{"id":"https://openalex.org/W2084376227","doi":"https://doi.org/10.1016/s0021-9150(00)80737-6","title":"Gene regulation by hypoxia","display_name":"Gene regulation by hypoxia","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2084376227","doi":"https://doi.org/10.1016/s0021-9150(00)80737-6","mag":"2084376227"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9150(00)80737-6","doi":"https://doi.org/10.1016/s0021-9150(00)80737-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0021-9150(00)80737-6","pdf_url":null,"source":{"id":"https://openalex.org/S206830620","display_name":"Atherosclerosis","issn_l":"0021-9150","issn":["0021-9150","1879-1484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023595055","display_name":"Christopher William Pugh","orcid":"https://orcid.org/0000-0002-5170-1662","observed_orcids":["https://orcid.org/0000-0002-5170-1662"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Pugh","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G.-W. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G.-W. Chang","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071215602","display_name":"Steven C. Clifford","orcid":"https://orcid.org/0000-0003-4893-2184","observed_orcids":["https://orcid.org/0000-0003-4893-2184"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Clifford","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069383807","display_name":"Matthew E. Cockman","orcid":"https://orcid.org/0000-0002-3310-4821","observed_orcids":["https://orcid.org/0000-0002-3310-4821"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Cockman","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109425769","display_name":"Anthony Epstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Epstein","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157741641","display_name":"P Jaakkola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Jaakkolla","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063108567","display_name":"Norma Masson","orcid":"https://orcid.org/0000-0002-9714-905X","observed_orcids":["https://orcid.org/0000-0002-9714-905X"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Masson","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036848232","display_name":"Patrick Henry Maxwell","orcid":"https://orcid.org/0000-0002-0338-2679","observed_orcids":["https://orcid.org/0000-0002-0338-2679"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Maxwell","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032440666","display_name":"Damian J. Mole","orcid":"https://orcid.org/0000-0001-6884-7302","observed_orcids":["https://orcid.org/0000-0001-6884-7302"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Mole","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064727417","display_name":"Peter John Ratcliffe","orcid":"https://orcid.org/0000-0002-2853-806X","observed_orcids":["https://orcid.org/0000-0002-2853-806X"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Ratcliffe","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108428244","display_name":"Ya Tian","orcid":"https://orcid.org/0009-0005-1067-2489","observed_orcids":["https://orcid.org/0009-0005-1067-2489"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Y.-M. Tian","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055590266","display_name":"Emma C. Vaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. Vaux","raw_affiliation_strings":["The Wellcome Trust Centre for Human Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome Trust Centre for Human Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.15222108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"151","issue":"1","first_page":"162","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.40630000829696655,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.40630000829696655,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.1339000016450882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.8044911026954651},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32434844970703125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29074913263320923},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.07996591925621033},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0021-9150(00)80737-6","doi":"https://doi.org/10.1016/s0021-9150(00)80737-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0021-9150(00)80737-6","pdf_url":null,"source":{"id":"https://openalex.org/S206830620","display_name":"Atherosclerosis","issn_l":"0021-9150","issn":["0021-9150","1879-1484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2887470126","https://openalex.org/W2574957594","https://openalex.org/W1965398042","https://openalex.org/W86983734","https://openalex.org/W4237601601","https://openalex.org/W1984566720","https://openalex.org/W2397342700","https://openalex.org/W2401400851","https://openalex.org/W4243742176","https://openalex.org/W2052597567"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
