{"id":"https://openalex.org/W2084469064","doi":"https://doi.org/10.1007/s10637-005-2910-4","title":"Phase I/II trial of pyrazoloacridine and carboplatin in patients with recurrent glioma: A North Central Cancer Treatment Group trial","display_name":"Phase I/II trial of pyrazoloacridine and carboplatin in patients with recurrent glioma: A North Central Cancer Treatment Group trial","publication_year":2005,"publication_date":"2005-08-13","ids":{"openalex":"https://openalex.org/W2084469064","doi":"https://doi.org/10.1007/s10637-005-2910-4","mag":"2084469064","pmid":"https://pubmed.ncbi.nlm.nih.gov/16133802"},"language":"en","primary_location":{"id":"doi:10.1007/s10637-005-2910-4","doi":"https://doi.org/10.1007/s10637-005-2910-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-005-2910-4","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017494786","display_name":"Evanthia Galanis","orcid":"https://orcid.org/0000-0001-8014-786X","observed_orcids":["https://orcid.org/0000-0001-8014-786X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Evanthia Galanis","raw_affiliation_strings":["Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. galanis.evanthia@mayo.edu","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. galanis.evanthia@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034104319","display_name":"Jan C. Buckner","orcid":"https://orcid.org/0000-0002-8688-266X","observed_orcids":["https://orcid.org/0000-0002-8688-266X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan C. Buckner","raw_affiliation_strings":["Division of Medical Oncology, 3915 Sunforest Court, Toledo, OH, 43623","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, 3915 Sunforest Court, Toledo, OH, 43623","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059417970","display_name":"Matthew John Maurer","orcid":"https://orcid.org/0000-0002-1867-0526","observed_orcids":["https://orcid.org/0000-0002-1867-0526"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Maurer","raw_affiliation_strings":["Division of Biostatistics, 3915 Sunforest Court, Toledo, OH, 43623","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, 3915 Sunforest Court, Toledo, OH, 43623","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027416118","display_name":"Joel M. Reid","orcid":"https://orcid.org/0000-0003-2872-3123","observed_orcids":["https://orcid.org/0000-0003-2872-3123"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel M. Reid","raw_affiliation_strings":["Division of Developmental Oncology Research, 3915 Sunforest Court, Toledo, OH, 43623","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Developmental Oncology Research, 3915 Sunforest Court, Toledo, OH, 43623","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110666944","display_name":"Mary J. Kuffel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary J. Kuffel","raw_affiliation_strings":["Division of Developmental Oncology Research, 3915 Sunforest Court, Toledo, OH, 43623","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Developmental Oncology Research, 3915 Sunforest Court, Toledo, OH, 43623","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066722006","display_name":"Matthew M. Ames","orcid":"https://orcid.org/0000-0003-3652-209X","observed_orcids":["https://orcid.org/0000-0003-3652-209X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew M. Ames","raw_affiliation_strings":["Division of Developmental Oncology Research, 3915 Sunforest Court, Toledo, OH, 43623","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Developmental Oncology Research, 3915 Sunforest Court, Toledo, OH, 43623","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110883848","display_name":"Bernd Walter Scheithauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernd W. Scheithauer","raw_affiliation_strings":["Department of Pathology, 3915 Sunforest Court, Toledo, OH, 43623","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, 3915 Sunforest Court, Toledo, OH, 43623","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032829264","display_name":"Julie E. Hammack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie E. Hammack","raw_affiliation_strings":["Department of Neurology, 3915 Sunforest Court, Toledo, OH, 43623","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, 3915 Sunforest Court, Toledo, OH, 43623","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035441527","display_name":"George Pipoly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210145631","display_name":"Hematology Oncology Associates","ror":"https://ror.org/04w3zd882","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210145631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Pipoly","raw_affiliation_strings":["Hematology Oncology Associates, Inc., 3915 Sunforest Court, Toledo, OH, 43623","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Oncology Associates, Inc., 3915 Sunforest Court, Toledo, OH, 43623","institution_ids":["https://openalex.org/I4210145631"]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002406337","display_name":"Steven A. Kuross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210165184","display_name":"Duluth Clinic","ror":"https://ror.org/05qydhq49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I143414431","https://openalex.org/I4210165184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Kuross","raw_affiliation_strings":["Duluth Clinic, 400 E 3rd St, Duluth, MN, 55806","Mayo Clinic, 200 First Street SW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duluth Clinic, 400 E 3rd St, Duluth, MN, 55806","institution_ids":["https://openalex.org/I4210165184"]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017494786"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":0.744,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.77228226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"23","issue":"5","first_page":"495","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.921999990940094},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acridine-derivatives","display_name":"acridine derivatives","score":0.7929999828338623},{"id":"https://openalex.org/keywords/platinum-complexes","display_name":"platinum complexes","score":0.7689999938011169},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9300000071525574},{"id":"https://openalex.org/keywords/enzyme-inducing-anticonvulsants","display_name":"enzyme-inducing anticonvulsants","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cytochrome-p450-induction","display_name":"cytochrome P450 induction","score":0.8199999928474426},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.8939999938011169},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7689999938011169},{"id":"https://openalex.org/keywords/north-central-cancer-treatment-group","display_name":"North Central Cancer Treatment Group","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.8394030332565308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6649829745292664},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6166761517524719},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5205144286155701},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5043867826461792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47144806385040283},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4638040065765381},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44141456484794617},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33117637038230896},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.17731142044067383},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08452054858207703}],"mesh":[{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10637-005-2910-4","doi":"https://doi.org/10.1007/s10637-005-2910-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-005-2910-4","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmid:16133802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16133802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W153301735","https://openalex.org/W1854349143","https://openalex.org/W1859693964","https://openalex.org/W1944104521","https://openalex.org/W1971320685","https://openalex.org/W1973710560","https://openalex.org/W1974210709","https://openalex.org/W2013981808","https://openalex.org/W2023949269","https://openalex.org/W2033028450","https://openalex.org/W2040069987","https://openalex.org/W2041704656","https://openalex.org/W2049320179","https://openalex.org/W2064542358","https://openalex.org/W2066179265","https://openalex.org/W2100968876","https://openalex.org/W2115783041","https://openalex.org/W2124196428","https://openalex.org/W2126355799","https://openalex.org/W2133305860","https://openalex.org/W2142479962","https://openalex.org/W2148433070","https://openalex.org/W2150405359","https://openalex.org/W2184796981","https://openalex.org/W4255992270"],"related_works":["https://openalex.org/W2064542358","https://openalex.org/W178060685","https://openalex.org/W2129244123","https://openalex.org/W1944104521","https://openalex.org/W1972053246","https://openalex.org/W153301735","https://openalex.org/W203170556","https://openalex.org/W2030410367","https://openalex.org/W2026408579","https://openalex.org/W251277906"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}