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.35141974687576294},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34835284948349},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.265342116355896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-4340","doi":"https://doi.org/10.1158/1538-7445.am10-4340","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-4340","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2616027325","https://openalex.org/W2023975343","https://openalex.org/W2074953588","https://openalex.org/W2373845867","https://openalex.org/W2888256452","https://openalex.org/W2049250232","https://openalex.org/W2347674024","https://openalex.org/W1558696226","https://openalex.org/W2057616978","https://openalex.org/W2781515787"],"abstract_inverted_index":{"Abstract":[0],"Ovarian":[1,18],"cancer":[2,7,20,141,153,374],"is":[3,22,97,115,133,144,187],"the":[4,48,147,168,199,238,245,367,388,404,409],"leading":[5],"gynecological":[6],"in":[8,39,146,167,197,211,251,378,381],"women":[9,33],"with":[10,109,205,214,241,258,291,347,391],"five":[11],"year":[12],"survival":[13],"rate":[14],"less":[15],"than":[16],"45%.":[17],"epithelial":[19,172,178],"(OEC)":[21],"responsible":[23],"for":[24,93,263,412],"80":[25],"to":[26,60,62,68,105,126,175,182,188,195,208,218,243,283,287,300,311,341,349,364,371],"90%":[27],"of":[28,37,45,151,157,202,233,248,279,295,323,403,408],"all":[29],"ovarian":[30,65,70,94,119,140,152,171,177,324,373],"cancers.":[31],"Postmenopausal":[32],"have":[34,78],"high":[35,43],"level":[36],"gonadotropin":[38,76],"blood":[40],"circulation":[41],"and":[42,54,82,85,124,149,162,181,272,314,315,345,354,380],"occurrence":[44],"OEC.":[46],"Therefore,":[47],"elevated":[49],"gonadotropin,":[50],"follicle-stimulating":[51],"hormone":[52,56],"(FSH)":[53],"luteinizing":[55],"(LH),":[57],"was":[58,285,339],"proposed":[59],"contribute":[61],"transforming":[63],"normal":[64,118],"surface":[66,71],"epithelium":[67,123],"neoplastic":[69],"epithelium.":[72],"The":[73,254,277],"studies":[74,129],"on":[75,117,138],"theory":[77],"shown":[79],"both":[80,377],"supporting":[81],"conflicting":[83],"epidemiological":[84],"animal":[86],"model":[87,322],"data.":[88],"Therefore":[89],"an":[90,292],"alternative":[91],"marker":[92],"tumor":[95,179],"detection":[96],"beneficial.":[98],"Follicule":[99],"Stimulating":[100],"Hormone":[101],"Receptor":[102],"(FSHR)":[103],"belongs":[104],"G":[106],"protein-coupled":[107],"receptor":[108],"substantial":[110],"extracellular":[111],"domains.":[112],"FSHR":[113,132,164,203,296],"normally":[114],"expressed":[116,137],"epithelium,":[120],"fallopian":[121],"tubal":[122],"similar":[125],"LHR.":[127],"Recent":[128],"showed":[130],"that":[131],"not":[134],"only":[135],"highly":[136],"many":[139],"cells":[142,250,255],"but":[143],"involved":[145],"development":[148],"progression":[150],"influencing":[154],"a":[155,190,225,305,319],"variety":[156],"oncogenes":[158],"(MAPK,":[159],"EGFR,":[160],"c-myc,":[161],"HER-2/neu).":[163],"expression":[165,201],"increases":[166],"following":[169],"order:":[170],"inclusions":[173],"(OEIs)":[174],"benigh":[176],"(OET),":[180],"borderline":[183],"OETs.":[184],"Our":[185],"objective":[186],"develop":[189],"small":[191],"molecular":[192],"weight":[193],"ligand":[194],"image":[196,209],"vivo":[198,382],"differential":[200],"associated":[204,215],"OEC,":[206],"possibility":[207],"OEC":[210,326],"different":[212],"stages":[213],"binding":[216,231,246,281,370],"molecules":[217],"FSHR.":[219],"D.W.":[220],"Lee":[221],"et.":[222],"al.":[223],"identified":[224],"deca":[226],"peptide":[227,240,313,369,390],"(BI-10)":[228],"from":[229,268],"FSH":[230],"inhibitor":[232],"bovine":[234],"serum.":[235],"We":[236,359],"conjugated":[237],"BI-10":[239,259,280,368,389],"fluorescein":[242],"quantify":[244],"affinity":[247],"OVCAR3":[249,284],"flow":[252],"cytometry.":[253],"were":[256,328],"incubated":[257],"at":[260],"various":[261,372,392],"concentrations":[262],"30":[264],"mins":[265],"before":[266],"removing":[267],"six-well":[269],"culture":[270],"plates":[271],"washing":[273],"off":[274],"free":[275],"peptides.":[276],"EC50":[278],"peptides":[282],"measured":[286,340],"be":[288,301,342],"160":[289],"\u03bcM,":[290],"average":[293],"number":[294],"receptors":[297],"per":[298],"cell":[299,375],"1.7\u00d7107.":[302],"After":[303],"conjugating":[304],"NIR":[306],"fluorochrome":[307],"(Alexa":[308],"Fluoro":[309],"750)":[310],"this":[312],"injection":[316],"(i.v.)":[317],"into":[318],"mouse":[320],"xenograft":[321],"cancer,":[325],"tumors":[327],"clearly":[329],"detected":[330],"by":[331,383],"optical":[332],"imaging.":[333],"A":[334],"tumor-to-reference":[335],"tissue":[336],"update":[337],"ratio":[338],"1.20,":[343],"1.26,":[344],"1.43":[346],"respect":[348],"injected":[350],"dose":[351],"15,":[352],"30,":[353],"120":[355],"\u03bcg":[356],"probe,":[357],"respectively.":[358],"are":[360],"currently":[361],"testing":[362],"techniques":[363],"further":[365],"increase":[366],"lines":[376],"vitro":[379],"constructing":[384],"multimeric":[385],"forms":[386],"including":[387],"flexible":[393],"linkers.":[394],"Citation":[395],"Format:":[396],"{Authors}.":[397],"{Abstract":[398],"title}":[399],"[abstract].":[400],"In:":[401],"Proceedings":[402],"101st":[405],"Annual":[406],"Meeting":[407],"American":[410],"Association":[411],"Cancer":[413,423],"Research;":[414],"2010":[415],"Apr":[416],"17-21;":[417],"Washington,":[418],"DC.":[419],"Philadelphia":[420],"(PA):":[421],"AACR;":[422],"Res":[424],"2010;70(8":[425],"Suppl):Abstract":[426],"nr":[427],"4340.":[428]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
